Job Description P15639 Confidence 100.00% Date Thu Jan 5 11:34:47 GMT 2012 Rank 2 Aligned Residues 498 % Identity 42% Template c1thzA_ PDB info PDB header:transferase, hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of avian aicar transformylase in complex2 with a novel inhibitor identified by virtual ligand3 screening Resolution 1.80 Å

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		6	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		P	V	R	R	A	L	L	S	V	S	D	K	A	G	I	V	E	F	A	Q	A	L	S	A	R	G	V	E	L	L	S	T	G	G	T	A	R	L	L	A	E	K	G	L	P	V	T	E	V	S	D	Y	T	G	F	P	E	M	M	D	G	R	V	K	T	L	H	P	K	V	H	G	G	I	L	G	R	R	G	Q
Query Conservation
Alig confidence																																																																														.
Template Conservation																																																																														.
Template Sequence		R	Q	Q	L	A	L	L	S	V	S	E	K	A	G	L	V	E	F	A	R	S	L	N	A	L	G	L	G	L	I	A	S	G	G	T	A	T	A	L	R	D	A	G	L	P	V	R	D	V	S	D	L	T	G	F	P	E	M	L	G	G	R	V	K	T	L	H	P	A	V	H	A	G	I	L	A	.	R	N	I
Template Known Secondary structure											S	S		T	T											T	T																T	T																G	G	G	T	T	T	T		S										.		S	S
Template Predicted Secondary structure																																																																														.
Template SS confidence
		4	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.		80	.	.
		86	.	.			.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.
Predicted Secondary structure					.	.
Query SS confidence					.	.
Query Sequence		D	D	A	.	.	I	M	E	E	H	Q	I	Q	P	I	D	M	V	V	V	N	L	Y	P	F	A	Q	T	V	A	R	E	G	C	S	L	E	D	A	V	E	N	I	D	I	G	G	P	T	M	V	R	S	A	A	K	N	H	K	D	V	A	I	V	V	K	S	S	D	Y	D	A	I	I	K	E	M	D	D	N
Query Conservation					.	.
Alig confidence					.	.
Template Conservation
Template Sequence		P	E	D	N	A	D	M	N	K	Q	D	F	S	L	V	R	V	V	V	C	N	L	Y	P	F	V	K	T	V	S	S	P	G	V	T	V	P	E	A	V	E	K	I	D	I	G	G	V	A	L	L	R	A	A	A	K	N	H	A	R	V	T	V	V	C	D	P	A	D	Y	S	S	V	A	K	E	M	A	A	S
Template Known Secondary structure												T																				S	T	T									T															T	T	T	T							G	G	G
Template Predicted Secondary structure
Template SS confidence
		83	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.
			164	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.
Predicted Secondary structure		.
Query SS confidence		.
Query Sequence		.	E	G	S	L	T	L	A	T	R	F	D	L	A	I	K	A	F	E	H	T	A	A	Y	D	S	M	I	A	N	Y	F	G	S	M	V	P	A	Y	H	G	E	S	K	E	A	A	G	R	F	P	R	T	L	N	L	N	F	I	K	K	L	D	M	R	Y	G	E	N	S	H	Q	Q	A	A	F	Y	I	E	E
Query Conservation		.
Alig confidence		.																																					.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		K	D	K	D	T	S	V	E	T	R	R	H	L	A	L	K	A	F	T	H	T	A	Q	Y	D	A	A	I	S	D	Y	F	R	K	E	Y	S	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	K	G	V	S	Q	L	P	L	R	Y	G	M	N	P	H	Q	S	P	A	Q	L	Y	T	T
Template Known Secondary structure		T	T	S	S																																		.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	B	T	T	T					S		S	S	S	T	T	S								S
Template Predicted Secondary structure																																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		163	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.																				200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.
		243	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280					.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.
Predicted Secondary structure																																								.	.	.	.																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																																								.	.	.	.																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		N	V	K	E	A	S	V	A	T	A	T	Q	V	Q	G	K	A	L	S	Y	N	N	I	A	D	T	D	A	A	L	E	C	V	K	E	F	A	E	.	.	.	.	P	A	C	V	I	V	K	H	A	N	P	C	G	V	A	I	G	N	S	I	L	D	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Conservation																																								.	.	.	.																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence				.	.	.	.	.																																.	.	.	.																							.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation				.	.	.	.	.
