Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	I	L	S	L	S	R	F	M	L	A	G	V	L	L	A	S	F	N	A	S	A	I	P	G	F	W	Q	Q	G	Y	G	Q	G	N	T	E	Y	S	V	T	E	A	S	G	K	T	F	T	I	N	C	T	G	N	P	D	Q	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?									?	?	?	?	?	?	?	?	?	?			?																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	F	Y	Q	H	S	V	F	L	T	L	A	D	D	K	M	V	S	S	H	D	D	D	T	T	I	T	V	V	M	D	H	Q	Q	Y	I	I	P	S	S	L	G	W	R	N	G	D	N	A	W	F	D	F	I	S	N	I	S	E	A
Secondary structure
SS confidence
Disorder													?		?				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.
Sequence		G	Q	F	D	V	Y	V	N	D	H	K	A	G	T	F	T	A	D	R	K	N	A	E	K	V	L	S	T	L	G	D	C	S	N	D
Secondary structure
SS confidence
Disorder																		?	?		?	?	?							?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1ylx chain A domain 1 Region: 44 - 94 Aligned: 48 Modelled: 51 Confidence: 63.6% Identity: 19% Fold: N domain of copper amine oxidase-like Superfamily: GK1464-like Family: GK1464-like Phyre2 PDB 2eg9 chain B Region: 102 - 153 Aligned: 52 Modelled: 52 Confidence: 26.4% Identity: 21% PDB header:hydrolase Chain: B: PDB Molecule:adp-ribosyl cyclase 1; PDBTitle: crystal structure of the truncated extracellular domain of2 mouse cd38 Phyre2 PDB 1uzv chain A Region: 122 - 136 Aligned: 15 Modelled: 15 Confidence: 25.5% Identity: 40% Fold: Calcium-mediated lectin Superfamily: Calcium-mediated lectin Family: Calcium-mediated lectin Phyre2 PDB 1wmx chain B Region: 33 - 134 Aligned: 92 Modelled: 92 Confidence: 21.6% Identity: 18% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: Family 30 carbohydrate binding module, CBM30 (PKD repeat) Phyre2 PDB 3eit chain B Region: 86 - 134 Aligned: 48 Modelled: 49 Confidence: 20.0% Identity: 17% PDB header:unknown function Chain: B: PDB Molecule:putative atp/gtp binding protein; PDBTitle: the 2.6 angstrom crystal structure of chbp, the cif homologue from2 burkholderia pseudomallei Phyre2 PDB 2chh chain A domain 1 Region: 122 - 136 Aligned: 15 Modelled: 15 Confidence: 18.9% Identity: 33% Fold: Calcium-mediated lectin Superfamily: Calcium-mediated lectin Family: Calcium-mediated lectin Phyre2 PDB 3hbk chain A Region: 37 - 138 Aligned: 102 Modelled: 102 Confidence: 18.6% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:putative glycosyl hydrolase; PDBTitle: crystal structure of putative glycosyl hydrolase, was domain of2 unknown function (duf1080) (yp_001302580.1) from parabacteroides3 distasonis atcc 8503 at 2.36 a resolution Phyre2 PDB 1r4x chain A domain 2 Region: 104 - 149 Aligned: 38 Modelled: 46 Confidence: 17.4% Identity: 16% Fold: Subdomain of clathrin and coatomer appendage domain Superfamily: Subdomain of clathrin and coatomer appendage domain Family: Coatomer appendage domain Phyre2 PDB 2khg chain A Region: 109 - 120 Aligned: 12 Modelled: 12 Confidence: 16.8% Identity: 33% PDB header:antimicrobial protein Chain: A: PDB Molecule:plnj; PDBTitle: plantaricin j in tfe Phyre2 PDB 2anu chain A Region: 106 - 130 Aligned: 25 Modelled: 25 Confidence: 16.6% Identity: 8% PDB header:metal binding protein Chain: A: PDB Molecule:hypothetical protein tm0559; PDBTitle: crystal structure of predicted metal-dependent phosphoesterase (php2 family) (tm0559) from thermotoga maritima at 2.40 a resolution Phyre2 PDB 2anu chain A domain 1 Region: 106 - 130 Aligned: 25 Modelled: 25 Confidence: 16.6% Identity: 8% Fold: 7-stranded beta/alpha barrel Superfamily: PHP domain-like Family: PHP domain Phyre2 PDB 2khf chain A Region: 109 - 120 Aligned: 12 Modelled: 12 Confidence: 16.5% Identity: 33% PDB header:antimicrobial protein Chain: A: PDB Molecule:plnj; PDBTitle: plantaricin j in dpc-micelles Phyre2 PDB 3efy chain B Region: 86 - 134 Aligned: 49 Modelled: 49 Confidence: 14.8% Identity: 16% PDB header:cell cycle Chain: B: PDB Molecule:cif (cell cycle inhibiting factor); PDBTitle: structure of the cyclomodulin cif from pathogenic2 escherichia coli Phyre2 PDB 2r0f