Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	E	F	I	T	V	A	R	P	Y	A	K	A	A	F	D	F	A	V	E	H	Q	S	V	E	R	W	Q	D	M	L	A	F	A	A	E	V	T	K	N	E	Q	M	A	E	L	L	S	G	A	L	A	P	E	T	L	A	E	S
Secondary structure
SS confidence
Disorder		?	?	?	?																			?	?																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	I	A	V	C	G	E	Q	L	D	E	N	G	Q	N	L	I	R	V	M	A	E	N	G	R	L	N	A	L	P	D	V	L	E	Q	F	I	H	L	R	A	V	S	E	A	T	A	E	V	D	V	I	S	A	A	A	L	S	E	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.
Sequence		Q	L	A	K	I	S	A	A	M	E	K	R	L	S	R	K	V	K	L	N	C	K	I	D	K	S	V	M	A	G	V	I	I	R	A	G	D	M	V	I	D	G	S	V	R	G	R	L	E	R	L	A	D	V	L	Q	S
Secondary structure
SS confidence
Disorder																																																								?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2wss chain S Region: 6 - 176 Aligned: 151 Modelled: 149 Confidence: 100.0% Identity: 26% PDB header:hydrolase Chain: S: PDB Molecule:atp synthase subunit o, mitochondrial; PDBTitle: the structure of the membrane extrinsic region of bovine2 atp synthase Phyre2 PDB 1abv chain A Region: 2 - 106 Aligned: 105 Modelled: 105 Confidence: 99.9% Identity: 100% Fold: ATPD N-terminal domain-like Superfamily: N-terminal domain of the delta subunit of the F1F0-ATP synthase Family: N-terminal domain of the delta subunit of the F1F0-ATP synthase Phyre2 PDB 2a7u chain B Region: 2 - 106 Aligned: 105 Modelled: 105 Confidence: 99.9% Identity: 100% PDB header:hydrolase Chain: B: PDB Molecule:atp synthase delta chain; PDBTitle: nmr solution structure of the e.coli f-atpase delta subunit n-terminal2 domain in complex with alpha subunit n-terminal 22 residues Phyre2 PDB 2jmx chain A Region: 6 - 111 Aligned: 106 Modelled: 106 Confidence: 99.8% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:atp synthase o subunit, mitochondrial; PDBTitle: oscp-nt (1-120) in complex with n-terminal (1-25) alpha2 subunit from f1-atpase Phyre2 PDB 2dm9 chain B Region: 90 - 175 Aligned: 82 Modelled: 86 Confidence: 93.8% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:v-type atp synthase subunit e; PDBTitle: crystal structure of ph1978 from pyrococcus horikoshii ot3 Phyre2 PDB 2dm9 chain A domain 1 Region: 90 - 175 Aligned: 82 Modelled: 86 Confidence: 93.7% Identity: 21% Fold: FwdE/GAPDH domain-like Superfamily: V-type ATPase subunit E-like Family: V-type ATPase subunit E Phyre2 PDB 3lg8 chain B Region: 122 - 175 Aligned: 54 Modelled: 54 Confidence: 85.1% Identity: 22% PDB header:hydrolase Chain: B: PDB Molecule:a-type atp synthase subunit e; PDBTitle: crystal structure of the c-terminal part of subunit e (e101-206) from2 methanocaldococcus jannaschii of a1ao atp synthase Phyre2 PDB 3k5b chain E Region: 144 - 175 Aligned: 32 Modelled: 31 Confidence: 78.6% Identity: 25% PDB header:hydrolase Chain: E: PDB Molecule:v-type atp synthase subunit e; PDBTitle: crystal structure of the peripheral stalk of thermus thermophilus h+-2 atpase/synthase Phyre2 PDB 3ipz chain A Region: 69 - 171 Aligned: 91 Modelled: 103 Confidence: 46.1% Identity: 10% PDB header:electron transport, oxidoreductase Chain: A: PDB Molecule:monothiol glutaredoxin-s14, chloroplastic; PDBTitle: crystal structure of arabidopsis monothiol glutaredoxin atgrxcp Phyre2 PDB 2aya chain A Region: 105 - 144 Aligned: 40 Modelled: 40 Confidence: 29.6% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:dna polymerase iii subunit tau; PDBTitle: solution structure of the c-terminal 14 kda domain of