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Job DescriptionP76578
Confidence100.00%DateWed Jan 25 15:21:09 GMT 2012
Rank2Aligned Residues1242
% Identity14%Templatec3cu7A_
PDB info PDB header:immune systemChain: A: PDB Molecule:complement c5; PDBTitle: human complement component 5
Resolution3.10 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   300.........310.........320.........330.........340.........350.. .......360.........370
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Query Sequence  HNRLDIFTQSLENGAAQQGIEVSLLNEKGQTLTQATSDAQGHVQLENDKNAAL. . . . . . . . . LLARKDGQTTLLDLKLPA
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Template Conservation 
    
 
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Template Sequence  GASENIVIQVYGYTEAF. DATISIKSYP. . . . DKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVS
Template Known Secondary structure  T






S

B.
TT....S


B

B
TTTTT









SS





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   34.....40.........50 .........60 .........70.........80.........90.........100........
 
   371........380.........390.........400.........410.........420.........430....... ..440.........
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Query Sequence  LDLAEFNIAGAPGYSKQFFMFGPRDLYRPGETVILNGLLRDADGKALPNQPIKLDVIKPDGQVLRSV. VSQPENGLYHFT
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Template Sequence  KHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKR. ETVLTFIDPEGSEVDMVEEIDHIGIISFPD
Template Known Secondary structure  SS




SS
S
TT


TT
S



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TTT




SSS


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   109110.........120.........130.........140.........150....... ..160.........170.........180.......
 
   450.........460.........470 .........480.........490.........500.. .......510.........520.....
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Query Sequence  WPLDSNAATGMWHIRANTGDN. . QYRMWDFHVEDFMPERMALNLTGEKTPLTPKD. . EVKFSVVGYYLYGAPANGNTLQG
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Template Conservation 
 

     
 
 
 
          
  
 






 


 
              


 
 
 
  
 

 
  
  
Template Sequence  FKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYI
Template Known Secondary structure 

SS


BSSS






SS

S
S
STTSS


TTT
S
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   188.190.........200.........210.........220.........230.........240.........250.........260.......
 
   526...530.........540.........550.........560.........570........ .580.........590........
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Query Sequence  QLFLRPLREAVSALPGFEFGDIAAENLSRTLDEVQLTLDDKGRGEVSTESQWK. . . . . . . ETHSPLQVIFQGSLLESGGR
Query Conservation   
                                    
  
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Template Conservation              ............               
                           
 
 


 
  
 
Template Sequence  TFGIREDLKDDQ. . . . . . . . . . . . KEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGG
Template Known Secondary structure  S
SS
S
............
SS

B


TTB

TTTTTTTTSS


STT

SSSS
Template Predicted Secondary structure 





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   268.270......... 280.........290.........300.........310.........320.........330.....
 
   599600 .........610.........620.........630.........640.........650.........660.........670......
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Query Sequence  PV. . TRRAEQAIWPADALPGIRPQFASKSVYDYRTDSTVKQPIVDEGSNAAFDIVYSDAQGVKKAVSGLQVRLIRERRDY
Query Conservation    ..       
      
                           
      
      
         
         
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Template Conservation           
        
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Template Sequence  FSEEAEIPGIKYVLSPYKLNLVAT. . . . . . . . . . . . . . . . PLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQ
Template Known Secondary structure 





S
S

BS
................
S
SSS
TT

B

S
TTS
Template Predicted Secondary structure 
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   336...340.........350......... 360.........370.........380.........390.........
 
   677..680.........690.........700.........710.........720........ .730.........740.........750.....
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Query Sequence  YWNWSEDEGWQSQFDQKDLIENEQTLDLKADETGKVSFPVEWGAYRLEVKAP. NEAVSSVRFWAGYSWQDNSDGSGAVRP
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Template Conservation   ...............           
   
     
  
       
 
                       
 
 
 
Template Sequence  E. . . . . . . . . . . . . . . TSDLDPSKSVTRVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSY
Template Known Secondary structure 
...............




SSS



TT

TTS
GGGS



TTS

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   400 .........410.........420.........430.........440.........450.........460....
 
