Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	E	S	I	Q	L	V	I	D	S	L	P	F	L	L	K	G	A	G	Y	T	L	Q	L	S	I	G	G	M	F	F	G	L	L	L	G	F	I	L	A	L	M	R	L	S	P	I	W	P	V	R	W	L	A	R	F	Y	I	S
Secondary structure
SS confidence
Disorder		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		I	F	R	G	T	P	L	I	A	Q	L	F	M	I	Y	Y	G	L	P	Q	F	G	I	E	L	D	P	I	P	S	A	M	I	G	L	S	L	N	T	A	A	Y	A	A	E	T	L	R	A	A	I	S	S	I	D	K	G	Q	W	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	A	A	S	I	G	M	T	P	W	Q	T	M	R	R	A	I	L	P	Q	A	A	R	V	A	L	P	P	L	S	N	S	F	I	S	L	V	K	D	T	S	L	A	A	T	I	Q	V	P	E	L	F	R	Q	A	Q	L	I	T	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.
Sequence		R	T	L	E	V	F	T	M	Y	L	A	A	S	L	I	Y	W	I	M	A	T	V	L	S	T	L	Q	N	H	F	E	N	Q	L	N	R	Q	E	R	E	P	K
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2onk chain C domain 1 Region: 3 - 210 Aligned: 207 Modelled: 208 Confidence: 100.0% Identity: 12% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2onk chain C Region: 3 - 210 Aligned: 207 Modelled: 208 Confidence: 100.0% Identity: 12% PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda Phyre2 PDB 3d31 chain D Region: 3 - 208 Aligned: 205 Modelled: 206 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease PDBTitle: modbc from methanosarcina acetivorans Phyre2 PDB 3d31 chain C domain 1 Region: 3 - 208 Aligned: 205 Modelled: 206 Confidence: 100.0% Identity: 13% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain F Region: 3 - 206 Aligned: 203 Modelled: 204 Confidence: 100.0% Identity: 15% PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter Phyre2 PDB 2r6g chain F domain 2 Region: 2 - 206 Aligned: 205 Modelled: 204 Confidence: 100.0% Identity: 17% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3fh6 chain F Region: 3 - 213 Aligned: 211 Modelled: 210 Confidence: 99.9% Identity: 14% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 3dhw chain A domain 1 Region: 14 - 208 Aligned: 194 Modelled: 195 Confidence: 99.9% Identity: 19% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain G domain 1 Region: 15 - 221 Aligned: 204 Modelled: 207 Confidence: 99.9% Identity: 18% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2jwa chain A Region: 20 - 53 Aligned: 34 Modelled: 34 Confidence: 59.8% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: erbb2 transmembrane segment dimer spatial structure Phyre2 PDB 1ntc chain A Region: 106 - 136 Aligned: 31 Modelled: 31 Confidence: 23.9% Identity: 19% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1umq chain A Region: 106 - 136 Aligned: 31 Modelled: 31 Confidence: 23.0% Identity: 16% PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity Phyre2 PDB 1umq chain A Region: 106 - 136 Aligned: 31 Modelled: 31 Confidence: 23.0% Identity: 16% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1fip chain A Region: 106 - 136 Aligned: 31 Modelled: 31 Confidence: 15.4% Identity: 16% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1eto chain B Region: 106 - 136 Aligned: 31 Modelled: 31 Confidence: 14.4% Identity: 16% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 3e7l chain D Region: 106 - 136 Aligned: 31 Modelled: 31 Confidence: 11.5% Identity: 16% PDB header:transcription regulator Chain: D: PDB Molecule:transcriptional regulator (ntrc family); PDBTitle: crystal structure of sigma54 activator ntrc4's dna binding2 domain Phyre2 PDB 1etx chain A Region: 106 - 136 Aligned: 31 Modelled: 31 Confidence: 11.2% Identity: 13% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 3nd0 chain A Region: 149 - 222 Aligned: 74 Modelled: 74 Confidence: 8.8% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:sll0855 protein; PDBTitle: x-ray crystal structure of a slow cyanobacterial cl-/h+ antiporter Phyre2 PDB 2ht2 chain B Region: 149 - 221 Aligned: 73 Modelled: 73 Confidence: 8.0% Identity: 14% PDB header:membrane protein Chain: B: PDB Molecule:h(+)/cl(-) exchange transporter clca; PDBTitle: structure of the escherichia coli clc chloride channel2 y445h mutant and fab complex Phyre2 PDB 3qnq chain D Region: 137 - 222 Aligned: 86 Modelled: 86 Confidence: 7.0% Identity: 6% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 1 d2onkc1 2 c2onkC_ 3 c3d31D_ 4 d3d31c1 5 c2r6gF_ 6 d2r6gf2 7 c3fh6F_ 8 d3dhwa1 9 d2r6gg1 10 c2jwaA_ 11 d1ntca_ 12 c1umqA_ 13 d1umqa_ 14 d1fipa_ 15 d1etob_ 16 c3e7lD_ 17 d1etxa_ 18 c3nd0A_ 19 c2ht2B_ 20 c3qnqD_ 21

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2onkc1 100.0 12 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 2 c2onkC_ 100.0 12 PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda 3 c3d31D_ 100.0 13 PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease PDBTitle: modbc from methanosarcina acetivorans 4 d3d31c1 100.0 13 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 5 c2r6gF_ 100.0 15 PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter 6 d2r6gf2 100.0 17 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 7 c3fh6F_ 99.9 14 PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli 8 d3dhwa1 99.9 19 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 9 d2r6gg1 99.9 18 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 10 c2jwaA_ 59.8 12 PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: erbb2 transmembrane segment dimer spatial structure 11 d1ntca_ 23.9 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 12 c1umqA_ 23.0 16 PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity 13 d1umqa_ 23.0 16 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 14 d1fipa_ 15.4 16 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 15 d1etob_ 14.4 16 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 16 c3e7lD_ 11.5 16 PDB header:transcription regulator Chain: D: PDB Molecule:transcriptional regulator (ntrc family); PDBTitle: crystal structure of sigma54 activator ntrc4's dna binding2 domain 17 d1etxa_ 11.2 13 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 18 c3nd0A_ 8.8 9 PDB header:transport protein Chain: A: PDB Molecule:sll0855 protein; PDBTitle: x-ray crystal structure of a slow cyanobacterial cl-/h+ antiporter 19 c2ht2B_ 8.0 14 PDB header:membrane protein Chain: B: PDB Molecule:h(+)/cl(-) exchange transporter clca; PDBTitle: structure of the escherichia coli clc chloride channel2 y445h mutant and fab complex 20 c3qnqD_ 7.0 6 PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system 21 d1g2ha_ not modelled 6.4 10 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0