Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	T	K	I	R	Y	G	L	S	A	A	V	L	A	L	I	G	A	G	A	S	A	P	Q	I	L	D	Q	F	L	D	E	K	E	G	N	H	T	M	A	Y	R	D	G	S	G	I	W	T	I	C	R	G	A	T	V	V	D	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?												?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	T	V	F	P	N	M	K	L	S	K	E	K	C	D	Q	V	N	A	I	E	R	D	K	A	L	A	W	V	E	R	N	I	K	V	P	L	T	E	P	Q	K	A	G	I	A	S	F	C	P	Y	N	I	G	P	G	K	C	F	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.
Sequence		S	T	F	Y	K	R	L	N	A	G	D	R	K	G	A	C	E	A	I	R	W	W	I	K	D	G	G	R	D	C	R	I	R	S	N	N	C	Y	G	Q	V	I	R	R	D	Q	E	S	A	L	T	C	W	G	I	E	Q
Secondary structure
SS confidence
Disorder																																	?	?	?	?	?																	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3hde chain A Region: 1 - 176 Aligned: 165 Modelled: 176 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of full-length endolysin r21 from phage 21 Phyre2 PDB 1xjt chain A Region: 10 - 176 Aligned: 155 Modelled: 167 Confidence: 100.0% Identity: 18% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 3hdf chain A Region: 32 - 174 Aligned: 132 Modelled: 143 Confidence: 100.0% Identity: 33% PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of truncated endolysin r21 from phage 21 Phyre2 PDB 2anx chain B Region: 25 - 173 Aligned: 140 Modelled: 149 Confidence: 100.0% Identity: 30% PDB header:hydrolase Chain: B: PDB Molecule:lysozyme; PDBTitle: crystal structure of bacteriophage p22 lysozyme mutant l87m Phyre2 PDB 1xju chain A Region: 25 - 176 Aligned: 138 Modelled: 152 Confidence: 100.0% Identity: 19% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1lpy chain A Region: 27 - 174 Aligned: 133 Modelled: 134 Confidence: 100.0% Identity: 20% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 176l chain A Region: 27 - 174 Aligned: 133 Modelled: 134 Confidence: 100.0% Identity: 23% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1jtm chain A Region: 27 - 174 Aligned: 135 Modelled: 148 Confidence: 100.0% Identity: 21% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 191l chain A Region: 27 - 174 Aligned: 135 Modelled: 148 Confidence: 100.0% Identity: 20% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 169l chain A Region: 27 - 174 Aligned: 135 Modelled: 148 Confidence: 100.0% Identity: 18% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1swy chain A Region: 27 - 174 Aligned: 133 Modelled: 134 Confidence: 100.0% Identity: 20% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1p37 chain A Region: 27 - 174 Aligned: 135 Modelled: 148 Confidence: 100.0% Identity: 21% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1t8f chain A Region: 27 - 174 Aligned: 135 Modelled: 148 Confidence: 100.0% Identity: 21% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 146l chain A Region: 27 - 174 Aligned: 133 Modelled: 134 Confidence: 100.0% Identity: 19% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 157l chain A Region: 27 - 174 Aligned: 135 Modelled: 148 Confidence: 100.0% Identity: 20% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 2f2q chain A domain 1 Region: 27 - 174 Aligned: 133 Modelled: 134 Confidence: 100.0% Identity: 19% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 1l64 chain A Region: 27 - 174 Aligned: 133 Modelled: 134 Confidence: 100.0% Identity: 20% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 189l chain A Region: 27 - 174 Aligned: 135 Modelled: 148 Confidence: 100.0% Identity: 19% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 PDB 2o4w chain A Region: 37 - 174 Aligned: 125 Modelled: 138 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: t4 lysozyme circular permutant Phyre2 PDB 1k28 chain A domain 3 Region: 27 - 166 Aligned: 130 Modelled: 140 Confidence: 100.0% Identity: 19% Fold: Lysozyme-like Superfamily: Lysozyme-like Family: Phage lysozyme Phyre2 1 c3hdeA_ 2 d1xjta_ 3 c3hdfA_ 4 c2anxB_ 5 d1xjua_ 6 d1lpya_ 7 d176la_ 8 d1jtma_ 9 d191la_ 10 d169la_ 11 d1swya_ 12 d1p37a_ 13 d1t8fa_ 14 d146la_ 15 d157la_ 16 d2f2qa1 17 d1l64a_ 18 d189la_ 19 c2o4wA_ 20 d1k28a3 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3hdeA_ 100.0 31 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of full-length endolysin r21 from phage 21 2 d1xjta_ 100.0 18 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 3 c3hdfA_ 100.0 33 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: crystal structure of truncated endolysin r21 from phage 21 4 c2anxB_ 100.0 30 PDB header:hydrolase Chain: B: PDB Molecule:lysozyme; PDBTitle: crystal structure of bacteriophage p22 lysozyme mutant l87m 5 d1xjua_ 100.0 19 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 6 d1lpya_ 100.0 20 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 7 d176la_ 100.0 23 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 8 d1jtma_ 100.0 21 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 