chain A Region: 119 - 145 Aligned: 27 Modelled: 27 Confidence: 14.0% Identity: 11% PDB header:sugar binding protein Chain: A: PDB Molecule:cgl3 lectin; PDBTitle: ligand free structure of fungal lectin cgl3 Phyre2 PDB 2boi chain A Region: 122 - 136 Aligned: 15 Modelled: 15 Confidence: 13.7% Identity: 13% PDB header:lectin Chain: A: PDB Molecule:cv-iil lectin; PDBTitle: 1.1a structure of chromobacterium violaceum lectin cv2l in2 complex with alpha-methyl-fucoside Phyre2 PDB 3dtd chain I Region: 36 - 151 Aligned: 109 Modelled: 116 Confidence: 12.7% Identity: 9% PDB header:structural genomics, unknown function Chain: I: PDB Molecule:invasion-associated protein b; PDBTitle: crystal structure of invasion associated protein b from bartonella2 henselae Phyre2 PDB 2zw7 chain A Region: 35 - 54 Aligned: 20 Modelled: 20 Confidence: 11.8% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:bleomycin acetyltransferase; PDBTitle: crystal structure of bleomycin n-acetyltransferase complexed2 with bleomycin a2 and coenzyme a Phyre2 PDB 3tdq chain B Region: 88 - 101 Aligned: 14 Modelled: 14 Confidence: 11.7% Identity: 43% PDB header:cell adhesion Chain: B: PDB Molecule:pily2 protein; PDBTitle: crystal structure of a fimbrial biogenesis protein pily22 (pily2_pa4555) from pseudomonas aeruginosa pao1 at 2.10 a resolution Phyre2 PDB 3n3f chain B Region: 78 - 104 Aligned: 27 Modelled: 27 Confidence: 11.6% Identity: 19% PDB header:protein binding Chain: B: PDB Molecule:collagen alpha-1(xv) chain; PDBTitle: crystal structure of the human collagen xv trimerization domain: a2 potent trimerizing unit common to multiplexin collagens Phyre2 PDB 2nn8 chain A domain 1 Region: 119 - 145 Aligned: 27 Modelled: 27 Confidence: 11.5% Identity: 26% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Galectin (animal S-lectin) Phyre2 1 d1ylxa1 2 c2eg9B_ 3 d1uzva_ 4 d1wmxb_ 5 c3eitB_ 6 d2chha1 7 c3hbkA_ 8 d1r4xa2 9 c2khgA_ 10 c2anuA_ 11 d2anua1 12 c2khfA_ 13 c3efyB_ 14 c2r0fA_ 15 c2boiA_ 16 c3dtdI_ 17 c2zw7A_ 18 c3tdqB_ 19 c3n3fB_ 20 d2nn8a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1ylxa1 63.6 19 Fold:N domain of copper amine oxidase-like Superfamily:GK1464-like Family:GK1464-like 2 c2eg9B_ 26.4 21 PDB header:hydrolase Chain: B: PDB Molecule:adp-ribosyl cyclase 1; PDBTitle: crystal structure of the truncated extracellular domain of2 mouse cd38 3 d1uzva_ 25.5 40 Fold:Calcium-mediated lectin Superfamily:Calcium-mediated lectin Family:Calcium-mediated lectin 4 d1wmxb_ 21.6 18 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Family 30 carbohydrate binding module, CBM30 (PKD repeat) 5 c3eitB_ 20.0 17 PDB header:unknown function Chain: B: PDB Molecule:putative atp/gtp binding protein; PDBTitle: the 2.6 angstrom crystal structure of chbp, the cif homologue from2 burkholderia pseudomallei 6 d2chha1 18.9 33 Fold:Calcium-mediated lectin Superfamily:Calcium-mediated lectin Family:Calcium-mediated lectin 7 c3hbkA_ 18.6 17 PDB header:hydrolase Chain: A: PDB Molecule:putative glycosyl hydrolase; PDBTitle: crystal structure of putative glycosyl hydrolase, was domain of2 unknown function (duf1080) (yp_001302580.1) from parabacteroides3 distasonis atcc 8503 at 2.36 a resolution 8 d1r4xa2 17.4 16 Fold:Subdomain of clathrin and coatomer appendage domain Superfamily:Subdomain of clathrin and coatomer appendage domain Family:Coatomer appendage domain 9 c2khgA_ 16.8 33 PDB header:antimicrobial protein Chain: A: PDB Molecule:plnj; PDBTitle: plantaricin j in tfe 10 c2anuA_ 16.6 8 PDB header:metal binding protein Chain: A: PDB Molecule:hypothetical protein tm0559; PDBTitle: crystal structure of predicted metal-dependent phosphoesterase (php2 family) (tm0559) from thermotoga maritima at 2.40 a resolution 11 d2anua1 16.6 8 Fold:7-stranded beta/alpha barrel Superfamily:PHP domain-like Family:PHP domain 12 c2khfA_ 16.5 33 PDB header:antimicrobial protein Chain: A: PDB Molecule:plnj; PDBTitle: