Secondary structure and disorder prediction

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Sequence		M	M	T	I	S	D	I	I	E	I	I	V	V	C	A	L	I	F	F	P	L	G	Y	L	A	R	H	S	L	R	R	I	R	D	T	L	R	L	F	F	A	K	P	R	Y	V	K	P	A	G	T	L	R	R	T	E	K	A	R	A
Secondary structure
SS confidence
Disorder		?	?	?																																								?	?				?	?			?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.
Sequence		T	K	K
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1u2z chain C Region: 4 - 25 Aligned: 22 Modelled: 22 Confidence: 20.4% Identity: 32% PDB header:transferase Chain: C: PDB Molecule:histone-lysine n-methyltransferase, h3 lysine-79 PDBTitle: crystal structure of histone k79 methyltransferase dot1p2 from yeast Phyre2 PDB 2iub chain A domain 2 Region: 6 - 25 Aligned: 20 Modelled: 20 Confidence: 9.4% Identity: 30% Fold: Transmembrane helix hairpin Superfamily: Magnesium transport protein CorA, transmembrane region Family: Magnesium transport protein CorA, transmembrane region Phyre2 PDB 2jm6 chain A Region: 29 - 38 Aligned: 10 Modelled: 10 Confidence: 9.0% Identity: 60% PDB header:apoptosis Chain: A: PDB Molecule:noxa; PDBTitle: solution structure of mcl-1 complexed with noxab Phyre2 PDB 2kbv chain A Region: 17 - 24 Aligned: 8 Modelled: 8 Confidence: 8.9% Identity: 75% PDB header:membrane protein Chain: A: PDB Molecule:sodium/hydrogen exchanger 1; PDBTitle: structural and functional analysis of tm xi of the nhe12 isoform of the na+/h+ exchanger Phyre2 PDB 1u2z chain A Region: 4 - 25 Aligned: 22 Modelled: 22 Confidence: 8.5% Identity: 32% Fold: S-adenosyl-L-methionine-dependent methyltransferases Superfamily: S-adenosyl-L-methionine-dependent methyltransferases Family: Catalytic, N-terminal domain of histone methyltransferase Dot1l Phyre2 PDB 3n4p chain A Region: 45 - 51 Aligned: 7 Modelled: 7 Confidence: 6.2% Identity: 71% PDB header:dna binding protein Chain: A: PDB Molecule:terminase subunit ul89 protein; PDBTitle: human cytomegalovirus terminase nuclease domain Phyre2 PDB 3n4q chain A Region: 45 - 51 Aligned: 7 Modelled: 7 Confidence: 6.0% Identity: 71% PDB header:dna binding protein Chain: A: PDB Molecule:terminase subunit ul89 protein; PDBTitle: human cytomegalovirus terminase nuclease domain, mn soaked Phyre2 PDB 2k5e chain A Region: 2 - 22 Aligned: 21 Modelled: 21 Confidence: 5.5% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of putative uncharacterized protein2 gsu1278 from methanocaldococcus jannaschii, northeast3 structural genomics consortium (nesg) target gsr195 Phyre2 PDB 2k53 chain A Region: 2 - 22 Aligned: 21 Modelled: 21 Confidence: 5.4% Identity: 33% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:a3dk08 protein; PDBTitle: nmr solution structure of a3dk08 protein from clostridium2 thermocellum: northeast structural genomics consortium3 target cmr9 Phyre2 PDB 2l1n chain A Region: 12 - 23 Aligned: 12 Modelled: 12 Confidence: 5.3% Identity: 42% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the protein yp_399305.1 Phyre2 1 c1u2zC_ 2 d2iuba2 3 c2jm6A_ 4 c2kbvA_ 5 d1u2za_ 6 c3n4pA_ 7 c3n4qA_ 8 c2k5eA_ 9 c2k53A_ 10 c2l1nA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1u2zC_ 20.4 32 PDB header:transferase Chain: C: PDB Molecule:histone-lysine n-methyltransferase, h3 lysine-79 PDBTitle: crystal structure of histone k79 methyltransferase dot1p2 from yeast 2 d2iuba2 9.4 30 Fold:Transmembrane helix hairpin Superfamily:Magnesium transport protein CorA, transmembrane region Family:Magnesium transport protein CorA, transmembrane region 3 c2jm6A_ 9.0 60 PDB header:apoptosis Chain: A: PDB Molecule:noxa; PDBTitle: solution structure of mcl-1 complexed with noxab 4 c2kbvA_ 8.9 75 PDB header:membrane protein Chain: A: PDB Molecule:sodium/hydrogen exchanger 1; PDBTitle: structural and functional analysis of tm xi of the nhe12 isoform of the na+/h+ exchanger 5 d1u2za_ 8.5 32 Fold:S-adenosyl-L-methionine-dependent methyltransferases Superfamily:S-adenosyl-L-methionine-dependent methyltransferases Family:Catalytic, N-terminal domain of histone methyltransferase Dot1l 6 c3n4pA_ 6.2 71 PDB header:dna binding protein Chain: A: PDB Molecule:terminase subunit ul89 protein; PDBTitle: human cytomegalovirus terminase nuclease domain 7 c3n4qA_ 6.0 71 PDB header:dna binding protein Chain: A: PDB Molecule:terminase subunit ul89 protein; PDBTitle: human cytomegalovirus terminase nuclease domain, mn soaked 8 c2k5eA_ 5.5 14 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of putative uncharacterized protein2 gsu1278 from methanocaldococcus jannaschii, northeast3 structural genomics consortium (nesg) target gsr195 9 c2k53A_ 5.4 33 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:a3dk08 protein; PDBTitle: nmr solution structure of a3dk08 protein from clostridium2 thermocellum: northeast structural genomics consortium3 target cmr9 10 c2l1nA_ 5.3 42 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the protein yp_399305.1

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0