|   |
3 | . | . | . | . | . | . | 10 | . | . | . | |
. | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | 20 | . | . | . | |
|
|
|
|
|
|
. | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |
|
|
|
|
| . |
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|  |  |  |  | . | . | . | . | . | . | . |  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
P | V | D | L | H | M | H | T | V | A | S | . |
T | H | A | Y | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
S | T | L | S | D | Y | . |
. |
. |
. |
. |
. |
. |
I | A | Q | A | K | Q | K | G | I | K | L | F | A | I | T | D | H | G | P | D | M | E | D | A | P | H | H | W | H | F |
Query Conservation |   |
  |
|
|
|
|   |
|
|   |   |
| . |   |
|
|   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |
|
|   | . | . | . | . | . | . | . |
|   |   |
|   |   |   |
|   |   |   |
|
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
| . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
|
|
|   |
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|
|
| . | . |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
M | N | D | L | H | A | H | A | S | Q | Y | K | N | L | G | I | G | M | D | K | E | L | L | P | W | L | N | N | Y | T | F | P | E | E | A | K | F | L | N | V | D | Y | A | K | K | T | Y | G | R | L | I | K | D | L | I | K | N | G | T | T | R | . |
. |
V | A | L | F | A | T | L | H | K | D | S | T | I | E | L | F | N |
Template Known Secondary structure |   |
 |  |  |  |  |  |  | G | G | G | G | G | G | T | T |
|
|
| S | S |
|  |  |  |  |  |  |  | T |  |  |  |  |  |  | G | G | G | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T |  |  |  | . | . |  |  |  |  |
|
| S |
|  |  |  |  |  |  |  |  |  |
Template Predicted Secondary structure |   |
|  |  |
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  | . | . |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
69 | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | |
|
130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . |
  |
  |   |
54 | . | . | . | . | . | 60 | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | |
|
|
|
|
. | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
| . | . | . | . | . |
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
I | N | M | R | I | W | P | R | V | V | D | G | V | G | I | L | R | G | I | E | A | N | I | K | N | . |
. |
. |
. |
. |
V | D | G | E | I | D | C | S | G | K | M | F | D | S | L | D | L | I | I | A | G | F | H | E | P | V | F | A | P | H | D | K | A | T | N | T | Q | A | M | I | A | T | I | A | S | G | N | V | H | I |
Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |
|
|   |
|   |   |
|   |
|   |   |   |   |   | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |
Template Sequence |   |
M | L | I | K | S | G | I | G | A | Y | V | G | K | V | N | M | D | Y | N | C | P | D | Y | L | T | E | N | Y | I | T | S | L | N | D | T | E | E | I | I | L | K | Y | K | D | K | S | N | I | V | K | P | I | I | T | P | R | F | V | P | S | C | S | N | E | L | M | D | G | L | G | K | L | S | Y | K | Y | R | L | P | V |
Template Known Secondary structure |   |
 |  |  |  |  | T |
|  |  |  |  |  |
|  |  |
|
| S | S |
|
| T | T | S |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | T |
| S | S |  |  |  |
| B |  |  |
|
| G | G | G |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | T |
|
|  |
Template Predicted Secondary structure |   |
 |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
147 | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . |
  |
  |   |
129 | 130 | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . |
Predicted Secondary structure |   |
 |  |
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |
|
|  |  |
|
|
|
|
|
|
|  |  |  |  |
Query SS confidence |   |
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
I | S | H | P | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
G | N | P | K | Y | E | I | D | V | K | A | V | A | E | A | A | A | K | H | Q | V | A | L | E | I | N | N | S | S | F | L | H | S | R | K | G | S | E | D | N | C |
Query Conservation |   |
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   | . | . |
Template Sequence |   |
Q | S | H | L | S | E | N | L | D | E | I | A | V | V | K | S | L | H | K | K | S | N | F | Y | G | E | V | Y | D | K | F | G | L | F | G | N | T | P | T | L | M | A | H | C | I | H | S | S | K | E | E | I | N | L | I | K | R | N | N | V | T | I | V | H | C | P | T | S | N | F | N | L | G | S | G | M | M | P | . |
. |
Template Known Secondary structure |   |
 |  |  |  | S |
|
|  |  |  |  |  |  |  |  |  |  |
| T | T |
| S | S |  |  |  |  |  |  |  | T | T |
| S | S | S | S |
|  |  |  |  |  |
|
| S |
|
|  |  |  |  |  |  |  |  |  | T | T |
|  |  |  |  |
|  |  |  |  |  |  | T | T |
|
|
|
|
| . | . |
Template Predicted Secondary structure |   |
 |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |
|  |  |  |  |  |  |  |
|
|
|
|
|
| . | . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
227 | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | |
|
  |
  |   |
174 | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | |
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | . | . | . | 220 |
Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |  |
|
|  |  |  |  |  |  |  |  |  | . | . | . | . | . | . | . | . | . | . | . | . |  |
|
|
|
|  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
R | E | V | A | A | A | V | R | D | A | G | G | W | V | A | L | G | S | D | S | H | T | A | F | T | M | G | E | F | E | E | C | L | K | I | L | D | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
A | V | D | F | P | P | E | R | I | L |
Query Conservation |   |
  |   |   |   |   |   |
|   |   |   |
|   |   |   |   |   |
|
|
|
|
|   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |
|   |
|   |
Alig confidence |   |
. | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
. | . | . |   |   |   |
|   |   |
|
|
|   |
|   |   |
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|   |   |
|
|
|
Template Sequence |   |
. |
. |
. |
V | R | K | Y | L | N | L | G | I | N | V | V | L | G | S | D | I | S | A | G | H | T | C | S | L | F | K | V | I | A | Y | A | I | Q | N | S | K | I | K | W | Q | E | S | G | K | K | D | M | F | L | S | T | S | E | A | F |
Template Known Secondary structure |   |
. | . | . |  |  |  |  |  |  | T | T |
|  |  |  |  |
|
|
| B | T | T | B |
|
| S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | S |
| S |
|
|
|
|  |  |  |  |  |
Template Predicted Secondary structure |   |
. | . | . |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
|
|
|
305 | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 |
  |