Job Description P24555 Confidence 100.00% Date Thu Jan 5 11:41:42 GMT 2012 Rank 2 Aligned Residues 658 % Identity 22% Template c1yr2A_ PDB info PDB header:hydrolase Chain: A: PDB Molecule:prolyl oligopeptidase; PDBTitle: structural and mechanistic analysis of two prolyl endopeptidases: role2 of inter-domain dynamics in catalysis and specificity Resolution 1.80 Å

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		2	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	P	K	A	A	R	I	P	H	A	M	T	L	H	G	D	T	R	I	D	N	Y	Y	W	L	R	D	D	T	R	S	Q	P	E	V	L	D	Y	L	Q	Q	E	N	S	Y	G	H	R	V	M	A	S	Q	Q	A	L	Q	D	R	I	L	K	E	I	I	D	R	I	P	Q	R	E	V	S	A	P	Y	I	K	N
Query Conservation
Alig confidence																																																							.
Template Conservation																																																							.
Template Sequence		Y	P	A	S	P	Q	V	P	L	V	E	D	H	F	G	E	K	V	S	D	P	W	R	W	L	E	A	D	V	R	T	D	A	K	V	A	A	W	V	Q	A	Q	S	A	Y	T	A	A	Y	L	K	Q	L	.	P	E	R	A	A	L	E	K	R	M	K	A	L	I	D	Y	E	R	F	G	L	P	Q	R	R	G
Template Known Secondary structure															T	T						T	T	G	G	G	G	S		T	T	T																				T	T		.	T	T												S												T
Template Predicted Secondary structure																																																							.
Template SS confidence
		40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.		.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.
		82	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	Y	R	Y	R	H	I	Y	E	P	G	C	E	Y	A	I	Y	Q	R	Q	S	A	F	S	E	E	W	D	E	W	E	T	L	L	D	A	N	K	R	A	A	H	S	E	F	Y	S	M	G	G	M	A	I	T	P	D	N	T	I	M	A	L	A	E	D	F	L	S	R	R	Q	Y	G	I	R	F	R	N	L	E
Query Conservation
Alig confidence																																										.	.	.	.	.
Template Conservation																																										.	.	.	.	.
Template Sequence		A	S	V	F	Y	S	W	N	S	G	L	M	N	Q	S	Q	L	L	V	R	P	A	D	A	P	V	G	T	K	G	R	V	L	L	D	P	N	T	W	A	.	.	.	.	.	T	A	L	D	A	W	A	A	S	D	D	G	R	L	L	A	Y	S	V	Q	D	G	G	S	D	W	R	T	V	K	F	V	G	V	A
Template Known Secondary structure		T									S	S		S	S								T	T	S		T	T									G	G	G			.	.	.	.	.										T	T	S	S									T	T		S									T	T
Template Predicted Secondary structure																																										.	.	.	.	.
Template SS confidence
		119	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.						.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.
		162	.	.	.	.	.	.	.	170	.	.	.	.		.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.		.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.
Predicted Secondary structure															.																																																.
Query SS confidence															.																																																.
Query Sequence		T	G	N	W	Y	P	E	L	L	D	N	V	E	.	P	S	F	V	W	A	N	D	S	W	I	F	Y	Y	V	R	K	H	P	V	T	L	L	P	Y	Q	V	W	R	H	A	I	G	T	P	A	S	Q	D	K	L	I	Y	E	E	K	D	.	D	T	Y	Y	V	S	L	H	K	T	T	S	K	H	Y	V	V	I
Query Conservation															.																																																.
Alig confidence															.																					.																											.
Template Conservation																																				.
Template Sequence		D	G	K	P	L	A	D	E	L	K	W	V	K	F	S	G	L	A	W	L	G	N	D	A	L	L	Y	S	R	F	A	E	P	L	.	N	Y	N	Q	T	V	W	L	H	R	L	G	T	P	Q	S	A	D	Q	P	V	F	A	T	P	E	L	P	K	R	G	H	G	A	S	V	S	S	D	G	R	W	V	V	I
Template Known Secondary structure		T													S						S	T	T	S												.											T	T	S		G	G	G								T	T		T	T									T	T	S
Template Predicted Secondary structure																																				.
Template SS confidence
		198	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.		.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.
		240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.				.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.
Predicted Secondary structure																								.	.	.
Query SS confidence																								.	.	.
Query Sequence		H	L	A	S	A	T	T	S	E	V	R	L	L	D	A	E	M	A	D	A	E	P	.	.	.	F	V	F	L	P	R	R	K	D	H	E	Y	S	L	D	H	Y	Q	H	R	F	Y	L	R	S	N	R	H	G	K	N	F	G	L	Y	R	T	R	M	R	D	E	Q	Q	W	E	E	L	I	P	P	R	E	N	I
Query Conservation																								.	.	.
Alig confidence																								.	.	.
Template Conservation
Template Sequence		T	S	S	E	G	T	D	P	V	N	T	V	H	V	A	R	V	T	N	G	K	I	G	P	V	T	A	L	I	P	D	L	K	A	Q	W	D	F	V	D	G	V	G	D	Q	L	W	F	V	S	G	D	G	A	P	L	K	K	I	V	R	V	D	L	S	G	S	T	P	R	F	D	T	V	V	P	E	S	K	D
Template Known Secondary structure						T	T		S											T	T											S	S	S	S									T	T								T	T		T	T									S	S	S	S											S	S
Template Predicted Secondary structure
Template SS confidence
		285	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.
