Job Description P33195 Confidence 99.94% Date Thu Jan 5 11:51:15 GMT 2012 Rank 18 Aligned Residues 400 % Identity 12% Template c3e9kA_ PDB info PDB header:hydrolase Chain: A: PDB Molecule:kynureninase; PDBTitle: crystal structure of homo sapiens kynureninase-3-hydroxyhippuric acid2 inhibitor complex Resolution 1.70 Å

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		23	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.				.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																							.	.	.
Query SS confidence																							.	.	.
Query Sequence		A	A	Q	Q	Q	E	M	L	N	A	V	G	A	Q	S	L	N	A	L	T	G	.	.	.	Q	I	V	P	K	D	I	Q	L	A	T	P	P	Q	V	G	A	P	A	T	E	Y	A	A	L	A	E	L	K	A	I	A	S	R	N	K	R	F	T	S	Y	I	G	M	G	Y	T	A	V	Q	L	P	P	V	I	L
Query Conservation																							.	.	.
Alig confidence																							.	.	.		.																												.	.	.	.
Template Conservation																											.																												.	.	.	.
Template Sequence		A	D	T	V	Q	R	I	A	A	E	L	K	C	H	P	T	D	E	R	V	A	L	H	L	D	.	E	E	D	K	L	R	H	F	R	E	F	Y	I	P	K	I	Q	D	L	P	P	V	D	L	S	L	V	.	.	.	.	N	K	D	E	N	A	I	Y	F	L	G	N	S	L	G	L	Q	P	K	M	V	K	T
Template Known Secondary structure													T	S		T	T	S									.		T		T	T	G	G	G	G			B			B	G	G	G	S	T	T			G	G	G	S	.	.	.	.		T	T		B					B	T	T	T	S			B		T	T
Template Predicted Secondary structure																											.																												.	.	.	.
Template SS confidence
		10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.		.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.					.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.
		100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.					120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.
Predicted Secondary structure																						.	.	.	.
Query SS confidence																						.	.	.	.
Query Sequence		R	N	M	L	E	N	P	G	W	Y	T	A	Y	T	P	Y	Q	P	E	V	.	.	.	.	S	Q	G	R	L	E	A	L	L	N	F	Q	Q	V	T	L	D	L	T	G	L	D	M	A	S	A	S	L	L	D	E	A	T	A	A	A	E	A	M	A	M	A	K	R	V	S	K	L	K	N	A	N	R	F	F	V
Query Conservation																						.	.	.	.
Alig confidence		.				.	.	.														.	.	.	.																																												.
Template Conservation		.				.	.	.																																																													.
Template Sequence		.	Y	L	E	.	.	.	E	E	L	D	K	W	A	K	I	A	A	Y	G	H	E	V	G	K	R	P	W	I	T	G	D	E	S	I	V	G	L	M	K	D	I	V	G	A	N	E	K	E	I	A	L	M	N	A	L	T	V	N	L	H	L	L	M	L	S	F	.	F	K	P	T	P	K	R	Y	K	I	L	L
Template Known Secondary structure		.				.	.	.										G	G	G	G	G	T	S	S	S	S		G	G	G	T	T					G	G	G					T			G	G	G					S														.					S	S	S
Template Predicted Secondary structure		.				.	.	.																																																													.
Template SS confidence
			86	.	.				.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.		.	150	.	.	.	.	.	.	.	.	.	160
		176	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.																	.	.	200	.	.	.	.	.	.	.	.			.	210	.	.	.	.	.	.	.	.	.		220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.
Predicted Secondary structure																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.												.	.												.
Query SS confidence																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.												.	.												.
Query Sequence		A	S	D	V	H	P	Q	T	L	D	V	V	R	T	R	A	E	T	F	G	F	E	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	V	I	V	D	D	A	Q	K	V	L	D	.	.	H	Q	D	V	F	G	V	L	L	Q	Q	.	V	G	T	T	G	E	I	H	D	Y	T	A	L	I	S	E	L
Query Conservation																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.												.	.												.
Alig confidence																								.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.												.	.												.