plantaricin j in dpc-micelles 13 c3efyB_ 14.8 16 PDB header:cell cycle Chain: B: PDB Molecule:cif (cell cycle inhibiting factor); PDBTitle: structure of the cyclomodulin cif from pathogenic2 escherichia coli 14 c2r0fA_ 14.0 11 PDB header:sugar binding protein Chain: A: PDB Molecule:cgl3 lectin; PDBTitle: ligand free structure of fungal lectin cgl3 15 c2boiA_ 13.7 13 PDB header:lectin Chain: A: PDB Molecule:cv-iil lectin; PDBTitle: 1.1a structure of chromobacterium violaceum lectin cv2l in2 complex with alpha-methyl-fucoside 16 c3dtdI_ 12.7 9 PDB header:structural genomics, unknown function Chain: I: PDB Molecule:invasion-associated protein b; PDBTitle: crystal structure of invasion associated protein b from bartonella2 henselae 17 c2zw7A_ 11.8 25 PDB header:transferase Chain: A: PDB Molecule:bleomycin acetyltransferase; PDBTitle: crystal structure of bleomycin n-acetyltransferase complexed2 with bleomycin a2 and coenzyme a 18 c3tdqB_ 11.7 43 PDB header:cell adhesion Chain: B: PDB Molecule:pily2 protein; PDBTitle: crystal structure of a fimbrial biogenesis protein pily22 (pily2_pa4555) from pseudomonas aeruginosa pao1 at 2.10 a resolution 19 c3n3fB_ 11.6 19 PDB header:protein binding Chain: B: PDB Molecule:collagen alpha-1(xv) chain; PDBTitle: crystal structure of the human collagen xv trimerization domain: a2 potent trimerizing unit common to multiplexin collagens 20 d2nn8a1 11.5 26 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Galectin (animal S-lectin) 21 d1wmxa_ not modelled 10.5 18 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Family 30 carbohydrate binding module, CBM30 (PKD repeat) 22 d1q56a_ not modelled 10.3 11 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Laminin G-like module 23 c3nv4A_ not modelled 10.1 19 PDB header:sugar binding protein Chain: A: PDB Molecule:galectin 9 short isoform variant; PDBTitle: crystal structure of human galectin-9 c-terminal crd in complex with2 sialyllactose 24 d1isia_ not modelled 9.8 19 Fold:Flavodoxin-like Superfamily:N-(deoxy)ribosyltransferase-like Family:ADP ribosyl cyclase-like 25 d1fyxa_ not modelled 9.1 25 Fold:Flavodoxin-like Superfamily:Toll/Interleukin receptor TIR domain Family:Toll/Interleukin receptor TIR domain 26 d1e5ba_ not modelled 8.8 24 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:Carbohydrate-binding domain Family:Cellulose-binding domain family II 27 d1d2sa_ not modelled 8.1 11 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Laminin G-like module 28 c2eg5C_ not modelled 8.0 22 PDB header:transferase Chain: C: PDB Molecule:xanthosine methyltransferase; PDBTitle: the structure of xanthosine methyltransferase 29 c3hshA_ not modelled 7.9 11 PDB header:protein binding Chain: A: PDB Molecule:collagen alpha-1(xviii) chain; PDBTitle: crystal structure of human collagen xviii trimerization domain2 (tetragonal crystal form) 30 d1kkea2 not modelled 7.9 13 Fold:Virus attachment protein globular domain Superfamily:Virus attachment protein globular domain Family:Reovirus attachment protein sigma 1 head domain 31 c2wjsA_ not modelled 7.7 11 PDB header:cell adhesion Chain: A: PDB Molecule:laminin subunit alpha-2; PDBTitle: crystal structure of the lg1-3 region of the laminin alpha22 chain 32 c3b9cB_ not modelled 7.5 20 PDB header:unknown function Chain: B: PDB Molecule:hspc159; PDBTitle: crystal structure of human grp crd 33 d1fyva_ not modelled 7.2 25 Fold:Flavodoxin-like Superfamily:Toll/Interleukin receptor TIR domain Family:Toll/Interleukin receptor TIR domain 34 d1uypa1 not modelled 7.1 24 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Glycosyl hydrolases family 32 C-terminal domain 35 c3kb8A_ not modelled 6.9 22 PDB header:transferase Chain: A: PDB Molecule:hypoxanthine phosphoribosyltransferase; PDBTitle: 2.09 angstrom resolution structure of a hypoxanthine-guanine2 phosphoribosyltransferase (hpt-1) from bacillus anthracis str. 