Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	I	I	H	P	L	L	A	S	S	S	A	P	N	Y	R	Q	S	W	R	L	A	G	V	W	R	R	A	I	N	L	M	T	E	S	G	E	L	L	T	L	H	R	Q	G	S	G	F	G	P	G	G	W	V	L	R	R	A	Q
Secondary structure
SS confidence
Disorder		?	?			?	?	?	?	?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	D	A	L	C	G	G	L	C	G	N	E	R	P	Q	V	V	A	Q	G	I	R	L	G	R	F	T	V	K	Q	P	Q	R	Y	C	L	L	R	I	T	P	P	A	H	P	Q	P	L	A	A	A	W	M	Q	R	A	E	E	T	G
Secondary structure
SS confidence
Disorder																																				?						?	?	?		?														?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	F	G	P	L	A	L	A	A	S	D	P	L	P	A	E	L	R	Q	F	R	H	C	F	Q	A	A	L	N	G	V	K	T	D	W	R	H	W	L	G	K	G	P	G	L	T	P	S	H	D	D	T	L	S	G	M	L	L	A	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		W	Y	Y	G	A	L	D	A	R	S	G	R	P	F	F	A	C	S	D	N	L	Q	L	V	T	T	A	V	S	V	S	Y	L	R	Y	A	A	Q	G	Y	F	A	S	P	L	L	H	F	V	H	A	L	S	C	P	K	R	T	A	V
Secondary structure
SS confidence
Disorder																				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.
Sequence		A	I	D	S	L	L	A	L	G	H	T	S	G	A	D	T	L	L	G	F	W	L	G	Q	Q	L	L	Q	G	K	P
Secondary structure
SS confidence
Disorder																													?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2l55 chain A Region: 13 - 77 Aligned: 57 Modelled: 65 Confidence: 39.5% Identity: 16% PDB header:metal binding protein Chain: A: PDB Molecule:silb,silver efflux protein, mfp component of the three PDBTitle: solution structure of the c-terminal domain of silb from cupriavidus2 metallidurans Phyre2 PDB 1gpr chain A Region: 19 - 83 Aligned: 55 Modelled: 65 Confidence: 29.7% Identity: 16% Fold: Barrel-sandwich hybrid Superfamily: Duplicated hybrid motif Family: Glucose permease-like Phyre2 PDB 2f3g chain A Region: 19 - 83 Aligned: 55 Modelled: 65 Confidence: 28.6% Identity: 18% Fold: Barrel-sandwich hybrid Superfamily: Duplicated hybrid motif Family: Glucose permease-like Phyre2 PDB 2gpr chain A Region: 19 - 83 Aligned: 55 Modelled: 65 Confidence: 27.5% Identity: 18% Fold: Barrel-sandwich hybrid Superfamily: Duplicated hybrid motif Family: Glucose permease-like Phyre2 PDB 2dch chain X Region: 164 - 179 Aligned: 16 Modelled: 16 Confidence: 26.8% Identity: 44% PDB header:hydrolase Chain: X: PDB Molecule:putative homing endonuclease; PDBTitle: crystal structure of archaeal intron-encoded homing endonuclease i-2 tsp061i Phyre2 PDB 1gla chain F Region: 19 - 83 Aligned: 55 Modelled: 65 Confidence: 24.6% Identity: 18% Fold: Barrel-sandwich hybrid Superfamily: Duplicated hybrid motif Family: Glucose permease-like Phyre2 PDB 1apj chain A Region: 153 - 171 Aligned: 19 Modelled: 19 Confidence: 23.8% Identity: 26% Fold: TB module/8-cys domain Superfamily: TB module/8-cys domain Family: TB module/8-cys domain Phyre2 PDB 2xgy chain A Region: 106 - 176 Aligned: 71 Modelled: 71 Confidence: 19.0% Identity: 17% PDB header:viral protein/isomerase Chain: A: PDB Molecule:relik capsid n-terminal domain; PDBTitle: complex of rabbit endogenous lentivirus (relik)capsid with2 cyclophilin a Phyre2 PDB 1ksq chain A Region: 153 - 170 Aligned: 18 Modelled: 18 Confidence: 17.7% Identity: 22% Fold: TB module/8-cys domain Superfamily: TB module/8-cys domain Family: TB module/8-cys domain Phyre2 PDB 1zeq chain X Region: 9 - 77 Aligned: 61 Modelled: 69 Confidence: 13.6% Identity: 3% PDB header:metal binding protein Chain: X: PDB Molecule:cation efflux system protein cusf; PDBTitle: 1.5 a structure of apo-cusf residues 6-88 from escherichia2 coli Phyre2 PDB 2j5d chain A Region: 219 - 266 Aligned: 33 Modelled: 48 Confidence: 12.4% Identity: 39% PDB header:membrane protein Chain: A: PDB Molecule:bcl2/adenovirus e1b 19 kda protein-interacting PDBTitle: nmr structure