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Job DescriptionP37624
Confidence100.00%DateThu Jan 5 11:55:58 GMT 2012
Rank1Aligned Residues478
% Identity24%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   2.......10.........20.. .......30.........40.........50.........60.........70........
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Query Sequence  THLELVPVPPVAQLAGVSQHY. . . GKTVALNNITLDIPARCMVGLIGPDGVGKSSLLSLISGARVIEQGNVMVLGGDMRD
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Template Conservation             
                 
         
    
 
  







  
 
      
 
   
     
Template Sequence  SGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRT
Template Known Secondary structure 




TT
S



SSTTS

S
TT


SSTTTTTSS

STTGGG
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   377..380.........390.........400.........410.........420.........430.........440.........450......
 
   7980.........90.........100.........110.........120.........130.........140 .......
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Query Sequence  PKHRRDVCPRIAWMPQGLGKNLYHTLSVYENVDFFARLFGHDKAEREVRINELLTSTGLAPF. . . . . . . . . . . RDRPAGK
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Template Sequence  IN. VRYLREIIGVVSQEP. . . VLFATTIAENIRYG. . . . . . REDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQ
Template Known Secondary structure  S
.SS
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SS
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SS

TT
TTSTTGGG


SSSS
S
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   457. .460.........470... ......480....... ..490.........500.........510.........520......
 
   148.150.........160.........170.........180.........190.........200.........210.........220.......
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Query Sequence  LSGGMKQKLGLCCALIHDPELLILDEPTTGVDPLSRSQFWDLIDSIRQRQSNMSVLVATAYMEEAERFDWLVAMNAGEVL
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Template Sequence  LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKARE. . . GRTTIVIAHRLSTVRNADVIAGFDGGVIV
Template Known Secondary structure  S


SBTT
SS
TT...SS
S
TT
S
SSS


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   527..530.........540.........550.........560.........570.... .....580.........590.........600...
 
   228.230.........240.........250.........260.........270..
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Query Sequence  ATGSAEELRQQTQSATLEEAFINLLPQAQRQAHQAVVIPPYQPEN. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation    
    
                                               
                        
Template Sequence  EQGNHDELMREKGIYFKLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGP
Template Known Secondary structure 

TST









TTT



SS
S
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   604.....610.........620.........630.........640.........650.........660.........670.........680...
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation                         
                   
   
   
               
 
  
   
   
Template Sequence  PETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQ
Template Known Secondary structure  TT

S
S

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   741........750.........760.........770.........780.........790.........800.........810.........820
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation          
   
          
        
 

 
    
                               
 
 
 
Template Sequence  VKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENF
Template Known Secondary structure  SS
STTTT
Template Predicted Secondary structure 
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   821........830.........840.........850.........860.........870.........880.........890.........900
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation    

                                                   
  
                     
Template Sequence  RTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFG
Template Known Secondary structure  TTTTT
SS

TTTT
S
STT
Template Predicted Secondary structure 





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   901........910.........920.........930.........940.........950.........960.........970.........980
 
   273......280...... ...290.........300...
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . AEIAIEARDLTMRF. . . GSFVAVDHVNFRIPRGE
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Template Conservation        
            
  

   
                    
 
    
   
       

  

  
  

Template Sequence  AMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQ
Template Known Secondary structure  TSSSS
SS




SS
S




TTT





S
GGG

SS


SSS
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   981........990.........1000.........1010.........1020.........1030.........1040.........1050.........1060
 
   304.....310.........320.........330.........340...... ...350.........360.........370.........380..
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Query Sequence  IFGFLGSNGCGKSTTMKMLTGLLPASEGEAWLFGQPVDPKDID. TRRRVGYMSQAFSLYNELTVRQNLELHARLFHIPEA
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Template Sequence  TLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDC. SIAENIAYGDNSRVVSYE
Template Known Secondary structure 
SSSTTTTSS

SSSSS
BTSS
TTS
SS



SS.BT


SS



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   1061........1070.........1080.........1090.........1100.........1110.........1120. ........1130.........
 
   383......390.........400...... ...410.........420.........430.........440.........450.
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Query Sequence  EIPARVAEMSERFKLNDVEDILPE. . . . . . . . . . . SLPLGIRQRLSLAVAVIHRPEMLILDEPTSGVDPVARDMFWQLMV
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Template Sequence  E. . . . IVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD
Template Known Secondary structure  ....T
SSTTTGGG
B
STTS
SS


SSS
SSS

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   1140 .........1150.........1160.........1170.........1180.........1190.........1200.........1210.....
 
   452.......460.........470.........480.........490.........
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Query Sequence  DLSRQDKVTIFISTHFMNEAERCDRISLMHAGKVLASGTPQELVEKRG
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Template Sequence  KA. . REGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKG
Template Known Secondary structure  ..SSSS

S
TTGGGS
STB
S
S
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   1216. ..1220.........1230.........1240.........1250.........1260.
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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