Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	D	F	A	K	V	E	Q	S	L	R	E	E	M	T	R	I	A	S	S	F	F	Q	R	G	Y	A	T	G	S	A	G	N	L	S	L	L	L	P	D	G	N	L	L	A	T	P	T	G	S	C	L	G	N	L	D	P	Q	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	S	K	V	A	A	D	G	E	W	L	S	G	D	K	P	S	K	E	V	L	F	H	L	A	L	Y	R	N	N	P	R	C	K	A	V	V	H	L	H	S	T	W	S	T	A	L	S	C	L	Q	G	L	D	S	S	N	V	I	R
Secondary structure
SS confidence
Disorder																																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	F	T	P	Y	V	V	M	R	M	G	N	V	P	L	V	P	Y	Y	R	P	G	D	K	R	I	A	Q	D	L	A	E	L	A	A	D	N	Q	A	F	L	L	A	N	H	G	P	V	V	C	G	E	S	L	Q	E	A	A	N	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.
Sequence		M	E	E	L	E	E	T	A	K	L	I	F	I	L	G	D	R	P	I	R	Y	L	T	A	G	E	I	A	E	L	R	S
Secondary structure
SS confidence
Disorder																?		?	?	?	?	?	?									?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1e4c chain P Region: 8 - 211 Aligned: 199 Modelled: 203 Confidence: 100.0% Identity: 28% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 1ojr chain A Region: 13 - 211 Aligned: 199 Modelled: 199 Confidence: 100.0% Identity: 25% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 3ocr chain A Region: 3 - 209 Aligned: 202 Modelled: 202 Confidence: 100.0% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:class ii aldolase/adducin domain protein; PDBTitle: crystal structure of aldolase ii superfamily protein from pseudomonas2 syringae Phyre2 PDB 2z7b chain A Region: 6 - 212 Aligned: 201 Modelled: 205 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:mlr6791 protein; PDBTitle: crystal structure of mesorhizobium loti 3-hydroxy-2-methylpyridine-4,2 5-dicarboxylate decarboxylase Phyre2 PDB 2opi chain B Region: 9 - 211 Aligned: 199 Modelled: 202 Confidence: 100.0% Identity: 28% PDB header:lyase Chain: B: PDB Molecule:l-fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from bacteroides2 thetaiotaomicron Phyre2 PDB 2fk5 chain B Region: 9 - 198 Aligned: 181 Modelled: 190 Confidence: 100.0% Identity: 29% PDB header:lyase Chain: B: PDB Molecule:fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from thermus2 thermophilus hb8 Phyre2 PDB 1k0w chain A Region: 9 - 209 Aligned: 197 Modelled: 201 Confidence: 100.0% Identity: 23% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 1pvt chain A Region: 7 - 201 Aligned: 195 Modelled: 193 Confidence: 100.0% Identity: 26% Fold: AraD/HMP-PK domain-like Superfamily: AraD/HMP-PK domain-like Family: AraD-like aldolase/epimerase Phyre2 PDB 2irp chain A Region: 6 - 195 Aligned: 190 Modelled: 190 Confidence: 100.0% Identity: 25% PDB header:lyase Chain: A: PDB Molecule:putative aldolase class 2 protein aq_1979; PDBTitle: crystal structure of the l-fuculose-1-phosphate aldolase (aq_1979)2 from aquifex aeolicus vf5 Phyre2 PDB 3m4r chain A Region: 13 - 192 Aligned: 166 Modelled: 180 Confidence: 100.0% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the n-terminal class ii aldolase domain of a conserved2 protein from thermoplasma acidophilum Phyre2 PDB 1w9y chain A domain 1 Region: 131 - 167 Aligned: 37 Modelled: 37 Confidence: 48.7% Identity: 19% Fold: Double-stranded beta-helix Superfamily: Clavaminate synthase-like Family: Penicillin synthase-like Phyre2 PDB 1gp6 chain A Region: 132 - 167 Aligned: 36 Modelled: 36 Confidence: 40.5% Identity: 25% Fold: Double-stranded beta-helix Superfamily: Clavaminate synthase-like Family: Penicillin synthase-like Phyre2 PDB 1odm chain A Region: 132 - 167 Aligned: 36 Modelled: 36 Confidence: 38.2% Identity: 36% Fold: Double-stranded beta-helix Superfamily: Clavaminate synthase-like Family: Penicillin synthase-like Phyre2 PDB 1dcs chain A Region: 132 - 167 Aligned: 36 Modelled: 36 Confidence: 32.4% Identity: 17% Fold: Double-stranded beta-helix Superfamily: Clavaminate synthase-like Family: Penicillin