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Job DescriptionP76578
Confidence100.00%DateWed Jan 25 15:21:09 GMT 2012
Rank3Aligned Residues1180
% Identity16%Templatec2b39B_
PDB info PDB header:immune systemChain: B: PDB Molecule:c3; PDBTitle: structure of mammalian c3 with an intact thioester at 3a resolution
Resolution3.00 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   363......370.........380.........390.........400.........410.........420.........430....... ..440
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Query Sequence  LLDLKLPALDLAEFNIAGAPGYSKQFFMFGPRDLYRPGETVILNGLLRDADGKALPNQPIKLDVIKPDGQVLRSV. . VSQ
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Template Sequence  FVTVVATFGNVQVEKVVLISLQSGYLFIQTDKTIYTPGSTVLYRVFTVDHKLLP. VGQTVFITIETPDGIPVKRDSKSSQ
Template Known Secondary structure  TT





S
S
TT
TTT.


TTTT
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   104.....110.........120.........130.........140.........150....... ..160.........170.........180..
 
   441........450.........460.........470 .........480.........490.........500. ........510......
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Query Sequence  PENGLYHFTWPLDSNAATGMWHIRANTGDN. . QYRMWDFHVEDFMPERMALNLTGEKTPLTPK. . DEVKFSVVGYYLYGA
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Template Conservation     
     
 

     
 
 
 
          
  
 






 


 
  

          
   
 
 
 

 
Template Sequence  NQFGILTLSWNIPELVNMGVWKIKAYYEDSPQQVFSAEFEVKEYVLPSFEVQLEPEEKFYYIDDPDGLKVNIIARFLYGE
Template Known Secondary structure  TTTS

SS




TT

SS
B







S
SSSS

S

SS


TTS
Template Predicted Secondary structure 



























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   183......190.........200.........210.........220.........230.........240.........250.........260..
 
   517..520.........530.........540.........550.........560.........570...... ...580.......
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Query Sequence  PANGNTLQGQLFLRPLREAVSALPGFEFGDIAAENLSRTLDEVQLTLDDKGRGEVSTESQ. . . . . . . . . WKETHSPLQVI
Query Conservation 

 
  
   
                                    
  
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Template Conservation 

 
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Template Sequence  QVDG. TAFVIFGVQDGDRRISLTH. . . . . . . . . . . . . . . . . SLTRVPINDGNGEAILKRQVLLNGVQPSRADALVGKSIY
Template Known Secondary structure  B

.


SS


GG.................G


SS


GGGTSSTT
S
SSSTTTT
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   263... ...270.........280..... ....290.........300.........310.........320....
 
   588.590.........600 .........610.........620.........630.........640.........650.........660.....
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Query Sequence  FQGSLLESGGRPV. . TRRAEQAIWPADALPGIRPQFASKSVYDYRTDSTVKQPIVDEGSNAAFDIVYSDAQGVKKAVSGL
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Template Conservation 
 


 
  
          
        
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Template Sequence  VSATVILQSGSDMVEAERTGIPIVTSPYQIHFTKT. . . . . . . . . . . . . . . . PKFFKPAMPFDLMVYVTNPDGSPARHIPV
Template Known Secondary structure  TTT



SSS
SSS................
S


TTS


BTTTB

SSB
Template Predicted Secondary structure 






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   325....330.........340.........350......... 360.........370.........380........
 
   666...670.........680.........690.........700.........710.........720.........730.........740.....
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Query Sequence  QVRLIRERRDYYWNWSEDEGWQSQFDQKDLIENEQTLDLKADETGKVSFPVEWGAYRLEVKAPNEAVSSVRFWAGYSWQD
Query Conservation   
                                 
                 
   
 
                    
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Template Conservation            
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Template Sequence  VTQGSNVQSLT. . . . . . . . . . . . . . . . . . . . . . . . . . QDDGVAKLSINTQNKRDPLTITVRTKKDNIPEGR. QATRTMQA
Template Known Secondary structure  TT

B

B
..........................SSSSB





S

S
B




TTS
TTS.






B
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   389390......... 400.........410.........420.........430... ......440.
 
   746...750.........760.........770.........780.... .....790.........800...... ...810......
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Query Sequence  NSDGSGAVRPDRVTLKLDKASYRPGDTIKLHIAAPTAGK. . . . . . . GYAMVESSEGPLWWQEIDVRAQ. . GLDLTIPVDK
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Template Conservation        
 
   
 
         
    
 
           
    
 
 


 

                 
 

 
Template Sequence  LPYNTQGNSNNYLHLSVPRVELKPGETLNVNFHLRTDPGEQAKIRYYTYMIMNKGKLLKVGRQYREPGQDLVVLPLTITS
Template Known Secondary structure 




SSS









SSS

SSGGGT



TT



TT
S




S
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   442.......450.........460.........470.........480.........490.........500.........510.........520.
 
