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Job DescriptionP24555
Confidence100.00%DateThu Jan 5 11:41:42 GMT 2012
Rank7Aligned Residues532
% Identity14%Templatec2g5tA_
PDB info PDB header:hydrolaseChain: A: PDB Molecule:dipeptidyl peptidase 4; PDBTitle: crystal structure of human dipeptidyl peptidase iv (dppiv)2 complexed with cyanopyrrolidine (c5-pro-pro) inhibitor 21ag
Resolution2.30 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   129130.........140.........150.........160.........170.... .....180........
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Query Sequence  MGGMAITPDNTIMALAEDFLSRRQYGIRFRNLETGNWYPELLDNVE. . . . . . . . . . . . . . . . . . . . PSFVWANDSWIFYY
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Template Sequence  TQWVTWSPVGHKLAYVWNND. . . . . . IYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAY
Template Known Secondary structure  B

SSSS
TT......SSTTS



S

BTTTSB

TSSSSB

TTSS
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   152.......160.........170. ........180.........190.........200.........210.........220.....
 
   189190.........200.........210....... ..220.........230
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Query Sequence  VRKHPVTLLPYQVWRHAIGTPASQDKLIY. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EEKDDTYYVSLHK
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Template Sequence  AQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTW
Template Known Secondary structure 
TT



STT
SS


BTTS


TTS

SSS







TS
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   226...230.........240.........250.........260.........270.........280.........290.........300.....
 
   231........240.. .......250.........260........ .270.........280.........290......
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Query Sequence  TTSKHYVVIHLA. SATTSEVRLLDAEMADAEPFVFLPRR. . . . . . . . . . . . . KDHEYSLDHYQHRFYLRSNRHGKNFGLY
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Template Sequence  ATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHIC
Template Known Secondary structure 
SSSSSTTGGGT

TTS

SSS
SSSSS




TTSS
TTS
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   306...310.........320.........330.........340.........350.........360.........370.........380.....
 
   297..300.........310.........320.........330..... ....340.........350....... ..360.........370..
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Query Sequence  RTRMRDEQQWEELIPPRENIMLEGFTLFTDWLVVEERQR. . GLTSLRQINRKTREVIGIAFDD. . PAYVTWIAYNPEPET
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Template Sequence  YFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEA
Template Known Secondary structure  TT
SS
S

SSS

SSS
GGG
TT
BTT
TT
SSTTT
TTTB
B
TTS
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   386...390.........400.........410.........420.........430.........440.........450.........460.....
 
   373......380.........390.........400...... ...410.........420.........430.........440.........450
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Query Sequence  ARLRYGYSSMTTPDTLFELDMDTGERRVLKQTEV. . PGFYAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVY
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Template Sequence  KYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLD
Template Known Secondary structure  S
SBSS
TTTT

TTB


TT
TT

TTS
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   466...470.........480.........490.........500.........510.........520.........530.........540.....
 
   451....... .460.........470.........480.........490.........500.........510.........520.......
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Query Sequence  GYGSYGAS. . . IDADFSFSRLSLLDRGFVYAIVHVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCY
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Template Sequence  VYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIA
Template Known Secondary structure 


TT




S



STT



TT
SSS
GGGTT
TTSTTSSS
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   546...550.........560.........570.........580.........590.........600.........610.........620.....
 
   528.530.........540.........550.........560.........570.........580.........590.........600.......
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Query Sequence  AMGGSAGGMLMGVAINQRPELFHGVIAQVPFVDVVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDNVTAQAYP
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Template Sequence  IWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYY. . . . . . . DSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQV
Template Known Secondary structure  TTS




SS



GGGS.......B

SSTTTTT
SGGGGGGGGGS
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   626...630.........640.........650.........660.. .......670.........680.........690........
 
   608.610.........620.........630.........640.........650.........660.........670.......
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Query Sequence  HLLVTTGLHDSQVQYWEPAKWVAKLRELKTDDHLLLLCTDMDSGHGGKSGRFKSYEGVAMEYAFLVALAQ
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Template Sequence  EYLLIHGTADDNVHFQQSAQISKALVDVGVD. . . FQAMWYTDEDHGIAS. STAHQHIYTHMSHFIKQCFS
Template Known Secondary structure  TT
SSS
T

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TT

TT

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   699700.........710.........720......... 730.........740.... .....750.........760....
 
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Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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