Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP0AC19
DateThu Jan 5 11:16:56 GMT 2012
Unique Job ID9154692843e9dfca

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template d1b9la_
Top template information
Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:DHN aldolase/epimerase
Confidence and coverage
Confidence:100.0% Coverage: 99%
119 residues ( 99% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MAQPAAIIRIKNLRLRTFIGIKEEEINNRQDIVINVTIHYPADKARTSEDINDALNYRTV
Secondary structure 


















SS confidence 



























































Disorder  ?????






















































Disorder confidence 



























































 
   .........70.........80.........90.........100.........110.........120
Sequence  TKNIIQHVENNRFSLLEKLTQDVLDIAREHHWVTYAEVEIDKLHALRYADSVSMTLSWQR
Secondary structure 




















SS confidence 



























































Disorder 


























































?
Disorder confidence 



























































 
  
Sequence 
Secondary structure 
SS confidence 
Disorder 
Disorder confidence 
 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 1b9l chain A

3D model

Region: 2 - 120
Aligned: 119
Modelled: 119
Confidence: 100.0%
Identity: 100%
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Family: DHN aldolase/epimerase

Phyre2

PDB 1sql chain N

3D model

Region: 6 - 120
Aligned: 115
Modelled: 115
Confidence: 100.0%
Identity: 20%
PDB header:lyase
Chain: N: PDB Molecule:dihydroneopterin aldolase;
PDBTitle: crystal structure of 7,8-dihydroneopterin aldolase in2 complex with guanine

Phyre2

PDB 2o90 chain A

3D model

Region: 5 - 118
Aligned: 114
Modelled: 114
Confidence: 100.0%
Identity: 25%
PDB header:lyase
Chain: A: PDB Molecule:dihydroneopterin aldolase;
PDBTitle: atomic resolution crystal structure of e.coli2 dihydroneopterin aldolase in complex with neopterin

Phyre2

PDB 1sql chain A

3D model

Region: 6 - 120
Aligned: 115
Modelled: 115
Confidence: 100.0%
Identity: 20%
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Family: DHN aldolase/epimerase

Phyre2

PDB 1nbu chain A

3D model

Region: 5 - 120
Aligned: 116
Modelled: 116
Confidence: 100.0%
Identity: 23%
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Family: DHN aldolase/epimerase

Phyre2

PDB 1dhn chain A

3D model

Region: 6 - 120
Aligned: 115
Modelled: 115
Confidence: 100.0%
Identity: 20%
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Family: DHN aldolase/epimerase

Phyre2

PDB 2cg8 chain B

3D model

Region: 5 - 120
Aligned: 112
Modelled: 112
Confidence: 100.0%
Identity: 19%
PDB header:lyase/transferase
Chain: B: PDB Molecule:dihydroneopterin aldolase 6-hydroxymethyl-7,8-
PDBTitle: the bifunctional dihydroneopterin aldolase 6-hydroxymethyl-2 7,8-dihydropterin synthase from streptococcus pneumoniae

Phyre2

PDB 2iba chain A domain 1

3D model

Region: 32 - 101
Aligned: 70
Modelled: 70
Confidence: 91.7%
Identity: 14%
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Family: Urate oxidase (uricase)

Phyre2

PDB 2yzc chain A domain 1

3D model

Region: 32 - 101
Aligned: 69
Modelled: 70
Confidence: 88.7%
Identity: 14%
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Family: Urate oxidase (uricase)

Phyre2

PDB 1j2g chain A domain 1

3D model

Region: 32 - 101
Aligned: 70
Modelled: 70
Confidence: 87.8%
Identity: 9%
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Family: Urate oxidase (uricase)

Phyre2

PDB 1r56 chain H

3D model

Region: 32 - 101
Aligned: 70
Modelled: 70
Confidence: 85.9%
Identity: 14%
PDB header:oxidoreductase
Chain: H: PDB Molecule:uricase;
PDBTitle: uncomplexed urate oxidase from aspergillus flavus

Phyre2

PDB 2yzb chain A

3D model

Region: 32 - 101
Aligned: 69
Modelled: 70
Confidence: 83.6%
Identity: 14%
PDB header:oxidoreductase
Chain: A: PDB Molecule:uricase;
PDBTitle: crystal structure of uricase from arthrobacter globiformis2 in complex with uric acid (substrate)