   817..820.........830.........840.........850.........860.........870.........880.........890......
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Query Sequence  TWNRHDLYLSTLVVRPGDKSRSATPKRAVGVLHLPLGDENRRLDLALETPAKMRPNQPLTVKIKASTKNGEKPKQVNVLV
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Template Sequence  DF. IPSFRLVAYYTLINAKGQREVVADSVWVDVKDSCMGTLVVKNGGKEEKHHRPGQQITLKIEADQ. . . . . . . GARVGL
Template Known Secondary structure  TT.SS

B
TTS
B



S

SS

SS


S
B
TT


T.......T
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   522. ......530.........540.........550.........560.........570.........580....... ..590...
 
   897..900........
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Query Sequence  SAVDSGVLNITD. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation   


 

  
     

   
       
 
     
     

  


   
                           
Template Sequence  VAVDKGVFVLNKKNKLTQRKIWDVVEKADIGCTPGSGRNYAGVFTDAGLTLKTSQGLETQQRADPQCPQSVQLMEKRMDK
Template Known Secondary structure 

BTTSGGGS

TTTS
S
SS

STB



TT








SS




SS
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   594.....600.........610.........620.........630.........640.........650.........660.........670...
 
   909910.........920.........930........ .940.........950.........960.......
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Query Sequence  . . . . . . . . . . . . . . YVTPDPWQAFFGQKRYGADIYDIYGQVIEG. . . . . . . QGRLAALRFGGDGDELKRGGKPPVNHVNI
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Template Conservation                
    
       
                                             

  


Template Sequence  AGQYSSDLRKCCEDGMRDNPMKFPCQRRAQFILQGDACVKAFLDCCEYITQLRQQHSRDGALDDDIIPEEDIISRSQFPE
Template Known Secondary structure  S

GGGTTSS

SS


GGGB
S
TTTTS



S



SS








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   681........690.........700.........710.........720.........730.........740.........750.........760
 
   968.970. ........980.........990.........1000...... ...1010.. .......1020.........1030.........1040
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Query Sequence  VVQQ. . . . . ALPVTLNEQGEGSVTLPIGDFNGELRVMAQAWTAD. DFGSNE. SKVIVAAPVIAELNMPRFMASGDTSRLT
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Template Sequence  SWLWTVIEDLKQADKNGISTKLMNVFLKDSITTWEILAVSLSDKKGICVADPYEVTVMQDFFIDLRLPYSVVRNEQVEIR
Template Known Secondary structure 







S

SSS




SSS
TTT


B

S

S
SS
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   768.770.........780.........790.........800.........810.........820.........830.........840.......
 
   1041....... .1050.........1060......... 1070.........1080.........1090.........1100.........1110.....
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Query Sequence  LDITNLTD. KPQKLNVALTASGLLELVSDS. . . . PAAVELAPGVRTTLFIPVRALPGYGDGEIQATISGLALPGETVADQ
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Template Conservation 
 
 

       
 
 
                   
 
 
     
 
 
 
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Template Sequence  AILYNYREAENLKVRVELLYNPAFCSLATAKKRHQQTITIPARSSVAVPYVIVPLK. IGLHEVEVKAAV. . . . YNHFISD
Template Known Secondary structure 

SS




TT
SS
SS



SS



S.
....TTS

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   848.850.........860.........870.........880.........890.........900... ......910..... ....920..
 
   1116...1120.........1130........ .1140.........1150......... 1160.........1170.... .....1180
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Query Sequence  HKQWKIGVRPAFPAQTVNYGTAL. . . . . . . . QPGETWAIPADGLQNFSPVTL. EGQLLLSGKPPLNIA. . . . . . RYIKEL
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Template Conservation   
 
 
 
 


                                   

       


 
               
  
Template Sequence  GVKKTLKVVPEGVRVNKTVAVRTLNPEHLGQGGVQREEVPAADLSDQVPDTESETKILLQGTPVAQMTEDAIDGERLKHL
Template Known Secondary structure 
SS



BTTB




TTB
TT

SSTTSTTTGGGS
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   923......930.........940.........950.........960.........970.........980.........990.........1000..
 
