Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	K	L	T	L	Q	E	Q	L	L	K	A	G	L	V	T	S	K	K	A	A	K	V	E	R	T	A	K	K	S	R	V	Q	A	R	E	A	R	A	A	V	E	E	N	K	K	A	Q	L	E	R	D	K	Q	L	S	E	Q	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?											?										?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	Q	A	A	L	A	K	E	Y	K	A	Q	V	K	Q	L	I	E	M	N	R	I	T	I	A	N	G	D	I	G	F	N	F	T	D	G	N	L	I	K	K	I	F	V	D	K	L	T	Q	A	Q	L	I	N	G	R	L	A	I	A
Secondary structure
SS confidence
Disorder												?										?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.
Sequence		R	L	L	V	D	N	N	S	E	G	E	Y	A	I	I	P	A	S	V	A	D	K	I	A	Q	R	D	A	S	S	I	V	L	H	S	A	L	S	A	E	E	Q	D	E	D	D	P	Y	A	D	F	K	V	P	D	D	L	M	W
Secondary structure
SS confidence
Disorder					?		?	?	?																													?	?	?	?	?	?	?	?	?											?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2l0c chain A Region: 88 - 134 Aligned: 41 Modelled: 47 Confidence: 28.2% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative membrane protein; PDBTitle: solution nmr structure of protein sty4237 (residues 36-120) from2 salmonella enterica, northeast structural genomics consortium target3 slr115 Phyre2 PDB 3ep1 chain B Region: 72 - 97 Aligned: 26 Modelled: 26 Confidence: 20.9% Identity: 23% PDB header:immune system Chain: B: PDB Molecule:pgrp-hd - peptidoglycan recognition protein PDBTitle: structure of the pgrp-hd from alvinella pompejana Phyre2 PDB 3ky8 chain B Region: 5 - 18 Aligned: 14 Modelled: 14 Confidence: 18.0% Identity: 21% PDB header:biosynthetic protein Chain: B: PDB Molecule:putative riboflavin biosynthesis protein; PDBTitle: crystal structure of putative riboflavin biosynthesis protein2 (yp_001092907.1) from shewanella sp. pv-4 at 2.12 a resolution Phyre2 PDB 3jtw chain B Region: 5 - 18 Aligned: 14 Modelled: 14 Confidence: 17.7% Identity: 21% PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_805003.1)2 from pediococcus pentosaceus atcc 25745 at 1.90 a resolution Phyre2 PDB 2gd9 chain A Region: 5 - 18 Aligned: 14 Modelled: 14 Confidence: 15.9% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein yyap; PDBTitle: crystal structure of a putative dihydrofolate reductase (bsu40760,2 yyap) from bacillus subtilis at 2.30 a resolution Phyre2 PDB 3kgy chain A Region: 5 - 18 Aligned: 14 Modelled: 14 Confidence: 15.1% Identity: 36% PDB header:oxidoreductase Chain: A: PDB Molecule:bifunctional deaminase-reductase domain protein; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_001636057.1)2 from chloroflexus aurantiacus j-10-fl at 1.50 a resolution Phyre2 PDB 2xw7 chain A Region: 5 - 18 Aligned: 14 Modelled: 14 Confidence: 14.2% Identity: 21% PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: structure of mycobacterium smegmatis putative reductase ms0308 Phyre2 PDB 2xz8 chain A Region: 71 - 97 Aligned: 27 Modelled: 27 Confidence: 13.4% Identity: 22% PDB header:immune system Chain: A: PDB Molecule:peptidoglycan-recognition protein lf; PDBTitle: crystal structure of the lfw ectodomain of the2 peptidoglycan recognition protein lf Phyre2 PDB 1sxr chain A Region: 71 - 97 Aligned: 27 Modelled: 27 Confidence: 10.3% Identity: 22% Fold: N-acetylmuramoyl-L-alanine amidase-like Superfamily: N-acetylmuramoyl-L-alanine amidase-like Family: N-acetylmuramoyl-L-alanine amidase-like Phyre2 PDB 1d1g chain A Region: 5 - 18 Aligned: 14 Modelled: 14 Confidence: 10.1% Identity: 29% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: Dihydrofolate reductases Phyre2 PDB 3hls chain E Region: 132 - 143 Aligned: 12 Modelled: 12 Confidence: 9.9% Identity: 42% PDB header:signaling protein Chain: E: PDB Molecule:guanylate cyclase soluble subunit beta-1; PDBTitle: crystal structure of the signaling helix coiled-coil doimain2 of the beta-1 subunit of the soluble guanylyl cyclase Phyre2 PDB 2b3z chain A domain 1 Region: 5 - 18 Aligned: 14 Modelled: 14 Confidence: 9.5% Identity: 14% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: RibD C-terminal domain-like Phyre2 PDB 2d28 chain C domain 1 Region: 1 - 31 Aligned: 31 Modelled: 31 Confidence: 9.3% Identity: 13% Fold: Alpha-lytic