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Job DescriptionP37637
Confidence100.00%DateThu Jan 5 11:56:09 GMT 2012
Rank1Aligned Residues1006
% Identity72%Templatec1oy8A_
PDB info PDB header:membrane proteinChain: A: PDB Molecule:acriflavine resistance protein b; PDBTitle: structural basis of multiple drug binding capacity of the acrb2 multidrug efflux pump
Resolution3.63 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   7..10.........20.........30.........40.........50.........60.........70.........80......
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Query Sequence  DRPVFAWVLAIIMMLAGGLAIMNLPVAQYPQIAPPTITVSATYPGADAQTVEDSVTQVIEQNMNGLDGLMYMSSTSDAAG
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Template Conservation   

             
      
     
        
    



   

  

 


  
     
    
 
   
Template Sequence  DRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTG
Template Known Secondary structure 

TTS


SS


S


TT

TT



SS

TTS
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   7..10.........20.........30.........40.........50.........60.........70.........80......
 
   87..90.........100.........110.........120.........130.........140.........150.........160......
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Query Sequence  NASITLTFETGTSPDIAQVQVQNKLQLAMPSLPEAVQQQGISVDKSSSNILMVAAFISDNGSLNQYDIADYVASNIKDPL
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Template Conservation     
 
      
       
          

     
 
                          
       
   
Template Sequence  TVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAI
Template Known Secondary structure 

TT

TTTGGGS
TS





SSS


TTTTT
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   87..90.........100.........110.........120.........130.........140.........150.........160......
 
   167..170.........180.........190.........200.........210.........220.........230.........240......
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Query Sequence  SRTAGVGSVQLFGSEYAMRIWLDPQKLNKYNLVPSDVISQIKVQNNQISGGQLGGMPQAADQQLNASIIVQTRLQTPEEF
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Template Conservation    
 

  
   
    
 
  
   
    
    
   
         
                
            
Template Sequence  SRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEF
Template Known Secondary structure  TTTTTSS


TTT

S





S
SS

TT











S
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   167..170.........180.........190.........200.........210.........220.........230.........240......
 
   247..250.........260.........270.........280.........290.........300.........310.........320......
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Query Sequence  GKILLKVQQDGSQVLLRDVARVELGAEDYSTVARYNGKPAAGIAIKLAAGANALDTSRAVKEELNRLSAYFPASLKTVYP
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Template Conservation      
     
  
 
 


 
             

  

 
 
              
          

 
      
Template Sequence  GKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYP
Template Known Secondary structure  T
TTTS

S
TT
TT

TS

S
SSTTTSSS

SS

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   247..250.........260.........270.........280.........290.........300.........310.........320......
 
   327..330.........340.........350.........360.........370.........380.........390.........400......
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Query Sequence  YDTTPFIEISIQEVFKTLVEAIILVFLVMYLFLQNFRATIIPTIAVPVVILGTFAILSAVGFTINTLTMFGMVLAIGLLV
Query Conservation   
    
                

 


 
 

  
  

    

 
   
       
  

 


  
 
 


 
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Template Conservation   
    
                

 


 
 

  
  

    
  
   
       
  

 


    
 


 
Template Sequence  YDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLV
Template Known Secondary structure  SBS


TTTTTTTTTTT

S
Template Predicted Secondary structure 





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   327..330.........340.........350.........360.........370.........380.........390.........400......
 
   407..410.........420.........430.........440.........450.........460.........470.........480......
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Query Sequence  DDAIVVVENVERVIAEDKLPPKEATHKSMGQIQRALVGIAVVLSAVFMPMAFMSGATGEIYRQFSITLISSMLLSVFVAM
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Template Conservation 





   
 
     
     
   
   
   

 





 

  
 
        
    
     
  


 

Template Sequence  DDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVAL
Template Known Secondary structure  T


STTTTSTTTT


GGGTT
Template Predicted Secondary structure 








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   407..410.........420.........430.........440.........450.........460.........470.........480......
 
