Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	Y	K	H	L	I	L	S	L	S	L	I	M	L	G	P	L	A	H	A	E	E	I	G	S	V	D	T	V	F	K	M	I	G	P	D	H	K	I	V	V	E	A	F	D	D	P	D	V	K	N	V	T	C	Y	V	S	R	A
Secondary structure
SS confidence
Disorder		?	?	?	?											?	?	?		?	?																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	T	G	G	I	K	G	G	L	G	L	A	E	D	T	S	D	A	A	I	S	C	Q	Q	V	G	P	I	E	L	S	D	R	I	K	N	G	K	A	Q	G	E	V	V	F	K	K	R	T	S	L	V	F	K	S	L	Q	V	V	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.
Sequence		F	Y	D	A	K	R	N	A	L	A	Y	L	A	Y	S	D	K	V	V	E	G	S	P	K	N	A	I	S	A	V	P	V	M	P	W	R	Q
Secondary structure
SS confidence
Disorder																			?	?	?	?	?									?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3qsq chain A Region: 53 - 68 Aligned: 16 Modelled: 16 Confidence: 41.1% Identity: 31% PDB header:viral protein Chain: A: PDB Molecule:capsid polyprotein; PDBTitle: crystal structure of the projection domain of the human astrovirus2 capsid protein Phyre2 PDB 3bdk chain B Region: 31 - 53 Aligned: 23 Modelled: 23 Confidence: 41.0% Identity: 17% PDB header:lyase Chain: B: PDB Molecule:d-mannonate dehydratase; PDBTitle: crystal structure of streptococcus suis mannonate2 dehydratase complexed with substrate analogue Phyre2 PDB 1tz9 chain A Region: 31 - 53 Aligned: 23 Modelled: 23 Confidence: 27.6% Identity: 22% Fold: TIM beta/alpha-barrel Superfamily: Xylose isomerase-like Family: UxuA-like Phyre2 PDB 3ba3 chain A Region: 115 - 151 Aligned: 37 Modelled: 37 Confidence: 22.0% Identity: 22% PDB header:oxidoreductase Chain: A: PDB Molecule:pyridoxamine 5'-phosphate oxidase-like protein; PDBTitle: crystal structure of pyridoxamine 5'-phosphate oxidase-like protein2 (np_783940.1) from lactobacillus plantarum at 1.55 a resolution Phyre2 PDB 3cnk chain B Region: 70 - 145 Aligned: 74 Modelled: 76 Confidence: 19.0% Identity: 14% PDB header:structural protein Chain: B: PDB Molecule:filamin-a; PDBTitle: crystal structure of the dimerization domain of human2 filamin a Phyre2 PDB 2d7m chain A domain 1 Region: 64 - 151 Aligned: 85 Modelled: 88 Confidence: 12.9% Identity: 18% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Filamin repeat (rod domain) Phyre2 PDB 2q79 chain A domain 1 Region: 26 - 48 Aligned: 21 Modelled: 23 Confidence: 12.2% Identity: 19% Fold: Ferredoxin-like Superfamily: Viral DNA-binding domain Family: Viral DNA-binding domain Phyre2 PDB 2bp3 chain A domain 1 Region: 57 - 145 Aligned: 85 Modelled: 89 Confidence: 11.3% Identity: 18% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Filamin repeat (rod domain) Phyre2 PDB 1gk8 chain A domain 2 Region: 117 - 150 Aligned: 34 Modelled: 34 Confidence: 10.7% Identity: 26% Fold: Ferredoxin-like Superfamily: RuBisCO, large subunit, small (N-terminal) domain Family: Ribulose 1,5-bisphosphate carboxylase-oxygenase Phyre2 PDB 1rbl chain A domain 2 Region: 117 - 150 Aligned: 34 Modelled: 34 Confidence: 10.7% Identity: 21% Fold: Ferredoxin-like Superfamily: RuBisCO, large subunit, small (N-terminal) domain Family: Ribulose 1,5-bisphosphate carboxylase-oxygenase Phyre2 PDB 3isw chain A Region: 55 - 144 Aligned: 81 Modelled: 90 Confidence: 9.6% Identity: 14% PDB header:structural protein Chain: A: PDB Molecule:filamin-a; PDBTitle: