Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	G	T	I	Y	Q	R	I	E	D	N	A	H	F	R	E	L	V	E	K	R	Q	R	F	A	T	I	L	S	I	I	M	L	A	V	Y	I	G	F	I	L	L	I	A	F	A	P	G	W	L	G	T	P	L	N	P	N	T	S
Secondary structure
SS confidence
Disorder		?	?									?																																											?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.
Sequence		V	T	R	G	I	P	I	G	V	G	V	I	V	I	S	F	V	L	T	G	I	Y	I	W	R	A	N	G	E	F	D	R	L	N	N	E	V	L	H	E	V	Q	A	S
Secondary structure
SS confidence
Disorder																																										?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2dqb chain B Region: 5 - 39 Aligned: 35 Modelled: 35 Confidence: 51.4% Identity: 29% PDB header:hydrolase, dna binding protein Chain: B: PDB Molecule:deoxyguanosinetriphosphate triphosphohydrolase, putative; PDBTitle: crystal structure of dntp triphosphohydrolase from thermus2 thermophilus hb8, which is homologous to dgtp triphosphohydrolase Phyre2 PDB 2pgs chain A Region: 5 - 43 Aligned: 39 Modelled: 35 Confidence: 19.7% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyguanosinetriphosphate triphosphohydrolase; PDBTitle: crystal structure of a putative deoxyguanosinetriphosphate2 triphosphohydrolase from pseudomonas syringae pv. phaseolicola 1448a Phyre2 PDB 3lo3 chain E Region: 2 - 24 Aligned: 23 Modelled: 23 Confidence: 17.7% Identity: 9% PDB header:structure genomics, unknown function Chain: E: PDB Molecule:uncharacterized conserved protein; PDBTitle: the crystal structure of a conserved functionally unknown2 protein from colwellia psychrerythraea 34h. Phyre2 PDB 3fh6 chain F Region: 2 - 91 Aligned: 90 Modelled: 90 Confidence: 16.3% Identity: 12% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 2fiu chain A domain 1 Region: 2 - 24 Aligned: 23 Modelled: 23 Confidence: 13.5% Identity: 9% Fold: Ferredoxin-like Superfamily: Dimeric alpha+beta barrel Family: Atu0297-like Phyre2 PDB 2o6i chain A domain 1 Region: 2 - 20 Aligned: 19 Modelled: 19 Confidence: 12.6% Identity: 11% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 2o6i chain A Region: 2 - 20 Aligned: 19 Modelled: 19 Confidence: 12.6% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:hd domain protein; PDBTitle: structure of an enterococcus faecalis hd domain phosphohydrolase Phyre2 PDB 2q14 chain A Region: 2 - 20 Aligned: 19 Modelled: 19 Confidence: 12.2% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:phosphohydrolase; PDBTitle: crystal structure of phosphohydrolase (bt4208) from bacteroides2 thetaiotaomicron vpi-5482 at 2.20 a resolution Phyre2 PDB 2hek chain A domain 1 Region: 3 - 22 Aligned: 20 Modelled: 20 Confidence: 11.7% Identity: 25% Fold: HD-domain/PDEase-like Superfamily: HD-domain/PDEase-like Family: HD domain Phyre2 PDB 2kjg chain A Region: 9 - 34 Aligned: 26 Modelled: 26 Confidence: 11.3% Identity: 19% PDB header:metal binding protein Chain: A: PDB Molecule:archaeal protein sso6904; PDBTitle: solution structure of an archaeal protein sso6904 from2 hyperthermophilic sulfolobus solfataricus Phyre2 PDB 3bg2 chain A Region: 5 - 39 Aligned: 35 Modelled: 35 Confidence: 10.1% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:dgtp triphosphohydrolase; PDBTitle: crystal structure of deoxyguanosinetriphosphate triphosphohydrolase2 from flavobacterium sp. med217 Phyre2 PDB 1tu7 chain A domain 1 Region: 3 - 29 Aligned: 27 Modelled: 27 Confidence: 9.6% Identity: 26% Fold: GST C-terminal domain-like Superfamily: GST C-terminal domain-like Family: Glutathione S-transferase (GST), C-terminal domain Phyre2 