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Job DescriptionP36649
Confidence100.00%DateThu Jan 5 11:53:29 GMT 2012
Rank17Aligned Residues417
% Identity15%Templatec3cdzA_
PDB info PDB header:blood clottingChain: A: PDB Molecule:coagulation factor viii heavy chain; PDBTitle: crystal structure of human factor viii
Resolution3.98 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   70.........80.........90.........100.........110..... .. ..120.........130......
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Query Sequence  NGNLLGPAVKLQRGKAVTVDIYNQLTEETTLHWHGLEVPGEVDGGP. . . . . . . . . QG. . IIPPGGKRSVTLNVDQPAA. .
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Template Sequence  WMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPM
Template Known Secondary structure  S

S
TT

B
SSS



B
SSSB

TTS

B
S




TTS


TT





GGGS

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   68.70.........80.........90.........100.........110.........120.........130.........140.......
 
   137..140.........150.........160.........170.........180.........190.........200.........
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Query Sequence  . . . . . . . TCWFHPHQHGKTGRQVAMGLAGLVVIEDDEILKLMLPKQWGIDDVPVIVQDKKFSADGQIDYQLDVMTAAVGW
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Template Sequence  ASDPLCLTYSYLSHVD. . LVKDLNSGLIGALLVCREGSLAKEKTQ. . TLHKFILLFAVFDEGKSWHSSARA. . . . . . . . .
Template Known Secondary structure  SSS
S

B
BSS..

SS
STTTSSS
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TTSSS





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   148.150.........160... ......170.........180.........190 .........200.........210....
 
   210.........220...... ...230.........240.........250........ .260.........270.........280...
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Query Sequence  FGDTLLTNGAIYPQHAA. . . . PRGWLRLRLLNGCNARSLNFATSDNRPLYVIA. . SDGGLLPEPVKVSELPVLMGERFEV
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Template Sequence  WPKMHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEI. SPITFLTAQTLLMDLGQF
Template Known Secondary structure 





GGG

TT







SSS




SS







SS



SSS


SS


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SS





SS


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   228.230.........240.........250.........260.........270.........280........ .290.........300......
 
   284.....290
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Query Sequence  LVEVNDN. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                                                                                  
Template Sequence  LLFCHISSHQHDGMEAYVKVDSCPEEPKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFM
Template Known Secondary structure 





TT










SS







SS
S



SSSSTTTT
S
SSS

SS


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   307..310.........320.........330.........340.........350.........360.........370.........380......
 
   291........300.........310.........320.........330.........340.
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . KPFDLVTLPVSQMGMAIAPFDKPHPVMRIQPIAISASGALPDTLSSLPALP.
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Template Sequence  AYTDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIF
Template Known Secondary structure  SSSSTTSB



TTTTT



TT
SSS



S
SSS
S

STT
SSSSSS


SS
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   430.........440.........450.........460.........470.........480.........490.........500.........
 
   342.......350.........360.........370.........380..
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . SLEGLTVRKLQLSMDPMLDMMGMQMLMEKYGDQAMAGMDHS
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Template Conservation                                                                                  
Template Sequence  KYKWTVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTE
Template Known Secondary structure 

GGGS

SSS
S

SSSTTT



SSSSSS
SS




GGG
TTTT
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   510.........520.........530.........540.........550.........560.........570.........580.........
 
   383......390.........400.........410.........420.........430.........440. ........450.........460.
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Query Sequence  QMMGHMGHGNMNHMNHGGKFDFHHANKINGQAFDMNKPMFAAAKGQYERWVISGVGDMM. LHPFHIHGTQFRILSENGKP
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Template Sequence  NIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQ. . LSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKH. . . . . . .
Template Known Secondary structure  TSS

TT


S
TSTTB
TT
S
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B

TT
S

SS


SS

B
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   590.........600.........610.........620...... ...630.........640.........650.........660
 
   462.......470.........480.........490.........500.........510......
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Query Sequence  PAAHRAGWKDTVKVEGNVSEVLVKFNHDAPKEHAYMAHCHLLEHEDTGMMLGFTV
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Template Sequence  . . . . KMVYEDTLTLFPF. SGETVFMSMENPG. . LWILGCHNSDFRNRGMTALLKV
Template Known Secondary structure  ....TTS
BS

SS.




S..
B


BS
TTTTTSB



BB
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   661........670... ......680...... ...690.........700........
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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