of bnip3 transmembrane domain in lipid2 bicelles Phyre2 PDB 2d1k chain C Region: 166 - 176 Aligned: 11 Modelled: 11 Confidence: 11.9% Identity: 36% PDB header:structural protein Chain: C: PDB Molecule:metastasis suppressor protein 1; PDBTitle: ternary complex of the wh2 domain of mim with actin-dnase i Phyre2 PDB 2cbr chain A Region: 14 - 24 Aligned: 11 Modelled: 11 Confidence: 11.1% Identity: 27% Fold: Lipocalins Superfamily: Lipocalins Family: Fatty acid binding protein-like Phyre2 PDB 1gl4 chain A domain 1 Region: 25 - 78 Aligned: 54 Modelled: 54 Confidence: 10.6% Identity: 13% Fold: GFP-like Superfamily: GFP-like Family: Domain G2 of nidogen-1 Phyre2 PDB 1fas chain A Region: 159 - 173 Aligned: 14 Modelled: 15 Confidence: 10.0% Identity: 57% Fold: Snake toxin-like Superfamily: Snake toxin-like Family: Snake venom toxins Phyre2 PDB 1u0m chain A domain 2 Region: 220 - 271 Aligned: 52 Modelled: 52 Confidence: 9.9% Identity: 13% Fold: Thiolase-like Superfamily: Thiolase-like Family: Chalcone synthase-like Phyre2 PDB 1ve2 chain A domain 1 Region: 157 - 173 Aligned: 17 Modelled: 17 Confidence: 9.8% Identity: 41% Fold: Tetrapyrrole methylase Superfamily: Tetrapyrrole methylase Family: Tetrapyrrole methylase Phyre2 PDB 3h41 chain A Region: 149 - 181 Aligned: 30 Modelled: 33 Confidence: 9.3% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:nlp/p60 family protein; PDBTitle: crystal structure of a nlpc/p60 family protein (bce_2878) from2 bacillus cereus atcc 10987 at 1.79 a resolution Phyre2 PDB 1wl5 chain A Region: 217 - 271 Aligned: 55 Modelled: 55 Confidence: 9.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:acetyl-coenzyme a acetyltransferase 2; PDBTitle: human cytosolic acetoacetyl-coa thiolase Phyre2 PDB 2e4m chain C Region: 13 - 49 Aligned: 35 Modelled: 37 Confidence: 8.7% Identity: 20% PDB header:toxin Chain: C: PDB Molecule:ha-17; PDBTitle: crystal structure of hemagglutinin subcomponent complex (ha-2 33/ha-17) from clostridium botulinum serotype d strain 4947 Phyre2 1 c2l55A_ 2 d1gpra_ 3 d2f3ga_ 4 d2gpra_ 5 c2dchX_ 6 d1glaf_ 7 d1apja_ 8 c2xgyA_ 9 d1ksqa_ 10 c1zeqX_ 11 c2j5dA_ 12 c2d1kC_ 13 d2cbra_ 14 d1gl4a1 15 d1fasa_ 16 d1u0ma2 17 d1ve2a1 18 c3h41A_ 19 c1wl5A_ 20 c2e4mC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2l55A_ 39.5 16 PDB header:metal binding protein Chain: A: PDB Molecule:silb,silver efflux protein, mfp component of the three PDBTitle: solution structure of the c-terminal domain of silb from cupriavidus2 metallidurans 2 d1gpra_ 29.7 16 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 3 d2f3ga_ 28.6 18 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 4 d2gpra_ 27.5 18 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 5 c2dchX_ 26.8 44 PDB header:hydrolase Chain: X: PDB Molecule:putative homing endonuclease; PDBTitle: crystal structure of archaeal intron-encoded homing endonuclease i-2 tsp061i 6 d1glaf_ 24.6 18 Fold:Barrel-sandwich hybrid Superfamily:Duplicated hybrid motif Family:Glucose permease-like 7 d1apja_ 23.8 26 Fold:TB module/8-cys domain Superfamily:TB module/8-cys domain Family:TB module/8-cys domain 8 c2xgyA_ 19.0 17 PDB header:viral protein/isomerase Chain: A: PDB Molecule:relik capsid n-terminal domain; PDBTitle: complex of rabbit endogenous lentivirus (relik)capsid with2 cyclophilin a 9 d1ksqa_ 17.7 22 Fold:TB module/8-cys domain Superfamily:TB module/8-cys domain Family:TB module/8-cys domain 10 c1zeqX_ 13.6 3 PDB header:metal binding protein Chain: X: PDB Molecule:cation efflux system protein cusf; PDBTitle: 1.5 a structure of apo-cusf residues 6-88 from escherichia2 coli 11 c2j5dA_ 12.4 39 PDB