|   |
15 | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | |
|
|
|
|
|
. | . | . | . | . | 40 | . | . | . | . | . | . | . | . | |
|
|
|
. | 50 | . | . | . | . | . | . | . | . | . | 60 | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  | . | . | . | . | . | . |
|
|  |  |  |  |  |  |  |
|  |  |  |
| . | . | . | . |
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
T | T | L | G | R | E | L | G | K | G | G | E | G | A | V | Y | D | I | E | E | . |
. |
. |
. |
. |
. |
F | V | D | S | V | A | K | I | Y | H | T | P | P | P | . |
. |
. |
. |
A | L | K | Q | D | K | L | A | F | M | A | A | T | A | D | A | Q | L | L | N | Y | V | A | W | P | Q | A | T | L | H | G | G | R | G | G | K |
Query Conservation |   |
  |   |
|   |   |   |
|
|   |
|
|   |
|   |
|
|   |
|   |   | . | . | . | . | . | . |   |   |   |
|
|   |
|   |   |   |   |   |   |   | . | . | . | . |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . |
|
|
|
|
Template Conservation |   |
  |   |
|   |
|   |
|
|   |
|   |
|
|   |
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |
|
|   |   |
|   |
|
|
|
|
|   |
|   |
|   | . | . | . | . | . | . | . | . |   |   |   |   |
Template Sequence |   |
I | E | L | G | R | C | I | G | E | G | Q | F | G | D | V | H | Q | G | I | Y | M | S | P | E | N | P | A | M | A | V | A | I | K | T | C | K | N | C | T | S | D | S | V | R | E | K | F | L | Q | E | A | L | T | M | R | Q | F | D | H | P | H | I | V | K | L | I | G | V | . |
. |
. |
. |
. |
. |
. |
. |
I | T | E | N |
Template Known Secondary structure |   |
 |  |  |  |  |  |  |  |
|
| S | S |
|
|  |  |  |  |  |  |
|
| S | S | S |
|
|
|  |  |  |  |  |  |
| T | T | T | T | S |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T |
|
|
| T | T | B |
|
|  |  |  |  | . | . | . | . | . | . | . | . |  |
| S | S |
Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  | . | . | . | . | . | . | . | . |  |  |
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
422 | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
490 | . | . | . |
  |
  |   |
85 | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
V | I | G | F | M | M | P | K | V | S | G | K | E | P | I | H | M | I | Y | S | P | A | H | R | R | Q | S | Y | P | H | C | A | W | D | F | L | L | Y | V | A | R | N | I | A | S | S | F | A | T | V | H | E | H | G | H | V | V | G | D | V | N | Q | N | S | F | M | V | G | R | D | S | K | V | V | L | I | D | S | D | S |
Query Conservation |   |
  |   |   |
|
|
|
|   |   |   |
|   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|
|   |   |
|
|   |   |
|
|   |   |
|
|
|
|
|
|
|
|
|   |
|
|
|
|   |   |   |
|   |
|
|
|   |
|
|
|   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |
|
|
|
|   |   |   |   |
|
|
|   |   |   |
|   |   |   |   |   | . | . | . | . | . | . |   |
|   |   |   |   |   |   |   |   |   |   |
|
|
|   |
|
|   |
|
|
|   |   |   |
|
|
|   |
|
|
|   |   |
|
|
|
|   |   |   |   |   |   |
|
|   |
|
|
|
|
Template Sequence |   |
P | V | W | I | I | M | E | L | C | T | L | G | E | L | R | S | F | L | Q | V | R | K | F | . |
. |
. |
. |
. |
. |
S | L | D | L | A | S | L | I | L | Y | A | Y | Q | L | S | T | A | L | A | Y | L | E | S | K | R | F | V | H | R | D | I | A | A | R | N | V | L | V | S | A | T | D | C | V | K | L | G | D | F | G | L |
Template Known Secondary structure |   |
S |
|  |  |  |  |  |
|
| T | T |
| B |  |  |  |  |  |  |  | T | T | T | . | . | . | . | . | . | T |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | T |
|
|
| S |
|
| S | G | G | G |  |  |  |  |  | T | T |  |  |  |  |
|
|
|
|
|
Template Predicted Secondary structure |   |
|  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
| . | . | . | . | . | . |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
