Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	M	K	K	L	L	I	I	I	L	P	V	L	L	S	G	C	S	A	F	N	Q	L	V	E	R	M	Q	T	D	T	L	E	Y	Q	C	D	E	K	P	L	T	V	K	L	N	N	P	R	Q	E	V	S	F	V	Y	D	N	Q
Secondary structure
SS confidence
Disorder		?	?	?	?													?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.
Sequence		L	L	H	L	K	Q	G	I	S	A	S	G	A	R	Y	T	D	G	I	Y	V	F	W	S	K	G	D	E	A	T	V	Y	K	R	D	R	I	V	L	N	N	C	Q	L	Q	N	P	Q	R
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?	?																																?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2f09 chain A domain 1 Region: 29 - 109 Aligned: 81 Modelled: 81 Confidence: 99.9% Identity: 100% Fold: Streptavidin-like Superfamily: YdhA-like Family: YdhA-like Phyre2 PDB 3f6z chain B Region: 23 - 95 Aligned: 73 Modelled: 73 Confidence: 99.8% Identity: 37% PDB header:hydrolase Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of pseudomonas aeruginosa mlic in complex2 with hen egg white lysozyme Phyre2 PDB 3oe3 chain B Region: 29 - 104 Aligned: 76 Modelled: 76 Confidence: 99.8% Identity: 22% PDB header:hydrolase inhibitor Chain: B: PDB Molecule:putative periplasmic protein; PDBTitle: crystal structure of plic-st, periplasmic lysozyme inhibitor of c-type2 lysozyme from salmonella typhimurium Phyre2 PDB 1e88 chain A domain 3 Region: 68 - 91 Aligned: 24 Modelled: 24 Confidence: 54.1% Identity: 21% Fold: FnI-like domain Superfamily: FnI-like domain Family: Fibronectin type I module Phyre2 PDB 1zps chain A domain 1 Region: 41 - 102 Aligned: 62 Modelled: 62 Confidence: 31.2% Identity: 15% Fold: HisI-like Superfamily: HisI-like Family: HisI-like Phyre2 PDB 1c01 chain A Region: 71 - 92 Aligned: 22 Modelled: 22 Confidence: 21.3% Identity: 36% Fold: gamma-Crystallin-like Superfamily: gamma-Crystallin-like Family: Plant antimicrobial protein MIAMP1 Phyre2 PDB 1wmx chain B Region: 77 - 89 Aligned: 13 Modelled: 13 Confidence: 19.6% Identity: 38% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: Family 30 carbohydrate binding module, CBM30 (PKD repeat) Phyre2 PDB 3r7t chain A Region: 35 - 71 Aligned: 37 Modelled: 37 Confidence: 17.2% Identity: 8% PDB header:ligase Chain: A: PDB Molecule:adenylosuccinate synthetase; PDBTitle: crystal structure of adenylosuccinate synthetase from campylobacter2 jejuni Phyre2 PDB 1wmx chain A Region: 77 - 89 Aligned: 13 Modelled: 13 Confidence: 16.2% Identity: 38% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: Family 30 carbohydrate binding module, CBM30 (PKD repeat) Phyre2 PDB 1qf5 chain A Region: 35 - 71 Aligned: 37 Modelled: 37 Confidence: 15.0% Identity: 11% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Nitrogenase iron protein-like Phyre2 PDB 1p9b chain A Region: 35 - 71 Aligned: 37 Modelled: 37 Confidence: 14.0% Identity: 8% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Nitrogenase iron protein-like Phyre2 PDB 1iwe chain B Region: 35 - 71 Aligned: 37 Modelled: 37 Confidence: 12.8% Identity: 8% PDB header:ligase Chain: B: PDB Molecule:adenylosuccinate synthetase; PDBTitle: imp complex of the recombinant mouse-muscle2 adenylosuccinate synthetase Phyre2 PDB 2psm chain C domain 1 Region: 31 - 40 Aligned: 10 Modelled: 10 Confidence: 12.1% Identity: 20% Fold: Complement control module/SCR domain Superfamily: Complement control module/SCR domain Family: Complement control module/SCR domain Phyre2 PDB 1iwe chain A Region: 35 - 71 Aligned: 37 Modelled: 37 Confidence: 11.0% Identity: 8% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: Nitrogenase iron protein-like Phyre2 PDB 2jgw chain A Region: 31 - 40 Aligned: 10 Modelled: 10 Confidence: 10.9% Identity: 10% PDB header:immune response Chain: A: PDB Molecule:complement factor h; PDBTitle: structure of ccp module 7 of complement factor h - the amd2 at risk varient (402h) Phyre2 PDB 2j42 chain A Region: 77 - 98 Aligned: 22 Modelled: 22 Confidence: 10.1% Identity: 