Job Description P00722 Confidence 100.00% Date Thu Jan 5 10:56:50 GMT 2012 Rank 9 Aligned Residues 526 % Identity 27% Template c3lpgA_ PDB info PDB header:hydrolase/hydrolase inhibitor Chain: A: PDB Molecule:beta-glucuronidase; PDBTitle: structure of e. coli beta-glucuronidase bound with a novel, potent2 inhibitor 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-((6-methyl-2-oxo-1,3 2-dihydroquinolin-3-yl)methyl)urea Resolution 2.42 Å

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		47	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		R	P	S	Q	Q	L	R	S	L	N	G	E	W	R	F	A	W	F	P	A	P	E	A	V	P	E	S	W	L	E	C	D	L	P	E	A	D	T	V	V	V	P	S	N	W	Q	M	H	G	Y	D	A	P	I	Y	T	N	V	T	Y	P	I	T	V	N	P	P	F	V	P	T	E	N	P	T	G	C	Y	S	L
Query Conservation
Alig confidence																																																									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																																									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		T	P	T	R	E	I	K	K	L	D	G	L	W	A	F	S	L	D	R	E	N	C	G	I	D	Q	R	W	W	E	S	A	L	Q	E	S	R	A	I	A	V	P	G	S	F	N	D	Q	F	A	D	A	D	I	R	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N	Y	A	G	N	V	W	Y	Q	R
Template Known Secondary structure		S	S									S								S	S			T	T	T	T	T	G	G	G	S			T	T						S	S	S		S	S	G	G	G	T						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T			S
Template Predicted Secondary structure																																																									.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		7	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.																.	.	.	.	.	.	.	.	70	.
		127	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.		.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																																																										.																		.	.	.	.	.	.
Query SS confidence																																																										.																		.	.	.	.	.	.
Query Sequence		T	F	N	V	D	E	S	W	L	Q	E	G	Q	T	R	I	I	F	D	G	V	N	S	A	F	H	L	W	C	N	G	R	W	V	G	Y	G	Q	D	S	R	L	P	S	E	F	D	L	S	A	F	L	R	A	G	E	.	N	R	L	A	V	M	V	L	R	W	S	D	G	S	Y	L	E	.	.	.	.	.	.
Query Conservation																																																										.																		.	.	.	.	.	.
Alig confidence										.																																																.																		.	.	.	.	.	.
Template Conservation										.
Template Sequence		E	V	F	I	P	K	G	W	.	A	G	Q	R	I	V	L	R	F	D	A	V	T	H	Y	G	K	V	W	V	N	N	Q	E	V	X	E	H	Q	G	G	Y	T	P	F	E	A	D	V	T	P	Y	V	I	A	G	K	S	V	R	I	T	V	C	V	N	N	E	L	N	W	Q	T	I	P	P	G	X	V	I	T
Template Known Secondary structure							G	G	G	.	T	T	S							S			S	S							S	S									S	S	S							G	G	G			T	T	S														T	T	S	S	S
Template Predicted Secondary structure										.
Template SS confidence
		72	.	.	.	.	.	.	.		80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150
												200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.
Predicted Secondary structure		.	.	.	.	.	.	.	.	.	.
Query SS confidence		.	.	.	.	.	.	.	.	.	.
Query Sequence		.	.	.	.	.	.	.	.	.	.	D	Q	D	M	W	R	M	S	G	I	F	R	D	V	S	L	L	H	K	P	T	T	Q	I	S	D	F	H	V	A	T	R	F	N	D	D	F	S	R	A	V	L	E	A	E	V	Q	M	C	G	E	L	R	D	Y	L	R	V	T	V	S	L	W	Q	G	E	T	Q	V	A
Query Conservation		.	.	.	.	.	.	.	.	.	.
Alig confidence		.	.	.	.	.	.	.	.	.	.																																																			.	.	.	.	.	.
Template Conservation																																																														.	.	.	.	.	.