header:membrane protein Chain: A: PDB Molecule:bcl2/adenovirus e1b 19 kda protein-interacting PDBTitle: nmr structure of bnip3 transmembrane domain in lipid2 bicelles 12 c2d1kC_ 11.9 36 PDB header:structural protein Chain: C: PDB Molecule:metastasis suppressor protein 1; PDBTitle: ternary complex of the wh2 domain of mim with actin-dnase i 13 d2cbra_ 11.1 27 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 14 d1gl4a1 10.6 13 Fold:GFP-like Superfamily:GFP-like Family:Domain G2 of nidogen-1 15 d1fasa_ 10.0 57 Fold:Snake toxin-like Superfamily:Snake toxin-like Family:Snake venom toxins 16 d1u0ma2 9.9 13 Fold:Thiolase-like Superfamily:Thiolase-like Family:Chalcone synthase-like 17 d1ve2a1 9.8 41 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 18 c3h41A_ 9.3 20 PDB header:hydrolase Chain: A: PDB Molecule:nlp/p60 family protein; PDBTitle: crystal structure of a nlpc/p60 family protein (bce_2878) from2 bacillus cereus atcc 10987 at 1.79 a resolution 19 c1wl5A_ 9.0 20 PDB header:transferase Chain: A: PDB Molecule:acetyl-coenzyme a acetyltransferase 2; PDBTitle: human cytosolic acetoacetyl-coa thiolase 20 c2e4mC_ 8.7 20 PDB header:toxin Chain: C: PDB Molecule:ha-17; PDBTitle: crystal structure of hemagglutinin subcomponent complex (ha-2 33/ha-17) from clostridium botulinum serotype d strain 4947 21 c2e0kA_ not modelled 8.5 35 PDB header:transferase Chain: A: PDB Molecule:precorrin-2 c20-methyltransferase; PDBTitle: crystal structure of cbil, a methyltransferase involved in anaerobic2 vitamin b12 biosynthesis 22 c3nutC_ not modelled 8.2 41 PDB header:transferase Chain: C: PDB Molecule:precorrin-3 methylase; PDBTitle: crystal structure of the methyltransferase cobj 23 d1twda_ not modelled 8.1 100 Fold:TIM beta/alpha-barrel Superfamily:CutC-like Family:CutC-like 24 c1h4uA_ not modelled 8.1 13 PDB header:extracellular matrix protein Chain: A: PDB Molecule:nidogen-1; PDBTitle: domain g2 of mouse nidogen-1 25 c3iwpK_ not modelled 7.6 80 PDB header:metal binding protein Chain: K: PDB Molecule:copper homeostasis protein cutc homolog; PDBTitle: crystal structure of human copper homeostasis protein cutc 26 c2bb3B_ not modelled 7.4 22 PDB header:transferase Chain: B: PDB Molecule:cobalamin biosynthesis precorrin-6y methylase (cbie); PDBTitle: crystal structure of cobalamin biosynthesis precorrin-6y methylase2 (cbie) from archaeoglobus fulgidus 27 d1drsa_ not modelled 7.0 38 Fold:Snake toxin-like Superfamily:Snake toxin-like Family:Dendroaspin 28 d1cnza_ not modelled 6.9 29 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 29 c2kzqA_ not modelled 6.8 25 PDB header:membrane protein Chain: A: PDB Molecule:envelope glycoprotein e2 peptide; PDBTitle: s34r structure 30 c2vu2D_ not modelled 6.7 16 PDB header:transferase Chain: D: PDB Molecule:acetyl-coa acetyltransferase; PDBTitle: biosynthetic thiolase from z. ramigera. complex with s-2 pantetheine-11-pivalate. 31 d1va0a1 not modelled 6.6 41 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 32 d1wyza1 not modelled 6.6 18 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 33 d2eiaa2 not modelled 6.6 16 Fold:Retrovirus capsid protein, N-terminal core domain Superfamily:Retrovirus capsid protein, N-terminal core domain Family:Retrovirus capsid protein, N-terminal core domain 34 d1ycna_ not modelled 6.4 11 Fold:Annexin Superfamily:Annexin Family:Annexin 35 c1cbfA_ not modelled 6.3 35 PDB header:methyltransferase Chain: A: PDB Molecule:cobalt-precorrin-4 transmethylase; PDBTitle: the x-ray structure of a cobalamin biosynthetic enzyme, cobalt2 precorrin-4 methyltransferase, cbif 36 d1cbfa_ not modelled 6.3 35 