Template Conservation
Template Sequence		E	A	K	A	F	P	S	D	H	Y	A	I	E	S	Q	L	Q	L	H	G	L	N	I	E	E	S	M	R	M	I	K	P	R	E	G	E	E	T	L	R	I	E	D	I	L	E	V	I	E	K	E	G	D	S	I	A	V	I	L	F	S	G	V	H	F	Y	T	G	Q	H	F	N	I	P	A	I	T	K	A	G
Template Known Secondary structure			T	T																T	T														T	T		S	S														G	G	G								S	B		T	T	T		B	B
Template Predicted Secondary structure
Template SS confidence
		161	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
		237	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.		.	.	.	.	.	310	.	.	.	.	.
Predicted Secondary structure																																																																						.
Query SS confidence																																																																						.
Query Sequence		K	S	R	K	I	V	V	S	V	A	A	D	I	M	A	L	V	L	L	T	A	P	G	K	Q	G	A	D	I	V	F	G	S	A	Q	R	F	G	V	P	M	G	Y	G	G	P	H	A	A	F	F	A	A	K	D	E	Y	K	R	S	M	P	G	R	I	I	G	V	.	S	K	D	A	A	G	N	T	A	L	R
Query Conservation																																																																						.
Alig confidence																																							.	.	.																													.
Template Conservation																																							.	.	.
Template Sequence		Q	A	K	G	C	Y	V	G	F	D	L	A	H	A	V	G	N	V	E	L	Y	L	H	D	W	G	V	D	F	A	C	W	C	S	Y	K	Y	.	.	.	L	N	A	G	A	G	G	I	A	G	A	F	I	H	E	K	H	A	H	T	I	K	P	A	L	V	G	W	F	G	H	E	L	S	T	R	F	K	M	D
Template Known Secondary structure				T	T								T	T	T	T	T	T	S								T								S	S	S	T	.	.	.	T				T	T									G	G	G	T	T	T	S			S	S			G	G	G	B						T	T
Template Predicted Secondary structure																																							.	.	.
Template SS confidence
		241	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.				.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.
		316	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.			.	380	.	.	.	.					.	.	.	.	.
Predicted Secondary structure																																																																	.	.							.	.	.	.
Query SS confidence																																																																	.	.							.	.	.	.
Query Sequence		M	A	M	Q	T	R	E	Q	H	I	R	R	E	K	A	N	S	N	I	C	T	S	Q	V	L	L	A	N	I	A	S	L	Y	A	V	Y	H	G	P	V	G	L	K	R	I	A	N	R	I	H	R	L	T	D	I	L	A	A	G	L	Q	Q	K	.	.	G	L	K	L	R	H	.	.	.	.	A	H	Y	F	D
Query Conservation																																																																	.	.							.	.	.	.
Alig confidence																													.	.	.	.	.																																.	.							.	.	.	.
Template Conservation																													.	.	.	.	.
Template Sequence		N	K	L	Q	L	I	P	G	V	C	G	F	R	I	S	N	P	P	I	L	L	V	C	S	L	H	A	.	.	.	.	.	S	L	E	I	F	K	Q	A	T	M	K	A	L	R	K	K	S	V	L	L	T	G	Y	L	E	Y	L	I	K	H	N	Y	G	V	V	N	I	I	T	P	S	H	V	E	E	R	G	C
Template Known Secondary structure		S				B		S	S	G	G	G	G			S													.	.	.	.	.																																							S		S	S	G	G	G	B		S
Template Predicted Secondary structure																													.	.	.	.	.
Template SS confidence
		318	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.						.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.
		390	.	.	.	.	.	.		.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.		.	.	.	430	.	.	.	.	.	.	.	.	.	440
Predicted Secondary structure									.																															.
Query SS confidence									.																															.
Query Sequence		T	L	C	V	E	V	A	.	D	K	A	G	V	L	T	R	A	E	A	A	E	I	N	L	R	S	D	I	L	N	A	V	G	I	T	L	D	E	.	T	T	T	R	E	N	V	M	Q	L	F	N	V	L
Query Conservation									.																															.
Alig confidence									.																															.
Template Conservation
Template Sequence		Q	L	T	I	T	F	S	V	P	N	K	D	V	F	Q	E	L	E	K	R	G	V	V	C	D	K	R	N	P	N	G	I	R	V	A	P	V	P	L	Y	N	S	F	H	D	V	Y	K	F	T	N	L	L
Template Known Secondary structure										T	T									T	T	T							T	T	T					B			T	T	T
Template Predicted Secondary structure
Template SS confidence
		402	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.