the2 tau subunit from escherichia coli dna polymerase iii Phyre2 PDB 2jac chain A Region: 69 - 150 Aligned: 82 Modelled: 82 Confidence: 24.0% Identity: 10% PDB header:electron transport Chain: A: PDB Molecule:glutaredoxin-1; PDBTitle: glutaredoxin grx1p c30s mutant from yeast Phyre2 PDB 3gx8 chain A Region: 123 - 171 Aligned: 44 Modelled: 49 Confidence: 22.5% Identity: 14% PDB header:electron transport Chain: A: PDB Molecule:monothiol glutaredoxin-5, mitochondrial; PDBTitle: structural and biochemical characterization of yeast2 monothiol glutaredoxin grx5 Phyre2 PDB 1sqw chain A domain 2 Region: 116 - 137 Aligned: 22 Modelled: 22 Confidence: 20.9% Identity: 14% Fold: Cystatin-like Superfamily: Pre-PUA domain Family: Nip7p homolog, N-terminal domain Phyre2 PDB 3c1s chain A Region: 69 - 150 Aligned: 82 Modelled: 82 Confidence: 19.9% Identity: 10% PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin-1; PDBTitle: crystal structure of grx1 in glutathionylated form Phyre2 PDB 2uub chain C domain 1 Region: 105 - 140 Aligned: 36 Modelled: 36 Confidence: 19.5% Identity: 19% Fold: Alpha-lytic protease prodomain-like Superfamily: Prokaryotic type KH domain (KH-domain type II) Family: Prokaryotic type KH domain (KH-domain type II) Phyre2 PDB 3d5j chain B Region: 123 - 171 Aligned: 44 Modelled: 49 Confidence: 15.8% Identity: 20% PDB header:oxidoreductase Chain: B: PDB Molecule:glutaredoxin-2, mitochondrial; PDBTitle: structure of yeast grx2-c30s mutant with glutathionyl mixed2 disulfide Phyre2 PDB 2hc5 chain A domain 1 Region: 115 - 155 Aligned: 40 Modelled: 41 Confidence: 12.9% Identity: 20% Fold: FlaG-like Superfamily: FlaG-like Family: FlaG-like Phyre2 PDB 2klx chain A Region: 123 - 176 Aligned: 49 Modelled: 54 Confidence: 12.2% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin; PDBTitle: solution structure of glutaredoxin from bartonella henselae str.2 houston Phyre2 PDB 1okr chain A Region: 44 - 132 Aligned: 89 Modelled: 89 Confidence: 10.5% Identity: 11% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Penicillinase repressor Phyre2 PDB 3h8q chain B Region: 123 - 171 Aligned: 44 Modelled: 49 Confidence: 9.9% Identity: 20% PDB header:oxidoreductase Chain: B: PDB Molecule:thioredoxin reductase 3; PDBTitle: crystal structure of glutaredoxin domain of human thioredoxin2 reductase 3 Phyre2 1 c2wssS_ 2 d1abva_ 3 c2a7uB_ 4 c2jmxA_ 5 c2dm9B_ 6 d2dm9a1 7 c3lg8B_ 8 c3k5bE_ 9 c3ipzA_ 10 c2ayaA_ 11 c2jacA_ 12 c3gx8A_ 13 d1sqwa2 14 c3c1sA_ 15 d2uubc1 16 c3d5jB_ 17 d2hc5a1 18 c2klxA_ 19 d1okra_ 20 c3h8qB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2wssS_ 100.0 26 PDB header:hydrolase Chain: S: PDB Molecule:atp synthase subunit o, mitochondrial; PDBTitle: the structure of the membrane extrinsic region of bovine2 atp synthase 2 d1abva_ 99.9 100 Fold:ATPD N-terminal domain-like Superfamily:N-terminal domain of the delta subunit of the F1F0-ATP synthase Family:N-terminal domain of the delta subunit of the F1F0-ATP synthase 3 c2a7uB_ 99.9 100 PDB header:hydrolase Chain: B: PDB Molecule:atp synthase delta chain; PDBTitle: nmr solution structure of the e.coli f-atpase delta subunit n-terminal2 domain in complex with alpha subunit n-terminal 22 residues 4 c2jmxA_ 99.8 23 PDB header:hydrolase Chain: A: PDB Molecule:atp synthase o subunit, mitochondrial; PDBTitle: oscp-nt (1-120) in complex with n-terminal (1-25) alpha2 subunit from f1-atpase 5 c2dm9B_ 93.8 22 PDB