Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	N	L	F	V	R	S	G	I	S	F	V	D	R	S	E	V	L	T	H	I	G	N	E	M	L	A	K	G	V	V	H	D	T	W	P	Q	A	L	I	A	R	E	A	E	F	P	T	G	I	M	L	E	Q	H	A	I	A	I
Secondary structure
SS confidence
Disorder		?	?	?	?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	H	C	E	A	I	H	A	K	S	S	A	I	Y	L	L	R	P	T	N	K	V	H	F	Q	Q	A	D	D	D	N	D	V	A	V	S	L	V	I	A	L	I	V	E	N	P	Q	Q	Q	L	K	L	L	R	C	L	F	G	K	L
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150
Sequence		Q	Q	P	D	I	V	E	T	L	I	T	L	P	E	T	Q	L	K	E	Y	F	T	K	Y	V	L	D	S	D	E
Secondary structure
SS confidence
Disorder																												?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1xiz chain A Region: 2 - 147 Aligned: 146 Modelled: 146 Confidence: 100.0% Identity: 21% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 3oxp chain B Region: 1 - 144 Aligned: 140 Modelled: 144 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution Phyre2 PDB 3oxp chain A Region: 1 - 144 Aligned: 140 Modelled: 144 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution Phyre2 PDB 2oq3 chain A Region: 1 - 143 Aligned: 138 Modelled: 139 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:mannitol-specific cryptic phosphotransferase PDBTitle: solution structure of the mannitol- specific cryptic2 phosphotransferase enzyme iia cmtb from escherichia coli Phyre2 PDB 3urr chain B Region: 1 - 144 Aligned: 139 Modelled: 141 Confidence: 100.0% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn; PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn) Phyre2 PDB 1a3a chain A Region: 1 - 149 Aligned: 139 Modelled: 149 Confidence: 100.0% Identity: 22% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 3bjv chain A Region: 1 - 148 Aligned: 142 Modelled: 148 Confidence: 100.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:rmpa; PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans Phyre2 PDB 2oqt chain D Region: 1 - 144 Aligned: 138 Modelled: 142 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: D: PDB Molecule:hypothetical protein spy0176; PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas Phyre2 PDB 2a0j chain A Region: 1 - 141 Aligned: 137 Modelled: 138 Confidence: 99.9% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein; PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis Phyre2 PDB 1a6j chain A Region: 1 - 149 Aligned: 142 Modelled: 149 Confidence: 99.9% Identity: 18% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 1hyn chain Q Region: 63 - 148 Aligned: 84 Modelled: 86 Confidence: 96.9% Identity: 11% PDB header:membrane protein Chain: Q: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the cytoplasmic domain of human2 erythrocyte band-3 protein Phyre2 PDB 1hyn chain P Region: 63 - 148 Aligned: 84 Modelled: 86 Confidence: 96.9% Identity: 11% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: Anion transport protein, cytoplasmic domain Phyre2 PDB 2jya chain A Region: 5 - 25 Aligned: 21 Modelled: 21 Confidence: 7.6% Identity: 5% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein atu1810; PDBTitle: nmr solution structure of protein atu1810 from agrobacterium2 tumefaciens. northeast structural genomics consortium target atr23,3 ontario centre for structural proteomics target atc1776 Phyre2 PDB 1sxj chain B domain 1 Region: 13 - 42 Aligned: 30 Modelled: 30 Confidence: 7.3% Identity: 7% Fold: post-AAA+ oligomerization domain-like Superfamily: post-AAA+ oligomerization domain-like Family: DNA polymerase III clamp loader subunits, C-terminal domain Phyre2 PDB 1vlf chain M domain 2 Region: 14 - 28 Aligned: 15 Modelled: 15 Confidence: 5.7% Identity: 13% Fold: Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily: Formate dehydrogenase/DMSO reductase, domains 1-3 Family: Formate dehydrogenase/DMSO reductase, domains 1-3 Phyre2 PDB 1g8k chain A domain 2 Region: 14 - 28 Aligned: 15 Modelled: 15 Confidence: 5.5% Identity: 0% Fold: Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily: Formate dehydrogenase/DMSO reductase, domains 1-3 Family: Formate dehydrogenase/DMSO reductase, domains 1-3 Phyre2 1 d1xiza_ 2 c3oxpB_ 3 c3oxpA_ 4 c2oq3A_ 5 c3urrB_ 6 d1a3aa_ 7 c3bjvA_ 8 c2oqtD_ 9 c2a0jA_ 10 d1a6ja_ 11 c1hynQ_ 12 d1hynp_ 13 c2jyaA_ 14 d1sxjb1 15 d1vlfm2 16 d1g8ka2

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1xiza_ 100.0 21 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 2 c3oxpB_ 100.0 16 PDB header:transferase Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution 3 c3oxpA_ 100.0 16 PDB header:transferase Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution 4 c2oq3A_ 100.0 21 PDB header:transferase Chain: A: PDB Molecule:mannitol-specific cryptic phosphotransferase PDBTitle: solution structure of the mannitol- specific cryptic2 phosphotransferase enzyme iia cmtb from escherichia coli 5 c3urrB_ 100.0 24 PDB header:transferase Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn; PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn) 6 d1a3aa_ 100.0 22 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 7 c3bjvA_ 100.0 16 PDB header:transferase Chain: A: PDB Molecule:rmpa; PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans 8 c2oqtD_ 100.0 20 PDB header:transferase Chain: D: PDB Molecule:hypothetical protein spy0176; PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas 9 c2a0jA_ 99.9 21 PDB header:transferase Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein; PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis 10 d1a6ja_ 99.9 18 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 11 c1hynQ_ 96.9 11 PDB header:membrane protein Chain: Q: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the cytoplasmic domain of human2 erythrocyte band-3 protein 12 d1hynp_ 96.9 11 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:Anion transport protein, cytoplasmic domain 13 c2jyaA_ 7.6 5 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein atu1810; PDBTitle: nmr solution structure of protein atu1810 from agrobacterium2 tumefaciens. northeast structural genomics consortium target atr23,3 ontario centre for structural proteomics target atc1776 14 d1sxjb1 7.3 7 Fold:post-AAA+ oligomerization domain-like Superfamily:post-AAA+ oligomerization domain-like Family:DNA polymerase III clamp loader subunits, C-terminal domain 15 d1vlfm2 5.7 13 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3 16 d1g8ka2 5.5 0 Fold:Formate dehydrogenase/DMSO reductase, domains 1-3 Superfamily:Formate dehydrogenase/DMSO reductase, domains 1-3 Family:Formate dehydrogenase/DMSO reductase, domains 1-3

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0