Template Sequence		D	E	N	G	K	K	K	Q	S	Y	F	H	D	F	F	N	Y	A	G	I	H	R	S	V	X	L	Y	T	T	P	N	T	W	V	D	D	I	T	V	V	T	H	V	A	Q	D	C	N	H	A	S	V	D	W	Q	V	V	A	N	G	.	.	.	.	.	.	D	V	S	V	E	L	R	D	A	D	Q	Q	V	V
Template Known Secondary structure			T	T								S	S	S	B					S			S									S	S												S	S	S	S												S	S	.	.	.	.	.	.									T	T
Template Predicted Secondary structure																																																														.	.	.	.	.	.
Template SS confidence
		151	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210							.	.	.	.	.	.	.	.	.	220	.	.	.	.
		270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	G	T	A	P	F	G	G	E	I	I	D	E	R	G	G	Y	A	D	R	V	T	L	R	L	N	V	E	N	P	K	L	W	S	A	E	I	P	N	L	Y	R	A	V	V	E	L	H	T	A	D	G	T	L	I	E	A	E	A	C	D	V	G	F	R	E	V	R	I	E	N	G	L	L	L	L	N	G	K	P
Query Conservation
Alig confidence										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																									.	.
Template Conservation										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																									.	.
Template Sequence		A	T	G	Q	G	T	S	G	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	L	Q	V	V	N	P	H	L	W	Q	P	G	E	G	Y	L	Y	E	L	C	V	T	A	.	.	K	S	Q	T	E	C	D	I	Y	P	L	R	V	G	I	R	S	V	A	V	K	G	E	Q	F	L	I	N	H	K	P
Template Known Secondary structure						S	S	S		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.												T	T	T											.	.			S	S																		T	T					T	T
Template Predicted Secondary structure										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.																									.	.
Template SS confidence
		225	.	.	.	.	230	.	.																.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.			.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.
		350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.
Predicted Secondary structure																																																																											.	.	.	.	.	.	.
Query SS confidence																																																																											.	.	.	.	.	.	.
Query Sequence		L	L	I	R	G	V	N	R	H	E	H	H	P	L	H	G	Q	V	M	D	E	Q	T	M	V	Q	D	I	L	L	M	K	Q	N	N	F	N	A	V	R	C	S	H	Y	P	N	H	P	L	W	Y	T	L	C	D	R	Y	G	L	Y	V	V	D	E	A	N	I	E	T	H	G	M	V	.	.	.	.	.	.	.
Query Conservation																																																																											.	.	.	.	.	.	.
Alig confidence																																																																											.	.	.	.	.	.	.
Template Conservation
Template Sequence		F	Y	F	T	G	F	G	R	H	E	D	A	D	L	R	G	K	G	F	D	N	V	L	X	V	H	D	H	A	L	X	D	W	I	G	A	N	S	Y	R	T	S	H	Y	P	Y	A	E	E	X	L	D	W	A	D	E	H	G	I	V	V	I	D	E	T	A	A	V	G	F	N	L	S	L	G	I	G	F	E	A
Template Known Secondary structure											S		B	T	T	T	B	T																		T							T	T	S														T								S		B				S					S	S	S
Template Predicted Secondary structure
Template SS confidence
		288	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.
								423	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.						.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.
Predicted Secondary structure		.	.	.	.	.	.																																															.	.	.	.	.
Query SS confidence		.	.	.	.	.	.																																															.	.	.	.	.
Query Sequence		.	.	.	.	.	.	P	M	N	R	L	T	D	D	P	R	W	L	P	A	M	S	E	R	V	T	R	M	V	Q	R	D	R	N	H	P	S	V	I	I	W	S	L	G	N	E	S	G	H	G	A	N	.	.	.	.	.	H	D	A	L	Y	R	W	I	K	S	V	D	P	S	R	P	V	Q	Y	E	G	G	G
Query Conservation		.	.	.	.	.	.																																															.	.	.	.	.
Alig confidence		.	.	.	.	.	.																																															.	.	.	.	.
