Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	T	P	V	K	K	W	L	L	R	V	A	P	W	F	L	P	V	G	I	V	A	V	W	Q	L	A	S	S	V	G	W	L	S	T	R	I	L	P	S	P	E	G	V	V	T	A	F	W	T	L	S	A	S	G	E	L	W	Q
Secondary structure
SS confidence
Disorder		?	?	?	?																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	L	A	I	S	S	W	R	A	L	I	G	F	S	I	G	G	S	L	G	L	I	L	G	L	I	S	G	L	S	R	W	G	E	R	L	L	D	T	S	I	Q	M	L	R	N	V	P	H	L	A	L	I	P	L	V	I	L	W	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	I	D	E	S	A	K	I	F	L	V	A	L	G	T	L	F	P	I	Y	I	N	T	W	H	G	I	R	N	I	D	R	G	L	V	E	M	A	R	S	Y	G	L	S	G	I	P	L	F	I	H	V	I	L	P	G	A	L	P	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	M	V	G	V	R	F	A	L	G	L	M	W	L	T	L	I	V	A	E	T	I	S	A	N	S	G	I	G	Y	L	A	M	N	A	R	E	F	L	Q	T	D	V	V	V	V	A	I	I	L	Y	A	L	L	G	K	L	A	D	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.
Sequence		S	A	Q	L	L	E	R	L	W	L	R	W	N	P	A	Y	H	L	K	E	A	T	V
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3d31 chain C domain 1 Region: 14 - 243 Aligned: 230 Modelled: 230 Confidence: 100.0% Identity: 14% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3d31 chain D Region: 14 - 243 Aligned: 230 Modelled: 230 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease PDBTitle: modbc from methanosarcina acetivorans Phyre2 PDB 2onk chain C Region: 13 - 245 Aligned: 228 Modelled: 233 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda Phyre2 PDB 2onk chain C domain 1 Region: 13 - 245 Aligned: 228 Modelled: 233 Confidence: 100.0% Identity: 15% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3fh6 chain F Region: 9 - 255 Aligned: 247 Modelled: 247 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 2r6g chain F Region: 45 - 241 Aligned: 197 Modelled: 197 Confidence: 100.0% Identity: 12% PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter Phyre2 PDB 2r6g chain F domain 2 Region: 46 - 241 Aligned: 196 Modelled: 196 Confidence: 100.0% Identity: 12% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain G domain 1 Region: 2 - 259 Aligned: 255 Modelled: 258 Confidence: 100.0% Identity: 16% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3dhw chain A domain 1 Region: 58 - 243 Aligned: 186 Modelled: 186 Confidence: 99.9% Identity: 18% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 1ntc chain A Region: 142 - 172 Aligned: 31 Modelled: 31 Confidence: 31.7% Identity: 19% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1umq chain A Region: 142 - 172 Aligned: 31 Modelled: 31 Confidence: 27.0% Identity: 19% PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity Phyre2 PDB 1umq chain A Region: 142 - 172 Aligned: 31 Modelled: 31 Confidence: 27.0% Identity: 19% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1fip chain A Region: 142 - 172 Aligned: 31 Modelled: 31 Confidence: 17.7% Identity: 10% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 2hdl chain A Region: 247 - 262 Aligned: 16 Modelled: 16 Confidence: 17.0% Identity: 19% PDB header:cytokine Chain: A: PDB Molecule:small inducible cytokine b14; PDBTitle: solution structure of brak/cxcl14 Phyre2 PDB 1eto chain B Region: 142 - 172 Aligned: 31 Modelled: 31 Confidence: 16.9% Identity: 10% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1etx chain A Region: 142 - 172 Aligned: 31 Modelled: 31 Confidence: 13.8% Identity: 10% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 3e7l chain D Region: 142 - 172 Aligned: 31 Modelled: 31 Confidence: 13.6% Identity: 19% PDB header:transcription regulator Chain: D: PDB Molecule:transcriptional regulator (ntrc family); PDBTitle: crystal structure of sigma54 activator ntrc4's dna binding2 domain Phyre2 PDB 2cw1 chain A Region: 151 - 165 Aligned: 15 Modelled: 15 Confidence: 9.2% Identity: 40% PDB header:de novo protein Chain: A: PDB Molecule:sn4m; PDBTitle: solution structure of the de novo-designed lambda cro fold2 protein Phyre2 1 d3d31c1 2 c3d31D_ 3 c2onkC_ 4 d2onkc1 5 c3fh6F_ 6 c2r6gF_ 7 d2r6gf2 8 d2r6gg1 9 d3dhwa1 10 d1ntca_ 11 c1umqA_ 12 d1umqa_ 13 d1fipa_ 14 c2hdlA_ 15 d1etob_ 16 d1etxa_ 17 c3e7lD_ 18 c2cw1A_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d3d31c1 100.0 14 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 2 c3d31D_ 100.0 14 PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease PDBTitle: modbc from methanosarcina acetivorans 3 c2onkC_ 100.0 15 PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda 4 d2onkc1 100.0 15 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 5 c3fh6F_ 100.0 13 PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli 6 c2r6gF_ 100.0 12 PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter 7 d2r6gf2 100.0 12 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 8 d2r6gg1 100.0 16 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 9 d3dhwa1 99.9 18 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 10 d1ntca_ 31.7 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 11 c1umqA_ 27.0 19 PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity 12 d1umqa_ 27.0 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 13 d1fipa_ 17.7 10 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 14 c2hdlA_ 17.0 19 PDB header:cytokine Chain: A: PDB Molecule:small inducible cytokine b14; PDBTitle: solution structure of brak/cxcl14 15 d1etob_ 16.9 10 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 16 d1etxa_ 13.8 10 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 17 c3e7lD_ 13.6 19 PDB header:transcription regulator Chain: D: PDB Molecule:transcriptional regulator (ntrc family); PDBTitle: crystal structure of sigma54 activator ntrc4's dna binding2 domain 18 c2cw1A_ 9.2 40 PDB header:de novo protein Chain: A: PDB Molecule:sn4m; PDBTitle: solution structure of the de novo-designed lambda cro fold2 protein

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0