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Job DescriptionP04825
Confidence100.00%DateThu Jan 5 10:58:23 GMT 2012
Rank4Aligned Residues811
% Identity17%Templatec3se6A_
PDB info PDB header:hydrolaseChain: A: PDB Molecule:endoplasmic reticulum aminopeptidase 2; PDBTitle: crystal structure of the human endoplasmic reticulum aminopeptidase 2
Resolution3.08 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   4.....10 .... .....20.........30.........40.. .......50.........60.........70...
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Query Sequence  QPQAKYR. HDYR. APDYQITDIDLTFDLDAQKTVVTAVSQA. VRHGASDAPLRLNGEDLKLVSVHINDEPWTA. . . . . . .
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Template Conservation             


  
 
  
 
 
  
     
 
 
 
          
 
    
 
                   
Template Sequence  TNGERFPWQELRLPSVVIPLHYDLFVHPNLTSLDFVASEKIEVLVSNATQFIILHSKDLEITNATLQSEEYMKPGKELKV
Template Known Secondary structure  SSSS

S


SS

TTTTTTSS

S
SS




SS

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   57..60.........70.........80.........90.........100.........110.........120.........130......
 
   74.....80.... .....90.........100.........110.... .....120.........130........
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Query Sequence  . WKEEEGALVIS. . . . . NLPERFTLKIINEISPAANTALEGLYQSGD. . . . . . . . . ALCTQCEAEGFRHITYYLDRPDVL
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Template Conservation          
 
 
   
  
    
 
 
 
 
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Template Sequence  LSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLG. . DGFEGFYKSTYRTLGGETRILAVTDFEPTQARMAFPCFDEPLFK
Template Known Secondary structure  GGGT
SS


TT


B..SSSS
TTS

TTTTGGGTS
B

STT

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   140.........150.........160.........170... ......180.........190.........200.........210.......
 
   139140.........150.........160.........170.........180.........190.........200.........210........
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Query Sequence  ARFTTKIIADKIKYPFLLSNGNRVAQGELENGRHWVQWQDPFPKPCYLFALVAGDFDVLRDTFTTRSGREVALELYVDRG
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Template Conservation 
 
 


  
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Template Sequence  ANFSIKIRRESRH. . IALSNMPKVKTIELEGGLLEDHFETTVKMSTYLVAYIVCDFHSLSGF. . . . TSSGVKVSIYASPD
Template Known Secondary structure  B
TT
..SS

TTS




SB
GGG



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TT


GG
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   218.220.........230 .........240.........250.........260.........270....... ..280.........290.
 
   219220.........230.........240.........250.........260.........270.........280.........290........
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Query Sequence  NLDRAPWAMTSLKNSMKWDEERFGLEYDLDIYMIVAVDFFNMGAMENKGLNIFNSKYVLARTDTATDKDYLDIERVIGHE
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Template Conservation          
      
   
   
  

  


 
  
    
 


 


      

                 



Template Sequence  KRNQTHYALQASLKLLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAHE
Template Known Secondary structure  GGGGGT



SSSS
SSS

TTGGGT


TTT

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   292.......300.........310.........320.........330.........340.........350.........360.........370.
 
   299300.........310.........320.........330.........340.........350.........360....... ..370......
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Query Sequence  YFHNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSSDLGSRAVNRINNVRTMRGLQFAEDASPMAHPIRPD. . MVIEMNNFY
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Template Sequence  LAHQWFGNLVTMEWWNDIWLNEGFAKYMELIAVNATYPELQFDDYFLNVCFE. VITKDSLNSSRPISKPAETPTQIQEMF
Template Known Secondary structure  GGGTBTTTSSGGGT
GGG
.TTTTSTT


SS



STS
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   372.......380.........390.........400.........410.........420... ......430.........440.........450
 
