Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	L	F	S	I	P	P	P	T	L	L	A	G	F	L	A	V	L	I	G	Y	A	S	S	A	A	I	I	W	Q	A	A	I	V	A	G	A	T	T	A	Q	I	S	G	W	M	T	A	L	G	L	A	M	G	V	S	T	L	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																													?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	T	L	W	Y	R	V	P	V	L	T	A	W	S	T	P	G	A	A	L	L	V	T	G	L	Q	G	L	T	L	N	E	A	I	G	V	F	I	V	T	N	A	L	I	V	L	C	G	I	T	G	L	F	A	R	L	M	R	I	I
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	H	S	L	A	A	A	M	L	A	G	I	L	L	R	F	G	L	Q	A	F	A	S	L	D	G	Q	F	T	L	C	G	S	M	L	L	V	W	L	A	T	K	A	V	A	P	R	Y	A	V	I	A	A	M	I	I	G	I	V	I
Secondary structure
SS confidence
Disorder																							?																					?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	I	A	Q	G	D	V	V	T	T	D	V	V	F	K	P	V	L	P	T	Y	I	T	P	D	F	S	F	A	H	S	L	S	V	A	L	P	L	F	L	V	T	M	A	S	Q	N	A	P	G	I	A	A	M	K	A	A	G	Y	S
Secondary structure
SS confidence
Disorder								?	?	?		?	?		?																																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	P	V	S	P	L	I	V	F	T	G	L	L	A	L	V	F	S	P	F	G	V	Y	S	V	G	I	A	A	I	T	A	A	I	C	Q	S	P	E	A	H	P	D	K	D	Q	R	W	L	A	A	A	V	A	G	I	F	Y	L	L
Secondary structure
SS confidence
Disorder												?																			?	?				?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	G	L	F	G	S	A	I	T	G	M	M	A	A	L	P	V	S	W	I	Q	M	L	A	G	L	A	L	L	S	T	I	G	G	S	L	Y	Q	A	L	H	N	E	R	E	R	D	A	A	V	V	A	F	L	V	T	A	S	G	L
Secondary structure
SS confidence
Disorder																																									?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.
Sequence		T	L	V	G	I	G	S	A	F	W	G	L	I	A	G	G	V	C	Y	V	V	L	N	L	I	A	D	R	N	R	Y
Secondary structure
SS confidence
Disorder																								?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3qe7 chain A Region: 5 - 386 Aligned: 364 Modelled: 378 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:uracil permease; PDBTitle: crystal structure of uracil transporter--uraa Phyre2 PDB 3lpz chain A Region: 251 - 264 Aligned: 14 Modelled: 14 Confidence: 12.2% Identity: 36% PDB header:protein transport Chain: A: PDB Molecule:get4 (yor164c homolog); PDBTitle: crystal structure of c. therm. get4 Phyre2 PDB 1emz chain A Region: 367 - 379 Aligned: 13 Modelled: 13 Confidence: 7.1% Identity: 38% PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein e1; PDBTitle: solution structure of fragment (350-370) of the2 transmembrane domain of hepatitis c envelope glycoprotein3 e1 Phyre2 1 c3qe7A_ 2 c3lpzA_ 3 c1emzA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3qe7A_ 100.0 17 PDB header:transport protein Chain: A: PDB Molecule:uracil permease; PDBTitle: crystal structure of uracil transporter--uraa 2 c3lpzA_ 12.2 36 PDB header:protein transport Chain: A: PDB Molecule:get4 (yor164c homolog); PDBTitle: crystal structure of c. therm. get4 3 c1emzA_ 7.1 38 PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein e1; PDBTitle: solution structure of fragment (350-370) of the2 transmembrane domain of hepatitis c envelope glycoprotein3 e1

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0