Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	I	L	G	L	G	T	D	I	V	E	I	A	R	I	E	A	V	I	A	R	S	G	D	R	L	A	R	R	V	L	S	D	N	E	W	A	I	W	K	T	H	H	Q	P	V	R	F	L	A	K	R	F	A	V	K	E	A	A
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	K	A	F	G	T	G	I	R	N	G	L	A	F	N	Q	F	E	V	F	N	D	E	L	G	K	P	R	L	R	L	W	G	E	A	L	K	L	A	E	K	L	G	V	A	N	M	H	V	T	L	A	D	E	R	H	Y	A	C	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.
Sequence		T	V	I	I	E	S
Secondary structure
SS confidence
Disorder						?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3h88 chain A Region: 3 - 125 Aligned: 123 Modelled: 123 Confidence: 100.0% Identity: 56% PDB header:transferase Chain: A: PDB Molecule:holo-[acyl-carrier-protein] synthase; PDBTitle: crystal structure of 4'-phosphopantetheinyl transferase acps from2 vibrio cholerae o1 biovar eltor Phyre2 PDB 2jbz chain A Region: 1 - 125 Aligned: 122 Modelled: 125 Confidence: 100.0% Identity: 40% PDB header:transferase Chain: A: PDB Molecule:holo-[acyl-carrier-protein] synthase; PDBTitle: crystal structure of the streptomyces coelicolor holo-2 [acyl-carrier-protein] synthase (acps) in complex with3 coenzyme a at 1.6 a Phyre2 PDB 2qg8 chain A Region: 3 - 124 Aligned: 120 Modelled: 121 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:acyl carrier protein synthase py06285; PDBTitle: plasmodium yoelii acyl carrier protein synthase py06285 with adp bound Phyre2 PDB 1fth chain A Region: 2 - 125 Aligned: 113 Modelled: 123 Confidence: 100.0% Identity: 35% Fold: 4'-phosphopantetheinyl transferase Superfamily: 4'-phosphopantetheinyl transferase Family: Holo-(acyl carrier protein) synthase ACPS Phyre2 PDB 3ne9 chain B Region: 3 - 125 Aligned: 122 Modelled: 121 Confidence: 100.0% Identity: 29% PDB header:transferase Chain: B: PDB Molecule:phosphopantethiene protein transferase, ppt1p; PDBTitle: mycobacterium tuberculosis acyl carrier protein synthase adopts two2 different structural conformations: ph driven conformational changes3 of acps enzyme Phyre2 PDB 3hqj chain A Region: 3 - 126 Aligned: 109 Modelled: 115 Confidence: 100.0% Identity: 34% PDB header:transferase Chain: A: PDB Molecule:holo-[acyl-carrier-protein] synthase; PDBTitle: structure-function analysis of mycobacterium tuberculosis2 acyl carrier protein synthase (acps). Phyre2 PDB 1f7l chain A Region: 3 - 125 Aligned: 114 Modelled: 115 Confidence: 100.0% Identity: 43% Fold: 4'-phosphopantetheinyl transferase Superfamily: 4'-phosphopantetheinyl transferase Family: Holo-(acyl carrier protein) synthase ACPS Phyre2 PDB 2was chain A Region: 5 - 125 Aligned: 111 Modelled: 121 Confidence: 100.0% Identity: 28% PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase; PDBTitle: structure of the fungal type i fas ppt domain Phyre2 PDB 3hyk chain B Region: 2 - 126 Aligned: 111 Modelled: 124 Confidence: 100.0% Identity: 41% PDB header:transferase Chain: B: PDB Molecule:holo-[acyl-carrier-protein] synthase; PDBTitle: 2.31 angstrom resolution crystal structure of a holo-(acyl-carrier-2 protein) synthase from bacillus anthracis str. ames in complex with3 coa (3',5'-adp) Phyre2 PDB 3f09 chain B Region: 2 - 125 Aligned: 105 Modelled: 118 Confidence: 100.0% Identity: 42% PDB header:transferase Chain: B: PDB Molecule:holo-[acyl-carrier-protein] synthase; PDBTitle: 1.82 angstrom resolution crystal structure of holo-(acyl-carrier-2 protein) synthase (acps) from staphylococcus aureus Phyre2 PDB 1qr0 chain A domain 2 Region: 6 - 123 Aligned: 101 Modelled: 118 Confidence: 99.7% Identity: 22% Fold: 4'-phosphopantetheinyl transferase Superfamily: 4'-phosphopantetheinyl transferase Family: 4'-Phosphopantetheinyl transferase SFP Phyre2 PDB 1qr0 chain A Region: 6 - 123 Aligned: 100 Modelled: 118 Confidence: 99.6% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:4'-phosphopantetheinyl