|   |
135 | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | |
. | . | . | . | . | . | . | . | . | 210 | . | . | . |
Predicted Secondary structure |   |
|
|
|
|  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  | . |  |
|  |  |  |  |  |  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
K | H | T | F | D | N | F | V | E | G | K | S | N | Q | L | A | R | A | A | A | R | Q | V | A | D | N | P | G | G | A | Y | N | P | L | F | L | Y | G | G | T | G | L | G | K | T | H | L | L | H | A | V | G | N | G | I | M | A | R | K | P | N | A | K | V | V | Y | . |
M | H | S | E | R | F | V | Q | D | M | V | K | A |
Query Conservation |   |
  |   |
|
|
|   |   |   |   |
|   |   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|   |
|   |   |
|   |
|
|
|   |
|
|   |
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   | . |   |   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
|
|
|   |   |   |
|
|   |   |   |   |   |   |
|
|   |
|   |
|   |
|
|
|   |
|
|   |   |   |   |
|
|   |
|   | . |
|
|
|
|
|
|
|
|
|
|
|
|   |
|
|   |   |
|
|   |   |   |   |
|
|
|
|
|   |   |   |
|   |   |   |
|   |
|
|
|   |
|
|
Template Sequence |   |
K | F | Y | L | N | S | V | F | I | S | Q | S | G | Y | L | L | L | I | G | F | A | T | L | T | D | S | L | H | Q | K | Y | G | G | C | F | F | . |
G | P | A | G | T | G | K | T | E | T | V | K | A | F | G | Q | N | L | G | R | V | V | V | V | F | N | C | D | D | S | F | D | Y | Q | V | L | S | R | L | L | V | G | I |
Template Known Secondary structure |   |
 |  |
|
|
|  |  |
| S | S |
|  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  | T | T | T | T |  |  |  |  | . |
|
| T | T | S | S |  |  |  |  |  |  |  |  | T | S | S |
|
|
|
|
|
|  |  |
|
| S | S | S | S |
| S |  |  |  |  |  |  |  |  |  |  |
Template Predicted Secondary structure |   |
 |  |  |
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
| . |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
1733 | . | . | . | . | . | . | 1740 | . | . | . | . | . | . | . | . | . | 1750 | . | . | . | . | . | . | . | . | . | 1760 | . | . | . | . | . | . | . | . | |
. | 1770 | . | . | . | . | . | . | . | . | . | 1780 | . | . | . | . | . | . | . | . | . | 1790 | . | . | . | . | . | . | . | . | . | 1800 | . | . | . | . | . | . | . | . | . | 1810 | . |
  |
  |   |
214 | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | . | . | |
|
. | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | |
|
|
|
|
|
. | . | 280 | . | . | . | . | . |
Predicted Secondary structure |   |
 |  |
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |
|
|
|  |  |
|
|
|
| . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |
|
|
|  |  |  |  |  |  | . | . | . | . | . | . |  |  |  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
Query Sequence |   |
L | Q | N | N | A | I | E | E | F | K | R | Y | Y | R | S | V | D | A | L | L | I | D | D | I | Q | F | F | A | N | K | . |
. |
E | R | S | Q | E | E | F | F | H | T | F | N | A | L | L | E | G | N | Q | Q | I | I | L | T | S | D | R | Y | P | K | E | I | N | G | . |
. |
. |
. |
. |
. |
V | E | D | R | L | K | S | R |
Query Conservation |   |
  |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |
|
|   |
|
|
|
|   |   |
|   |   |   | . | . |   |   |   |
|   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|   |   |   |   |   |
|   |   |   |   |   | . | . | . | . | . | . |
|   |   |   |
|   |
|
|
Alig confidence |   |
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |
|
|
| . | . | . | . | . | . | . | . | . | . | . | . |   |
|
|
|
|
|
|
|
|   |   |   |
|
|
|
|
|
|   |
|
|   |   |
|   |   |
|
|   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |
|   |   |   |   |   |
|
|
|
|
|
|
|
|
|
|
|   |
|
Template Sequence |   |
T | Q | I | G | A | W | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
G | C | F | D | E | F | N | R | L | D | E | K | V | L | S | A | V | S | A | N | I | Q | Q | I | Q | N | G | L | Q | V | G | K | S | H | I | T | L | L | E | E | E | T | P | L | S | P | H | T | A | V | F | I | T | L | L | P | E | N | L | K | K | S |
Template Known Secondary structure |   |
 | T | T |
|
|
| . | . | . | . | . | . | . | . | . | . | . | . |
|  |  |
