|   |
233 | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | |
|
|
|
. | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  | . | . | . | . |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
Q | P | K | S | L | F | K | M | I | K | N | T | F | E | T | T | P | D | H | V | L | S | A | Y | K | D | N | A | A | V | M | E | G | S | E | V | G | R | Y | F | A | D | H | E | T | G | R | Y | D | F | H | Q | E | P | A | H | I | L | M | K | . |
. |
. |
. |
V | E | T | H | N | H | P | T | A | I | S | P | W | P | G | A |
Query Conservation |   |
  |   |   |   |
|   |   |   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|
| . | . | . | . |   |
|
|
|
|
|
|
|
|
|
|
|
|   |
|
|
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
|
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |
| . | . | . | . | . | . | . |
|
|
|
|
|   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |
|
|   |
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|
Template Sequence |   |
G | E | F | G | L | I | D | L | I | K | K | T | L | E | S | K | V | I | . |
. |
. |
. |
. |
. |
. |
D | D | T | A | P | V | E | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
K | L | L | L | T | T | D | V | L | N | E | G | V | H | F | L | R | S | Y | I | P | E | A | V | G |
Template Known Secondary structure |   |
|  |  |  |  |  |  |  |  |  |  |  |  | T |
| T | T |
| . | . | . | . | . | . | . |
|
| B |
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|  |  |  |  |  |  |  |  |  | B | T | T | T | B |
| T | T | S |
|  |  |  |  |  |
Template Predicted Secondary structure |   |
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|  |  |  |  |  | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
7 | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | |
|
|
|
|
|
|
. | . | . | . | . | 30 | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . |
  |
  |   |
309 | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|  |  |  |
|
|  |  |
|
|
|
|
|  |  |  |  |  |
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|  |  |  |
|
|
|  |  |
|
|  |  |
|
|
|  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
A | T | G | S | G | G | E | I | R | D | E | G | A | T | G | R | G | A | K | P | K | A | G | L | V | G | F | S | V | S | N | L | R | I | P | G | F | E | Q | P | W | E | E | D | F | G | K | P | E | R | I | V | T | A | L | D | I | M | T | E | G | P | L | G | G | A | A | F | N | N | E | F | G | R | P | A | L | N | G | Y |
Query Conservation |   |
|
|
|
|
|
|
|
|
|
|
|   |   |   |
|   |
|
|
|
|
|
|   |   |   |   |   |   |
|
|   |
|   |   |   |   |   |   |   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |
|
|
|   |
|
|
|   |   |
|
|
|
|
|   |
|   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |
|
|   |   |   |   |
|
|
|   |
|   |
| . | . |
|   |
|   |   |   |   |   |   |
|   |   |
|   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |
|   |   |
|   |   |
|
|   |   |   |   |   |   |   |
|
|   |
|
|
|
|
|
Template Sequence |   |
W | K | A | I | S | V | N | V | S | D | V | I | A | N | G | . |
. |
G | L | P | K | W | A | L | I | S | L | N | L | P | E | D | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
L | E | V | S | Y | V | E | R | F | Y | I | G | V | K | R | A | C | E | F | Y | K | C | E | V | V | G | G | N |
Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  | T | T | T | . | . |  |  |  |  |  |  |  |  |  |  |  |  |
| T | T | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
|  |  |  |  |
|
|
Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |  |
| . | . |
|  |  |  |  |  |  |  |  |  |  |
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
62 | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | |
|
. | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . |
  |
  |   |
389 | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
F | R | T | Y | E | E | K | V | N | S | H | N | G | E | E | L | R | G | Y | H | K | P | I | M | L | A | G | G | I | G | N | I | R | A | D | H | V | Q | K | G | E | I | N | V | G | A | K | L | V | V | L | G | G | P | A | M | N | I | G | L | G | G | G | A | A | S | S | M | A | S | G | Q | S | D | A | D | L | D | F | A |
Query Conservation |   |
  |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|
|
|
|   |   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |
|
|   |
|
|
|   |
|
|
|
|
|
|
|
|
|
|   |
|
|   |   |   |   |   |   |
|   |   |   |   |   |   |
Alig confidence |   |
| . |
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
Template Conservation |   |
| . |   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |
|   |
|
|   |
|
|   |   |   | . |   |   |
|   |   |   |   |
|   |   |
|
|   |
|
|
| . | . | . | . |
|
|   |   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   | . | . | . |
Template Sequence |   |
I | . |
S | K | S | E | K | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
I | G | I | S | V | F | L | V | G | E | T | E | . |
R | F | V | G | R | D | G | A | R | L | G | D | S | V | F | V | . |
. |
. |
. |
S | G | T | L | G | D | S | R | A | G | L | E | L | L | L | X | E | K | E | E | Y | E | P | . |
