Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	Y	L	V	I	S	V	F	L	I	T	A	F	I	C	L	Y	L	K	K	D	I	F	Y	P	A	V	C	V	N	I	I	F	A	L	V	L	L	G	Y	E	I	T	S	D	I	Y	A	F	Q	L	N	D	A	T	L	I	F	L
Secondary structure
SS confidence
Disorder		?	?																				?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	C	N	V	L	T	F	T	L	S	C	L	L	T	E	S	V	L	D	L	N	I	R	K	V	N	N	A	I	Y	S	I	P	S	K	K	V	H	N	V	G	L	L	V	I	S	F	S	M	I	Y	I	C	M	R	L	S	N	Y	Q
Secondary structure
SS confidence
Disorder																		?		?	?	?	?	?	?	?		?	?	?						?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	G	T	S	L	L	S	Y	M	N	L	I	R	D	A	D	V	E	D	T	S	R	N	F	S	A	Y	M	Q	P	I	I	L	T	T	F	A	L	F	I	W	S	K	K	F	T	N	T	K	V	S	K	T	F	T	L	L	V	F	I
Secondary structure
SS confidence
Disorder																					?																							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	F	I	F	A	I	I	L	N	T	G	K	Q	I	V	F	M	V	I	I	S	Y	A	F	I	V	G	V	N	R	V	K	H	Y	V	Y	L	I	T	A	V	G	V	L	F	S	L	Y	M	L	F	L	R	G	L	P	G	G	M	A
Secondary structure
SS confidence
Disorder																															?	?																				?		?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		Y	Y	L	S	M	Y	L	V	S	P	I	I	A	F	Q	E	F	Y	F	Q	Q	V	S	N	S	A	S	S	H	V	F	W	F	F	E	R	L	M	G	L	L	T	G	G	V	S	M	S	L	H	K	E	F	V	W	V	G	L	P	T
Secondary structure
SS confidence
Disorder																																										?	?	?		?		?	?					?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		N	V	Y	T	A	F	S	D	Y	V	Y	I	S	A	E	L	S	Y	L	M	M	V	I	H	G	C	I	S	G	V	L	W	R	L	S	R	N	Y	I	S	V	K	I	F	Y	S	Y	F	I	Y	T	F	S	F	I	F	Y	H	E	S
Secondary structure
SS confidence
Disorder																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.
Sequence		F	M	T	N	I	S	S	W	I	Q	I	T	L	C	I	I	V	F	S	Q	F	L	K	A	Q	K	I	K
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1ohe chain A domain 1 Region: 305 - 342 Aligned: 38 Modelled: 38 Confidence: 6.4% Identity: 8% Fold: (Phosphotyrosine protein) phosphatases II Superfamily: (Phosphotyrosine protein) phosphatases II Family: Dual specificity phosphatase-like Phyre2 PDB 2hac chain A Region: 320 - 336 Aligned: 17 Modelled: 17 Confidence: 6.2% Identity: 24% PDB header:membrane protein Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 zeta chain; PDBTitle: structure of zeta-zeta transmembrane dimer Phyre2 1 d1ohea1 2 c2hacA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1ohea1 6.4 8 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Dual specificity phosphatase-like 2 c2hacA_ 6.2 24 PDB header:membrane protein Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 zeta chain; PDBTitle: structure of zeta-zeta transmembrane dimer

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0