protease prodomain-like Superfamily: EspE N-terminal domain-like Family: GSPII protein E N-terminal domain-like Phyre2 PDB 2v5i chain A Region: 88 - 99 Aligned: 12 Modelled: 12 Confidence: 9.0% Identity: 58% PDB header:viral protein Chain: A: PDB Molecule:salmonella typhimurium db7155 bacteriophage det7 PDBTitle: structure of the receptor-binding protein of bacteriophage2 det7: a podoviral tailspike in a myovirus Phyre2 PDB 3iyj chain E Region: 157 - 171 Aligned: 15 Modelled: 15 Confidence: 8.9% Identity: 40% PDB header:virus Chain: E: PDB Molecule:major capsid protein l1; PDBTitle: bovine papillomavirus type 1 outer capsid Phyre2 PDB 2azn chain A domain 1 Region: 5 - 18 Aligned: 14 Modelled: 14 Confidence: 8.7% Identity: 43% Fold: Dihydrofolate reductase-like Superfamily: Dihydrofolate reductase-like Family: RibD C-terminal domain-like Phyre2 PDB 1s2j chain A Region: 71 - 97 Aligned: 27 Modelled: 27 Confidence: 8.3% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:peptidoglycan recognition protein sa cg11709-pa; PDBTitle: crystal structure of the drosophila pattern-recognition2 receptor pgrp-sa Phyre2 PDB 3op0 chain B Region: 89 - 136 Aligned: 36 Modelled: 48 Confidence: 8.2% Identity: 25% PDB header:signaling protein/signaling protein regu Chain: B: PDB Molecule:signal transduction protein cbl-c; PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide Phyre2 PDB 2p4g chain A Region: 5 - 18 Aligned: 14 Modelled: 14 Confidence: 8.2% Identity: 29% PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a pyrimidine reductase-like protein (dip1392)2 from corynebacterium diphtheriae nctc at 2.30 a resolution Phyre2 PDB 1hk9 chain A Region: 5 - 13 Aligned: 9 Modelled: 9 Confidence: 8.0% Identity: 44% Fold: Sm-like fold Superfamily: Sm-like ribonucleoproteins Family: Pleiotropic translational regulator Hfq Phyre2 1 c2l0cA_ 2 c3ep1B_ 3 c3ky8B_ 4 c3jtwB_ 5 c2gd9A_ 6 c3kgyA_ 7 c2xw7A_ 8 c2xz8A_ 9 d1sxra_ 10 d1d1ga_ 11 c3hlsE_ 12 d2b3za1 13 d2d28c1 14 c2v5iA_ 15 c3iyjE_ 16 d2azna1 17 c1s2jA_ 18 c3op0B_ 19 c2p4gA_ 20 d1hk9a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2l0cA_ 28.2 17 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative membrane protein; PDBTitle: solution nmr structure of protein sty4237 (residues 36-120) from2 salmonella enterica, northeast structural genomics consortium target3 slr115 2 c3ep1B_ 20.9 23 PDB header:immune system Chain: B: PDB Molecule:pgrp-hd - peptidoglycan recognition protein PDBTitle: structure of the pgrp-hd from alvinella pompejana 3 c3ky8B_ 18.0 21 PDB header:biosynthetic protein Chain: B: PDB Molecule:putative riboflavin biosynthesis protein; PDBTitle: crystal structure of putative riboflavin biosynthesis protein2 (yp_001092907.1) from shewanella sp. pv-4 at 2.12 a resolution 4 c3jtwB_ 17.7 21 PDB header:oxidoreductase Chain: B: PDB Molecule:dihydrofolate reductase; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_805003.1)2 from pediococcus pentosaceus atcc 25745 at 1.90 a resolution 5 c2gd9A_ 15.9 29 PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein yyap; PDBTitle: crystal structure of a putative dihydrofolate reductase (bsu40760,2 yyap) from bacillus subtilis at 2.30 a resolution 6 c3kgyA_ 15.1 36 PDB header:oxidoreductase Chain: A: PDB Molecule:bifunctional deaminase-reductase domain protein; PDBTitle: crystal structure of putative dihydrofolate reductase (yp_001636057.1)2 from chloroflexus aurantiacus j-10-fl at 1.50 a resolution 7 c2xw7A_ 14.2 21 PDB header:oxidoreductase Chain: A: PDB Molecule:dihydrofolate reductase; PDBTitle: structure of mycobacterium smegmatis putative reductase ms0308 8 c2xz8A_ 13.4 22 PDB header:immune system Chain: A: PDB Molecule:peptidoglycan-recognition protein lf; PDBTitle: crystal structure of the lfw ectodomain of the2 peptidoglycan recognition protein lf 9 d1sxra_ 10.3 22 Fold:N-acetylmuramoyl-L-alanine amidase-like Superfamily:N-acetylmuramoyl-L-alanine amidase-like Family:N-acetylmuramoyl-L-alanine amidase-like 10 d1d1ga_ 10.1 29 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:Dihydrofolate