Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Y	F	M	T	K	K	M	L	T	F	V	Q	T	P	K	E	G	L	S	F	A	M	T	T	Y	L	N	L	F	V	K	L	L	I	F	L	Y	I	Q	N	T	K	A	C	L	S	I	N	N	V	N	N	N	S	K	N	K	L	R
Secondary structure
SS confidence
Disorder		?	?	?	?																																															?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.
Sequence		S	G	V	S	Y	Y	I	I	N	L	K	M	S	M	L	F	T	E	Q	I	V	T	I	Y	N	K	L	I	F
Secondary structure
SS confidence
Disorder																												?		?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1avw chain B Region: 49 - 68 Aligned: 20 Modelled: 20 Confidence: 37.6% Identity: 40% Fold: beta-Trefoil Superfamily: STI-like Family: Kunitz (STI) inhibitors Phyre2 PDB 1eyl chain A Region: 49 - 68 Aligned: 20 Modelled: 20 Confidence: 34.2% Identity: 20% Fold: beta-Trefoil Superfamily: STI-like Family: Kunitz (STI) inhibitors Phyre2 PDB 3bx1 chain C domain 1 Region: 51 - 68 Aligned: 18 Modelled: 18 Confidence: 32.4% Identity: 28% Fold: beta-Trefoil Superfamily: STI-like Family: Kunitz (STI) inhibitors Phyre2 PDB 3s8j chain B Region: 51 - 68 Aligned: 18 Modelled: 18 Confidence: 31.6% Identity: 17% PDB header:hydrolase inhibitor Chain: B: PDB Molecule:latex serine proteinase inhibitor; PDBTitle: crystal structure of a papaya latex serine protease inhibitor (ppi) at2 2.6a resolution Phyre2 PDB 2qn4 chain B Region: 47 - 68 Aligned: 22 Modelled: 22 Confidence: 27.4% Identity: 23% PDB header:hydrolase inhibitor Chain: B: PDB Molecule:alpha-amylase/subtilisin inhibitor; PDBTitle: structure and function study of rice bifunctional alpha-2 amylase/subtilisin inhibitor from oryza sativa Phyre2 PDB 2dre chain A Region: 51 - 68 Aligned: 18 Modelled: 18 Confidence: 27.3% Identity: 28% PDB header:plant protein Chain: A: PDB Molecule:water-soluble chlorophyll protein; PDBTitle: crystal structure of water-soluble chlorophyll protein from2 lepidium virginicum at 2.00 angstrom resolution Phyre2 PDB 1tie chain A Region: 51 - 68 Aligned: 18 Modelled: 18 Confidence: 26.6% Identity: 17% Fold: beta-Trefoil Superfamily: STI-like Family: Kunitz (STI) inhibitors Phyre2 PDB 1wba chain A Region: 49 - 68 Aligned: 20 Modelled: 20 Confidence: 25.7% Identity: 30% Fold: beta-Trefoil Superfamily: STI-like Family: Kunitz (STI) inhibitors Phyre2 PDB 1r8n chain A Region: 51 - 68 Aligned: 18 Modelled: 18 Confidence: 24.9% Identity: 28% Fold: beta-Trefoil Superfamily: STI-like Family: Kunitz (STI) inhibitors Phyre2 PDB 3iir chain A Region: 49 - 68 Aligned: 20 Modelled: 20 Confidence: 23.9% Identity: 15% PDB header:hydrolase inhibitor Chain: A: PDB Molecule:trypsin inhibitor; PDBTitle: crystal structure of miraculin like protein from seeds of murraya2 koenigii Phyre2 PDB 1r8o chain A Region: 51 - 68 Aligned: 18 Modelled: 18 Confidence: 14.1% Identity: 22% PDB header:hydrolase inhibitor Chain: A: PDB Molecule:kunitz trypsin inhibitor; PDBTitle: crystal structure of an unusual kunitz-type trypsin inhibitor from2 copaifera langsdorffii seeds Phyre2 PDB 2go2 chain A Region: 51 - 68 Aligned: 18 Modelled: 18 Confidence: 13.5% Identity: 22% PDB header:protein binding Chain: A: PDB Molecule:kunitz-type serine protease inhibitor bbki; PDBTitle: crystal structure of bbki, a kunitz-type kallikrein inhibitor Phyre2 PDB 1sdo chain A Region: 24 - 66 Aligned: 42 Modelled: 43 