Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	L	R	D	S	L	A	E	N	K	S	I	R	L	Q	A	E	A	E	T	W	Q	E	A	V	K	I	G	V	D	L	L	V	A	A	D	V	V	E	P	R	Y	Y	Q	A	I	L	D	G	V	E	Q	F	G	P	Y	F	V	I
Secondary structure
SS confidence
Disorder		?	?	?			?	?																															?	?																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	P	G	L	A	M	P	H	G	R	P	E	E	G	V	K	K	T	G	F	S	L	V	T	L	K	K	P	L	E	F	N	H	D	D	N	D	P	V	D	I	L	I	T	M	A	A	V	D	A	N	T	H	Q	E	V	G	I	M	Q
Secondary structure
SS confidence
Disorder																																?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.
Sequence		I	V	N	L	F	E	D	E	E	N	F	D	R	L	R	A	C	R	T	E	Q	E	V	L	D	L	I	D	R	T	N	A	A	A
Secondary structure
SS confidence
Disorder																															?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3bjv chain A Region: 1 - 153 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 43% PDB header:transferase Chain: A: PDB Molecule:rmpa; PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans Phyre2 PDB 2oqt chain D Region: 2 - 153 Aligned: 150 Modelled: 150 Confidence: 100.0% Identity: 42% PDB header:transferase Chain: D: PDB Molecule:hypothetical protein spy0176; PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas Phyre2 PDB 3oxp chain B Region: 3 - 150 Aligned: 147 Modelled: 147 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution Phyre2 PDB 3oxp chain A Region: 3 - 150 Aligned: 147 Modelled: 147 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution Phyre2 PDB 2oq3 chain A Region: 1 - 149 Aligned: 146 Modelled: 149 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:mannitol-specific cryptic phosphotransferase PDBTitle: solution structure of the mannitol- specific cryptic2 phosphotransferase enzyme iia cmtb from escherichia coli Phyre2 PDB 3urr chain B Region: 1 - 151 Aligned: 147 Modelled: 151 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn; PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn) Phyre2 PDB 1a6j chain A Region: 1 - 151 Aligned: 148 Modelled: 151 Confidence: 100.0% Identity: 24% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 1a3a chain A Region: 8 - 148 Aligned: 137 Modelled: 141 Confidence: 100.0% Identity: 31% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 2a0j chain A Region: 2 - 147 Aligned: 143 Modelled: 146 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein; PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis Phyre2 PDB 1xiz chain A Region: 3 - 151 Aligned: 147 Modelled: 149 Confidence: 100.0% Identity: 18% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: IIA domain of mannitol-specific and ntr phosphotransferase EII Phyre2 PDB 1hyn chain P Region: 4 - 150 Aligned: 143 Modelled: 147 Confidence: 97.6% Identity: 13% Fold: Phoshotransferase/anion transport protein Superfamily: Phoshotransferase/anion transport protein Family: Anion transport protein, cytoplasmic domain Phyre2 PDB 1hyn chain Q Region: 4 - 150 Aligned: 146 Modelled: 147 Confidence: 97.5% Identity: 15% PDB header:membrane protein Chain: Q: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the cytoplasmic domain of human2 erythrocyte band-3 protein Phyre2 PDB 1k4n chain A Region: 80 - 110 Aligned: 28 Modelled: 31 Confidence: 11.4% Identity: 14% Fold: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Superfamily: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Family: Hypothetical protein YecM (EC4020) Phyre2 PDB 2xvs chain A Region: 54 - 89 Aligned: 36 Modelled: 36 Confidence: 10.6% Identity: 25% PDB header:antitumor protein Chain: A: PDB Molecule:tetratricopeptide repeat protein 5; PDBTitle: crystal structure of human ttc5 (strap) c-terminal ob2 domain Phyre2 PDB 1gtd chain A Region: 11 - 41 Aligned: 31 Modelled: 31 Confidence: 7.8% Identity: 13% Fold: PurS-like Superfamily: PurS-like Family: PurS subunit of FGAM synthetase Phyre2 PDB 2cs7 chain A domain 1 Region: 61 - 81 Aligned: 21 Modelled: 21 Confidence: 6.7% Identity: 24% Fold: IL8-like Superfamily: PhtA domain-like