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Job DescriptionP54746
Confidence100.00%DateThu Jan 5 12:06:04 GMT 2012
Rank1Aligned Residues835
% Identity29%Templatec2wyhA_
PDB info PDB header:hydrolaseChain: A: PDB Molecule:alpha-mannosidase; PDBTitle: structure of the streptococcus pyogenes family gh38 alpha-2 mannosidase
Resolution1.90 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   1........10.........20.........30.........40.........50.........60.........70.........80
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Query Sequence  MKAVSRVHITPHMHWDREWYFTTEESRILLVNNMEEILCRLEQDNEYKYYVLDGQTAILEDYFAVKPENKDRVKKQVEAG
Query Conservation        
 

 


 
  

 
              

  
   
   
                 
     

 

  
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Template Conservation     .  
 

 


 
  

 
              

  
   
   
     
        
  

    

 

  
Template Sequence  MAT. KKVHIISHSHWDREWYMAYEQHHMRLINLIDDLLEVFQTDPDFHSFHLDGQTIILDDYLKVRPEREPEIRQAIASG
Template Known Secondary structure 


.B
B

SSSSS

TT



TTBT
GGGTT
Template Predicted Secondary structure 


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   1.. ......10.........20.........30.........40.........50.........60.........70.........
 
   81........90.........100.........110.........120.........130.........140.........150.
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Query Sequence  KLIIGPWYTQTDTTIVSAESIVRNLMYGMRDCLAFGEPMKIGYLPDSFGMSGQLPHIYNGFGITRTMFWRG. . . . . . . . .
Query Conservation 

 


  
  

 
   





   
      

    
 
  
 

 
  




   

      
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Template Conservation 





  
  

   
 






  
      

      
 

 

 
  




   

   
  
          
Template Sequence  KLRIGPFYILQDDFLTSSESNVRNMLIGKEDCDRWGASVPLGYFPDTFGNMGQTPQLMLKAGLQAAAFGRGIRPTGFNNQ
Template Known Secondary structure  S

SBSS
B
STTS
T


SSSS
SSB
TTTTT


SS


SSS
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   80.........90.........100.........110.........120.........130.........140.........150.........
 
   152.......160.........170.........180.........190.........200.........210.........220.........
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Query Sequence  . . CSERHGTDKTEFLWQSSDGSEVTAQVLPLGYAIGKYLPADENGLRKRLDSYFDVLEKASVTKEILLPNGHDQMPLQQN
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Template Conservation               
 
 
 


 
        
                                 
   
 
       
Template Sequence  VDTSEKYSSQFSEISWQGPDNSRILGLLFANWYSNGNEIPTTEAEARLFWDKKLADAERFASTKHLLMMNGCDHQPVQLD
Template Known Secondary structure 

TT
TTSSS
TT


TT
TTTT
S

SS
SSS

BT



TT
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   160.........170.........180.........190.........200.........210.........220.........230.........
 
   230.........240.........250.........260. ........270......... 280.........290.........300......
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Query Sequence  IFEVMDKLREIYPQRKFVMSRFEEVFEKIEAQ. RDNLATLKGEFIDGKYMR. . VHRTIGSTRMDIKIAHARIENKIVNLL
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Template Conservation      
   
          

   

  
       

   


            
  


  

  

  
  
    
Template Sequence  VTKAIALANQLYPDYEFVHSCFEDYLADLADDLPENLSTVQGEITSQETDGWYTLANTASARIYLKQANTRVSRQLENIT
Template Known Secondary structure 
TT

S
S


S
BS
TTS
SSSS
GGGGGTTT
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   240.........250.........260.........270.........280.........290.........300.........310.........
 
   307..310.........320.........330.........340.........350.........360.........370.........380..
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Query Sequence  EPLATLAWTLGFEYHHGLLEKMWKEILKNHAHDSIGCCCSDKVHREIVARFELAEDMADNLIRFYMRKIADNMPQS. . . .
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Template Conservation 
 
   
           
  


 

  
 

 
 


   
  
                   
  
           
Template Sequence  EPLAAMAYEVTSTYPHDQLRYAWKTLMQNHPHDSICGCSVDSVHREMMTRFEKAYEVGHYLAKEAAKQIADAIDTRDFPM
Template Known Secondary structure  S


TT
BTT
S
TB

TTS
T
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   320.........330.........340.........350.........360.........370.........380.........390.........
 