   1181........1190.........1200.........1210... ......1220.........1230.........1240.........1250.......
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Query Sequence  KAYPYGCLEQTASGLFPSLYTNAAQLQALGIKG. . . DSDEKRRASVDIGISRLLQMQRDNGGFALWDKNGDEEYWLTAYV
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Template Sequence  IQTPSGCGEQNMIGMTPTVIAVHYLDSTDQWEKFGLEKRQESLELIRKGYTQQLAFRQKSSAYAAF. QYRPPSTWLTAYV
Template Known Secondary structure 
SS


STTGGGGGTT
GGGS
TTTTB
TTS
B
SS.TTS


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   1003......1010.........1020.........1030.........1040.........1050.........1060........ .1070.........1080.
 
   1258.1260.........1270.........1280... ......1290.........1300..... ....1310.........1320..
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Query Sequence  MDFLVRAGEQGYSVPTDAINRGNERL. LRYLQDPGMMSIPYADNLKASK. . . . . . . . . . FAVQSYAALVLARQQKA. . . .
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Template Sequence  VKVFALAAN. LIAIDSKDLCETVKWLILEKQKPDGIFQEDGPVIHQEMIGGFRDTREKDVSLTAFVLIALHEAKDICEAQ
Template Known Secondary structure  TT.TS


TB
TTS
B


S


SGGGS

TT

SSTTTTTTTTTT
Template Predicted Secondary structure  .



































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   1082.......1090 .........1100.........1110.........1120.........1130.........1140.........1150.........1160
 
   1323......1330.........1340.........1350.........1360.........1370.........1380.... .....1390..
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Query Sequence  . . . . . . . PLGALREIWEHRADAASGLPLLQLGVALKTMGDATRGEEAIALALKTPRNSDERIWLGDYGS. . . SLRDNALM
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Template Sequence  VNSLGRSIAKAGDFLENHYRELRRPYTVAIAAYALALLGKLEG. . . . . DRLTKFLNTAKEKNRWEEPNQKLYNVEATSYA
Template Known Secondary structure 
SSGGG

STT


T.....T
BTTTB


SS
Template Predicted Secondary structure 






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   1161........1170.........1180.........1190.........1200... ......1210.........1220.........1230.....
 
   1393......1400.........1410........ .1420.........1430.........1440. ........1450.........1460.........1470
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Query Sequence  LSLLEENKLLPDEQYTLLNTLSQQAF. GERWLSTQESNALFLAARTIQDL. PGKWQAQTSFSAEQLTGEKAQNSNLNSDQ
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Template Sequence  LLALLARKDYDTTPP. VVRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDVPDHKELNLDVSIQLPSRNSAVRHRILWES
Template Known Secondary structure  TT
GGG
.


BTTBB
SS

STT

SSSSS
SSS
Template Predicted Secondary structure 


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   1236...1240.........1250 .........1260.........1270.........1280.........1290.........1300.........1310....
 
   1471. .......1480.........1490.........1500.........1510.........1520.........1530.........
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Query Sequence  LV. . . . . . . . . . . TLQVSNSGDQPLWLRMDASGYPQSAPLPANNVLQIERHILGTDGKSKSLDSLRSGDLVLVWLQVKAS
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Template Sequence  ASLLRSEETKENERFTVKAEGKGQGTLSVVTVYHAKLKGKVSCKKFDLRVSIRPAPETVKKPQ. . DAKGSMILDICTKYL
Template Known Secondary structure  S
SSS


SS




TTSS
BS

TTS


T..TSS

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   1315....1320.........1330.........1340.........1350.........1360.........1370....... ..1380.........1390..
 
   1540.. .......1550 .........1560.........1570.........1580.........1590... ......1600......... 1610..
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Query Sequence  NSV. PDALVVDL. LPAGLELENQNLANGSASLEQSGGEVQNLLNQMQQASIKHIEF. . . . RDDRFVAAVAVDEYQP. VTL
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Template Sequence  GDQDATMSILDISMMTGFSPDVEDLKTLSTGVDRY. . . . . . . . . . . . . . . ISKYEMNRDSNKNTLIIYLDKVSHTVEDCL
Template Known Secondary structure  SSS
B
S

TT
SSB
S...............
SSSSSS
S
B
SSS
Template Predicted Secondary structure 

















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   1393......1400.........1410.........1420....... ..1430.........1440.........1450.......
 
   1613......1620........ .1630.........1640..
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Query Sequence  VYLARAVTPGTYQVPQ. PMVESMYVPQWRAT
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Template Conservation   
       
    

 
 




 
    
Template Sequence  SFKVHQYFNVGLIQPGAVKVYSYYNLDETCI
Template Known Secondary structure 
SS


TT
Template Predicted Secondary structure 











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   1458.1460.........1470.........1480........
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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