Family: PhtA domain-like Phyre2 PDB 1ydh chain A Region: 100 - 150 Aligned: 51 Modelled: 49 Confidence: 6.3% Identity: 8% Fold: MCP/YpsA-like Superfamily: MCP/YpsA-like Family: MoCo carrier protein-like Phyre2 PDB 3b0v chain D Region: 128 - 151 Aligned: 24 Modelled: 24 Confidence: 6.1% Identity: 13% PDB header:oxidoreductase/rna Chain: D: PDB Molecule:trna-dihydrouridine synthase; PDBTitle: trna-dihydrouridine synthase from thermus thermophilus in complex with2 trna Phyre2 PDB 2hnt chain E Region: 66 - 93 Aligned: 28 Modelled: 28 Confidence: 5.3% Identity: 29% PDB header:serine protease Chain: E: PDB Molecule:gamma-thrombin; PDBTitle: crystallographic structure of human gamma-thrombin Phyre2 1 c3bjvA_ 2 c2oqtD_ 3 c3oxpB_ 4 c3oxpA_ 5 c2oq3A_ 6 c3urrB_ 7 d1a6ja_ 8 d1a3aa_ 9 c2a0jA_ 10 d1xiza_ 11 d1hynp_ 12 c1hynQ_ 13 d1k4na_ 14 c2xvsA_ 15 d1gtda_ 16 d2cs7a1 17 d1ydha_ 18 c3b0vD_ 19 c2hntE_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3bjvA_ 100.0 43 PDB header:transferase Chain: A: PDB Molecule:rmpa; PDBTitle: the crystal structure of a putative pts iia(ptxa) from streptococcus2 mutans 2 c2oqtD_ 100.0 42 PDB header:transferase Chain: D: PDB Molecule:hypothetical protein spy0176; PDBTitle: structural genomics, the crystal structure of a putative2 pts iia domain from streptococcus pyogenes m1 gas 3 c3oxpB_ 100.0 36 PDB header:transferase Chain: B: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution 4 c3oxpA_ 100.0 36 PDB header:transferase Chain: A: PDB Molecule:phosphotransferase enzyme ii, a component; PDBTitle: structure of phosphotransferase enzyme ii, a component from yersinia2 pestis co92 at 1.2 a resolution 5 c2oq3A_ 100.0 36 PDB header:transferase Chain: A: PDB Molecule:mannitol-specific cryptic phosphotransferase PDBTitle: solution structure of the mannitol- specific cryptic2 phosphotransferase enzyme iia cmtb from escherichia coli 6 c3urrB_ 100.0 18 PDB header:transferase Chain: B: PDB Molecule:pts iia-like nitrogen-regulatory protein ptsn; PDBTitle: structure of pts iia-like nitrogen-regulatory protein ptsn (bth_i0484)2 (ptsn) 7 d1a6ja_ 100.0 24 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 8 d1a3aa_ 100.0 31 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 9 c2a0jA_ 100.0 17 PDB header:transferase Chain: A: PDB Molecule:pts system, nitrogen regulatory iia protein; PDBTitle: crystal structure of nitrogen regulatory protein iia-ntr from2 neisseria meningitidis 10 d1xiza_ 100.0 18 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:IIA domain of mannitol-specific and ntr phosphotransferase EII 11 d1hynp_ 97.6 13 Fold:Phoshotransferase/anion transport protein Superfamily:Phoshotransferase/anion transport protein Family:Anion transport protein, cytoplasmic domain 12 c1hynQ_ 97.5 15 PDB header:membrane protein Chain: Q: PDB Molecule:band 3 anion transport protein; PDBTitle: crystal structure of the cytoplasmic domain of human2 erythrocyte band-3 protein 13 d1k4na_ 11.4 14 Fold:Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Superfamily:Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Family:Hypothetical protein YecM (EC4020) 14 c2xvsA_ 10.6 25 PDB header:antitumor protein Chain: A: PDB Molecule:tetratricopeptide repeat protein 5; PDBTitle: crystal structure of human ttc5 (strap) c-terminal ob2 domain 15 d1gtda_ 7.8 13 Fold:PurS-like Superfamily:PurS-like Family:PurS subunit of FGAM synthetase 16 d2cs7a1 6.7 24 Fold:IL8-like Superfamily:PhtA domain-like Family:PhtA domain-like 17 d1ydha_ 6.3 8 Fold:MCP/YpsA-like Superfamily:MCP/YpsA-like Family:MoCo carrier protein-like 18 c3b0vD_ 6.1 13 PDB header:oxidoreductase/rna Chain: D: PDB Molecule:trna-dihydrouridine synthase; PDBTitle: trna-dihydrouridine synthase from thermus thermophilus in complex with2 trna 19 c2hntE_ 5.3 29 PDB header:serine protease Chain: E: PDB Molecule:gamma-thrombin; PDBTitle: crystallographic structure of human gamma-thrombin

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0