|   |
216 | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | |
. | . | . | . | 240 | . | . | . | . | . | . | . | . | |
|
. | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | |
|
|
|
|
|
|
|
. | . | . | . | . | . | 280 | . | . | . | . |
Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
| . |
|
|
|
|
|
|
|  |  |  |  |  |  | . | . |
|
|  |  |  |
|
|  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
Y | Q | T | Y | V | V | V | I | G | E | S | A | R | R | D | A | L | G | A | F | . |
G | G | H | W | D | N | T | P | F | A | S | S | V | . |
. |
N | G | L | I | F | A | D | Y | I | A | A | S | G | S | T | Q | K | S | L | G | L | T | L | N | R | . |
. |
. |
. |
. |
. |
. |
. |
V | V | D | G | K | P | Q | F | Q | D | N |
Query Conservation |   |
  |   |
|
|
|
|
|
|   |
|
|   |   |   |   |   |   |   |   |   | . |
|   |   |   |   |   |
|
|   |
|   |   |   | . | . |   |   |   |   |
|   |
|   |   |
|   |   |   |   |
|   |   |
|   |   |   |   |   |
|   | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
|
|   |
|
|
|
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |
|
|   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
Template Sequence |   |
K | K | P | V | A | L | I | I | L | D | G | F | A | L | R | D | E | T | Y | G | N | A | V | A | Q | A | N | K | P | N | F | D | R | Y | W | N | E | Y | P | H | T | T | L | K | A | C | G | E | A | V | G | L | P | E | G | Q | M | G | N | S | E | V | G | H | L | N | I | G | A | G | R | I | V | Y | T | N | L | D | N | T |
Template Known Secondary structure |   |
|
|
|  |  |  |  |  |  | T | T |
|
|
|
| S |
|
| T | T |
|  |  |  |  | S |
|
|  |  |  |  |  |  |  |  |  | S |
|  |  |  |  |  |
| S | G | G | G | G | T | S |
| T | T |
|
|
|
|  |  |  |  |  |  |  |  |  |  | T | S |
|
|
|
|
|
|
| S |
|
Template Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
3 | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60 | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . |
  |
  |   |
285 | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | |
|
|
|
|
|
. | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  | . | . | . | . | . | . |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
F | V | T | L | A | N | R | A | G | F | Q | T | W | W | F | S | N | Q | G | Q | I | G | E | Y | D | T | A | I | A | S | . |
. |
. |
. |
. |
. |
I | A | K | R | A | D | E | V | Y | F | L | K | E | G | N | F | E | A | D | K | N | T | K | D | E | A | L | L | D | M | T | A | Q | V | L | A | Q | E | H | S | Q | P | Q | L |
Query Conservation |   |
|   |   |   |
|
|   |   |
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |   |   |   |   |
|   |   |   |   |   |   |
|   |
|
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
Template Conservation |   |
|   |   |   |
|   |   |   |
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   | . | . |   |   |   |   |
|   |   |
Template Sequence |   |
I | G | E | V | L | S | Q | H | G | L | R | Q | L | R | I | A | E | T | E | K | Y | P | H | V | T | F | F | M | S | G | G | R | E | E | E | F | P | G | E | D | R | I | L | I | N | S | P | K | V | P | T | Y | D | L | K | P | E | M | S | A | Y | E | V | T | D | A | L | L | K | E | I | . |
. |
E | A | D | K | Y | D | A |
Template Known Secondary structure |   |
 |  |  |  |  |  |  | T | T |
|
|  |  |  |  |  |  | G | G | G |  |  |  |  | T | T | T | T | T | T | S |
|
| S |
|
| T | T |  |  |  |  |  |  |
|
|
| S |
| S | S | G | G | G | S | T | T | T | T |  |  |  |  |  |  |  |  |  |  |  |  | . | . |  | T | T |
|
| S |  |
Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  | . | . |
|
|
|
|
|
|  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
317 | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | |
|
. | . | 390 | . | . | . | . |
  |
  |   |
359 | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
I | V | L | H | L | M | G | S | H | P | Q | A | C | D | R | T | Q | G | K | Y | E | T | F | V | Q | S | K | E | T | S | C | Y | L | Y | T | M | T | Q | T | D | D | L | L | R | K | L | Y | D | Q | L | R | N | S | G | S | S | F | S | L | V | Y | F | S | D | H | G | L | A | F | K | E | R | G | K | D | V | Q | Y | L | A |
Query Conservation |   |
  |   |   |   |   |   |   |   |
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |
|   |
|   |   |
|   |   |   |
|   |   |
|
|   |   |   |   |   |
|
|
|
|   |   |
|
|
|
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . |
|   |   |   |
|   |   |   |
|   |   |
|
|   |
|   |   |   |   |   |   | . | . |   |   |
|
|
|
|
|
|
|
|
|
|   |   |   |   |   |   |   | . | . | . | . |   |   |   |
Template Sequence |   |
I | I | L | N | Y | A | N | P | D | M | V | G | H | S | G | K | L | E | P | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
T | I | K | A | V | E | A | V | D | E | C | L | G | K | V | V | D | A | I | L | A | . |
. |
K | G | G | I | A | I | I | T | A | D | H | G | N | A | D | E | V | L | T | . |
. |
. |
. |
P | D | G |
Template Known Secondary structure |   |
 |  |  |  |  |
|  |  |  |  |  |  | T | T | T |
|  |  |  | . | . | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | T | T |
|  |  |  |  |  |
| S | S | B | S | T | T |
|
| B |
| . | . | . | . | T | T | S |
Template Predicted Secondary structure |   |
 |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  | . | . | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| . | . |
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
395 | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | |
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | |
|
. | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | |
|
|
|
. | . | . |
  |
  |   |
439 | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | . | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
H | D | D | K | Y | Q | Q | N | F | Q | V | P | F | M | V | I | S | S | D | D | K | A | H | R | V | I | K | A | R | R | S | A | N | D | F | L | G | F | F | S | Q | W | T | G | I | K | A | K | E | I | N | I | K | Y | P | F | I |
Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |
|
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |
|   |   |   |
|   |
|
|   |   |   |   |   |   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |
|
|
|
|
|   |   |
|   |   |   | . | . | . | . |   |   |   |   |   |   |   |   |
|
|
|
|
|
|
|   |
|
|
|   |   |   |
|   |   |   |   |
|   |
|
|
|
Template Sequence |   |
K | P | Q | T | A | H | T | T | N | P | V | P | V | I | V | T | K | K | G | I | K | . |
. |
. |
. |
L | R | D | G | G | I | L | G | D | L | A | P | T | M | L | D | L | L | G | L | P | Q | P | K | E | M | T | G | K | S | L | I |
Template Known Secondary structure |   |
| B |
|
| S |
| B |
|
|
|  |  |  |  |  |
|
| T | T |
|
| . | . | . | . | B |
| S | S |  |  | G | G | G |  |  |  |  |  |  |  |  |  | T |
|
|
|
| T | T |
|
|
|
|
| S | B |
Template Predicted Secondary structure |   |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|  | . | . | . | . |  |
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
457 | . | . | 460 | . | . | . | . | . | . | . | . | . | 470 | . | . | . | . | . | . | . | |
|
|
|
. | . | 480 | . | . | . | . | . | . | . | . | . | 490 | . | . | . | . | . | . | . | . | . | 500 | . | . | . | . | . | . | . | . | . |
  |