crystal structure of filamin-a immunoglobulin-like repeat 21 bound to2 an n-terminal peptide of cftr Phyre2 PDB 1wf9 chain A domain 1 Region: 125 - 135 Aligned: 11 Modelled: 11 Confidence: 9.6% Identity: 36% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 2nyt chain B Region: 53 - 60 Aligned: 8 Modelled: 8 Confidence: 9.0% Identity: 63% PDB header:hydrolase Chain: B: PDB Molecule:probable c->u-editing enzyme apobec-2; PDBTitle: the apobec2 crystal structure and functional implications2 for aid Phyre2 PDB 1vkn chain C Region: 116 - 147 Aligned: 32 Modelled: 32 Confidence: 9.0% Identity: 19% PDB header:oxidoreductase Chain: C: PDB Molecule:n-acetyl-gamma-glutamyl-phosphate reductase; PDBTitle: crystal structure of n-acetyl-gamma-glutamyl-phosphate reductase2 (tm1782) from thermotoga maritima at 1.80 a resolution Phyre2 PDB 2kbo chain A Region: 53 - 58 Aligned: 6 Modelled: 6 Confidence: 8.8% Identity: 67% PDB header:hydrolase Chain: A: PDB Molecule:dna dc->du-editing enzyme apobec-3g; PDBTitle: structure, interaction, and real-time monitoring of the2 enzymatic reaction of wild type apobec3g Phyre2 PDB 2o62 chain A domain 2 Region: 114 - 143 Aligned: 29 Modelled: 30 Confidence: 8.7% Identity: 24% Fold: Lipocalins Superfamily: Lipocalins Family: All1756-like Phyre2 PDB 2eec chain A Region: 70 - 144 Aligned: 70 Modelled: 70 Confidence: 8.4% Identity: 23% PDB header:structural protein Chain: A: PDB Molecule:filamin-b; PDBTitle: solution structure of the 23th filamin domain from human2 filamin-b Phyre2 PDB 8ruc chain A domain 2 Region: 117 - 150 Aligned: 34 Modelled: 34 Confidence: 7.8% Identity: 21% Fold: Ferredoxin-like Superfamily: RuBisCO, large subunit, small (N-terminal) domain Family: Ribulose 1,5-bisphosphate carboxylase-oxygenase Phyre2 PDB 2e9i chain A domain 1 Region: 74 - 144 Aligned: 69 Modelled: 71 Confidence: 7.5% Identity: 16% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Filamin repeat (rod domain) Phyre2 PDB 2zw3 chain B Region: 46 - 60 Aligned: 15 Modelled: 15 Confidence: 7.5% Identity: 40% PDB header:cell adhesion Chain: B: PDB Molecule:gap junction beta-2 protein; PDBTitle: structure of the connexin-26 gap junction channel at 3.52 angstrom resolution Phyre2 1 c3qsqA_ 2 c3bdkB_ 3 d1tz9a_ 4 c3ba3A_ 5 c3cnkB_ 6 d2d7ma1 7 d2q79a1 8 d2bp3a1 9 d1gk8a2 10 d1rbla2 11 c3iswA_ 12 d1wf9a1 13 c2nytB_ 14 c1vknC_ 15 c2kboA_ 16 d2o62a2 17 c2eecA_ 18 d8ruca2 19 d2e9ia1 20 c2zw3B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3qsqA_ 41.1 31 PDB header:viral protein Chain: A: PDB Molecule:capsid polyprotein; PDBTitle: crystal structure of the projection domain of the human astrovirus2 capsid protein 2 c3bdkB_ 41.0 17 PDB header:lyase Chain: B: PDB Molecule:d-mannonate dehydratase; PDBTitle: crystal structure of streptococcus suis mannonate2 dehydratase complexed with substrate analogue 3 d1tz9a_ 27.6 22 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:UxuA-like 4 c3ba3A_ 22.0 22 PDB header:oxidoreductase Chain: A: PDB Molecule:pyridoxamine 5'-phosphate oxidase-like protein; PDBTitle: crystal structure of pyridoxamine 5'-phosphate oxidase-like protein2 (np_783940.1) from lactobacillus plantarum at 1.55 a resolution 5 c3cnkB_ 19.0 