Template Conservation
Template Sequence		G	N	K	P	K	E	L	Y	S	E	E	A	V	N	G	E	T	Q	Q	A	H	L	Q	A	I	K	E	L	I	A	R	D	K	N	H	P	S	V	V	X	W	S	I	A	N	E	P	D	T	R	P	Q	G	A	R	E	Y	F	A	P	L	A	E	A	T	R	K	L	D	P	T	R	P	I	T	C	V	N	V	X
Template Known Secondary structure						S		S	S	B	T	T	T	B																				T	T		T	T														S	T																		S	S	S						B		T
Template Predicted Secondary structure
Template SS confidence
		368	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.
		492	.								.	.	.	.	.	.	500	.	.	.						.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540								.	.	.	.	.	.	.	.	.
Predicted Secondary structure				.	.	.	.	.	.	.											.	.	.	.	.																																						.	.	.	.	.	.	.										.	.	.
Query SS confidence				.	.	.	.	.	.	.											.	.	.	.	.																																						.	.	.	.	.	.	.										.	.	.
Query Sequence		A	D	.	.	.	.	.	.	.	T	T	A	T	D	I	I	C	P	M	.	.	.	.	.	Y	A	R	V	D	E	D	Q	P	F	P	A	V	P	K	W	S	I	K	K	W	L	S	L	P	G	E	T	R	P	L	I	L	C	E	Y	A	.	.	.	.	.	.	.	H	A	M	G	N	S	L	G	G	.	.	.
Query Conservation				.	.	.	.	.	.	.											.	.	.	.	.																																						.	.	.	.	.	.	.										.	.	.
Alig confidence				.	.	.	.	.	.	.											.	.	.	.	.																											.	.										.	.	.	.	.	.	.										.	.	.
Template Conservation																																																				.	.
Template Sequence		F	C	D	A	H	T	D	T	I	S	D	L	F	D	V	L	C	L	N	R	Y	Y	G	W	Y	V	Q	S	G	D	L	E	T	A	E	K	V	L	E	K	E	L	L	A	W	Q	E	K	L	H	.	.	Q	P	I	I	I	T	E	Y	G	V	D	T	L	A	G	L	H	S	X	Y	T	D	X	W	S	E	E	Y
Template Known Secondary structure		T	S		T	T	T		S	S	G	G	G	S	S	S							B	T	T	T	B	S	T	T																						.	.														T	T				T	T			T	T	S
Template Predicted Secondary structure																																																				.	.
Template SS confidence
		448	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.			.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.
						550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.
Predicted Secondary structure		.	.	.	.
Query SS confidence		.	.	.	.
Query Sequence		.	.	.	.	F	A	K	Y	W	Q	A	F	R	Q	Y	P	R	L	Q	G	G	F	V	W	D	W	V	D	Q	S	L	I	K	Y	D	E	N	G	N	P	W	S	A	Y	G	G	D	F	G	D	T	P	N	D	R	Q	F	C	M	N	G	L	V	F	A	D	R	T	P	H	P	A	L	T	E	A	K	H	Q	Q
Query Conservation		.	.	.	.
Alig confidence		.	.	.	.																															.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		Q	C	A	W	L	D	X	Y	H	R	V	F	D	R	V	S	A	V	V	G	E	Q	V	W	N	F	A	D	F	A	T	S	Q	G	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	I	L	R	V	G	G	N	K	K	G	I	F	T	R	D	R	K	P	K	S	A	A	F	L	L	Q	K	R	W
Template Known Secondary structure														T	T		T	T							S					B		B			B	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	B	S	S	S	B							T	T			B		T
Template Predicted Secondary structure																																				.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		526	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.																		560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.
		626	.	.	.	630
Predicted Secondary structure
Query SS confidence
Query Sequence		Q	F	F	Q	F
Query Conservation
Alig confidence
Template Conservation
Template Sequence		T	G	X	N	F
Template Known Secondary structure				S		T
Template Predicted Secondary structure
Template SS confidence
		589	590	.	.	.