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 37 d1niya_ not modelled 6.3 58 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:omega toxin-like Family:Spider toxins 38 d1mb6a_ not modelled 6.3 33 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:omega toxin-like Family:Spider toxins 39 c2npnA_ not modelled 6.3 35 PDB header:transferase Chain: A: PDB Molecule:putative cobalamin synthesis related protein; PDBTitle: crystal structure of putative cobalamin synthesis related protein2 (cobf) from corynebacterium diphtheriae 40 c3ndcB_ not modelled 6.2 41 PDB header:transferase Chain: B: PDB Molecule:precorrin-4 c(11)-methyltransferase; PDBTitle: crystal structure of precorrin-4 c11-methyltransferase from2 rhodobacter capsulatus 41 d1cm7a_ not modelled 6.1 29 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 42 d2bb3a1 not modelled 6.0 25 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 43 c2avuF_ not modelled 6.0 18 PDB header:transcription activator Chain: F: PDB Molecule:flagellar transcriptional activator flhc; PDBTitle: structure of the escherichia coli flhdc complex, a2 prokaryotic heteromeric regulator of transcription 44 d1pkla1 not modelled 5.9 6 Fold:PK beta-barrel domain-like Superfamily:PK beta-barrel domain-like Family:Pyruvate kinase beta-barrel domain 45 d1v53a1 not modelled 5.8 29 Fold:Isocitrate/Isopropylmalate dehydrogenase-like Superfamily:Isocitrate/Isopropylmalate dehydrogenase-like Family:Dimeric isocitrate & isopropylmalate dehydrogenases 46 d1dq3a3 not modelled 5.8 31 Fold:Homing endonuclease-like Superfamily:Homing endonucleases Family:Intein endonuclease 47 c4a1cX_ not modelled 5.6 27 PDB header:ribosome Chain: X: PDB Molecule:60s ribosomal protein l32; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna,3 5.8s rrna and proteins of molecule 4. 48 d1pjqa2 not modelled 5.6 41 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 49 d1q90g_ not modelled 5.5 44 Fold:Single transmembrane helix Superfamily:PetG subunit of the cytochrome b6f complex Family:PetG subunit of the cytochrome b6f complex 50 c1q90G_ not modelled 5.5 44 PDB header:photosynthesis Chain: G: PDB Molecule:cytochrome b6f complex subunit petg; PDBTitle: structure of the cytochrome b6f (plastohydroquinone : plastocyanin2 oxidoreductase) from chlamydomonas reinhardtii 51 d2d0oa1 not modelled 5.4 80 Fold:The "swivelling" beta/beta/alpha domain Superfamily:Swiveling domain of dehydratase reactivase alpha subunit Family:Swiveling domain of dehydratase reactivase alpha subunit 52 d1vhva_ not modelled 5.3 12 Fold:Tetrapyrrole methylase Superfamily:Tetrapyrrole methylase Family:Tetrapyrrole methylase 53 c3u1hA_ not modelled 5.2 29 PDB header:oxidoreductase Chain: A: PDB Molecule:3-isopropylmalate dehydrogenase; PDBTitle: crystal structure of ipmdh from the last common ancestor of bacillus 54 c2zvbA_ not modelled 5.2 47 PDB header:transferase Chain: A: PDB Molecule:precorrin-3 c17-methyltransferase; PDBTitle: crystal structure of tt0207 from thermus thermophilus hb8 55 d1y7ma1 not modelled 5.1 8 Fold:L,D-transpeptidase catalytic domain-like Superfamily:L,D-transpeptidase catalytic domain-like Family:L,D-transpeptidase catalytic domain-like 56 d1ep3b2 not modelled 5.1 40 Fold:Ferredoxin reductase-like, C-terminal NADP-linked domain Superfamily:Ferredoxin reductase-like, C-terminal NADP-linked domain Family:Dihydroorotate dehydrogenase B, PyrK subunit 57 c3kwpA_ not modelled 5.0 13 PDB header:transferase Chain: A: PDB Molecule:predicted methyltransferase; PDBTitle: crystal structure of putative methyltransferase from lactobacillus2 brevis

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0