synthase-like Phyre2 PDB 2yzt chain A Region: 166 - 184 Aligned: 19 Modelled: 19 Confidence: 31.5% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha1756; PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8 Phyre2 PDB 3on7 chain C Region: 131 - 167 Aligned: 34 Modelled: 33 Confidence: 25.2% Identity: 21% PDB header:oxidoreductase Chain: C: PDB Molecule:oxidoreductase, iron/ascorbate family; PDBTitle: crystal structure of a putative oxygenase (so_2589) from shewanella2 oneidensis at 2.20 a resolution Phyre2 PDB 3kv4 chain A Region: 35 - 88 Aligned: 46 Modelled: 54 Confidence: 15.0% Identity: 26% PDB header:h3k4me3 binding protein, transferase Chain: A: PDB Molecule:phd finger protein 8; PDBTitle: structure of phf8 in complex with histone h3 Phyre2 PDB 3m9b chain K Region: 9 - 101 Aligned: 92 Modelled: 92 Confidence: 14.9% Identity: 13% PDB header:chaperone Chain: K: PDB Molecule:proteasome-associated atpase; PDBTitle: crystal structure of the amino terminal coiled coil domain and the2 inter domain of the mycobacterium tuberculosis proteasomal atpase mpa Phyre2 PDB 2ra9 chain A Region: 38 - 69 Aligned: 32 Modelled: 32 Confidence: 13.2% Identity: 19% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein duf1285; PDBTitle: crystal structure of a duf1285 family protein (sbal_2486) from2 shewanella baltica os155 at 1.40 a resolution Phyre2 PDB 1chd chain A Region: 38 - 97 Aligned: 60 Modelled: 60 Confidence: 12.5% Identity: 18% Fold: Methylesterase CheB, C-terminal domain Superfamily: Methylesterase CheB, C-terminal domain Family: Methylesterase CheB, C-terminal domain Phyre2 1 d1e4cp_ 2 d1ojra_ 3 c3ocrA_ 4 c2z7bA_ 5 c2opiB_ 6 c2fk5B_ 7 d1k0wa_ 8 d1pvta_ 9 c2irpA_ 10 c3m4rA_ 11 d1w9ya1 12 d1gp6a_ 13 d1odma_ 14 d1dcsa_ 15 c2yztA_ 16 c3on7C_ 17 c3kv4A_ 18 c3m9bK_ 19 c2ra9A_ 20 d1chda_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1e4cp_ 100.0 28 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 2 d1ojra_ 100.0 25 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 3 c3ocrA_ 100.0 18 PDB header:lyase Chain: A: PDB Molecule:class ii aldolase/adducin domain protein; PDBTitle: crystal structure of aldolase ii superfamily protein from pseudomonas2 syringae 4 c2z7bA_ 100.0 21 PDB header:lyase Chain: A: PDB Molecule:mlr6791 protein; PDBTitle: crystal structure of mesorhizobium loti 3-hydroxy-2-methylpyridine-4,2 5-dicarboxylate decarboxylase 5 c2opiB_ 100.0 28 PDB header:lyase Chain: B: PDB Molecule:l-fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from bacteroides2 thetaiotaomicron 6 c2fk5B_ 100.0 29 PDB header:lyase Chain: B: PDB Molecule:fuculose-1-phosphate aldolase; PDBTitle: crystal structure of l-fuculose-1-phosphate aldolase from thermus2 thermophilus hb8 7 d1k0wa_ 100.0 23 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 8 d1pvta_ 100.0 26 Fold:AraD/HMP-PK domain-like Superfamily:AraD/HMP-PK domain-like Family:AraD-like aldolase/epimerase 9 c2irpA_ 100.0 25 PDB header:lyase Chain: A: PDB Molecule:putative aldolase class 2 protein aq_1979; PDBTitle: crystal structure of the l-fuculose-1-phosphate aldolase (aq_1979)2 from aquifex aeolicus vf5 10 c3m4rA_ 100.0 23 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: structure of the n-terminal class ii aldolase domain of a conserved2 protein from thermoplasma acidophilum 11 d1w9ya1 48.7 19 Fold:Double-stranded beta-helix Superfamily:Clavaminate synthase-like Family:Penicillin synthase-like 12 d1gp6a_ 40.5 25 Fold:Double-stranded beta-helix Superfamily:Clavaminate synthase-like Family:Penicillin synthase-like 13 d1odma_ 38.2 36 Fold:Double-stranded beta-helix Superfamily:Clavaminate synthase-like Family:Penicillin synthase-like 14 d1dcsa_ 32.4 17 Fold:Double-stranded beta-helix Superfamily:Clavaminate synthase-like Family:Penicillin