		317	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		M	L	E	G	F	T	L	F	T	D	W	L	V	V	E	E	R	Q	R	G	L	T	S	L	R	Q	I	N	R	K	T	R	E	V	I	G	I	A	F	D	D	P	A	Y	V	T	W	I	A	Y	N	P	E	P	E	T	A	R	L	R	Y	G	Y	S	S	M	T	T	P	D	T	L	F	E	L	D	M	D	T	G
Query Conservation
Alig confidence																																													.	.
Template Conservation																																													.	.
Template Sequence		N	L	E	S	V	G	I	A	G	N	R	L	F	A	S	Y	I	H	D	A	K	S	Q	V	L	A	F	D	L	D	G	K	P	A	G	A	V	S	L	P	G	I	G	.	.	S	A	S	G	L	S	G	R	P	G	D	R	H	A	Y	L	S	F	S	S	F	T	Q	P	A	T	V	L	A	L	D	P	A	T	A
Template Known Secondary structure										B	T									T	T									T	T	S							B		S	S	S		.	.									B	T		S									T	T										T	T	T	T
Template Predicted Secondary structure																																													.	.
Template SS confidence
		365	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.			.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.
		397	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		E	R	R	V	L	K	Q	T	E	V	P	G	F	Y	A	A	N	Y	R	S	E	H	L	W	I	V	A	R	D	G	V	E	V	P	V	S	L	V	Y	H	R	K	H	F	R	K	G	H	N	P	L	L	V	Y	G	Y	G	S	Y	G	A	S	I	D	A	D	F	S	F	S	R	L	S	L	L	D	R	G	F	V
Query Conservation
Alig confidence												.																																	.	.
Template Conservation												.																																	.	.
Template Sequence		K	T	T	P	W	E	P	V	H	L	.	T	F	D	P	A	D	F	R	V	E	Q	V	F	Y	P	S	K	D	G	T	K	V	P	M	F	I	V	R	R	K	D	A	.	.	K	G	P	L	P	T	L	L	Y	G	Y	G	G	F	N	V	A	L	T	P	W	F	S	A	G	F	M	T	W	I	D	S	G	G	A
Template Known Secondary structure							S					.	S	S		G	G	G											T	T	S											T	T		.	.		S												T	T																T	T	T
Template Predicted Secondary structure												.																																	.	.
Template SS confidence
		443	.	.	.	.	.	.	450	.	.		.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.			.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.
		477	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	A	I	V	H	V	R	G	G	G	E	L	G	Q	Q	W	Y	E	D	G	K	F	L	K	K	K	N	T	F	N	D	Y	L	D	A	C	D	A	L	L	K	L	G	Y	G	S	P	S	L	C	Y	A	M	G	G	S	A	G	G	M	L	M	G	V	A	I	N	Q	R	P	E	L	F	H	G	V	I	A	Q	V
Query Conservation
Alig confidence
Template Conservation
Template Sequence		F	A	L	A	N	L	R	G	G	G	E	Y	G	D	A	W	H	D	A	G	R	R	D	K	K	Q	N	V	F	D	D	F	I	A	A	G	E	W	L	I	A	N	G	V	T	P	R	H	G	L	A	I	E	G	G	S	N	G	G	L	L	I	G	A	V	T	N	Q	R	P	D	L	F	A	A	A	S	P	A	V
Template Known Secondary structure								T	T	S	S	T	T							T	T	S	G	G	G	T																	T	T	S	S		T	T								T														G	G	G		S						S
Template Predicted Secondary structure
Template SS confidence
		520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.
		557	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.		.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.
Predicted Secondary structure																																																			.
Query SS confidence																																																			.
Query Sequence		P	F	V	D	V	V	T	T	M	L	D	E	S	I	P	L	T	T	G	E	F	E	E	W	G	N	P	Q	D	P	Q	Y	Y	E	Y	M	K	S	Y	S	P	Y	D	N	V	T	A	Q	A	.	Y	P	H	L	L	V	T	T	G	L	H	D	S	Q	V	Q	Y	W	E	P	A	K	W	V	A	K	L	R	E	L
Query Conservation																																																			.
Alig confidence										.	.	.																																							.
Template Conservation										.	.	.
Template Sequence		G	V	M	D	M	L	R	F	.	.	.	D	Q	F	T	A	G	R	Y	W	V	D	D	Y	G	Y	P	E	K	E	A	D	W	R	V	L	R	R	Y	S	P	Y	H	N	V	R	S	G	V	D	Y	P	A	I	L	V	T	T	A	D	T	D	D	R	V	V	P	G	H	S	F	K	Y	T	A	A	L	Q	T	A
Template Known Secondary structure						T	T	S	G	.	.	.	G	G	S	T	T	G	G	G	G							T	T	S									T	T		G	G	G				T	T	S											S			S	S	S		T													S
Template Predicted Secondary structure										.	.	.
Template SS confidence
		600	.	.	.	.	.	.	.				.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.
		636	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		K	T	D	D	H	L	L	L	L	C	T	D	M	D	S	G	H	G	G	K	S	G	R	F	K	S	Y	E	G	V	A	M	E	Y	A	F	L	V	A	L	A	Q	G	T	L	P	A	T
Query Conservation
Alig confidence																			.	.	.	.	.	.	.	.	.
Template Conservation																			.	.	.	.	.	.	.	.	.
Template Sequence		A	I	G	P	K	P	H	L	I	R	I	E	P	I	D	K	Q	.	.	.	.	.	.	.	.	.	I	E	E	T	A	D	V	Q	A	F	L	A	H	F	T	G	L	T	P	R	P	W
Template Known Secondary structure					S	S													.	.	.	.	.	.	.	.	.																T
Template Predicted Secondary structure																			.	.	.	.	.	.	.	.	.
Template SS confidence
		677	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.										.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.