header:hydrolase Chain: B: PDB Molecule:v-type atp synthase subunit e; PDBTitle: crystal structure of ph1978 from pyrococcus horikoshii ot3 6 d2dm9a1 93.7 21 Fold:FwdE/GAPDH domain-like Superfamily:V-type ATPase subunit E-like Family:V-type ATPase subunit E 7 c3lg8B_ 85.1 22 PDB header:hydrolase Chain: B: PDB Molecule:a-type atp synthase subunit e; PDBTitle: crystal structure of the c-terminal part of subunit e (e101-206) from2 methanocaldococcus jannaschii of a1ao atp synthase 8 c3k5bE_ 78.6 25 PDB header:hydrolase Chain: E: PDB Molecule:v-type atp synthase subunit e; PDBTitle: crystal structure of the peripheral stalk of thermus thermophilus h+-2 atpase/synthase 9 c3ipzA_ 46.1 10 PDB header:electron transport, oxidoreductase Chain: A: PDB Molecule:monothiol glutaredoxin-s14, chloroplastic; PDBTitle: crystal structure of arabidopsis monothiol glutaredoxin atgrxcp 10 c2ayaA_ 29.6 15 PDB header:transferase Chain: A: PDB Molecule:dna polymerase iii subunit tau; PDBTitle: solution structure of the c-terminal 14 kda domain of the2 tau subunit from escherichia coli dna polymerase iii 11 c2jacA_ 24.0 10 PDB header:electron transport Chain: A: PDB Molecule:glutaredoxin-1; PDBTitle: glutaredoxin grx1p c30s mutant from yeast 12 c3gx8A_ 22.5 14 PDB header:electron transport Chain: A: PDB Molecule:monothiol glutaredoxin-5, mitochondrial; PDBTitle: structural and biochemical characterization of yeast2 monothiol glutaredoxin grx5 13 d1sqwa2 20.9 14 Fold:Cystatin-like Superfamily:Pre-PUA domain Family:Nip7p homolog, N-terminal domain 14 c3c1sA_ 19.9 10 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin-1; PDBTitle: crystal structure of grx1 in glutathionylated form 15 d2uubc1 19.5 19 Fold:Alpha-lytic protease prodomain-like Superfamily:Prokaryotic type KH domain (KH-domain type II) Family:Prokaryotic type KH domain (KH-domain type II) 16 c3d5jB_ 15.8 20 PDB header:oxidoreductase Chain: B: PDB Molecule:glutaredoxin-2, mitochondrial; PDBTitle: structure of yeast grx2-c30s mutant with glutathionyl mixed2 disulfide 17 d2hc5a1 12.9 20 Fold:FlaG-like Superfamily:FlaG-like Family:FlaG-like 18 c2klxA_ 12.2 14 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin; PDBTitle: solution structure of glutaredoxin from bartonella henselae str.2 houston 19 d1okra_ 10.5 11 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Penicillinase repressor 20 c3h8qB_ 9.9 20 PDB header:oxidoreductase Chain: B: PDB Molecule:thioredoxin reductase 3; PDBTitle: crystal structure of glutaredoxin domain of human thioredoxin2 reductase 3 21 d1ktea_ not modelled 9.5 16 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 22 c2rrnA_ not modelled 9.3 12 PDB header:protein transport Chain: A: PDB Molecule:probable secdf protein-export membrane protein; PDBTitle: solution structure of secdf periplasmic domain p4 23 c2hzfA_ not modelled 9.0 14 PDB header:electron transport, oxidoreductase Chain: A: PDB Molecule:glutaredoxin-1; PDBTitle: crystal structures of a poxviral glutaredoxin in the oxidized and2 reduced states show redox-correlated structural changes 24 d1ts9a_ not modelled 8.8 14 Fold:Rof/RNase P subunit-like Superfamily:Rof/RNase P subunit-like Family:RNase P subunit p29-like 25 d1w5fa2 not modelled 7.9 10 Fold:Bacillus chorismate mutase-like Superfamily:Tubulin C-terminal domain-like Family:Tubulin, C-terminal domain 26 c1sqwA_ not modelled 7.7 14 PDB header:unknown function Chain: A: PDB