   383......390.........400........ .410.........420.........430.........
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Query Sequence  DADKLVLFNLMPWPREEVINTTVRLR. . . . . . . . . . . . . . . . . . . . . . . ASQFNLRDDRGQPVPYFIRHAREIDPGLIDR
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Template Conservation      
 


 
   
   
                                   
 
  
  
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Template Sequence  DSQPFVLFNTSGHSKTSVAELSLTWKKYHFGQRFPKEVYQEAQEYLARLSQSFQIIDTSGQVRPEAEILG. TSIAFDYDL
Template Known Secondary structure  TS
SSS

TTS
T

S
TT

B
TT
.
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   400.........410.........420.........430.........440.........450.........460......... 470........
 
   440.........450.........460.........470.........480.........490.........500.........510.........
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Query Sequence  QIVHYGNYDPFMEFDIQINQIVPSMGYRTLYIEANQPGNVIAAKSDAEGILENAFWQIALNEDGSLQLVDKDSGVRYDRV
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Template Conservation                       

  
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Template Sequence  PKRSFREPYFAIKVRLRLPITLPAMSWKTLALKLGNTVSLYD. . . DSNQCLENGFLKVMIQTDGRLTITDKQSGLIYQDL
Template Known Secondary structure 
SSS


TT



S...TTTT
SS
TTS
TTT

Template Predicted Secondary structure 



























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   479480.........490.........500.........510.........520 .........530.........540.........550.....
 
   520.........530.........540.........550..... ....560.........570........ .580..
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Query Sequence  LQIEESSDDGDEYDYSPAKEEWVITAANAKPQCDII. HEAWQSRAVIRYDMAVPLNLSER. . . . . . . . . . . . . . . . SARQ
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Template Conservation         
 
  
       
                                
                          
Template Sequence  LRFEDCGDIGNEYISRQPNHDQPFYADQGTIKLNIISNTAQVAELEIQQTFAIPISADKLLQAEMEAVIDITERQARRSQ
Template Known Secondary structure  S

S
SS




TT


GGGS
SSSSB
TTT

GGG



B
S
Template Predicted Secondary structure 




































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   562.......570.........580.........590.........600.........610.........620.........630.........640.
 
   583......590.........600.........610.........620.........630.........640.........650.........660..
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Query Sequence  STGRVGVVLVVTLSHNSRRIDVDINLDNQADDHRLRVLVPTPFNTDSVLADTQFGSLTRPVNDSAMNNWQQEGWKEAPVP
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Template Conservation        
   
 
      
     

       

  

          
   
 
 
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Template Sequence  EKAELTLTTLIRMEKNNPRLQFTTRFDNQMTNHRLRVLFPTHLKTDHHLADSIFETVKRPNHPDA. . . . . . . TFWKNPSN
Template Known Secondary structure 
TT
S



S




STTSS

T.......TT


S

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   642.......650.........660.........670.........680.........690.........700...... ...710....
 
   663......670.........680.........690.........700.........710.........720.........730.........740..
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Query Sequence  VWNMLNYVALQEGRNGMAVFSEGLREFEVIGEEKKTFAITLLRGVGLLGKEDLLLRPGRPSGIKMPVPDSQLRGLLSCRL
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Template Conservation    
    
 
 
   




     
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Template Sequence  PQHQECFVSLFDGENGVTIGNYGLNEYEILP. DTNTIAITLLRSVGEMGDWGY. . . . . . . . . . . FPTPEAQCLGKHSLSY
Template Known Secondary structure 

SS
SSSS

T.TTT
SB

TTS
...........
B
GGGG

Template Predicted Secondary structure 









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   715....720.........730.........740..... ....750.........760...... ...770.........780..
 
   743......750.........760.........770.........780.........790.........800.........810.........820..
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Query Sequence  SLLSYTGTPTAAGVAQQARAWLTPVQCYNKIPWDVMKLNKAGFNVPESYSLLKMPPVGCLISALKKAEDRQEVILRLFNP
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Template Conservation   
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Template Sequence  SFESITKQTQFASYWR. AQEGQVPVITT. . . . . . . . QTNQHEGTLAAEYSYLTGTNDQVALTAFKRRLADNALITRSYNL
Template Known Secondary structure  TTT.TTS

........

S


SB
SS
B


TT
TTT

S
Template Predicted Secondary structure 





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   783......790........ .800......... 810.........820.........830.........840.........850...
 
   823......830.........840.........850.........860.........870.....
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Query Sequence  AESATCDATVAFSREVISCSETMMDEHITTEENQGSNLSGPFLPGQSRTFSYR
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Template Conservation       ..                


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Template Sequence  SNDKT. . CDFSLSLPNYNAKVTNLLEKDSKQSTPSQ. . . . . LGKAEILTLAWK
Template Known Secondary structure 
SS

..


B
TT
TT

B
S



S.....
TT
Template Predicted Secondary structure 


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   854.... .860.........870.........880....... ..890.........
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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