'ames3 ancestor' in complex with gmp 36 d2ef1a1 not modelled 6.9 17 Fold:Flavodoxin-like Superfamily:N-(deoxy)ribosyltransferase-like Family:ADP ribosyl cyclase-like 37 c3mpbA_ not modelled 6.8 21 PDB header:isomerase Chain: A: PDB Molecule:sugar isomerase; PDBTitle: z5688 from e. coli o157:h7 bound to fructose 38 c3b5iB_ not modelled 6.8 19 PDB header:transferase Chain: B: PDB Molecule:s-adenosyl-l-methionine:salicylic acid carboxyl PDBTitle: crystal structure of indole-3-acetic acid methyltransferase 39 d1wdja_ not modelled 6.7 12 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:Hypothetical protein TT1808 (TTHA1514) 40 d2f20a1 not modelled 6.6 11 Fold:BB1717-like Superfamily:BB1717-like Family:BB1717-like 41 c1vjqB_ not modelled 6.6 21 PDB header:structural genomics, de novo protein Chain: B: PDB Molecule:designed protein; PDBTitle: designed protein based on backbone conformation of2 procarboxypeptidase-a (1aye) with sidechains chosen for maximal3 predicted stability. 42 c1kkeA_ not modelled 6.5 13 PDB header:viral protein Chain: A: PDB Molecule:sigma 1 protein; PDBTitle: crystal structure of reovirus attachment protein sigma12 trimer 43 d2gala_ not modelled 6.5 22 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Galectin (animal S-lectin) 44 d1qhoa3 not modelled 6.4 19 Fold:Glycosyl hydrolase domain Superfamily:Glycosyl hydrolase domain Family:alpha-Amylases, C-terminal beta-sheet domain 45 c3gqjA_ not modelled 6.3 16 PDB header:unknown function Chain: A: PDB Molecule:cell inhibiting factor (cif); PDBTitle: crystal structure of cell inhibiting factor (cif) from photorhabdus2 luminescens 46 c2yroA_ not modelled 6.2 20 PDB header:sugar binding protein Chain: A: PDB Molecule:galectin-8; PDBTitle: solution structure of the c-terminal gal-bind lectin2 protein from human galectin-8 47 d2aw2a1 not modelled 6.2 14 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:V set domains (antibody variable domain-like) 48 c1qu0D_ not modelled 6.2 9 PDB header:metal binding protein Chain: D: PDB Molecule:laminin alpha2 chain; PDBTitle: crystal structure of the fifth laminin g-like module of the2 mouse laminin alpha2 chain 49 c1qu0A_ not modelled 6.2 9 PDB header:metal binding protein Chain: A: PDB Molecule:laminin alpha2 chain; PDBTitle: crystal structure of the fifth laminin g-like module of the2 mouse laminin alpha2 chain 50 d2axwa1 not modelled 6.1 18 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:Bacterial adhesins Family:Pilus subunits 51 d2ftxb1 not modelled 6.1 0 Fold:Kinetochore globular domain-like Superfamily:Kinetochore globular domain Family:Spc24-like 52 c2fv4B_ not modelled 6.1 0 PDB header:structural protein, protein binding Chain: B: PDB Molecule:hypothetical 24.6 kda protein in ilv2-ade17 PDBTitle: nmr solution structure of the yeast kinetochore spc24/spc252 globular domain 53 d1xaua_ not modelled 5.8 15 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:I set domains 54 c1x50A_ not modelled 5.5 22 PDB header:sugar binding protein Chain: A: PDB Molecule:galectin-4; PDBTitle: solution structure of the c-terminal gal-bind lectin domain2 from human galectin-4 55 d2uz9a1 not modelled 5.4 29 Fold:Composite domain of metallo-dependent hydrolases Superfamily:Composite domain of metallo-dependent hydrolases Family:SAH/MTA deaminase-like 56 d1c1la_ not modelled 5.3 17 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Galectin (animal S-lectin) 57 c2ealB_ not modelled 5.2 25 PDB header:sugar binding protein Chain: B: PDB Molecule:galectin-9; PDBTitle: crystal structure of human galectin-9 n-terminal crd in complex with2 forssman pentasaccharide 58 d1wdjb_ not modelled 5.2 12 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:Hypothetical protein TT1808 (TTHA1514) 59 d1fltx_ not modelled 5.1 15 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:I set domains

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0