Phyre2

PDB 1j2g chain C

3D model

Region: 32 - 101
Aligned: 70
Modelled: 70
Confidence: 77.0%
Identity: 9%
PDB header:oxidoreductase
Chain: C: PDB Molecule:uricase;
PDBTitle: crystal structure of urate oxidase from bacillus sp. tb-90 co-2 crystallized with 8-azaxanthine

Phyre2

PDB 1y13 chain A

3D model

Region: 25 - 101
Aligned: 71
Modelled: 77
Confidence: 53.4%
Identity: 13%
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Family: 6-pyruvoyl tetrahydropterin synthase

Phyre2

PDB 2dj6 chain B

3D model

Region: 25 - 101
Aligned: 70
Modelled: 77
Confidence: 45.4%
Identity: 13%
PDB header:lyase
Chain: B: PDB Molecule:hypothetical protein ph0634;
PDBTitle: crystal structure of 6-pyruvoyl tetrahydrobiopterin synthase from2 pyrococcus horikoshii ot3

Phyre2

PDB 2a0s chain A domain 1

3D model

Region: 25 - 101
Aligned: 71
Modelled: 77
Confidence: 41.0%
Identity: 13%
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Family: 6-pyruvoyl tetrahydropterin synthase

Phyre2

PDB 2r5r chain A

3D model

Region: 4 - 101
Aligned: 85
Modelled: 90
Confidence: 33.0%
Identity: 11%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:upf0343 protein ne1163;
PDBTitle: the crystal structure of duf198 from nitrosomonas europaea2 atcc 19718

Phyre2

PDB 1j2g chain A domain 2

3D model

Region: 33 - 100
Aligned: 68
Modelled: 68
Confidence: 27.0%
Identity: 7%
Fold: T-fold
Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like
Family: Urate oxidase (uricase)

Phyre2

PDB 3d2o chain B

3D model

Region: 4 - 101
Aligned: 84
Modelled: 98
Confidence: 20.3%
Identity: 19%
PDB header:hydrolase, biosynthetic protein
Chain: B: PDB Molecule:upf0343 protein ngo0387;
PDBTitle: crystal structure of manganese-metallated gtp cyclohydrolase2 type ib

Phyre2

PDB 1ghh chain A

3D model

Region: 74 - 118
Aligned: 39
Modelled: 45
Confidence: 14.5%
Identity: 10%
Fold: DNA damage-inducible protein DinI
Superfamily: DNA damage-inducible protein DinI
Family: DNA damage-inducible protein DinI

Phyre2
1

d1b9la_
2

c1sqlN_
3

c2o90A_
4

d1sqla_
5

d1nbua_
6

d1dhna_
7

c2cg8B_
8

d2ibaa1
9

d2yzca1
10

d1j2ga1
11

c1r56H_
12

c2yzbA_
13

c1j2gC_
14

d1y13a_
15

c2dj6B_
16

d2a0sa1
17

c2r5rA_
18

d1j2ga2
19

c3d2oB_
20

d1ghha_
21



22



23



24



25



26



27



28



29



30



31



32



33



34



35



36






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1d1b9la_



100.0 100 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:DHN aldolase/epimerase
2c1sqlN_



100.0 20 PDB header:lyase
Chain: N: PDB Molecule:dihydroneopterin aldolase;
PDBTitle: crystal structure of 7,8-dihydroneopterin aldolase in2 complex with guanine
3c2o90A_



100.0 25 PDB header:lyase
Chain: A: PDB Molecule:dihydroneopterin aldolase;
PDBTitle: atomic resolution crystal structure of e.coli2 dihydroneopterin aldolase in complex with neopterin
4d1sqla_



100.0 20 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:DHN aldolase/epimerase
5d1nbua_



100.0 23 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:DHN aldolase/epimerase
6d1dhna_



100.0 20 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:DHN aldolase/epimerase
7c2cg8B_



100.0 19 PDB header:lyase/transferase
Chain: B: PDB Molecule:dihydroneopterin aldolase 6-hydroxymethyl-7,8-
PDBTitle: the bifunctional dihydroneopterin aldolase 6-hydroxymethyl-2 7,8-dihydropterin synthase from streptococcus pneumoniae
8d2ibaa1



91.7 14 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:Urate oxidase (uricase)
9d2yzca1



88.7 14 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:Urate oxidase (uricase)
10d1j2ga1



87.8 9 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:Urate oxidase (uricase)
11c1r56H_



85.9 14 PDB header:oxidoreductase
Chain: H: PDB Molecule:uricase;
PDBTitle: uncomplexed urate oxidase from aspergillus flavus
12c2yzbA_