9 d191la_ 100.0 20 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 10 d169la_ 100.0 18 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 11 d1swya_ 100.0 20 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 12 d1p37a_ 100.0 21 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 13 d1t8fa_ 100.0 21 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 14 d146la_ 100.0 19 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 15 d157la_ 100.0 20 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 16 d2f2qa1 100.0 19 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 17 d1l64a_ 100.0 20 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 18 d189la_ 100.0 19 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 19 c2o4wA_ 100.0 20 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: t4 lysozyme circular permutant 20 d1k28a3 100.0 19 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 21 d1p5ca_ not modelled 100.0 20 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Phage lysozyme 22 c2qb0D_ not modelled 100.0 17 PDB header:hydrolase regulator Chain: D: PDB Molecule:telsam domain - lysozyme chimera; PDBTitle: structure of the 2tel crystallization module fused to t4 lysozyme with2 an ala-gly-pro linker. 23 c3sn6R_ not modelled 99.9 21 PDB header:signaling protein/hydrolase Chain: R: PDB Molecule:lysozyme, beta-2 adrenergic receptor; PDBTitle: crystal structure of the beta2 adrenergic receptor-gs protein complex 24 c1pdlC_ not modelled 99.9 21 PDB header:hydrolase Chain: C: PDB Molecule:tail-associated lysozyme; PDBTitle: fitting of gp5 in the cryoem reconstruction of the2 bacteriophage t4 baseplate 25 c2o7aA_ not modelled 99.8 19 PDB header:hydrolase Chain: A: PDB Molecule:lysozyme; PDBTitle: t4 lysozyme c-terminal fragment 26 d2ikba1 not modelled 46.9 16 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:NMB1012-like 27 d1xima_ not modelled 37.0 21 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 28 d2nr7a1 not modelled 24.4 16 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:NMB1012-like 29 d1xlma_ not modelled 19.2 21 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 30 d1thqa_ not modelled 14.8 15 Fold:Transmembrane beta-barrels Superfamily:OMPA-like Family:Outer membrane enzyme PagP 31 c2qvwA_ not modelled 14.3 14 PDB header:hydrolase Chain: A: PDB Molecule:glp_546_48378_50642; PDBTitle: structure of giardia dicer refined against twinned data 32 c3gabC_ not modelled 11.4 17 PDB header:hydrolase Chain: C: PDB Molecule:dna mismatch repair protein mutl; PDBTitle: c-terminal domain of bacillus subtilis mutl crystal form i 33 d2glka1 not modelled 10.0 18 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 34 c1tolA_ not modelled 9.7 18 PDB header:viral protein Chain: A: PDB Molecule:protein (fusion protein consisting of minor coat PDBTitle: fusion of n-terminal domain of the minor coat protein from2 gene iii in phage m13, and c-terminal domain of e. coli3 protein-tola 35 c2gboB_ not modelled 9.0 10 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:upf0358 protein ef2458; PDBTitle: protein of unknown function ef2458 from enterococcus faecalis 36 d2gboa1 not modelled 9.0 10 Fold:Open three-helical up-and-down bundle Superfamily:EF2458-like Family:EF2458-like 37 c2bvbA_ not modelled 8.6 16 PDB header:adhesion Chain: A: PDB Molecule:micronemal protein 1; PDBTitle: the c-terminal domain from micronemal protein 1 (mic1) from2 toxoplasma gondii 38 d1ulza1 not modelled 8.4 13 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 39 d1w96c1 not modelled 7.1 5 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:BC C-terminal domain-like 40 d1muwa_ not modelled 7.0 24 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 41 c3cz6A_ not modelled 6.9 19 PDB header:protein binding Chain: A: PDB Molecule:dna-binding protein rap1; PDBTitle: crystal structure of the rap1 c-terminus 42 d1mqma_ not modelled 6.4 23 Fold:Viral protein domain Superfamily:Viral protein domain Family:Influenza hemagglutinin headpiece 43 d1a77a1 not modelled 6.4 19 Fold:SAM domain-like Superfamily:5' to 3' exonuclease, C-terminal subdomain Family:5' to 3' exonuclease, C-terminal subdomain 44 d2viua_ not modelled 5.9 23 Fold:Viral protein domain Superfamily:Viral protein domain Family:Influenza hemagglutinin headpiece 45 c2x0kB_ not modelled 5.8 18 PDB header:transferase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribf; PDBTitle: crystal structure of modular fad synthetase from2 corynebacterium ammoniagenes 46 d1qt1a_ not modelled 5.7 18 Fold:TIM beta/alpha-barrel Superfamily:Xylose isomerase-like Family:Xylose isomerase 47 c3ncvB_ not modelled 5.4 6 PDB header:hydrolase Chain: B: PDB Molecule:dna mismatch repair protein mutl; PDBTitle: ngol

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0