   377..380.........390.........400.........410.........420.........430. ... .....440.........450...
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Query Sequence  TLTVYEKGAEVIRMIHTLLGEENFQKGMQLYFERHDGSAATCDDFVQAMEDASNV. . DLS. HFRRWYSQSGTPIVTVKDD
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Template Conservation    
 
 

  

 

   

   
   
  

           

   
                
    
 
 
 
   
Template Sequence  DEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWSSLSNSLGENAEVKEMMTTWTLQKGIPLLVVKQD
Template Known Secondary structure  S
TT








S
S
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   451........460.........470.........480.........490.........500.........510.........520.........530
 
   454.....460.........470.........480.........490.........500.........510.........520.........530...
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Query Sequence  YNPETEQYTLTISQRTPATPDQAEKQPLHIPFAIELYDNEGKVIPLQKGGHPVNSVLNVTQAEQTFVFDNVYFQPVPALL
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Template Sequence  GC. . . . . . SLRLQQERFLQ. . GQERYLWHIPLTY. . . . . . . . . . . . STSSSNVIHRHILKSKTDTLDLPEKTS. . WVKFN
Template Known Secondary structure  TT......


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SS
SS

S..
S
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   556. ..560........ .570.........580. ........590.........600........ .610...
 
   534.....540.........550 .........560.........570.........580.........590.........600.......
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Query Sequence  CEFSAPVKLEYKWSDQQ. LTFLMRHARNDFSRWDAAQSLLATYIKLNVARHQQGQPLSLPVHVADAFRAVLLDEK. . . . .
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Template Conservation      
 


 

      
   
           
  
  
   

  
       
 

  
  
    

  
   
 
Template Sequence  VDSNGYYIVHYEGHGWDQLITQLNQNHTLLRPKDRVGLIHDVFQLVGAGRLTLDKALDMTYYLQHETSSPALLEGLSYLE
Template Known Secondary structure  GGG
SS
TTGGGS
TTSS
TTGGGT


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   625....630.........640.........650.........660.........670.........680.........690.........700....
 
   608.610.........620.........630.........640.........650.........660.........670....
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Query Sequence  . . . . . . . . . . . . . IDPALAAEILTLPSVNEMAELFDIIDPIAIAEVREALTRTLATELADELLAIYNANYQSEYRVEHED
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Template Conservation   
   
           
      
       
            

  

  

  
   
   
   
          
Template Sequence  SFYHMMDRRNISDISENLKRYLLQYFKPVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSGKL
Template Known Secondary structure  S

TT

SS

S
TT
TTT
S
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   705....710.........720.........730.........740.........750.........760.........770.........780....
 
   675....680.........690.........700.........710.........720.........730.........740.........750....
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Query Sequence  IAKRTLRNACLRFLAFGETHLADVLVSKQFHEANNMTDALAALSAAVAAQLPCRDALMQEYDDKWHQNGLVMDKWFILQA
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Template Sequence  NIPTDVLKIVYSVGA. . QTTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQ. . . EKLLKLIELGMEGKVI. . . . . . . . .
Template Known Secondary structure 


T..TS
S
TT


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   785....790......... 800.........810.........820.........830.... .....840.........850
 
   755....760.........770.........780.........790.........800.........810..... ....820.........830...
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Query Sequence  TSPAANVLETVRGLLQHRSFTMSNPNRIRSLIGAFAGSNPAAFHAEDGSGYLFLVEMLTDL. NSRNPQVASRLIEPLIRL
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Template Sequence  . . KTQNLAALLHAIARRPK. . . . . . . . GQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFES
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GGGSTT........S
TTSTTTTT

S
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   851........860....... ..870.........880.........890.........900.........910.........920
 
   834.....840.........850.........860.........
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Query Sequence  KRYDAKRQEKMRAALEQLKGLENLSGDLYEKITKAL
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Template Conservation            
   

 
  

 
       
  

Template Sequence  LEAQGSHLDIFQTVLETITKNIKWLEKNLPTLRTWL
Template Known Secondary structure  S
SSS


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   921........930.........940.........950......
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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