Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	Y	I	Y	S	A	T	T	N	S	F	Y	P	L	E	M	K	E	D	Y	T	Q	A	G	S	W	P	D	D	A	V	E	V	D	E	Q	V	Y	I	E	F	S	G	L	P	P	K	G	K	I	R	I	A	G	E	N	G	F	P
Secondary structure
SS confidence
Disorder		?	?																						?																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	W	S	E	I	P	P	P	T	H	E	E	Q	I	A	A	A	E	L	K	K	Q	Q	L	I	N	Q	A	N	D	Y	M	N	S	K	Q	W	A	G	K	A	A	I	G	R	L	K	G	E	E	L	A	Q	Y	N	L	W	L	D	Y
Secondary structure
SS confidence
Disorder										?																										?		?				?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.
Sequence		L	D	A	L	E	L	V	D	T	S	S	A	P	D	I	E	W	P	T	P	P	A	V	Q	A	R
Secondary structure
SS confidence
Disorder								?													?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2kz6 chain A Region: 70 - 141 Aligned: 61 Modelled: 72 Confidence: 98.4% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of protein cv0426 from chromobacterium violaceum,2 northeast structural genomics consortium (nesg) target cvt2 Phyre2 PDB 3o0r chain C Region: 106 - 133 Aligned: 25 Modelled: 28 Confidence: 28.1% Identity: 20% PDB header:immune system/oxidoreductase Chain: C: PDB Molecule:nitric oxide reductase subunit c; PDBTitle: crystal structure of nitric oxide reductase from pseudomonas2 aeruginosa in complex with antibody fragment Phyre2 PDB 1y2o chain A domain 1 Region: 71 - 126 Aligned: 56 Modelled: 56 Confidence: 26.3% Identity: 13% Fold: BAR/IMD domain-like Superfamily: BAR/IMD domain-like Family: IMD domain Phyre2 PDB 1x4t chain A domain 1 Region: 58 - 116 Aligned: 53 Modelled: 59 Confidence: 21.4% Identity: 21% Fold: Long alpha-hairpin Superfamily: ISY1 domain-like Family: ISY1 N-terminal domain-like Phyre2 PDB 1fcu chain A Region: 1 - 63 Aligned: 60 Modelled: 63 Confidence: 21.1% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: crystal structure (trigonal) of bee venom hyaluronidase Phyre2 PDB 1fcq chain A Region: 1 - 80 Aligned: 74 Modelled: 77 Confidence: 19.7% Identity: 18% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: Bee venom hyaluronidase Phyre2 PDB 3ok8 chain A Region: 71 - 126 Aligned: 56 Modelled: 56 Confidence: 16.5% Identity: 11% PDB header:protein binding Chain: A: PDB Molecule:brain-specific angiogenesis inhibitor 1-associated protein PDBTitle: i-bar of pinkbar Phyre2 PDB 2fiq chain A domain 1 Region: 20 - 86 Aligned: 63 Modelled: 67 Confidence: 15.4% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Aldolase Family: GatZ-like Phyre2 PDB 2cly chain E Region: 105 - 137 Aligned: 33 Modelled: 33 Confidence: 13.3% Identity: 15% PDB header:hydrolase Chain: E: PDB Molecule:atp synthase d chain, mitochondrial; PDBTitle: subcomplex of the stator of bovine mitochondrial atp2 synthase Phyre2 PDB 2gu3 chain A domain 1 Region: 34 - 62 Aligned: 29 Modelled: 29 Confidence: 12.7% Identity: 10% Fold: Cystatin-like Superfamily: Cystatin/monellin Family: PepSY-like Phyre2 PDB 2w56 chain B Region: 5 - 27 Aligned: 23 Modelled: 23 Confidence: 10.2% Identity: 43% PDB header:unknown function Chain: B: PDB Molecule:vc0508; PDBTitle: structure of the hypothetical protein vc0508 from vibrio cholerae2 vsp-ii pathogenicity island Phyre2 PDB 2cly chain B domain 1 Region: 105 - 137 Aligned: 33 Modelled: 33 Confidence: 9.3% Identity: 15% Fold: ATP synthase D chain-like Superfamily: ATP synthase D chain-like Family: ATP synthase D chain-like Phyre2 PDB 2atm chain A Region: 1 - 63 Aligned: 60 Modelled: 60 Confidence: 9.1% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: crystal structure of the recombinant allergen ves v 2 Phyre2 PDB 2ahm chain G Region: 122 - 138 Aligned: 17 Modelled: 17 Confidence: 8.4% Identity: 24% PDB header:viral protein, replication Chain: G: PDB Molecule:replicase polyprotein 1ab, heavy chain; PDBTitle: crystal structure of sars-cov super complex of non-structural2 proteins: the hexadecamer Phyre2 PDB 2v1l chain A Region: 5 - 27 Aligned: 23 Modelled: 23 Confidence: 8.1% Identity: 35% PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: structure of the conserved hypothetical protein vc1805 from2 pathogenicity island vpi-2 of vibrio cholerae o1 biovar3 eltor str. n16961 shares structural homology with the4 human p32 protein Phyre2 PDB 1bgv chain A domain 2 Region: 106 - 130 Aligned: 25 Modelled: 25 Confidence: 7.6% Identity: 8% Fold: Aminoacid dehydrogenase-like, N-terminal domain Superfamily: Aminoacid dehydrogenase-like, N-terminal domain Family: Aminoacid dehydrogenases Phyre2 PDB 1lrz chain A domain 2 Region: 32 - 49 Aligned: 18 Modelled: 18 Confidence: 7.4% Identity: 11% Fold: Acyl-CoA N-acyltransferases (Nat) Superfamily: Acyl-CoA N-acyltransferases (Nat) Family: FemXAB nonribosomal peptidyltransferases Phyre2 PDB 2odk chain D Region: 39 - 77 Aligned: 39 Modelled: 39 Confidence: 6.9% Identity: 21% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical protein; PDBTitle: putative prevent-host-death protein from nitrosomonas europaea Phyre2 PDB 2q22 chain A domain 1 Region: 78 - 139 Aligned: 58 Modelled: 62 Confidence: 6.7% Identity: 14% Fold: Ava3019-like Superfamily: Ava3019-like Family: Ava3019-like Phyre2 PDB 1zak chain A domain 2 Region: 136 - 146 Aligned: 11 Modelled: 11 Confidence: 6.7% Identity: 18% Fold: Rubredoxin-like Superfamily: Microbial and mitochondrial ADK, insert "zinc finger" domain Family: Microbial and mitochondrial ADK, insert "zinc finger" domain Phyre2 1 c2kz6A_ 2 c3o0rC_ 3 d1y2oa1 4 d1x4ta1 5 c1fcuA_ 6 d1fcqa_ 7 c3ok8A_ 8 d2fiqa1 9 c2clyE_ 10 d2gu3a1 11 c2w56B_ 12 d2clyb1 13 c2atmA_ 14 c2ahmG_ 15 c2v1lA_ 16 d1bgva2 17 d1lrza2 18 c2odkD_ 19 d2q22a1 20 d1zaka2 21 22 23 24 25 26 27 28 29

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2kz6A_ 98.4 18 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of protein cv0426 from chromobacterium violaceum,2 northeast structural genomics consortium (nesg) target cvt2 2 c3o0rC_ 28.1 20 PDB header:immune system/oxidoreductase Chain: C: PDB Molecule:nitric oxide reductase subunit c; PDBTitle: crystal structure of nitric oxide reductase from pseudomonas2 aeruginosa in complex with antibody fragment 3 d1y2oa1 26.3 13 Fold:BAR/IMD domain-like Superfamily:BAR/IMD domain-like Family:IMD domain 4 d1x4ta1 21.4 21 Fold:Long alpha-hairpin Superfamily:ISY1 domain-like Family:ISY1 N-terminal domain-like 5 c1fcuA_ 21.1 15 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: crystal structure (trigonal) of bee venom hyaluronidase 6 d1fcqa_ 19.7 18 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Bee venom hyaluronidase 7 c3ok8A_ 16.5 11 PDB header:protein binding Chain: A: PDB Molecule:brain-specific angiogenesis inhibitor 1-associated protein PDBTitle: i-bar of pinkbar 8 d2fiqa1 15.4 