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Job DescriptionP24555
Confidence100.00%DateThu Jan 5 11:41:42 GMT 2012
Rank3Aligned Residues661
% Identity26%Templatec2bklB_
PDB info PDB header:hydrolaseChain: B: PDB Molecule:prolyl endopeptidase; PDBTitle: structural and mechanistic analysis of two prolyl2 endopeptidases: role of inter-domain dynamics in3 catalysis and specificity
Resolution1.5 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   3......10.........20.........30.........40.........50.........60.........70.........80..
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Query Sequence  PKAARIPHAMTLHGDTRIDNYYWLRDDTRSQPEVLDYLQQENSYGHRVMASQQALQDRILKEIIDRIPQREVSAPYIKNG
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Template Sequence  PATRAEQVVDTLHGVQVADPYRWLED. . EKAPEVQTWMTAQNAHAREALAKFP. GREALAARFKELFYTDSVSTPSRRNG
Template Known Secondary structure  S






TT
TTGGGG
..TTSTST.TS




TT
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   4.....10.........20......... 30.........40.........50.... .....60.........70.........80
 
   83......90.........100.........110.........120.........130.........140.........150.........160..
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Query Sequence  YRYRHIYEPGCEYAIYQRQSAFSEEWDEWETLLDANKRAAHSEFYSMGGMAITPDNTIMALAEDFLSRRQYGIRFRNLET
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Template Sequence  RFFYVRTHKDKEKAILYWRQGES. . . GQEKVLLDPNGWSKDG. TVSLGTWAVSWDGKKVAFAQKPNAADEAVLHVIDVDS
Template Known Secondary structure 
TT
SS
TTT...S


GGGSSSSS.

TTSSTT
S

TTT
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   81........90.........100... ......110......... 120.........130.........140.........150......
 
   163......170.... .....180.........190... ......200.........210.........220 .........230..
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Query Sequence  GNWYPELLDNVE. . PSFVWANDSWIFYYVRKHP. . . . . . . VTLLPYQVWRHAIGTPASQDKLIYEEK. DDTYYVSLHKTT
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Template Conservation 
                 

 

  
 
                   
    

       

               
 
Template Sequence  GEWSKVDVIEGGKYATPKWTPDSKGFYYEWLPTDPSIKVDERPGYTTIRYHTLGTEPSKDTVVHERTGDPTTFLQSDLSR
Template Known Secondary structure 

B
SS

BS

TT



TTSS



TTS
TTTGGGG
TTS
GGG





TT

T
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   157..160.........170.........180.........190.........200.........210.........220.........230......
 
   233......240.........250.........260.........270.........280.........290.........300... ......310
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Query Sequence  SKHYVVIHLASATTSEVRLLDAEMADAEPFVFLPRRKDHEYSLDHYQHRFYLRSNRHGKNFGLYRTRMRDE. . QQWEELI
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Template Sequence  DGKYLFVYILRGWSENDVYW. . KRPGEKDFRLLVKGVGAKYEVHAWKDRFYVLTDEGAPRQRVFEVDPAKPARASWKEIV
Template Known Secondary structure  TSS
TTT..
TT
SS

SS

TT
TT
TT
BTTB
SGGG
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   237..240.........250...... ...260.........270.........280.........290.........300.........310....
 
   311........320.........330.........340.........350.........360.........370.........380.........390
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Query Sequence  PPRENIMLEGFTLFTDWLVVEERQRGLTSLRQINRKTREVIGIAFDDPAYVTWIAYNPEPETARLRYGYSSMTTPDTLFE
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Template Conservation         
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Template Sequence  PEDSSASLLSVSIVGGHLSLEYLKDATSEVRVATLKGKPVRTVQLPGVG. . AASNLMGLEDLDDAYYVFTSFTTPRQIYK
Template Known Secondary structure 


SS
TTTTTT




SSSS..


BS
TT
STT
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   315....320.........330.........340.........350.........360... ......370.........380.........390..
 
   391........400.........410.........420.........430.........440.........450.........460.........470
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Query Sequence  LDMDTGERRVLKQTEVPGFYAANYRSEHLWIVARDGVEVPVSLVYHRKHFRKGHNPLLVYGYGSYGASIDADFSFSRLSL
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Template Sequence  TSVSTGKSELWAKVDV. PMNPEQYQVEQVFYASKDGTKVPMFVVHRKDLKRDGNAPTLLYGYGGFNVNMEANFRSSILPW
Template Known Secondary structure  TTT




.S

GGG
TTS
TT


SS






TT







GGG
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   393......400........ .410.........420.........430.........440.........450.........460.........470.
 
   471........480.........490.........500.........510.........520.........530.........540.........550
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Query Sequence  LDRGFVYAIVHVRGGGELGQQWYEDGKFLKKKNTFNDYLDACDALLKLGYGSPSLCYAMGGSAGGMLMGVAINQRPELFH
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Template Sequence  LDAGGVYAVANLRGGGEYGKAWHDAGRLDKKQNVFDDFHAAAEYLVQQKYTQPKRLAIYGGSNGGLLVGAAMTQRPELYG
Template Known Secondary structure  TT


TTSSTT
TTSGGGTTTS

GGGT
GGG
S
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   472.......480.........490.........500.........510.........520.........530.........540.........550.
 
   551........560.........570.........580.........590.........600..... ....610.........620.........
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Query Sequence  GVIAQVPFVDVVTTMLDESIPLTTGEFEEWGNPQDPQYYEYMKSYSPYDNVTAQA. YPHLLVTTGLHDSQVQYWEPAKWV
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Template Sequence  AVVCAVPLLDMVRYHLFGSGRT. . . WIPEYGTAEKPEDFKTLHAYSPYHHVRPDVRYPALLMMAADHDDRVDPMHARKFV
Template Known Secondary structure  S



TTTGGGSTTGGG...G

TTS
GGG


SS



TT
SSS
T
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   552.......560.........570... ......580.........590.........600.........610.........620........
 
   630.........640.........650.........660.........670........
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Query Sequence  AKLRELKTDDHLLLLCTDMDSGHGGKSGRFKSYEGVAMEYAFLVALAQG
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Template Conservation    

          
      


            
    
    
  
Template Sequence  AAVQNSPGNPATALLRIEANAGHGGADQVAKAIESSVDLYSFLFQVLDV
Template Known Secondary structure  TSTT

S
TT
BTTB
S
TT
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   629630.........640.........650.........660.........670.......
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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