Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	W	Q	Q	R	V	R	V	A	T	G	L	S	C	W	Q	I	M	L	H	L	L	V	V	A	L	L	V	V	G	W	M	S	K	T	L	V	H	V	G	V	G	L	C	A	L	Y	C	V	T	V	V	M	M	L	V	F	Q	R
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	P	E	Q	R	W	R	E	V	A	D	V	L	E	E	L	T	T	T	W	Y	F	G	A	A	L	I	V	L	W	L	L	S	R	V	L	E	N	N	F	L	L	A	I	A	G	L	A	I	L	A	G	P	A	V	V	S	L	L	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.
Sequence		K	D	K	K	L	H	H	L	T	S	K	H	R	V	R	R
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?	?			?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2r2v chain B Region: 66 - 84 Aligned: 19 Modelled: 19 Confidence: 19.8% Identity: 42% PDB header:de novo protein Chain: B: PDB Molecule:gcn4 leucine zipper; PDBTitle: sequence determinants of the topology of the lac repressor2 tetrameric coiled coil Phyre2 PDB 2laf chain A Region: 56 - 75 Aligned: 20 Modelled: 20 Confidence: 12.1% Identity: 30% PDB header:membrane protein Chain: A: PDB Molecule:lipoprotein 34; PDBTitle: nmr solution structure of the n-terminal domain of the e. coli2 lipoprotein bamc Phyre2 PDB 2k7w chain B Region: 64 - 71 Aligned: 8 Modelled: 8 Confidence: 11.5% Identity: 38% PDB header:apoptosis Chain: B: PDB Molecule:bcl-2-like protein 11; PDBTitle: bax activation is initiated at a novel interaction site Phyre2 PDB 3kj1 chain B Region: 64 - 71 Aligned: 8 Modelled: 8 Confidence: 11.3% Identity: 38% PDB header:apoptosis Chain: B: PDB Molecule:bcl-2-like protein 11; PDBTitle: mcl-1 in complex with bim bh3 mutant i2da Phyre2 PDB 3kj2 chain B Region: 64 - 71 Aligned: 8 Modelled: 8 Confidence: 10.9% Identity: 38% PDB header:apoptosis Chain: B: PDB Molecule:bcl-2-like protein 11; PDBTitle: mcl-1 in complex with bim bh3 mutant f4ae Phyre2 PDB 3kz0 chain D Region: 64 - 71 Aligned: 8 Modelled: 8 Confidence: 9.1% Identity: 38% PDB header:apoptosis Chain: D: PDB Molecule:mcl-1 specific peptide mb7; PDBTitle: mcl-1 complex with mcl-1-specific selected peptide Phyre2 PDB 3kz0 chain C Region: 64 - 71 Aligned: 8 Modelled: 8 Confidence: 9.1% Identity: 38% PDB header:apoptosis Chain: C: PDB Molecule:mcl-1 specific peptide mb7; PDBTitle: mcl-1 complex with mcl-1-specific selected peptide Phyre2 PDB 1pq1 chain B Region: 64 - 82 Aligned: 19 Modelled: 19 Confidence: 8.7% Identity: 32% PDB header:apoptosis Chain: B: PDB Molecule:bcl2-like protein 11; PDBTitle: crystal structure of bcl-xl/bim Phyre2 PDB 3io9 chain B Region: 64 - 71 Aligned: 8 Modelled: 8 Confidence: 6.3% Identity: 38% PDB header:apoptosis Chain: B: PDB Molecule:bcl-2-like protein 11; PDBTitle: biml12y in complex with mcl-1 Phyre2 PDB 2z15 chain A domain 1 Region: 49 - 81 Aligned: 33 Modelled: 33 Confidence: 6.2% Identity: 18% Fold: BTG domain-like Superfamily: BTG domain-like Family: BTG domain-like Phyre2 PDB 3cf4 chain A Region: 30 - 47 Aligned: 18 Modelled: 18 Confidence: 5.6% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:acetyl-coa decarboxylase/synthase alpha subunit; PDBTitle: structure of the codh component of the m. barkeri acds complex Phyre2 PDB 1ery chain A Region: 35 - 50 Aligned: 16 Modelled: 16 Confidence: 5.2% Identity: 31% Fold: Protozoan pheromone-like Superfamily: Protozoan pheromone proteins Family: Protozoan pheromone proteins Phyre2 1 c2r2vB_ 2 c2lafA_ 3 c2k7wB_ 4 c3kj1B_ 5 c3kj2B_ 6 c3kz0D_ 7 c3kz0C_ 8 c1pq1B_ 9 c3io9B_ 10 d2z15a1 11 c3cf4A_ 12 d1erya_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2r2vB_ 19.8 42 PDB header:de novo protein Chain: B: PDB Molecule:gcn4 leucine zipper; PDBTitle: sequence determinants of the topology of the lac repressor2 tetrameric coiled coil 2 c2lafA_ 12.1 30 PDB header:membrane protein Chain: A: PDB Molecule:lipoprotein 34; PDBTitle: nmr solution structure of the n-terminal domain of the e. coli2 lipoprotein bamc 3 c2k7wB_ 11.5 38 PDB header:apoptosis Chain: B: PDB Molecule:bcl-2-like protein 11; PDBTitle: bax activation is initiated at a novel interaction site 4 c3kj1B_ 11.3 38 PDB header:apoptosis Chain: B: PDB Molecule:bcl-2-like protein 11; PDBTitle: mcl-1 in complex with bim bh3 mutant i2da 5 c3kj2B_ 10.9 38 PDB header:apoptosis Chain: B: PDB Molecule:bcl-2-like protein 11; PDBTitle: mcl-1 in complex with bim bh3 mutant f4ae 6 c3kz0D_ 9.1 38 PDB header:apoptosis Chain: D: PDB Molecule:mcl-1 specific peptide mb7; PDBTitle: mcl-1 complex with mcl-1-specific selected peptide 7 c3kz0C_ 9.1 38 PDB header:apoptosis Chain: C: PDB Molecule:mcl-1 specific peptide mb7; PDBTitle: mcl-1 complex with mcl-1-specific selected peptide 8 c1pq1B_ 8.7 32 PDB header:apoptosis Chain: B: PDB Molecule:bcl2-like protein 11; PDBTitle: crystal structure of bcl-xl/bim 9 c3io9B_ 6.3 38 PDB header:apoptosis Chain: B: PDB Molecule:bcl-2-like protein 11; PDBTitle: biml12y in complex with mcl-1 10 d2z15a1 6.2 18 Fold:BTG domain-like Superfamily:BTG domain-like Family:BTG domain-like 11 c3cf4A_ 5.6 22 PDB header:oxidoreductase Chain: A: PDB Molecule:acetyl-coa decarboxylase/synthase alpha subunit; PDBTitle: structure of the codh component of the m. barkeri acds complex 12 d1erya_ 5.2 31 Fold:Protozoan pheromone-like Superfamily:Protozoan pheromone proteins Family:Protozoan pheromone proteins

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0