reductases 11 c3hlsE_ 9.9 42 PDB header:signaling protein Chain: E: PDB Molecule:guanylate cyclase soluble subunit beta-1; PDBTitle: crystal structure of the signaling helix coiled-coil doimain2 of the beta-1 subunit of the soluble guanylyl cyclase 12 d2b3za1 9.5 14 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like 13 d2d28c1 9.3 13 Fold:Alpha-lytic protease prodomain-like Superfamily:EspE N-terminal domain-like Family:GSPII protein E N-terminal domain-like 14 c2v5iA_ 9.0 58 PDB header:viral protein Chain: A: PDB Molecule:salmonella typhimurium db7155 bacteriophage det7 PDBTitle: structure of the receptor-binding protein of bacteriophage2 det7: a podoviral tailspike in a myovirus 15 c3iyjE_ 8.9 40 PDB header:virus Chain: E: PDB Molecule:major capsid protein l1; PDBTitle: bovine papillomavirus type 1 outer capsid 16 d2azna1 8.7 43 Fold:Dihydrofolate reductase-like Superfamily:Dihydrofolate reductase-like Family:RibD C-terminal domain-like 17 c1s2jA_ 8.3 22 PDB header:hydrolase Chain: A: PDB Molecule:peptidoglycan recognition protein sa cg11709-pa; PDBTitle: crystal structure of the drosophila pattern-recognition2 receptor pgrp-sa 18 c3op0B_ 8.2 25 PDB header:signaling protein/signaling protein regu Chain: B: PDB Molecule:signal transduction protein cbl-c; PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide 19 c2p4gA_ 8.2 29 PDB header:oxidoreductase Chain: A: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of a pyrimidine reductase-like protein (dip1392)2 from corynebacterium diphtheriae nctc at 2.30 a resolution 20 d1hk9a_ 8.0 44 Fold:Sm-like fold Superfamily:Sm-like ribonucleoproteins Family:Pleiotropic translational regulator Hfq 21 c2o7pA_ not modelled 8.0 57 PDB header:hydrolase, oxidoreductase Chain: A: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: the crystal structure of ribd from escherichia coli in complex with2 the oxidised nadp+ cofactor in the active site of the reductase3 domain 22 d1vr0a1 not modelled 7.8 17 Fold:ComB-like Superfamily:ComB-like Family:ComB-like 23 c2zxeG_ not modelled 7.8 33 PDB header:hydrolase/transport protein Chain: G: PDB Molecule:phospholemman-like protein; PDBTitle: crystal structure of the sodium - potassium pump in the e2.2k+.pi2 state 24 c2zy3A_ not modelled 7.7 16 PDB header:lyase Chain: A: PDB Molecule:l-aspartate beta-decarboxylase; PDBTitle: dodecameric l-aspartate beta-decarboxylase 25 d2p4pa1 not modelled 7.1 21 Fold:FAD-binding/transporter-associated domain-like Superfamily:FAD-binding/transporter-associated domain-like Family:CorC/HlyC domain-like 26 c3ol0C_ not modelled 7.1 18 PDB header:de novo protein Chain: C: PDB Molecule:de novo designed monomer trefoil-fold sub-domain which PDBTitle: crystal structure of monofoil-4p homo-trimer: de novo designed monomer2 trefoil-fold sub-domain which forms homo-trimer assembly 27 d1zhva1 not modelled 6.9 48 Fold:Ferredoxin-like Superfamily:ACT-like Family:Atu0741-like 28 c2d5nB_ not modelled 6.1 14 PDB header:hydrolase, oxidoreductase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: crystal structure of a bifunctional deaminase and reductase2 involved in riboflavin biosynthesis 29 d1z7ga1 not modelled 5.7 21 Fold:PRTase-like Superfamily:PRTase-like Family:Phosphoribosyltransferases (PRTases) 30 d1u1sa1 not modelled 5.5 33 Fold:Sm-like fold Superfamily:Sm-like ribonucleoproteins Family:Pleiotropic translational regulator Hfq 31 d1dzla_ not modelled 5.4 13 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Group I dsDNA viruses Family:Papovaviridae-like VP 32 c1dzlA_ not modelled 5.4 13 PDB header:virus Chain: A: PDB Molecule:late major capsid protein l1; PDBTitle: l1 protein of human papillomavirus 16 33 d1tzpa_ not modelled 5.2 25 Fold:Hedgehog/DD-peptidase Superfamily:Hedgehog/DD-peptidase Family:MepA-like 34 c3dsoA_ not modelled 5.2 25 PDB header:metal binding protein Chain: A: PDB Molecule:putative uncharacterized protein copk; PDBTitle: crystal structure of cu(i) bound copper resistance protein copk

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0