18% PDB header:toxin Chain: A: PDB Molecule:c2 toxin component-ii; PDBTitle: low quality crystal structure of the transport component c2-2 ii of the c2-toxin from clostridium botulinum Phyre2 PDB 2bos chain A Region: 37 - 62 Aligned: 26 Modelled: 26 Confidence: 9.7% Identity: 8% Fold: OB-fold Superfamily: Bacterial enterotoxins Family: Bacterial AB5 toxins, B-subunits Phyre2 PDB 1w44 chain A Region: 72 - 89 Aligned: 18 Modelled: 18 Confidence: 9.2% Identity: 33% Fold: P-loop containing nucleoside triphosphate hydrolases Superfamily: P-loop containing nucleoside triphosphate hydrolases Family: RecA protein-like (ATPase-domain) Phyre2 PDB 3c0u chain A Region: 57 - 95 Aligned: 38 Modelled: 39 Confidence: 9.0% Identity: 26% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein yaeq; PDBTitle: crystal structure of e.coli yaeq protein Phyre2 PDB 1hcc chain A Region: 31 - 40 Aligned: 10 Modelled: 10 Confidence: 9.0% Identity: 30% Fold: Complement control module/SCR domain Superfamily: Complement control module/SCR domain Family: Complement control module/SCR domain Phyre2 1 d2f09a1 2 c3f6zB_ 3 c3oe3B_ 4 d1e88a3 5 d1zpsa1 6 d1c01a_ 7 d1wmxb_ 8 c3r7tA_ 9 d1wmxa_ 10 d1qf5a_ 11 d1p9ba_ 12 c1iweB_ 13 d2psmc1 14 d1iwea_ 15 c2jgwA_ 16 c2j42A_ 17 d2bosa_ 18 d1w44a_ 19 c3c0uA_ 20 d1hcca_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2f09a1 99.9 100 Fold:Streptavidin-like Superfamily:YdhA-like Family:YdhA-like 2 c3f6zB_ 99.8 37 PDB header:hydrolase Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of pseudomonas aeruginosa mlic in complex2 with hen egg white lysozyme 3 c3oe3B_ 99.8 22 PDB header:hydrolase inhibitor Chain: B: PDB Molecule:putative periplasmic protein; PDBTitle: crystal structure of plic-st, periplasmic lysozyme inhibitor of c-type2 lysozyme from salmonella typhimurium 4 d1e88a3 54.1 21 Fold:FnI-like domain Superfamily:FnI-like domain Family:Fibronectin type I module 5 d1zpsa1 31.2 15 Fold:HisI-like Superfamily:HisI-like Family:HisI-like 6 d1c01a_ 21.3 36 Fold:gamma-Crystallin-like Superfamily:gamma-Crystallin-like Family:Plant antimicrobial protein MIAMP1 7 d1wmxb_ 19.6 38 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Family 30 carbohydrate binding module, CBM30 (PKD repeat) 8 c3r7tA_ 17.2 8 PDB header:ligase Chain: A: PDB Molecule:adenylosuccinate synthetase; PDBTitle: crystal structure of adenylosuccinate synthetase from campylobacter2 jejuni 9 d1wmxa_ 16.2 38 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:Family 30 carbohydrate binding module, CBM30 (PKD repeat) 10 d1qf5a_ 15.0 11 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nitrogenase iron protein-like 11 d1p9ba_ 14.0 8 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nitrogenase iron protein-like 12 c1iweB_ 12.8 8 PDB header:ligase Chain: B: PDB Molecule:adenylosuccinate synthetase; PDBTitle: imp complex of the recombinant mouse-muscle2 adenylosuccinate synthetase 13 d2psmc1 12.1 20 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 14 d1iwea_ 11.0 8 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nitrogenase iron protein-like 15 c2jgwA_ 10.9 10 PDB header:immune response Chain: A: PDB Molecule:complement factor h; PDBTitle: structure of ccp module 7 of complement factor h - the amd2 at risk varient (402h) 16 c2j42A_ 10.1 18 PDB header:toxin Chain: A: PDB Molecule:c2 toxin component-ii; PDBTitle: low quality crystal structure of the transport component c2-2 ii of the c2-toxin from clostridium botulinum 17 d2bosa_ 9.7 8 Fold:OB-fold Superfamily:Bacterial enterotoxins Family:Bacterial AB5 toxins, B-subunits 18 d1w44a_ 9.2 33 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:RecA protein-like (ATPase-domain) 19 c3c0uA_ 9.0 26 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein yaeq; PDBTitle: crystal structure of e.coli yaeq protein 20 d1hcca_ 9.0 30 