494 | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . | 510 | . | . | . | . | . | . | |
|
|
|
|
|
. | . | . | 520 | . | . | . | . | . | . | . | . | . | 530 | . | . | . | . | . | . | . | . | . | 540 | . | . | . | . | . | . | . | . | . | 550 | . | . | . | . | . | . | . | . | . | 560 | . | . | . | . | . | . | . |
  |
  |   |
165 | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
F | Q | I | N | A | N | G | T | L | H | L | C | E | V | G | V | S | H | F | T | P | P | E | L | Q | T | L | P | S | F | V | G | F | E | R | T | E | N | H | D | N | F | G | L | A | L | L | I | F | H | V | L | F | G | G | R | H | P | Y | S | G | V | P | L | I | S | D | A | G | N | A | L | E | T | D | I | T | H | F | R |
Query Conservation |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|   |   |   |
|
|
|   |   |
|
|
|   |   |   |
|   |   |   |   |   |   |
|
|
|
|
|
|
|
|   |
|
|
|   |
|   |   |
|   |   |
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
Template Conservation |   |
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |
|   |   |   |
|
|
|   |
|   |   |   |   |   |   |   |   |
|
|
|
|
|
|
|
|   |
|   |
|
|
|
|   |
|   |   |
|
|   |   |   |   |   |   |   |
|   |   |   |
|   |   |
|   |
|   | . | . | . |
Template Sequence |   |
S | R | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
L | P | I | K | W | M | A | P | E | S | I | N | F | R | R | F | T | S | A | S | D | V | W | M | F | G | V | C | M | W | E | I | L | M | H | G | V | K | P | F | Q | G | V | K | N | N | D | V | I | G | R | I | E | N | G | E | R | L | . |
. |
. |
Template Known Secondary structure |   |
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
| G | G | G |
|
|  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | S |
|
| T | T | T | T |
|
|  |  |  |  |  |  |  |  |  | T | T |
|
|
| . | . | . |
Template Predicted Secondary structure |   |
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|  |  |  |
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
| . | . | . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
568 | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
570 | . | . | . | . | . | . | . | . | . | 580 | . | . | . | . | . | . | . | . | . | 590 | . | . | . | . | . | . | . | . | . | 600 | . | . | . | . | . | . | . | . | . | 610 | . | . | . | . | . | . | . | . | . | 620 | . | . | . | . | . | . | . | |
|
|
  |
  |   |
245 | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
Y | A | Y | A | S | D | N | Q | R | R | G | L | K | P | P | P | R | S | I | P | L | S | M | L | P | S | D | V | E | A | M | F | Q | Q | A | F | T | E | S | G | V | A | T | G | R | P | T | A | K | A | W | V | A | A | L | D | S | L | R |
Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|   |   |   |
|   |   |   |   |   |
|   |   |
|
|
|   |   |   |   |   |   |   |
|   |   |   |   |
Alig confidence |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |
|   |   |   |
|   |   |
|   |   |
|
|   |   |
|
|   |   |
| . | . |
|   |   |
|
|
|   |   |   |
|   |   |   |
|   |   |
|   |
Template Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
P | M | P | P | N | C | P | P | T | L | Y | S | L | M | T | K | C | W | A | Y | D | . |
. |
P | S | R | R | P | R | F | T | E | L | K | A | Q | L | S | T | I | L |
Template Known Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
| T | T |
|
|  |  |  |  |  |  |  |  |  | T | T |
| S | S | . | . | G | G | G | S |
|
|  |  |  |  |  |  |  |  |  |  |  |  |
Template Predicted Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|
| . | . |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
642 | . | . | . | . | . | . | . | 650 | . | . | . | . | . | . | . | . | . | 660 | . | . | |
|
. | . | . | . | . | . | . | 670 | . | . | . | . | . | . | . | . | . | 680 |
  |