14 PDB header:structural protein Chain: B: PDB Molecule:filamin-a; PDBTitle: crystal structure of the dimerization domain of human2 filamin a 6 d2d7ma1 12.9 18 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Filamin repeat (rod domain) 7 d2q79a1 12.2 19 Fold:Ferredoxin-like Superfamily:Viral DNA-binding domain Family:Viral DNA-binding domain 8 d2bp3a1 11.3 18 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Filamin repeat (rod domain) 9 d1gk8a2 10.7 26 Fold:Ferredoxin-like Superfamily:RuBisCO, large subunit, small (N-terminal) domain Family:Ribulose 1,5-bisphosphate carboxylase-oxygenase 10 d1rbla2 10.7 21 Fold:Ferredoxin-like Superfamily:RuBisCO, large subunit, small (N-terminal) domain Family:Ribulose 1,5-bisphosphate carboxylase-oxygenase 11 c3iswA_ 9.6 14 PDB header:structural protein Chain: A: PDB Molecule:filamin-a; PDBTitle: crystal structure of filamin-a immunoglobulin-like repeat 21 bound to2 an n-terminal peptide of cftr 12 d1wf9a1 9.6 36 Fold:beta-Grasp (ubiquitin-like) Superfamily:Ubiquitin-like Family:Ubiquitin-related 13 c2nytB_ 9.0 63 PDB header:hydrolase Chain: B: PDB Molecule:probable c->u-editing enzyme apobec-2; PDBTitle: the apobec2 crystal structure and functional implications2 for aid 14 c1vknC_ 9.0 19 PDB header:oxidoreductase Chain: C: PDB Molecule:n-acetyl-gamma-glutamyl-phosphate reductase; PDBTitle: crystal structure of n-acetyl-gamma-glutamyl-phosphate reductase2 (tm1782) from thermotoga maritima at 1.80 a resolution 15 c2kboA_ 8.8 67 PDB header:hydrolase Chain: A: PDB Molecule:dna dc->du-editing enzyme apobec-3g; PDBTitle: structure, interaction, and real-time monitoring of the2 enzymatic reaction of wild type apobec3g 16 d2o62a2 8.7 24 Fold:Lipocalins Superfamily:Lipocalins Family:All1756-like 17 c2eecA_ 8.4 23 PDB header:structural protein Chain: A: PDB Molecule:filamin-b; PDBTitle: solution structure of the 23th filamin domain from human2 filamin-b 18 d8ruca2 7.8 21 Fold:Ferredoxin-like Superfamily:RuBisCO, large subunit, small (N-terminal) domain Family:Ribulose 1,5-bisphosphate carboxylase-oxygenase 19 d2e9ia1 7.5 16 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Filamin repeat (rod domain) 20 c2zw3B_ 7.5 40 PDB header:cell adhesion Chain: B: PDB Molecule:gap junction beta-2 protein; PDBTitle: structure of the connexin-26 gap junction channel at 3.52 angstrom resolution 21 c3khpB_ not modelled 7.3 14 PDB header:oxidoreductase Chain: B: PDB Molecule:maoc family protein; PDBTitle: crystal structure of a possible dehydrogenase from2 mycobacterium tuberculosis at 2.3a resolution 22 c1moxB_ not modelled 7.2 14 PDB header:transferase/growth factor Chain: B: PDB Molecule:epidermal growth factor receptor; PDBTitle: crystal structure of human epidermal growth factor receptor (residues2 1-501) in complex with tgf-alpha 23 d1zl0a2 not modelled 6.9 54 Fold:Flavodoxin-like Superfamily:Class I glutamine amidotransferase-like Family:LD-carboxypeptidase A N-terminal domain-like 24 c3hsbB_ not modelled 6.7 42 PDB header:rna binding protein/rna Chain: B: PDB Molecule:protein hfq; PDBTitle: crystal structure of ymah (hfq) from bacillus subtilis in complex with2 an rna aptamer 25 d1k8wa3 not modelled 6.6 17 Fold:PUA