| T | T | T | T | S | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | S | T | T | S | S | S |
|
|
|
|
| S | S |
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|
|  |  |  |  | T | T |
Template Predicted Secondary structure |   |
 |  |  |
|
|  | . | . | . | . | . | . | . | . | . | . | . | . |  |  |  |
|
|  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|  |  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
1839 | 1840 | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | 1850 | . | . | . | . | . | . | . | . | . | 1860 | . | . | . | . | . | . | . | . | . | 1870 | . | . | . | . | . | . | . | . | . | 1880 | . | . | . | . | . | . | . | . | . | 1890 | . | . | . | . | . | . | . | . | . | 1900 | . | . | . | . | . | . |
  |
  |   |
286 | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . |
Predicted Secondary structure |   |
 |  |
|
|  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  | . | . | . | . | . | . | . | . | . | . | . | . | . |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
F | G | W | G | L | T | V | A | I | E | P | P | E | L | E | T | R | V | A | I | L | M | K | K | A | D | E | N | D | I | R | L | P | G | E | V | A | F | F | I | A | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
K | R | L | R | S | N | V | R | E | L | E | G | A | L | N | R | V | I | A | N | A | N | F | T | G | R |
Query Conservation |   |
  |   |   |   |
|   |   |   |
|   |   |
|   |   |   |   |
|   |   |
|
|   |   |   |   |   |   |   |   |
|   |   |   |   |
|   |
|   |   |
|
| . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |
|
|   |
|   |   |   |
|   |   |
|   |   |   |
|   |   |   |   |   |
Alig confidence |   |
|
| . | . | . |
|
|
|
| . |
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
|
| . | . | . |
|
|   |
| . |   |
|
|   |   | . | . | . |   |
|   |
|
|   |
|   |
|   |
|
|   |   |
|   |   |
|
|   |
|
|   |   |
|   |   |
|   |   |   |   |
|
|   |
|   |
|
|
|
|
|
|
|
|
|
|   |
|
|   |   |
|
|   |   |   |
|   |   |   |   |
Template Sequence |   |
F | R | . |
. |
. |
E | F | S | M | . |
K | S | Q | S | G | . |
. |
. |
T | I | A | E | M | I | L | Q | I | M | G | F | E | D | S | K | S | L | A | S | K | I | V | H | F | L | E | L | L | S | S | K | C | S | S | M | N | H | Y | H | F | G | L | R | T | L | K | G | V | L | R | N | C | S | P | L | I | S | E | F | G | E |
Template Known Secondary structure |   |
T |
| . | . | . |  |  |  |
| . |
|
|
|  |  | . | . | . |  |  |  |  |  |  |  |  |  |  |  | T | S | S |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| S | S | S |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
| S | S |
|
Template Predicted Secondary structure |   |
|
| . | . | . |
|  |  |  | . |
|
|
|  |  | . | . | . |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
1916 | . | |
|
|
. | . | 1920 | . | |
. | . | . | . | . | |
|
|
. | . | . | 1930 | . | . | . | . | . | . | . | . | . | 1940 | . | . | . | . | . | . | . | . | . | 1950 | . | . | . | . | . | . | . | . | . | 1960 | . | . | . | . | . | . | . | . | . | 1970 | . | . | . | . | . | . | . | . | . | 1980 | . | . | . | . | . | . | . | . |
  |
  |   |
353 | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
A | I | T | I | D | F | V | R | E | A | L | R | D | L | L | A | L | Q | E | K | L | V | T | I | D | N | I | Q | K | T | V | A | E | Y | Y |
Query Conservation |   |
  |
|
|   |   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |   |
Alig confidence |   |
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
| . | . |   |   |   |
|   |   |
|
|   |   |   |   |   |
|
|
|   |   |   |
|   |   |
|
|   |   |
|
|   |
|   |
|
Template Sequence |   |
G | . |
. |
E | K | T | V | V | E | S | L | K | R | V | I | L | P | S | L | G | D | T | D | E | L | V | F | K | D | E | L | S | K | S | K |
Template Known Secondary structure |   |
S | . | . | S |  |  |  |  |  |  |  |  |  |  |
|
| S | S | S | S | T | T |  |  |  |  |  |  |  |  |  |  |
|
|  |
Template Predicted Secondary structure |   |
 | . | . |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
1990 | |
|
. | . | . | . | . | . | . | . | . | 2000 | . | . | . | . | . | . | . | . | . | 2010 | . | . | . | . | . | . | . | . | . | 2020 | . | . |
  |