transferase sfp; PDBTitle: crystal structure of the 4'-phosphopantetheinyl transferase sfp-2 coenzyme a complex Phyre2 PDB 2cg5 chain A Region: 6 - 123 Aligned: 117 Modelled: 118 Confidence: 99.5% Identity: 16% PDB header:transferase/hydrolase Chain: A: PDB Molecule:l-aminoadipate-semialdehyde dehydrogenase- PDBTitle: structure of aminoadipate-semialdehyde dehydrogenase-2 phosphopantetheinyl transferase in complex with cytosolic3 acyl carrier protein and coenzyme a Phyre2 PDB 1qr0 chain A domain 1 Region: 28 - 119 Aligned: 74 Modelled: 92 Confidence: 98.3% Identity: 14% Fold: 4'-phosphopantetheinyl transferase Superfamily: 4'-phosphopantetheinyl transferase Family: 4'-Phosphopantetheinyl transferase SFP Phyre2 PDB 2im5 chain C Region: 32 - 97 Aligned: 54 Modelled: 66 Confidence: 29.0% Identity: 15% PDB header:transferase Chain: C: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of nicotinate phosphoribosyltransferase2 from porphyromonas gingivalis Phyre2 PDB 3frw chain F Region: 25 - 50 Aligned: 26 Modelled: 24 Confidence: 17.6% Identity: 15% PDB header:structural genomics, unknown function Chain: F: PDB Molecule:putative trp repressor protein; PDBTitle: crystal structure of putative trpr protein from ruminococcus obeum Phyre2 PDB 2z0r chain A Region: 54 - 66 Aligned: 13 Modelled: 12 Confidence: 15.6% Identity: 46% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha0547; PDBTitle: crystal structure of hypothetical protein ttha0547 Phyre2 PDB 2knj chain A Region: 28 - 42 Aligned: 15 Modelled: 15 Confidence: 15.3% Identity: 0% PDB header:antimicrobial protein Chain: A: PDB Molecule:microplusin preprotein; PDBTitle: nmr structure of microplusin a antimicrobial peptide from2 rhipicephalus (boophilus) microplus Phyre2 PDB 3kor chain D Region: 25 - 52 Aligned: 28 Modelled: 26 Confidence: 12.9% Identity: 11% PDB header:transcription Chain: D: PDB Molecule:possible trp repressor; PDBTitle: crystal structure of a putative trp repressor from staphylococcus2 aureus Phyre2 PDB 1p65 chain A Region: 28 - 42 Aligned: 15 Modelled: 15 Confidence: 12.1% Identity: 13% Fold: Nucleocapsid protein dimerization domain Superfamily: Nucleocapsid protein dimerization domain Family: Arterivirus nucleocapsid protein Phyre2 1 c3h88A_ 2 c2jbzA_ 3 c2qg8A_ 4 d1ftha_ 5 c3ne9B_ 6 c3hqjA_ 7 d1f7la_ 8 c2wasA_ 9 c3hykB_ 10 c3f09B_ 11 d1qr0a2 12 c1qr0A_ 13 c2cg5A_ 14 d1qr0a1 15 c2im5C_ 16 c3frwF_ 17 c2z0rA_ 18 c2knjA_ 19 c3korD_ 20 d1p65a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3h88A_ 100.0 56 PDB header:transferase Chain: A: PDB Molecule:holo-[acyl-carrier-protein] synthase; PDBTitle: crystal structure of 4'-phosphopantetheinyl transferase acps from2 vibrio cholerae o1 biovar eltor 2 c2jbzA_ 100.0 40 PDB header:transferase Chain: A: PDB Molecule:holo-[acyl-carrier-protein] synthase; PDBTitle: crystal structure of the streptomyces coelicolor holo-2 [acyl-carrier-protein] synthase (acps) in complex with3 coenzyme a at 1.6 a 3 c2qg8A_ 100.0 33 PDB header:transferase Chain: A: PDB Molecule:acyl carrier protein synthase py06285; PDBTitle: plasmodium yoelii acyl carrier protein synthase py06285 with adp bound 4 d1ftha_ 100.0 35 Fold:4'-phosphopantetheinyl transferase Superfamily:4'-phosphopantetheinyl transferase Family:Holo-(acyl carrier protein) synthase ACPS 5 c3ne9B_ 100.0 29 PDB header:transferase Chain: B: PDB Molecule:phosphopantethiene protein transferase, ppt1p; PDBTitle: mycobacterium tuberculosis acyl carrier protein synthase adopts two2 different structural conformations: ph driven conformational changes3 of acps enzyme 6 c3hqjA_ 100.0 34 PDB header:transferase Chain: A: PDB Molecule:holo-[acyl-carrier-protein] synthase; PDBTitle: structure-function analysis of mycobacterium tuberculosis2 acyl carrier protein synthase (acps). 