17 Fold:TIM beta/alpha-barrel Superfamily:Aldolase Family:GatZ-like 9 c2clyE_ 13.3 15 PDB header:hydrolase Chain: E: PDB Molecule:atp synthase d chain, mitochondrial; PDBTitle: subcomplex of the stator of bovine mitochondrial atp2 synthase 10 d2gu3a1 12.7 10 Fold:Cystatin-like Superfamily:Cystatin/monellin Family:PepSY-like 11 c2w56B_ 10.2 43 PDB header:unknown function Chain: B: PDB Molecule:vc0508; PDBTitle: structure of the hypothetical protein vc0508 from vibrio cholerae2 vsp-ii pathogenicity island 12 d2clyb1 9.3 15 Fold:ATP synthase D chain-like Superfamily:ATP synthase D chain-like Family:ATP synthase D chain-like 13 c2atmA_ 9.1 15 PDB header:hydrolase Chain: A: PDB Molecule:hyaluronoglucosaminidase; PDBTitle: crystal structure of the recombinant allergen ves v 2 14 c2ahmG_ 8.4 24 PDB header:viral protein, replication Chain: G: PDB Molecule:replicase polyprotein 1ab, heavy chain; PDBTitle: crystal structure of sars-cov super complex of non-structural2 proteins: the hexadecamer 15 c2v1lA_ 8.1 35 PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein; PDBTitle: structure of the conserved hypothetical protein vc1805 from2 pathogenicity island vpi-2 of vibrio cholerae o1 biovar3 eltor str. n16961 shares structural homology with the4 human p32 protein 16 d1bgva2 7.6 8 Fold:Aminoacid dehydrogenase-like, N-terminal domain Superfamily:Aminoacid dehydrogenase-like, N-terminal domain Family:Aminoacid dehydrogenases 17 d1lrza2 7.4 11 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:FemXAB nonribosomal peptidyltransferases 18 c2odkD_ 6.9 21 PDB header:structural genomics, unknown function Chain: D: PDB Molecule:hypothetical protein; PDBTitle: putative prevent-host-death protein from nitrosomonas europaea 19 d2q22a1 6.7 14 Fold:Ava3019-like Superfamily:Ava3019-like Family:Ava3019-like 20 d1zaka2 6.7 18 Fold:Rubredoxin-like Superfamily:Microbial and mitochondrial ADK, insert "zinc finger" domain Family:Microbial and mitochondrial ADK, insert "zinc finger" domain 21 d2ahme1 not modelled 6.2 24 Fold:Coronavirus NSP8-like Superfamily:Coronavirus NSP8-like Family:Coronavirus NSP8-like 22 d2pbza2 not modelled 6.1 17 Fold:ATP-grasp Superfamily:Glutathione synthetase ATP-binding domain-like Family:PurP ATP-binding domain-like 23 d1zs4a1 not modelled 5.6 12 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:Bacteriophage CII protein 24 d2odka1 not modelled 5.5 21 Fold:YefM-like Superfamily:YefM-like Family:YefM-like 25 c1p9cA_ not modelled 5.5 32 PDB header:ligand binding protein Chain: A: PDB Molecule:26s proteasome non-atpase regulatory subunit 4; PDBTitle: nmr solution structure of the c-terminal ubiquitin-2 interacting motif of the proteasome subunit s5a 26 d1k4na_ not modelled 5.3 11 Fold:Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Superfamily:Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase Family:Hypothetical protein YecM (EC4020) 27 d1nira1 not modelled 5.2 18 Fold:Cytochrome c Superfamily:Cytochrome c Family:N-terminal (heme c) domain of cytochrome cd1-nitrite reductase 28 d2hq9a1 not modelled 5.2 15 Fold:Split barrel-like Superfamily:FMN-binding split barrel Family:PNP-oxidase like 29 d2fg9a1 not modelled 5.1 13 Fold:Split barrel-like Superfamily:FMN-binding split barrel Family:PNP-oxidase like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0