. |
. |
Template Known Secondary structure |   |
 | . |  |  |
| S | S | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|  |  |  |  |  |  |  |  |  |  | S | . | S |
|
|
| S | S |
|
|
| T | T |
|  |  |  |  | . | . | . | . |
| S |
| S | S |  |  |  |  |  |  |  |  |  |  | T | T |
| S | S |
|
|  | . | . | . |
Template Predicted Secondary structure |   |
| . |
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  | . | . | . | . |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
| . | . | . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
120 | |
. | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | 130 | . | . | . | . | . | . | . | |
. | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | |
|
|
|
. | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | |
|
|
  |
  |   |
469 | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | |
|
|
|
. | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | . | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | |
|
|
|
|
|
|
|
. |
Predicted Secondary structure |   |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . | . |
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
| . | . | . | . | . | . | . | . |
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
|
Query Sequence |   |
S | V | Q | R | D | N | P | E | M | E | R | R | C | Q | E | V | I | D | R | C | W | Q | L | G | D | . |
. |
. |
. |
A | N | P | I | L | F | I | H | D | V | G | A | G | G | L | S | N | A | M | P | E | L | V | S | D | G | G | R | G | G | K | F | E | L | R | E | I | L | S | D | E | P | . |
. |
. |
. |
. |
. |
. |
. |
G |
Query Conservation |   |
|
|
|   |
|
|
|   |   |
|
|
|
|   |   |
|
|   |   |   |
|
|   |   |   | . | . | . | . |   |   |   |
|   |   |
|   |
|   |
|
|
|
|
|
|   |
|   |   |
|
|
|   |   |   |
|   |
|   |   |
|   |
|
|   |
|
|   |
|   |   | . | . | . | . | . | . | . | . |
|
Alig confidence |   |
. | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . |
|
Template Conservation |   |
. | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|
| . |
|
|   |   |   |
|   |
|
|
|   |   |
|   |   |
|   |   |
|   |   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
. |
. |
. |
. |
. |
. |
. |
F | E | L | A | L | I | Q | R | H | L | R | P | T | A | R | I | D | Y | V | K | H | I | Q | K | Y | A | N | A | S | X | D | I | S | D | . |
G | L | V | A | D | A | N | H | L | A | Q | R | S | G | V | K | I | E | I | L | S | E | K | L | P | L | S | N | E | L | K | X | Y | C | E | K | Y | G |
Template Known Secondary structure |   |
. | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  | S |
|
|
|
| G | G | G |  |  |  |  |  |  |  |
| S |  |  |  |  |  |
| S | . |
|  |  |  |  |  |  |  |  |  |  |  | T | T |
|  |  |  |  |
| G | G | G | S |
|
|
|  |  |  |  |  |  |  |  |  | T | T |
Template Predicted Secondary structure |   |
. | . | . | . | . | . | . |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
| . |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
|
|
|
|
|
|
|
177 | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | |
. | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . |
  |
  |   |
537 | . | . | 540 | . | . | . | . | . | . | . | . | . | |
550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . | . | . | 570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |
|
| . |
|  |  |  |  |  |
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |
|
|
|
|
|  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
M | S | P | L | E | I | W | C | N | E | S | Q | E | . |
R | Y | V | L | A | V | A | A | D | Q | L | P | L | F | D | E | L | C | K | R | E | R | A | P | Y | A | V | I | G | E | A | T | E | E | L | H | L | S | L | H | D | R | H | F | D | N | Q | P |
Query Conservation |   |
|   |
|   |
|
|   |   |
|
|
|
|
| . |
|
|   |
|   |
|   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |
|
|
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |
|
|   |   |   |   |
|
|   |   |
|   |   |
|   |   |   |   |   | . | . | . | . | . | . | . | . |
|   |   |   |   |
|
|   |
|   |   |
|   |
|
|   |
| . | . |   |
|   |   |
|   |
|
Template Sequence |   |
K | N | P | I | E | Y | A | L | F | G | G | E | D | Y | Q | L | L | F | T | H | P | K | E | R | W | N | P | F | . |
. |
. |
. |
. |
. |
. |
. |
L | D | X | T | E | I | G | R | V | E | E | G | E | G | V | F | V | . |
. |
D | G | K | K | V | E | P |
Template Known Secondary structure |   |
|
|  |  |  |  |  |  | S |
|
|
|
|
|  |  |  |  |  |  |
| G | G | G |
|
| S | S | . | . | . | . | . | . | . | . | S |
|
|  |  |  |  |  |  |  | S | S | S |
|  |  |  | . | . | T | T |  |  |
|
|
|
Template Predicted Secondary structure |   |
|
|  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |
|  |  |  |  |  |
|
| . | . | . | . | . | . | . | . |
|
|
|  |  |  |  |  |  |  |
|
|
|
|  |  |  | . | . |
|
|  |  |
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
249 | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | |
|
|
|
|
|
|
|
. | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | |
|
. | . | . | . | . | . | 300 |
  |