   487..490.........500.........510.........520.........530.........540.........550.........560......
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Query Sequence  SLTPALCATILKAAPEGGHKPNALFARFNTLFEKSTQHYTDSTRSLLRCTGRYMVVYLLICAGMAVLFLRTPTSFLPEED
Query Conservation 
  


                                        
                             
   
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Template Conservation     


     
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Template Sequence  ILTPALCATMLKF. . . . . . . . . . . . GWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRLPSSFLPDED
Template Known Secondary structure  TS


............T

SS
B
SS



Template Predicted Secondary structure 


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   487..490......... 500.........510.........520.........530.........540.........550....
 
   567..570.........580.........590.........600.........610.........620.........630.........640......
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Query Sequence  QGVFMTTAQLPSGATMVNTTKVLQQVTDYYLTKEKDNVQSVFTVGGFGFSGQGQNNGLAFISLKPWSERVGEENSVTAII
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Template Conservation            
 
     
      

  
                                
                 
Template Sequence  QGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAIT
Template Known Secondary structure 
S

TT

TS
TTT
SS


GGG

SSTTS
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   569570.........580.........590.........600.........610.........620.........630.........640........
 
   647..650.........660.........670.........680.........690.........700.........710.........720......
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Query Sequence  QRAMIALSSINKAVVFPFNLPAVAELGTASGFDMELLDNGNLGHEKLTQARNELLSLAAQSPNQVTGVRPNGLEDTPMFK
Query Conservation        
                                       
                    
            
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Template Conservation                                          
     
      
   
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Template Sequence  MRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPM. LTSVRPNGLEDTPQFK
Template Known Secondary structure  TTS
SS

B


SS
SS

SS
SS




.


S



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   649650.........660.........670.........680.........690.........700.........710. ........720.......
 
   727..730.........740.........750.........760.........770.........780.........790.........800......
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Query Sequence  VNVNAAKAEAMGVALSDINQTISTAFGSSYVNDFLNQGRVKKVYVQAGTPFRMLPDNINQWYVRNASGTMAPLSAYSSTE
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Template Conservation     
   
   


   
   
     
              
              
  
 
    
  
 
  

   
Template Sequence  IDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSR
Template Known Secondary structure 


T

T
TT


GGGSSSGGGGGG

TTS


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   729730.........740.........750.........760.........770.........780.........790.........800........
 
   807..810.........820.........830.........840.........850.........860.........870.........880......
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Query Sequence  WTYGSPRLERYNGIPSMEILGEAAAGKSTGDAMKFMADLVAKLPAGVGYSWTGLSYQEALSSNQAPALYAISLVVVFLAL
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Template Conservation         
 
        
                   
   

 
      
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Template Sequence  WEYGSPRLERYNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWSGNQAPS. . . . . . . . . LYAISLIVVFLCL
Template Known Secondary structure 

STT

SSS
TTS
TT


T.........T
Template Predicted Secondary structure 














.........
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   809810.........820.........830.........840.........850.........860...... ...870.........
 
   887..890.........900.........910.........920.........930.........940.........950.........960......
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Query Sequence  AALYESWSIPFSVMLVVPLGVVGALLATDLRGLSNDVYFQVGLLTTIGLSAKNAILIVEFAVEMMQKEGKTPIEAIIEAA
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Template Conservation   
 
 
    



  
 
   
    
 
 
  
   
 

 
 



 

  
 

          
     

  
 
Template Sequence  AALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAV
Template Known Secondary structure  TSS

SSSGGGTGGGSS

B
SSS


TTT
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   889890.........900.........910.........920.........930.........940.........950.........960........
 
   967..970.........980.........990.........1000.........1010.........1020.........1030....
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Query Sequence  RMRLRPILMTSLAFILGVLPLVISHGAGSGAQNAVGTGVMGGMFAATVLAIYFVPVFFVVVEHLFARF
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Template Sequence  RMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFVVVRRRFSRK
Template Known Secondary structure  TTTSTT

SS
STSSSSSSTTT
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   969970.........980.........990.........1000.........1010.........1020.........1030......
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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