Molecule:saccharomyces cerevisiae nip7p homolog; PDBTitle: crystal structure of kd93, a novel protein expressed in the2 human pro 27 c2q2gA_ not modelled 7.1 25 PDB header:chaperone Chain: A: PDB Molecule:heat shock 40 kda protein, putative (fragment); PDBTitle: crystal structure of dimerization domain of hsp40 from2 cryptosporidium parvum, cgd2_1800 28 c2ht9A_ not modelled 6.7 10 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin-2; PDBTitle: the structure of dimeric human glutaredoxin 2 29 c3ic4A_ not modelled 6.6 12 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin (grx-1); PDBTitle: the crystal structure of the glutaredoxin(grx-1) from archaeoglobus2 fulgidus 30 c2nn6E_ not modelled 6.5 20 PDB header:hydrolase/transferase Chain: E: PDB Molecule:exosome complex exonuclease rrp42; PDBTitle: structure of the human rna exosome composed of rrp41, rrp45,2 rrp46, rrp43, mtr3, rrp42, csl4, rrp4, and rrp40 31 c2kwaA_ not modelled 6.5 26 PDB header:transferase inhibitor Chain: A: PDB Molecule:kinase a inhibitor; PDBTitle: 1h, 13c and 15n backbone and side chain resonance assignments of the2 n-terminal domain of the histidine kinase inhibitor kipi from3 bacillus subtilis 32 c2d4gA_ not modelled 6.3 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein bsu11850; PDBTitle: structure of yjcg protein, a putative 2'-5' rna ligase from2 bacillus subtilis 33 c3fzaA_ not modelled 6.1 18 PDB header:oxidoreductase Chain: A: PDB Molecule:glutaredoxin; PDBTitle: crystal structure of poplar glutaredoxin s12 in complex with2 glutathione and beta-mercaptoethanol 34 c3qmxA_ not modelled 6.1 18 PDB header:electron transport Chain: A: PDB Molecule:glutaredoxin a; PDBTitle: x-ray crystal structure of synechocystis sp. pcc 6803 glutaredoxin a 35 d1jhba_ not modelled 6.0 14 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:Thioltransferase 36 c2e7pC_ not modelled 5.7 17 PDB header:electron transport Chain: C: PDB Molecule:glutaredoxin; PDBTitle: crystal structure of the holo form of glutaredoxin c1 from populus2 tremula x tremuloides 37 c2zdiA_ not modelled 5.7 13 PDB header:chaperone Chain: A: PDB Molecule:prefoldin subunit beta; PDBTitle: crystal structure of prefoldin from pyrococcus horikoshii2 ot3 38 d1h72c1 not modelled 5.7 12 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:GHMP Kinase, N-terminal domain 39 d1iqca2 not modelled 5.5 13 Fold:Cytochrome c Superfamily:Cytochrome c Family:Di-heme cytochrome c peroxidase 40 c3pp5A_ not modelled 5.3 31 PDB header:structural protein Chain: A: PDB Molecule:brk1; PDBTitle: high-resolution structure of the trimeric scar/wave complex precursor2 brk1 41 d1l8na1 not modelled 5.3 11 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:alpha-D-glucuronidase/Hyaluronidase catalytic domain 42 d2ff4a1 not modelled 5.3 0 Fold:DNA/RNA-binding 3-helical bundle Superfamily:C-terminal effector domain of the bipartite response regulators Family:PhoB-like 43 c2ve7C_ not modelled 5.2 13 PDB header:cell cycle Chain: C: PDB Molecule:kinetochore protein nuf2, kinetochore protein spc24; PDBTitle: crystal structure of a bonsai version of the human ndc802 complex 44 c2vhdB_ not modelled 5.1 13 PDB header:oxidoreductase Chain: B: PDB Molecule:cytochrome c551 peroxidase; PDBTitle: crystal structure of the di-haem cytochrome c peroxidase2 from pseudomonas aeruginosa - mixed valence form

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0