domain-like Superfamily:PUA domain-like Family:PUA domain 26 c2e9jA_ not modelled 6.3 18 PDB header:structural protein Chain: A: PDB Molecule:filamin-b; PDBTitle: solution structure of the 14th filamin domain from human2 filamin-b 27 d2o62a1 not modelled 6.3 25 Fold:Lipocalins Superfamily:Lipocalins Family:All1756-like 28 c2jf1A_ not modelled 6.2 18 PDB header:cell adhesion Chain: A: PDB Molecule:filamin-a; PDBTitle: crystal structure of the filamin a repeat 21 complexed with2 the integrin beta2 cytoplasmic tail peptide 29 d1ej7l2 not modelled 6.0 29 Fold:Ferredoxin-like Superfamily:RuBisCO, large subunit, small (N-terminal) domain Family:Ribulose 1,5-bisphosphate carboxylase-oxygenase 30 c2e2zA_ not modelled 5.9 35 PDB header:protein transport, chaperone regulator Chain: A: PDB Molecule:tim15; PDBTitle: solution nmr structure of yeast tim15, co-chaperone of2 mitochondrial hsp70 31 d1bwva2 not modelled 5.9 26 Fold:Ferredoxin-like Superfamily:RuBisCO, large subunit, small (N-terminal) domain Family:Ribulose 1,5-bisphosphate carboxylase-oxygenase 32 d1dbda_ not modelled 5.8 13 Fold:Ferredoxin-like Superfamily:Viral DNA-binding domain Family:Viral DNA-binding domain 33 d1hk9a_ not modelled 5.8 39 Fold:Sm-like fold Superfamily:Sm-like ribonucleoproteins Family:Pleiotropic translational regulator Hfq 34 d1f9fa_ not modelled 5.7 5 Fold:Ferredoxin-like Superfamily:Viral DNA-binding domain Family:Viral DNA-binding domain 35 d1bxna2 not modelled 5.7 24 Fold:Ferredoxin-like Superfamily:RuBisCO, large subunit, small (N-terminal) domain Family:Ribulose 1,5-bisphosphate carboxylase-oxygenase 36 d2b59b2 not modelled 5.6 28 Fold:Prealbumin-like Superfamily:Carboxypeptidase regulatory domain-like Family:Pre-dockerin domain 37 c3g23A_ not modelled 5.6 23 PDB header:hydrolase Chain: A: PDB Molecule:ld-carboxypeptidase a; PDBTitle: crystal structure of a ld-carboxypeptidase a (saro_1426) from2 novosphingobium aromaticivorans dsm at 1.89 a resolution 38 c1rcxH_ not modelled 5.6 24 PDB header:lyase (carbon-carbon) Chain: H: PDB Molecule:ribulose bisphosphate carboxylase/oxygenase; PDBTitle: non-activated spinach rubisco in complex with its substrate2 ribulose-1,5-bisphosphate 39 c2q49B_ not modelled 5.4 19 PDB header:oxidoreductase Chain: B: PDB Molecule:probable n-acetyl-gamma-glutamyl-phosphate reductase; PDBTitle: ensemble refinement of the protein crystal structure of gene product2 from arabidopsis thaliana at2g19940 40 d1svda2 not modelled 5.4 24 Fold:Ferredoxin-like Superfamily:RuBisCO, large subunit, small (N-terminal) domain Family:Ribulose 1,5-bisphosphate carboxylase-oxygenase 41 d2dtge4 not modelled 5.4 21 Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:L domain 42 d2auna2 not modelled 5.3 54 Fold:Flavodoxin-like Superfamily:Class I glutamine amidotransferase-like Family:LD-carboxypeptidase A N-terminal domain-like 43 c3b2uI_ not modelled 5.2 14 PDB header:immune system/transferase Chain: I: PDB Molecule:epidermal growth factor receptor; PDBTitle: crystal structure of isolated domain iii of the extracellular region2 of the epidermal growth factor receptor in complex with the fab3 fragment of imc-11f8

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0