PDB 3sjb chain C Region: 82 - 97 Aligned: 16 Modelled: 16 Confidence: 9.0% Identity: 31% PDB header:hydrolase/transport protein Chain: C: PDB Molecule:golgi to er traffic protein 1; PDBTitle: crystal structure of s. cerevisiae get3 in the open state in complex2 with get1 cytosolic domain Phyre2 PDB 1q59 chain A Region: 52 - 99 Aligned: 45 Modelled: 48 Confidence: 8.6% Identity: 2% Fold: Toxins' membrane translocation domains Superfamily: Bcl-2 inhibitors of programmed cell death Family: Bcl-2 inhibitors of programmed cell death Phyre2 PDB 3u1n chain C Region: 3 - 22 Aligned: 20 Modelled: 20 Confidence: 8.3% Identity: 25% PDB header:hydrolase Chain: C: PDB Molecule:sam domain and hd domain-containing protein 1; PDBTitle: structure of the catalytic core of human samhd1 Phyre2 PDB 3qnq chain D Region: 48 - 102 Aligned: 53 Modelled: 55 Confidence: 7.8% Identity: 9% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 1w6k chain A domain 2 Region: 78 - 101 Aligned: 24 Modelled: 24 Confidence: 7.5% Identity: 21% Fold: alpha/alpha toroid Superfamily: Terpenoid cyclases/Protein prenyltransferases Family: Terpene synthases Phyre2 PDB 2o2f chain A Region: 51 - 101 Aligned: 45 Modelled: 51 Confidence: 7.5% Identity: 13% PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: solution structure of the anti-apoptotic protein bcl-2 in2 complex with an acyl-sulfonamide-based ligand Phyre2 PDB 3sja chain G Region: 82 - 99 Aligned: 18 Modelled: 18 Confidence: 7.4% Identity: 28% PDB header:hydrolase/transport protein Chain: G: PDB Molecule:golgi to er traffic protein 1; PDBTitle: crystal structure of s. cerevisiae get3 in the open state in complex2 with get1 cytosolic domain Phyre2 PDB 1pv7 chain A Region: 22 - 76 Aligned: 54 Modelled: 55 Confidence: 6.5% Identity: 13% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: LacY-like proton/sugar symporter Phyre2 1 c2dqbB_ 2 c2pgsA_ 3 c3lo3E_ 4 c3fh6F_ 5 d2fiua1 6 d2o6ia1 7 c2o6iA_ 8 c2q14A_ 9 d2heka1 10 c2kjgA_ 11 c3bg2A_ 12 d1tu7a1 13 c3sjbC_ 14 d1q59a_ 15 c3u1nC_ 16 c3qnqD_ 17 d1w6ka2 18 c2o2fA_ 19 c3sjaG_ 20 d1pv7a_ 21 22 23 24 25 26 27 28 29

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2dqbB_ 51.4 29 PDB header:hydrolase, dna binding protein Chain: B: PDB Molecule:deoxyguanosinetriphosphate triphosphohydrolase, putative; PDBTitle: crystal structure of dntp triphosphohydrolase from thermus2 thermophilus hb8, which is homologous to dgtp triphosphohydrolase 2 c2pgsA_ 19.7 23 PDB header:hydrolase Chain: A: PDB Molecule:putative deoxyguanosinetriphosphate triphosphohydrolase; PDBTitle: crystal structure of a putative deoxyguanosinetriphosphate2 triphosphohydrolase from pseudomonas syringae pv. phaseolicola 1448a 3 c3lo3E_ 17.7 9 PDB header:structure genomics, unknown function Chain: E: PDB Molecule:uncharacterized conserved protein; PDBTitle: the crystal structure of a conserved functionally unknown2 protein from colwellia psychrerythraea 34h. 4 c3fh6F_ 16.3 12 PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli 5 d2fiua1 13.5 9 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Atu0297-like 6 d2o6ia1 12.6 11 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 7 c2o6iA_ 12.6 11 PDB header:hydrolase Chain: A: PDB Molecule:hd domain protein; PDBTitle: structure of an enterococcus faecalis hd domain phosphohydrolase 8 c2q14A_ 12.2 11 PDB header:hydrolase Chain: A: PDB Molecule:phosphohydrolase; PDBTitle: crystal structure of phosphohydrolase (bt4208) from bacteroides2 thetaiotaomicron