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 21 c1hccA_ not modelled 9.0 30 PDB header:glycoprotein Chain: A: PDB Molecule:16th complement control protein; PDBTitle: three-dimensional structure of a complement control protein2 module in solution 22 c2z3rF_ not modelled 8.9 20 PDB header:cytokine/cytokine receptor Chain: F: PDB Molecule:interleukin-15 receptor alpha chain; PDBTitle: crystal structure of the il-15/il-15ra complex 23 d2z3qb1 not modelled 8.6 20 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 24 c1x3xA_ not modelled 8.2 23 PDB header:electron transport Chain: A: PDB Molecule:cytochrome b5; PDBTitle: crystal structure of cytochrome b5 from ascaris suum 25 d1c4qa_ not modelled 7.6 12 Fold:OB-fold Superfamily:Bacterial enterotoxins Family:Bacterial AB5 toxins, B-subunits 26 d2o39c1 not modelled 7.3 20 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 27 c2jraB_ not modelled 7.1 8 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein rpa2121; PDBTitle: a novel domain-swapped solution nmr structure of protein rpa2121 from2 rhodopseudomonas palustris. northeast structural genomics target rpt6 28 c2jgxA_ not modelled 7.0 10 PDB header:immune response Chain: A: PDB Molecule:complement factor h; PDBTitle: structure of ccp module 7 of complement factor h - the amd2 not at risk varient (402y) 29 d1zjka2 not modelled 7.0 10 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 30 d1gpza2 not modelled 7.0 20 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 31 d1r4pb_ not modelled 6.8 12 Fold:OB-fold Superfamily:Bacterial enterotoxins Family:Bacterial AB5 toxins, B-subunits 32 d1ly2a2 not modelled 6.8 20 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 33 d1gkna1 not modelled 6.8 30 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 34 c2qzfA_ not modelled 6.6 30 PDB header:immune system Chain: A: PDB Molecule:complement decay-accelerating factor; PDBTitle: scr1 of daf from 1ojv fitted into cryoem density 35 d1edqa1 not modelled 6.6 13 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:E-set domains of sugar-utilizing enzymes 36 d1ok3a2 not modelled 6.5 30 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 37 d1gkga2 not modelled 6.2 20 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 38 c2d7uA_ not modelled 6.2 16 PDB header:ligase Chain: A: PDB Molecule:adenylosuccinate synthetase; PDBTitle: crystal structure of hypothetical adenylosuccinate synthetase, ph04382 from pyrococcus horikoshii ot3 39 c3f0nB_ not modelled 6.1 37 PDB header:lyase Chain: B: PDB Molecule:mevalonate pyrophosphate decarboxylase; PDBTitle: mus musculus mevalonate pyrophosphate decarboxylase 40 d1ok3a1 not modelled 6.0 30 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 41 d1dj2a_ not modelled 5.8 8 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nitrogenase iron protein-like 42 d1quba1 not modelled 5.8 20 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 43 d1dj3a_ not modelled 5.6 8 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nitrogenase iron protein-like 44 d1h03p2 not modelled 5.5 20 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 45 d1g40a2 not modelled 5.5 20 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 46 c2fipA_ not modelled 5.5 67 PDB header:transcription Chain: A: PDB Molecule:late genes activator; PDBTitle: phage phi29 transcription regulator p4 47 c2hkeB_ not modelled 5.4 44 PDB header:lyase Chain: B: PDB Molecule:diphosphomevalonate decarboxylase, putative; PDBTitle: mevalonate diphosphate decarboxylase from trypanosoma brucei 48 c1sy6A_ not modelled 5.3 12 PDB header:signaling protein/antibiotic Chain: A: PDB Molecule:t-cell surface glycoprotein cd3 gamma/epsilon PDBTitle: crystal structure of cd3gammaepsilon heterodimer in complex2 with okt3 fab fragment 49 d2o39c2 not modelled 5.2 20 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0