   756...760.........770.........780.. .......790.........800... ......810.........820........
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Query Sequence  DRVTLKLDKASYRPGDTIKLHIAAPTA. . . . . GKGYAMVESSEGPLWWQEIDV. . RAQGLDLTIPVDKTWNRHDLYLSTL
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Template Conservation    
    
      
    
 
 
            
 




 
                
 
 

  
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Template Sequence  LYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNM. VPSSRLLVY
Template Known Secondary structure 


SSSSB
TT




S




TT

SSSS


GGG.SS
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   465....470.........480.........490.........500.........510.........520.........530.... .....540...
 
   829830.........840.........850..... ....860...... ...870.........880.........890.........900......
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Query Sequence  VVRPGDKSRSATPKRAVGVLHLPLGDE. NRRLDLALETP. AKMRPNQPLTVKIKASTKNGEKPKQVNVLVSAVDSGVLNI
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Template Sequence  YIVTGEQTAE. . . . LVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGM. . . . . . . DSWVALAAVDSAVYGV
Template Known Secondary structure 

SSS
....B



SS



SS

SSB
TT

SS.......

BTTTT
S
Template Predicted Secondary structure 






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   544.....550... ......560.........570.........580.........590...... ...600.........610..
 
   907..910.........920.........930........
Predicted Secondary structure 
















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Query Sequence  TDYVTPDPWQAFFGQKRYGADIYDIYGQVIEG. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation       

   
       
       
     

  


   
                                     
Template Sequence  QRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILLQKKIEEIAAKYKHSVVKK
Template Known Secondary structure  S

TT
STTTT



SSS

SSSTT
SSS



SSS




S



TGGG

SS
Template Predicted Secondary structure 































































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   613......620.........630.........640.........650.........660.........670.........680.........690..
 
   939940.........950.........960.........970........
Predicted Secondary structure  ........................................



























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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . QGRLAALRFGGDGDELKRGGKPPVNHVNIVVQQALPVTLN
Query Conservation  ........................................                                        
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Template Conservation      
           
             
                               

  






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Template Sequence  CCYDGACVNNDETCEQRAARISLGPRCIKAFTECCVVASQLRANISLGRLHMKTLLPVSKPEIRSYFPESWLWEV. . . HL
Template Known Secondary structure  GGGS


SS
T

S
TTTTT












TT

S





B


...
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   698.700.........710.........720.........730.........740.........750.........760.........770.. ..
 
   979980.........990.........1000.........1010.. .......1020.........1030.........1040.........1050.......
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Query Sequence  EQGEGSVTLPIGDFNGELRVMAQAWTADDFGSNE. SKVIVAAPVIAELNMPRFMASGDTSRLTLDITNLTDKPQKLNVAL
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Template Sequence  VPRRKQLQFALPDSLTTWEIQGIGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKM
Template Known Secondary structure  SS

SSS
TT




S

S
TT


SSS
B



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   780.........790.........800.........810.........820.........830.........840.........850.........
 
   1058.1060......... 1070.........1080.........1090.........1100.........1110.........1120.........1130......
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Query Sequence  TASGLLELVSDS. PAAVELAPGVRTTLFIPVRALPGYGDGEIQATISGLALPGETVADQHKQWKIGVRPAFPAQTVNYGT
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Template Sequence  SAVEGICTSESPKCVRQKVEGSSSHLVTFTVLPLE. IGLHNINFSLETWF. . . . . . GKEILVKTLRVVPEGVKRESYSGV
Template Known Secondary structure 


TT
SS







B
TT


S.SS


TT......



S
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   860.........870.........880.........890.... .....900........ .910.........920.........930..
 
   1137..1140 .........1150........ .1160.........1170.... .....1180.........1190.........1200..
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Query Sequence  ALQP. . . . . . . GETWAIPADGLQNFSPVT. LEGQLLLSGKPPLNIA. . . . . . RYIKELKAYPYGCLEQTASGLFPSLYTN
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Template Conservation   
                  

   

 
     

  
   
           
  

  
 

 




   
 
   
Template Sequence  TLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVF
Template Known Secondary structure  BTT
TTTS
B






TTB
TT


SSTTSSSS


SSS

S
SSTTS
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   943......950.........960.........970.........980.........990.........1000.........1010.........1020..
 
   1203......1210.. .......1220.........1230.........1240.........1250.........1260.........1270......
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Query Sequence  AAQLQALGIK. . . . . . GDSDEKRRASVDIGISRLLQMQRDNGGFALWDKNGDEEYWLTAYVMDFLVRAGEQGYSVPTDAI
Query Conservation    
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Template Conservation   

  
 
                  
  

 
 
 

  




 
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Template Sequence  HYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVW. KGGSASTWLTAFALRVLGQVNKYVE. QNQNSI
Template Known Secondary structure  TT
GGG
SS
GGGGB
TTS
B
SS.SSS


TTS
.

