Phyre 2 Results for P56980

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Email | l.a.kelley@imperial.ac.uk
Description | P56980
Date | Wed Jan 25 15:20:58 GMT 2012
Unique Job ID | 86e31b4d43a33ea8

Summary |

Top model
Image coloured by rainbow N → C terminus
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Model (left) based on template c1zllE_
Top template information
PDB header:membrane protein/signaling protein Chain: E: PDB Molecule:cardiac phospholamban; PDBTitle: nmr structure of unphosphorylated human phospholamban2 pentamer
Confidence and coverage
Confidence: | 7.5% | Coverage: | 62%
15 residues ( 62% of your sequence) have been modelled with 7.5% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
Please note: You must be registered and logged in to use Phyrealarm.
3D viewing
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Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | .
Sequence |  | M | P | G | K | V | Q | D | F | F | L | C | S | L | L | L | C | I | V | S | A | G | W | C | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c1zllE_ |

### PDB 1zll chain E

Region: 4 - 18
Aligned: 15
Modelled: 15
Confidence: 7.5%
Identity: 67%
PDB header:membrane protein/signaling protein
Chain: E: PDB Molecule:cardiac phospholamban;
PDBTitle: nmr structure of unphosphorylated human phospholamban2 pentamer

Phyre2
2 |
| c2p7vA_ |

### PDB 2p7v chain A

Region: 4 - 21
Aligned: 16
Modelled: 18
Confidence: 7.1%
Identity: 50%
PDB header:transcription
Chain: A: PDB Molecule:regulator of sigma d;
PDBTitle: crystal structure of the escherichia coli regulator of sigma 70, rsd,2 in complex with sigma 70 domain 4

Phyre2
3 |
| d1cmra_ |

### PDB 1cmr chain A

Region: 19 - 23
Aligned: 5
Modelled: 5
Confidence: 5.9%
Identity: 80%
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: Scorpion toxin-like
Family: Short-chain scorpion toxins

Phyre2
4 |
| d1nj1a2 |

### PDB 1nj1 chain A domain 2

Region: 17 - 25
Aligned: 9
Modelled: 9
Confidence: 5.4%
Identity: 56%
Fold: IF3-like
Superfamily: C-terminal domain of ProRS
Family: C-terminal domain of ProRS

Phyre2
5 |
| d1en2a2 |

### PDB 1en2 chain A domain 2

Region: 21 - 24
Aligned: 4
Modelled: 4
Confidence: 5.2%
Identity: 100%
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: Plant lectins/antimicrobial peptides
Family: Hevein-like agglutinin (lectin) domain

Phyre2

Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c1zllE_ |
|  | 7.5 | 67 | PDB header:membrane protein/signaling protein Chain: E: PDB Molecule:cardiac phospholamban; PDBTitle: nmr structure of unphosphorylated human phospholamban2 pentamer
2 | c2p7vA_ |
|  | 7.1 | 50 | PDB header:transcription Chain: A: PDB Molecule:regulator of sigma d; PDBTitle: crystal structure of the escherichia coli regulator of sigma 70, rsd,2 in complex with sigma 70 domain 4
3 | d1cmra_ |
|  | 5.9 | 80 | Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Scorpion toxin-like Family:Short-chain scorpion toxins
4 | d1nj1a2 |
|  | 5.4 | 56 | Fold:IF3-like Superfamily:C-terminal domain of ProRS Family:C-terminal domain of ProRS
5 | d1en2a2 |
|  | 5.2 | 100 | Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Plant lectins/antimicrobial peptides Family:Hevein-like agglutinin (lectin) domain

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0