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Job DescriptionP27298
Confidence100.00%DateWed Jan 25 15:20:46 GMT 2012
Rank9Aligned Residues531
% Identity16%Templatec2c6nA_
PDB info PDB header:hydrolase/hydrolase inhibitorChain: A: PDB Molecule:angiotensin-converting enzyme, somatic isoform; PDBTitle: structure of human somatic angiontensin-i converting enzyme n domain2 with lisinopril
Resolution3.00 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   43......50.........60.........70.........80.........90.........100.........110.........120..
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Query Sequence  QGAPYTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSPELREAYEQTLPLLSEYSTWVGQHEGLYKAYRDLRDGDHYATL
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Template Sequence  SADEAGAQLFAQSYNSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWG. . . . . . QKAKELYEPIWQNFT
Template Known Secondary structure 
SSGGGS

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   11........20.........30.........40.........50.........60......... 70.........80....
 
   123......130.........140.........150.........160.........170.........180.........190.........200..
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Query Sequence  NTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIATRLSELGNQYSNNVLDATMGWTKLVTDEAELAGMPESALAAAKAQA
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Template Sequence  DPQLRRIIGAVR. . . TLGSANLPLAKRQQYNALLSNMSRIYSTA. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . KV
Template Known Secondary structure 
S...

TTTTS

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   85....90...... ...100.........110.........120..... ..
 
   203......210.........220.........230.........240.........250.........260.........270.........280..
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Query Sequence  EAKELEGYLLTLDIPSYLPVMTYCDNQALREEMYRAYSTRASDQGPNAGKWDNSKVMEEILALRHELAQLLGFENYAFKS
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Template Sequence  CLPNKTATCWSLD. PDLTNILASSRSYAMLLFAWEGWHNAAGIP. . . . . . . . LKPLYEDFTALSNEAYKQDGFTDTGAYW
Template Known Secondary structure 

SS




TT.T


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   128.130.........140 .........150.........160.........170 .........180.........190........
 
   283......290.........300.........310.........320.........330..... ....340.........350.........360
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Query Sequence  LATKMAENPQQVLDFLTDLAKRARPQGEKELAQLRAFAKAEFGVDELQPWDIA. . YYSEKQKQHLYSISDEQLRPYFPEN
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Template Sequence  RSW. . . YNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKP
Template Known Secondary structure  TTT...T

TT
TTT

TTS
TTSSSSTT
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TTS
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   199200. ........210.........220.........230.........240.........250.........260.........270.....
 
   361. .......370.........380.........390.........400.........410.........420........
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Query Sequence  KA. . . . . . . . . . . . VNGLFEVVKRIYGITAKERKDVDVWHPDVRFFELYDENNELRGSFYLDLYARENKRGGAWMDDCVG
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Template Conservation                   
      

  

        
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Template Sequence  NLDVTSTMLQQGWNATHMFRVAEEFFTSLELSPMPPEFW. . . . . . . . . . . . . . . . . . . . EGSMLEKPADGREVVCHASAW
Template Known Secondary structure 
S
TTS


TT




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B
S

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   276...280.........290.........300.........310.... .....320.........330.....
 
   429430.........440.........450.........460.........470.........480.........490.........500........
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Query Sequence  QMRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITLFHEFGHGLHHMLTRIETAGVSGISGVPWDAVELPSQFMENW
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Template Sequence  DFY. . . . . . NRKDFRIKQCTRV. . . . . . . . . TMDQLSTVHHEMGHIQYYLQYKDLPVSLRR. . GANPGFHEAIGDVLALS
Template Known Secondary structure 
S......SSS





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   336.. .340.........350. ........360.........370.........380. ........390........
 
   509510.........520.........530.........540. ........550.........560.........570.........580.....
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Query Sequence  CWEPEALAFISGHYETGEPLPKELLDKMLAAKN. . . YQAALFILRQLEFGLFDFRLHAEFRPDQGAKILETLAEIKKLVA
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Template Sequence  VSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFS. . . . . . . GRTPPSRYNFDWWYLRTKYQ
Template Known Secondary structure  STTS





STT.......TSS
GGG
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   399400.........410.........420.........430.........440.........450. ........460.........470.
 
   586...590 .........600.........610.........620.........630.... .....640.........650
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Query Sequence  VVPSP. . . . SWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSRFEEEGIF. . . . . . . . . . . NRETGQSFLDNILSRG
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Template Sequence  GICPPVTRNETHFDAGAKFHVPNVTP. . . YIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRK. VLQAG
Template Known Secondary structure 

SS


TT

SGGGSTTTTTT

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   472.......480.........490....... ..500.........510.........520.........530.........540.. .....
 
   651........660.... .....670......
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Query Sequence  GSEEPMDLFKRFRG. REPQLDAMLEHY
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Template Conservation   
    
 
   

  
     

 

Template Sequence  SSRPWQEVLKDMVGLDALDAQPLLKYF
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   548.550.........560.........570....
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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