Template Predicted Secondary structure 














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   1023......1030.........1040.........1050.........1060......... 1070.........1080.........1090.... .....1100
 
   1277..1280...... ...1290.........1300...... ...1310.........1320.. .......1330.....
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Query Sequence  NRGNERLLRY. LQDPGMMSIPYADNLKASKF. . . . . . . . . . . AVQSYAALVLARQQKA. . . . . . . . . PLGALREIWEHRA
Query Conservation        
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Template Conservation    
  

    
   
 
 
        
 
            


 

 

 
               

   
     
Template Sequence  CNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTL
Template Known Secondary structure  SB
TTS
B


SS






S
TGGGS

S
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   1101........1110.........1120.........1130.........1140.........1150.........1160.........1170.........1180
 
   1336...1340.........1350.... .....1360.........1370.........1380.... .....1390........
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Query Sequence  DAASGLPLLQLGVALKTMG. DATRGEEAIALALKTPRNSDERIWLGDYGS. . . . . . . . . . . . . . . . SLRDNALMLSLLEE
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Template Conservation       
  

 



 
              
   
           
                
  









 
 
Template Sequence  PAQSTFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLN
Template Known Secondary structure  S
S
TTS
TT

TTTTS

S
SS

SS


S


Template Predicted Secondary structure 






























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   1181........1190.........1200.........1210.........1220.........1230.........1240.........1250.........1260
 
   13991400.........1410........ .1420.........1430.........1440.........1450.........1460.........1470..
Predicted Secondary structure 




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Query Sequence  NKLLPDEQYTLLNTLSQQAF. GERWLSTQESNALFLAARTIQDLPGKWQAQTSFSAEQLTGEKAQNSNLNSDQLV. . . . .
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Template Conservation    .    
  

 

  


  


 





 

 

  
            
 
                
 
     
Template Sequence  LK. DINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALHNYKMTDKNFLGRPVE
Template Known Secondary structure  TT.
S
SSS

STTTTS









SSS








SSS
S


Template Predicted Secondary structure 

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   1261. .......1270.........1280.........1290.........1300.........1310.........1320.........1330.........
 
   1473......1480.........1490.........1500.........1510.........1520.........1530....... ..1540..
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Query Sequence  . . . . . . TLQVSNSGDQPLWLRMDASGYPQSAPLPANNVLQIERHILGTDGKSKSLDSLRSGDLVLVWLQVK. . . . ASNSV
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Template Conservation               
 
         
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Template Sequence  VLLNDDLIVSTGFGSGLATVHVTTVVHKT. STSEEVCSFYLKIDTQDIYK. . . . . . . . . . . . RIVACASYKPSREESSSG
Template Known Secondary structure 

SSS



S

S
BS.

SSS

S



............


TT

SS
Template Predicted Secondary structure 






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   1340.........1350.........1360........ .1370.........1380........ .1390.........1400......
 
   1543......1550 .........1560.........1570.........1580.........1590.........1600......... 1610.........1620
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Query Sequence  PDALVVDL. LPAGLELENQNLANGSASLEQSGGEVQNLLNQMQQASIKHIEFRDDRFVAAVAVDEYQP. VTLVYLARAVT
Query Conservation      
 
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Template Conservation 
 
 
 

 
 


      
  
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Template Sequence  SSHAVMDISLPTGISANEEDLKALVEGVDQL. . . . . . . . . . . . . . . FTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELF
Template Known Secondary structure 

S

TT

SSTT
S...............
SB

TTS


SSS

SS
Template Predicted Secondary structure 











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   14191420.........1430.........1440......... 1450.........1460.........1470.........1480...
 
   1621....... .1630.........1640...
Predicted Secondary structure 


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Query Sequence  PGTYQVPQ. PMVESMYVPQWRATG
Query Conservation   
    
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Template Conservation   
   


 
 




 
    
 
Template Sequence  EVGFLSPATFTVYEYHRPDKQCTM
Template Known Secondary structure 

SS


TT
Template Predicted Secondary structure 











Template SS confidence 























   1484.....1490.........1500.......
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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