83.6 14 PDB header:oxidoreductase
Chain: A: PDB Molecule:uricase;
PDBTitle: crystal structure of uricase from arthrobacter globiformis2 in complex with uric acid (substrate)
13c1j2gC_



77.0 9 PDB header:oxidoreductase
Chain: C: PDB Molecule:uricase;
PDBTitle: crystal structure of urate oxidase from bacillus sp. tb-90 co-2 crystallized with 8-azaxanthine
14d1y13a_



53.4 13 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:6-pyruvoyl tetrahydropterin synthase
15c2dj6B_



45.4 13 PDB header:lyase
Chain: B: PDB Molecule:hypothetical protein ph0634;
PDBTitle: crystal structure of 6-pyruvoyl tetrahydrobiopterin synthase from2 pyrococcus horikoshii ot3
16d2a0sa1



41.0 13 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:6-pyruvoyl tetrahydropterin synthase
17c2r5rA_



33.0 11 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:upf0343 protein ne1163;
PDBTitle: the crystal structure of duf198 from nitrosomonas europaea2 atcc 19718
18d1j2ga2



27.0 7 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:Urate oxidase (uricase)
19c3d2oB_



20.3 19 PDB header:hydrolase, biosynthetic protein
Chain: B: PDB Molecule:upf0343 protein ngo0387;
PDBTitle: crystal structure of manganese-metallated gtp cyclohydrolase2 type ib
20d1ghha_



14.5 10 Fold:DNA damage-inducible protein DinI
Superfamily:DNA damage-inducible protein DinI
Family:DNA damage-inducible protein DinI
21d2ieca1



not modelled 12.1 23 Fold:MK0786-like
Superfamily:MK0786-like
Family:MK0786-like
22d1oaoc_



not modelled 11.9 14 Fold:Prismane protein-like
Superfamily:Prismane protein-like
Family:Acetyl-CoA synthase
23d1ru3a_



not modelled 11.1 19 Fold:Prismane protein-like
Superfamily:Prismane protein-like
Family:Acetyl-CoA synthase
24c2obaE_



not modelled 9.4 11 PDB header:lyase
Chain: E: PDB Molecule:probable 6-pyruvoyl tetrahydrobiopterin synthase;
PDBTitle: pseudomonas aeruginosa 6-pyruvoyl tetrahydrobiopterin synthase
25d1a04a2



not modelled 8.1 16 Fold:Flavodoxin-like
Superfamily:CheY-like
Family:CheY-related
26d1wpla_



not modelled 7.3 17 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:GTP cyclohydrolase I
27c1is7F_



not modelled 7.3 17 PDB header:hydrolase/protein binding
Chain: F: PDB Molecule:gtp cyclohydrolase i;
PDBTitle: crystal structure of rat gtpchi/gfrp stimulatory complex
28d2i52a1



not modelled 7.3 7 Fold:MK0786-like
Superfamily:MK0786-like
Family:MK0786-like
29d2yzca2



not modelled 7.2 11 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:Urate oxidase (uricase)
30c2zw2B_



not modelled 7.1 14 PDB header:ligase
Chain: B: PDB Molecule:putative uncharacterized protein sts178;
PDBTitle: crystal structure of formylglycinamide ribonucleotide amidotransferase2 iii from sulfolobus tokodaii (stpurs)
31c2i44A_



not modelled 7.0 5 PDB header:hydrolase
Chain: A: PDB Molecule:serine-threonine phosphatase 2c;
PDBTitle: crystal structure of serine-threonine phosphatase 2c from2 toxoplasma gondii
32d1a8ra_



not modelled 6.7 21 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:GTP cyclohydrolase I
33c2ogfD_



not modelled 6.6 16 PDB header:structural genomics, unknown function
Chain: D: PDB Molecule:hypothetical protein mj0408;
PDBTitle: crystal structure of protein mj0408 from methanococcus jannaschii,2 pfam duf372
34d1gpma3



not modelled 5.8 10 Fold:Alpha-lytic protease prodomain-like
Superfamily:GMP synthetase C-terminal dimerisation domain
Family:GMP synthetase C-terminal dimerisation domain
35d1a6qa2



not modelled 5.7 16 Fold:PP2C-like
Superfamily:PP2C-like
Family:PP2C-like
36d1b66a_



not modelled 5.6 15 Fold:T-fold
Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like
Family:6-pyruvoyl tetrahydropterin synthase

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0