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Job DescriptionP76123
Confidence99.95%DateThu Jan 5 12:19:16 GMT 2012
Rank11Aligned Residues308
% Identity15%Templatec3fxiA_
PDB info PDB header:immune systemChain: A: PDB Molecule:toll-like receptor 4; PDBTitle: crystal structure of the human tlr4-human md-2-e.coli lps ra complex
Resolution3.10 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   2.......10.........20....... ..30.........40.........50 .........60.........70.......
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Query Sequence  ITDLILHNHPRMKTITLNDNHIAHLN. . . AKNTTKLEYLNLSNNNLLPTNDI. DQLISSKHLWHVLVNGINNDPLAQMQY
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Template Conservation 
    
  
  
  
 

 
 
  
    
  
  
  
 

 
 
  
    
  
  
  
 

 
 
  
       
Template Sequence  LGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGH
Template Known Secondary structure  B
TT


S
TT


TT




TTSSTT
SS


TT




TTTTTT
TT


TTS



STT
TTTT
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   6970.........80.........90.........100.........110.........120.........130.........140........
 
   78.80.........90.........100.........110.........120...
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Query Sequence  WTAVRNIIDDTNEVTIDLSGLNLTTQPPGLQNFTSINLDNNQFTHF. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation 
  
  
 

 
                
  
                       
                        
Template Sequence  LKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRL
Template Known Secondary structure 
TT



SS







GGGTT
TT



SS



GGGGTTGGG
SS



TT




TTTTTT
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   149150.........160.........170.........180.........190.........200.........210.........220........
 
  
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                                                                                  
Template Sequence  HKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLAYLDYYLDDIIDLFNCLT
Template Known Secondary structure  S

SSTTT


TTS


S


TTTTGGGGGSSS



STTTSGGGS
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   229230.........240.........250.........260.........270.........280.........290.........300........
 
   124....
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DATNY
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Template Conservation                                                                    
             
Template Sequence  NVSSFSLVSVTIERVKDFSYNFGWQHLELVNCKFGQFPTLKLKSLKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFK
Template Known Secondary structure  S
SB
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SS
B
SS





SS

S
BS
SB





TT



SS

B
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   309310.........320.........330.........340.........350.........360.........370.........380........
 
   129130.........140.........150.........160.........170.........180.........190.........200........
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Query Sequence  DRLVKLSLNSNALESINFPQGRNVSITHISMNNNALRNIDIDRLSSVTYFSAAHNQLEFVQLESCEWLQYLNLSHNQLTD
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Template Conservation                                     
                        
                   
Template Sequence  GCCSQSDFGTTSLKYLDLSFNGVITMSSNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLDISHTHTRVAFNGIFN
Template Known Secondary structure  T
S




S
ST
TT


TTSSTBTTBTTTT
TT


TTS


B

TTTTT
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   389390.........400.........410.........420.........430.........440.........450.........460........
 
   209210.........220.........230.........240.........250. ........260.........270.........280.......
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Query Sequence  IVAGNKNELLLLDLSHNKLTSLHNDLFPNLNTLLINNNLLSEI. KIFYSNFCNVQTLNAANNQLKYINLDFLTYLPSIKS
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Template Conservation      
  
                     
  
 

 
 
  
    
  
  
  
 

 
 
  
       
  
  
Template Sequence  GLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQV
Template Known Secondary structure  T
SS



B
TT

BGGG


S

TT

S



B
TTS


S

TTSGGG
SS



B
TTS

SS


SGGGG
TT


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   469470.........480.........490.........500.........510.........520.........530.........540........
 
   288.290.........300...... ...
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Query Sequence  LRLDNNKITHIDTNNTSDI. GTL
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Template Sequence  LDYSLNHIMTSKKQELQHFPSSL
Template Known Secondary structure 



SS




S


TT


TT
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   549550.........560.........570.
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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