synthase-like 15 c2yztA_ 31.5 16 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative uncharacterized protein ttha1756; PDBTitle: crystal structure of uncharacterized conserved protein from thermus2 thermophilus hb8 16 c3on7C_ 25.2 21 PDB header:oxidoreductase Chain: C: PDB Molecule:oxidoreductase, iron/ascorbate family; PDBTitle: crystal structure of a putative oxygenase (so_2589) from shewanella2 oneidensis at 2.20 a resolution 17 c3kv4A_ 15.0 26 PDB header:h3k4me3 binding protein, transferase Chain: A: PDB Molecule:phd finger protein 8; PDBTitle: structure of phf8 in complex with histone h3 18 c3m9bK_ 14.9 13 PDB header:chaperone Chain: K: PDB Molecule:proteasome-associated atpase; PDBTitle: crystal structure of the amino terminal coiled coil domain and the2 inter domain of the mycobacterium tuberculosis proteasomal atpase mpa 19 c2ra9A_ 13.2 19 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein duf1285; PDBTitle: crystal structure of a duf1285 family protein (sbal_2486) from2 shewanella baltica os155 at 1.40 a resolution 20 d1chda_ 12.5 18 Fold:Methylesterase CheB, C-terminal domain Superfamily:Methylesterase CheB, C-terminal domain Family:Methylesterase CheB, C-terminal domain 21 d1jw3a_ not modelled 10.6 28 Fold:MTH1598-like Superfamily:MTH1598-like Family:MTH1598-like 22 c3pvjB_ not modelled 10.2 10 PDB header:oxidoreductase Chain: B: PDB Molecule:alpha-ketoglutarate-dependent taurine dioxygenase; PDBTitle: crystal structure of the fe(ii)/alpha-ketoglutarate dependent taurine2 dioxygenase from pseudomonas putida kt2440 23 d1j5ua_ not modelled 10.2 16 Fold:MTH1598-like Superfamily:MTH1598-like Family:MTH1598-like 24 c3ooxA_ not modelled 9.2 19 PDB header:oxidoreductase Chain: A: PDB Molecule:putative 2og-fe(ii) oxygenase family protein; PDBTitle: crystal structure of a putative 2og-fe(ii) oxygenase family protein2 (cc_0200) from caulobacter crescentus at 1.44 a resolution 25 c1a2oB_ not modelled 8.8 18 PDB header:bacterial chemotaxis Chain: B: PDB Molecule:cheb methylesterase; PDBTitle: structural basis for methylesterase cheb regulation by a2 phosphorylation-activated domain 26 d1hj3a1 not modelled 7.9 13 Fold:Cytochrome c Superfamily:Cytochrome c Family:N-terminal (heme c) domain of cytochrome cd1-nitrite reductase 27 d1w96c1 not modelled 7.4 22 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 28 d2dsya1 not modelled 7.0 25 Fold:TTHA1013/TTHA0281-like Superfamily:TTHA1013/TTHA0281-like Family:TTHA0281-like 29 c3sftA_ not modelled 6.9 13 PDB header:hydrolase Chain: A: PDB Molecule:chemotaxis response regulator protein-glutamate PDBTitle: crystal structure of thermotoga maritima cheb methylesterase catalytic2 domain 30 c2ri0B_ not modelled 6.5 20 PDB header:hydrolase Chain: B: PDB Molecule:glucosamine-6-phosphate deaminase; PDBTitle: crystal structure of glucosamine 6-phosphate deaminase (nagb) from s.2 mutans 31 c2re3A_ not modelled 6.2 20 PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a duf1285 family protein (spo_0140) from2 silicibacter pomeroyi dss-3 at 2.50 a resolution 32 c3dclC_ not modelled 6.2 27 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:tm1086; PDBTitle: crystal structure of tm1086 33 d2c9wa2 not modelled 6.1 19 Fold:SH2-like Superfamily:SH2 domain Family:SH2 domain 34 c1w7vD_ not modelled 6.0 13 PDB header:hydrolase Chain: D: PDB Molecule:xaa-pro aminopeptidase; PDBTitle: znmg substituted aminopeptidase p from e. coli 35 d1ulza1 not modelled 5.9 17 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 36 d1w96a1 not modelled 5.8 22 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 37 d1otja_ not modelled 5.5 13 Fold:Double-stranded beta-helix Superfamily:Clavaminate synthase-like Family:TauD/TfdA-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0