vpi-5482 at 2.20 a resolution 9 d2heka1 11.7 25 Fold:HD-domain/PDEase-like Superfamily:HD-domain/PDEase-like Family:HD domain 10 c2kjgA_ 11.3 19 PDB header:metal binding protein Chain: A: PDB Molecule:archaeal protein sso6904; PDBTitle: solution structure of an archaeal protein sso6904 from2 hyperthermophilic sulfolobus solfataricus 11 c3bg2A_ 10.1 31 PDB header:hydrolase Chain: A: PDB Molecule:dgtp triphosphohydrolase; PDBTitle: crystal structure of deoxyguanosinetriphosphate triphosphohydrolase2 from flavobacterium sp. med217 12 d1tu7a1 9.6 26 Fold:GST C-terminal domain-like Superfamily:GST C-terminal domain-like Family:Glutathione S-transferase (GST), C-terminal domain 13 c3sjbC_ 9.0 31 PDB header:hydrolase/transport protein Chain: C: PDB Molecule:golgi to er traffic protein 1; PDBTitle: crystal structure of s. cerevisiae get3 in the open state in complex2 with get1 cytosolic domain 14 d1q59a_ 8.6 2 Fold:Toxins' membrane translocation domains Superfamily:Bcl-2 inhibitors of programmed cell death Family:Bcl-2 inhibitors of programmed cell death 15 c3u1nC_ 8.3 25 PDB header:hydrolase Chain: C: PDB Molecule:sam domain and hd domain-containing protein 1; PDBTitle: structure of the catalytic core of human samhd1 16 c3qnqD_ 7.8 9 PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system 17 d1w6ka2 7.5 21 Fold:alpha/alpha toroid Superfamily:Terpenoid cyclases/Protein prenyltransferases Family:Terpene synthases 18 c2o2fA_ 7.5 13 PDB header:apoptosis Chain: A: PDB Molecule:apoptosis regulator bcl-2; PDBTitle: solution structure of the anti-apoptotic protein bcl-2 in2 complex with an acyl-sulfonamide-based ligand 19 c3sjaG_ 7.4 28 PDB header:hydrolase/transport protein Chain: G: PDB Molecule:golgi to er traffic protein 1; PDBTitle: crystal structure of s. cerevisiae get3 in the open state in complex2 with get1 cytosolic domain 20 d1pv7a_ 6.5 13 Fold:MFS general substrate transporter Superfamily:MFS general substrate transporter Family:LacY-like proton/sugar symporter 21 c1sseB_ not modelled 6.4 23 PDB header:transcription activator Chain: B: PDB Molecule:ap-1 like transcription factor yap1; PDBTitle: solution structure of the oxidized form of the yap1 redox2 domain 22 d1vpua_ not modelled 6.1 25 Fold:HIV-1 VPU cytoplasmic domain Superfamily:HIV-1 VPU cytoplasmic domain Family:HIV-1 VPU cytoplasmic domain 23 d2gw6a1 not modelled 5.5 17 Fold:Restriction endonuclease-like Superfamily:tRNA-intron endonuclease catalytic domain-like Family:tRNA-intron endonuclease catalytic domain-like 24 d1tuwa_ not modelled 5.5 15 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Polyketide synthesis cyclase 25 c2vofA_ not modelled 5.4 4 PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-related protein a1; PDBTitle: structure of mouse a1 bound to the puma bh3-domain 26 c1ei0A_ not modelled 5.3 24 PDB header:cell cycle Chain: A: PDB Molecule:p8mtcp1; PDBTitle: nmr structure of the alpha-helical hairpin of p8mtcp1 27 c3a0hX_ not modelled 5.3 23 PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of i-substituted photosystem ii complex 28 c3a0hx_ not modelled 5.3 23 PDB header:electron transport Chain: X: PDB Molecule:photosystem ii reaction center protein x; PDBTitle: crystal structure of i-substituted photosystem ii complex 29 c1s5lx_ not modelled 5.1 25 PDB header:photosynthesis Chain: X: PDB Molecule:photosystem ii psbx protein; PDBTitle: architecture of the photosynthetic oxygen evolving center

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0