Return to main results Retrieve Phyre Job Id

Job DescriptionP0AFY6
Confidence99.89%DateThu Jan 5 11:27:34 GMT 2012
Rank5Aligned Residues326
% Identity8%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   68.70.........80.........90.........100.........110.........120.........130 ...
Predicted Secondary structure 








..............
Query SS confidence 






























































. . . . . . . . . . . . . .


Query Sequence  VGLFALFWFIYSPHRWQYWSILGTALIIFVTWFLVEVGVAVNAWYAPFYDLIQTALSSPHKVT. . . . . . . . . . . . . . IEQ
Query Conservation     
  

       
  
  

 



      
 
 
  
 
   





          ..............   
Alig confidence 








....








..






































..............


Template Conservation   

 

 
 ....        
.. 
  
  
                
                               
Template Sequence  VSVLTMFRY. . . . AGWLDRLYM. . LVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEE
Template Known Secondary structure 
TTT
....

..
SS
S
Template Predicted Secondary structure 

....

..










Template SS confidence 















































































   33......40. ........50 .........60.........70.........80.........90.........100......
 
   134.....140.........150.........160.........170....... ..180.........190.........200......
Predicted Secondary structure  .......





Query SS confidence 











































. . . . . . .




























Query Sequence  FYREVGVFLGIALIAVVISVLNNFFVSHYVFRWRTAMNEYYMAN. . . . . . . WQQLRHIEGAAQRVQEDTMRFASTLENMG
Query Conservation 
   
  
  

   
   
    
   
  


  

      .......
   
  






 


  
      
 
Alig confidence 











































.......




























Template Conservation            
                    
    

  
  
 
            
 
   
  

  
        
Template Sequence  MTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKI
Template Known Secondary structure  TTSS
S
Template Predicted Secondary structure 






Template SS confidence 















































































   107..110.........120.........130.........140.........150.........160.........170.........180......
 
   207..210.........220.........230.........240.........250.........260.........270.........280......
Predicted Secondary structure 




Query SS confidence 















































































Query Sequence  VSFINAIMTLIAFLPVLVTLSAHVPELPIIGHIPYGLVIAAIVWSLMGTGLLAVVGIKLPGLEFKNQRVEAAYRKELVYG
Query Conservation 
 

 





 

 


 

  


      


 

  




 
 
 
   


 
  
    
  




  

  
Alig confidence 






























.....











































Template Conservation            
            
 
  
  .....  
                               
 
 

  

Template Sequence  GMFFQAMATFFGGFIIGFTRGWKLTLVILAI. . . . . SPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVI
Template Known Secondary structure  TTTTS.....TTT




Template Predicted Secondary structure  .....
Template SS confidence 















































































   187..190.........200.........210....... ..220.........230.........240.........250.........260.
 
   287..290.........300.........310.........320.........330.........340.........350.........360......
Predicted Secondary structure 




Query SS confidence 















































































Query Sequence  EDDATRATPPTVRELFSAVRKNYFRLYFHYMYFNIARILYLQVDNVFGLFLLFPSIVAGTITLGLMTQITNVFGQVRGAF
Query Conservation 




  
   
   
  
  
  

      
         
  


  
 

   

 



 
 
   

 

   
Alig confidence 















































































Template Conservation      
                                         
           
 

             
    
Template Sequence  AFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSV
Template Known Secondary structure  TT



STTTSSS
SS
Template Predicted Secondary structure 









Template SS confidence 















































































   262.......270.........280.........290.........300.........310.........320.........330.........340.
 
   367..370.........380.........390.........400....
Predicted Secondary structure 







Query SS confidence 





































Query Sequence  QYLINSWTTLVELMSIYKRLRSFEHELDGDKIQEVTHT
Query Conservation    

  
  


  
   

  
   
      
 

 
Alig confidence 





































Template Conservation    
            
  

   
              
Template Sequence  GQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGH
Template Known Secondary structure  TTS




SS

S


Template Predicted Secondary structure 











Template SS confidence 





































   342.......350.........360.........370.........
 
Download:Text version FASTA pairwise alignment 3D Model in PDB format

View in Jmol

Send structure to FirstGlance for more viewing options


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
Disclaimer
Terms and Conditions