Template Sequence		R	P	.	.	.	.	.	K	L	P	L	T	V	V	N	G	S	P	G	F	I	N	L	C	D	A	L	N	A	W	Q	L	V	K	E	L	K	Q	A	L	G	I	P	A	A	A	S	F	K	H	V	S	P	A	G	A	A	V	G	I	P	L	S	E	E	E	A	Q	V	C	M	V	H	D	L	H	K	T	L	T
Template Known Secondary structure		S	S	.	.	.	.	.	S		S						S																										S								T	T																			T	T		G	G	G	G	G	G
Template Predicted Secondary structure				.	.	.	.	.
Template SS confidence
		224	.						.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.
						303	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.		.
Predicted Secondary structure		.	.	.	.																																																																											.
Query SS confidence		.	.	.	.																																																																											.
Query Sequence		.	.	.	.	A	Y	D	R	A	Y	K	T	D	P	T	S	A	F	G	G	I	I	A	F	N	R	E	L	D	A	E	T	A	Q	A	I	I	S	R	Q	F	V	E	V	I	I	A	P	S	A	S	E	E	A	L	K	I	T	A	A	K	Q	N	V	R	V	L	T	C	G	Q	W	G	E	R	V	P	G	.	L
Query Conservation		.	.	.	.																																																																											.
Alig confidence		.	.	.	.																																.																																											.
Template Conservation																																					.
Template Sequence		P	L	A	S	A	Y	A	R	S	R	G	A	D	R	M	S	S	F	G	D	F	I	A	L	S	D	I	C	D	V	P	T	A	K	I	.	I	S	R	E	V	S	D	G	V	V	A	P	G	Y	E	E	E	A	L	K	I	L	S	K	K	K	N	G	G	Y	C	V	L	Q	M	D	P	N	Y	E	P	D	D	N
Template Known Secondary structure													S		T	T	T	T	T	T						S	S		B								.			T	S								S		B										T					T								T	T					S
Template Predicted Secondary structure																																					.
Template SS confidence
		299	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.		.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.
		378	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410			.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.
Predicted Secondary structure																																			.	.
Query SS confidence																																			.	.
Query Sequence		D	F	K	R	V	N	G	G	L	L	V	Q	D	R	D	L	G	M	V	G	A	E	E	L	R	V	V	T	K	R	Q	P	S	.	.	E	Q	E	L	R	D	A	L	F	C	W	K	V	A	K	F	V	K	S	N	A	I	V	Y	A	K	N	N	M	T	I	G	I	G	A	G	Q	M	S	R	V	Y	S	A	K
Query Conservation																																			.	.
Alig confidence																																			.	.
Template Conservation
Template Sequence		E	I	R	T	L	Y	G	L	Q	L	M	Q	K	R	N	N	A	V	I	D	R	S	L	F	K	N	I	V	T	K	N	K	T	L	P	E	S	A	V	R	D	L	I	V	A	S	I	A	V	K	Y	T	Q	S	N	S	V	C	Y	A	K	D	G	Q	V	I	G	I	G	A	G	Q	Q	S	R	I	H	C	T	R
Template Known Secondary structure							T	T													S	G	G	G	G			B		S	S																					T	S		S	S							T	T								S		S	S
Template Predicted Secondary structure
Template SS confidence
		378	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.
		456	.	.	.	460	.	.	.	.	.	.																																																															.	.	.	470	.	.	.
Predicted Secondary structure													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		I	A	G	I	K	A	A	D	E	G	L	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	E	V	K	G	S	S	M
Query Conservation													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence													.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		L	A	G	D	K	A	N	S	W	W	L	R	H	H	P	R	V	L	S	M	K	F	K	A	G	V	K	R	A	E	V	S	N	A	I	D	Q	Y	V	T	G	T	I	G	E	D	E	D	L	V	K	W	Q	A	M	F	E	E	V	P	A	Q	L	T	E	A	E	K	K	Q	W	I	A	K	L	T	A	V	S	L
Template Known Secondary structure													T	T						T					T	T															T	T		S		S									T	T																		T	T
Template Predicted Secondary structure
Template SS confidence
		458	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.
		474	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	S	D	A	F	F	P	F	R	D	G	I	D	A	A	A	A	A	G	V	T	C	V	I	Q	P	G	G	S	I	R	D	D	E	V	I	A	A	A	D	E	H	G	I	A	M	L	F	T	D	M	R	H	F	R	H
Query Conservation
Alig confidence
Template Conservation
Template Sequence		S	S	D	A	F	F	P	F	R	D	N	V	D	R	A	K	R	I	G	V	Q	F	I	V	A	P	S	G	S	A	A	D	E	V	V	I	E	A	C	N	E	L	G	I	T	L	I	H	T	N	L	R	L	F	H	H
Template Known Secondary structure				S	S			S	S	T								T	T	T											T	T											T	T							S
Template Predicted Secondary structure
Template SS confidence
		538	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.