Secondary structure and disorder prediction

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Sequence

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Secondary structure

SS confidence

Disorder

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Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1zll chain E Region: 4 - 18 Aligned: 15 Modelled: 15 Confidence: 7.5% Identity: 67% PDB header:membrane protein/signaling protein Chain: E: PDB Molecule:cardiac phospholamban; PDBTitle: nmr structure of unphosphorylated human phospholamban2 pentamer Phyre2 PDB 2p7v chain A Region: 4 - 21 Aligned: 16 Modelled: 18 Confidence: 7.1% Identity: 50% PDB header:transcription Chain: A: PDB Molecule:regulator of sigma d; PDBTitle: crystal structure of the escherichia coli regulator of sigma 70, rsd,2 in complex with sigma 70 domain 4 Phyre2 PDB 1cmr chain A Region: 19 - 23 Aligned: 5 Modelled: 5 Confidence: 5.9% Identity: 80% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Scorpion toxin-like Family: Short-chain scorpion toxins Phyre2 PDB 1nj1 chain A domain 2 Region: 17 - 25 Aligned: 9 Modelled: 9 Confidence: 5.4% Identity: 56% Fold: IF3-like Superfamily: C-terminal domain of ProRS Family: C-terminal domain of ProRS Phyre2 PDB 1en2 chain A domain 2 Region: 21 - 24 Aligned: 4 Modelled: 4 Confidence: 5.2% Identity: 100% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Plant lectins/antimicrobial peptides Family: Hevein-like agglutinin (lectin) domain Phyre2 1 c1zllE_ 2 c2p7vA_ 3 d1cmra_ 4 d1nj1a2 5 d1en2a2

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1zllE_ 7.5 67 PDB header:membrane protein/signaling protein Chain: E: PDB Molecule:cardiac phospholamban; PDBTitle: nmr structure of unphosphorylated human phospholamban2 pentamer 2 c2p7vA_ 7.1 50 PDB header:transcription Chain: A: PDB Molecule:regulator of sigma d; PDBTitle: crystal structure of the escherichia coli regulator of sigma 70, rsd,2 in complex with sigma 70 domain 4 3 d1cmra_ 5.9 80 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Scorpion toxin-like Family:Short-chain scorpion toxins 4 d1nj1a2 5.4 56 Fold:IF3-like Superfamily:C-terminal domain of ProRS Family:C-terminal domain of ProRS 5 d1en2a2 5.2 100 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Plant lectins/antimicrobial peptides Family:Hevein-like agglutinin (lectin) domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0