7 d1f7la_ 100.0 43 Fold:4'-phosphopantetheinyl transferase Superfamily:4'-phosphopantetheinyl transferase Family:Holo-(acyl carrier protein) synthase ACPS 8 c2wasA_ 100.0 28 PDB header:transferase Chain: A: PDB Molecule:3-oxoacyl-[acyl-carrier-protein] synthase; PDBTitle: structure of the fungal type i fas ppt domain 9 c3hykB_ 100.0 41 PDB header:transferase Chain: B: PDB Molecule:holo-[acyl-carrier-protein] synthase; PDBTitle: 2.31 angstrom resolution crystal structure of a holo-(acyl-carrier-2 protein) synthase from bacillus anthracis str. ames in complex with3 coa (3',5'-adp) 10 c3f09B_ 100.0 42 PDB header:transferase Chain: B: PDB Molecule:holo-[acyl-carrier-protein] synthase; PDBTitle: 1.82 angstrom resolution crystal structure of holo-(acyl-carrier-2 protein) synthase (acps) from staphylococcus aureus 11 d1qr0a2 99.7 22 Fold:4'-phosphopantetheinyl transferase Superfamily:4'-phosphopantetheinyl transferase Family:4'-Phosphopantetheinyl transferase SFP 12 c1qr0A_ 99.6 21 PDB header:transferase Chain: A: PDB Molecule:4'-phosphopantetheinyl transferase sfp; PDBTitle: crystal structure of the 4'-phosphopantetheinyl transferase sfp-2 coenzyme a complex 13 c2cg5A_ 99.5 16 PDB header:transferase/hydrolase Chain: A: PDB Molecule:l-aminoadipate-semialdehyde dehydrogenase- PDBTitle: structure of aminoadipate-semialdehyde dehydrogenase-2 phosphopantetheinyl transferase in complex with cytosolic3 acyl carrier protein and coenzyme a 14 d1qr0a1 98.3 14 Fold:4'-phosphopantetheinyl transferase Superfamily:4'-phosphopantetheinyl transferase Family:4'-Phosphopantetheinyl transferase SFP 15 c2im5C_ 29.0 15 PDB header:transferase Chain: C: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of nicotinate phosphoribosyltransferase2 from porphyromonas gingivalis 16 c3frwF_ 17.6 15 PDB header:structural genomics, unknown function Chain: F: PDB Molecule:putative trp repressor protein; PDBTitle: crystal structure of putative trpr protein from ruminococcus obeum 17 c2z0rA_ 15.6 46 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha0547; PDBTitle: crystal structure of hypothetical protein ttha0547 18 c2knjA_ 15.3 0 PDB header:antimicrobial protein Chain: A: PDB Molecule:microplusin preprotein; PDBTitle: nmr structure of microplusin a antimicrobial peptide from2 rhipicephalus (boophilus) microplus 19 c3korD_ 12.9 11 PDB header:transcription Chain: D: PDB Molecule:possible trp repressor; PDBTitle: crystal structure of a putative trp repressor from staphylococcus2 aureus 20 d1p65a_ 12.1 13 Fold:Nucleocapsid protein dimerization domain Superfamily:Nucleocapsid protein dimerization domain Family:Arterivirus nucleocapsid protein 21 c1p65A_ not modelled 12.1 13 PDB header:viral protein Chain: A: PDB Molecule:nucleocapsid protein; PDBTitle: crystal structure of the nucleocapsid protein of porcine reproductive2 and respiratory syndrome virus (prrsv) 22 c1bh1A_ not modelled 10.8 25 PDB header:toxin Chain: A: PDB Molecule:melittin; PDBTitle: structural studies of d-pro melittin, nmr, 20 structures 23 d2ae8a2 not modelled 10.0 38 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:Imidazole glycerol phosphate dehydratase 24 c1f93F_ not modelled 9.5 56 PDB header:transcription Chain: F: PDB Molecule:hepatocyte nuclear factor 1-alpha; PDBTitle: crystal structure of a complex between the dimerization2 domain of hnf-1 alpha and the coactivator dcoh 25 d1f93f_ not modelled 9.5 56 Fold:Dimerisation interlock Superfamily:Dimerization cofactor of HNF-1 alpha Family:Dimerization cofactor of HNF-1 alpha 26 c1g39D_ not modelled 8.9 56 PDB header:transcription Chain: D: PDB Molecule:hepatocyte nuclear factor 1-alpha; PDBTitle: wild-type hnf-1alpha dimerization domain 