Confidence: 10.6% Identity: 31% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Restriction endonuclease BstyI Phyre2 PDB 3rnv chain A Region: 15 - 43 Aligned: 24 Modelled: 29 Confidence: 8.8% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:helper component proteinase; PDBTitle: structure of the autocatalytic cysteine protease domain of potyvirus2 helper-component proteinase Phyre2 PDB 1agg chain A Region: 17 - 22 Aligned: 6 Modelled: 6 Confidence: 7.0% Identity: 100% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: omega toxin-like Family: Spider toxins Phyre2 PDB 1e88 chain A domain 3 Region: 61 - 66 Aligned: 6 Modelled: 6 Confidence: 5.7% Identity: 67% Fold: FnI-like domain Superfamily: FnI-like domain Family: Fibronectin type I module Phyre2 1 d1avwb_ 2 d1eyla_ 3 d3bx1c1 4 c3s8jB_ 5 c2qn4B_ 6 c2dreA_ 7 d1tiea_ 8 d1wbaa_ 9 d1r8na_ 10 c3iirA_ 11 c1r8oA_ 12 c2go2A_ 13 d1sdoa_ 14 c3rnvA_ 15 d1agga_ 16 d1e88a3

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1avwb_ 37.6 40 Fold:beta-Trefoil Superfamily:STI-like Family:Kunitz (STI) inhibitors 2 d1eyla_ 34.2 20 Fold:beta-Trefoil Superfamily:STI-like Family:Kunitz (STI) inhibitors 3 d3bx1c1 32.4 28 Fold:beta-Trefoil Superfamily:STI-like Family:Kunitz (STI) inhibitors 4 c3s8jB_ 31.6 17 PDB header:hydrolase inhibitor Chain: B: PDB Molecule:latex serine proteinase inhibitor; PDBTitle: crystal structure of a papaya latex serine protease inhibitor (ppi) at2 2.6a resolution 5 c2qn4B_ 27.4 23 PDB header:hydrolase inhibitor Chain: B: PDB Molecule:alpha-amylase/subtilisin inhibitor; PDBTitle: structure and function study of rice bifunctional alpha-2 amylase/subtilisin inhibitor from oryza sativa 6 c2dreA_ 27.3 28 PDB header:plant protein Chain: A: PDB Molecule:water-soluble chlorophyll protein; PDBTitle: crystal structure of water-soluble chlorophyll protein from2 lepidium virginicum at 2.00 angstrom resolution 7 d1tiea_ 26.6 17 Fold:beta-Trefoil Superfamily:STI-like Family:Kunitz (STI) inhibitors 8 d1wbaa_ 25.7 30 Fold:beta-Trefoil Superfamily:STI-like Family:Kunitz (STI) inhibitors 9 d1r8na_ 24.9 28 Fold:beta-Trefoil Superfamily:STI-like Family:Kunitz (STI) inhibitors 10 c3iirA_ 23.9 15 PDB header:hydrolase inhibitor Chain: A: PDB Molecule:trypsin inhibitor; PDBTitle: crystal structure of miraculin like protein from seeds of murraya2 koenigii 11 c1r8oA_ 14.1 22 PDB header:hydrolase inhibitor Chain: A: PDB Molecule:kunitz trypsin inhibitor; PDBTitle: crystal structure of an unusual kunitz-type trypsin inhibitor from2 copaifera langsdorffii seeds 12 c2go2A_ 13.5 22 PDB header:protein binding Chain: A: PDB Molecule:kunitz-type serine protease inhibitor bbki; PDBTitle: crystal structure of bbki, a kunitz-type kallikrein inhibitor 13 d1sdoa_ 10.6 31 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:Restriction endonuclease BstyI 14 c3rnvA_ 8.8 33 PDB header:hydrolase Chain: A: PDB Molecule:helper component proteinase; PDBTitle: structure of the autocatalytic cysteine protease domain of potyvirus2 helper-component proteinase 15 d1agga_ 7.0 100 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:omega toxin-like Family:Spider toxins 16 d1e88a3 5.7 67 Fold:FnI-like domain Superfamily:FnI-like domain Family:Fibronectin type I module

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0