27 c1g39B_ not modelled 8.9 56 PDB header:transcription Chain: B: PDB Molecule:hepatocyte nuclear factor 1-alpha; PDBTitle: wild-type hnf-1alpha dimerization domain 28 c2gypA_ not modelled 8.8 50 PDB header:transcription regulator Chain: A: PDB Molecule:hepatocyte nuclear factor 1-alpha; PDBTitle: diabetes mellitus due to a frustrated schellman motif in hnf-1a 29 c2gypB_ not modelled 8.8 50 PDB header:transcription regulator Chain: B: PDB Molecule:hepatocyte nuclear factor 1-alpha; PDBTitle: diabetes mellitus due to a frustrated schellman motif in hnf-1a 30 c1g2yA_ not modelled 8.7 56 PDB header:transcription Chain: A: PDB Molecule:hepatocyte nuclear factor 1-alpha; PDBTitle: hnf-1alpha dimerization domain, with selenomethionine2 substitued at leu 12 31 d1g2ya_ not modelled 8.7 56 Fold:Dimerisation interlock Superfamily:Dimerization cofactor of HNF-1 alpha Family:Dimerization cofactor of HNF-1 alpha 32 c1g2zB_ not modelled 8.6 50 PDB header:transcription Chain: B: PDB Molecule:hepatocyte nuclear factor 1-alpha; PDBTitle: dimerization domain of hnf-1alpha with a leu 13 selenomethionine2 substitution 33 c1f93E_ not modelled 8.6 56 PDB header:transcription Chain: E: PDB Molecule:hepatocyte nuclear factor 1-alpha; PDBTitle: crystal structure of a complex between the dimerization2 domain of hnf-1 alpha and the coactivator dcoh 34 c1jb6A_ not modelled 8.6 50 PDB header:transcription Chain: A: PDB Molecule:hepatocyte nuclear factor 1-alpha; PDBTitle: crystal structure of dimerization domain (1-33) of hnf-1alpha 35 d1g2za_ not modelled 8.5 50 Fold:Dimerisation interlock Superfamily:Dimerization cofactor of HNF-1 alpha Family:Dimerization cofactor of HNF-1 alpha 36 c1g2zA_ not modelled 8.5 50 PDB header:transcription Chain: A: PDB Molecule:hepatocyte nuclear factor 1-alpha; PDBTitle: dimerization domain of hnf-1alpha with a leu 13 selenomethionine2 substitution 37 d2fr2a1 not modelled 8.1 19 Fold:Lipocalins Superfamily:Lipocalins Family:Rv2717c-like 38 c2mltA_ not modelled 8.0 25 PDB header:toxin (hemolytic polypeptide) Chain: A: PDB Molecule:melittin; PDBTitle: melittin 39 d2i6ha1 not modelled 7.7 15 Fold:alpha-alpha superhelix Superfamily:TPR-like Family:Atu0120-like 40 c2i6hA_ not modelled 7.7 15 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein atu0120; PDBTitle: structure of protein of unknown function atu0120 from agrobacterium2 tumefaciens 41 d2f1da2 not modelled 7.6 63 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:Imidazole glycerol phosphate dehydratase 42 c2mltB_ not modelled 7.5 25 PDB header:toxin (hemolytic polypeptide) Chain: B: PDB Molecule:melittin; PDBTitle: melittin 43 d1rhya2 not modelled 6.7 50 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:Imidazole glycerol phosphate dehydratase 44 c3qrxB_ not modelled 6.6 25 PDB header:metal binding protein/toxin Chain: B: PDB Molecule:melittin; PDBTitle: chlamydomonas reinhardtii centrin bound to melittin 45 d1trra_ not modelled 6.5 23 Fold:DNA/RNA-binding 3-helical bundle Superfamily:TrpR-like Family:Trp repressor, TrpR 46 d1jhga_ not modelled 6.2 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:TrpR-like Family:Trp repressor, TrpR 47 d1vlpa1 not modelled 5.9 14 Fold:alpha/beta-Hammerhead Superfamily:Nicotinate/Quinolinate PRTase N-terminal domain-like Family:Monomeric nicotinate phosphoribosyltransferase N-terminal domain-like 48 d1qasa3 not modelled 5.8 21 Fold:TIM beta/alpha-barrel Superfamily:PLC-like phosphodiesterases Family:Mammalian PLC 49 c3me5A_ not modelled 5.7 20 PDB header:transferase Chain: A: PDB Molecule:cytosine-specific methyltransferase; PDBTitle: crystal structure of putative dna cytosine methylase from shigella2 flexneri 2a str. 301

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0