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Job DescriptionP26648
Confidence100.00%DateThu Jan 5 11:43:06 GMT 2012
Rank17Aligned Residues374
% Identity18%Templatec3cdzA_
PDB info PDB header:blood clottingChain: A: PDB Molecule:coagulation factor viii heavy chain; PDBTitle: crystal structure of human factor viii
Resolution3.98 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   71........80.........90.........100.........110...... .. .120.........130.......
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Query Sequence  NGRYLGPTIRVWKGDDVKLIYSNRLTENVSMTVAGLQVPGPLMGGP. . . . . . . . . AR. . MMSPNADWAPVLPIRQNAA. .
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Template Sequence  WMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPM
Template Known Secondary structure  S

S
TT

B
SSS



B
SSSB

TTS

B
S




TTS


TT





GGGS

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   68.70.........80.........90.........100.........110.........120.........130.........140.......
 
   138.140.........150.........160.........170.........180.........190.........200.........210
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Query Sequence  . . . . . . . TLWYHANTPNRTAQQVYNGLAGMWLVEDEVSKSLPIPNHYGVDDFPVIIQDKRLDNFGTPEYNEPGSGGFVGD
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Template Sequence  ASDPLCLTYSYLSHVD. . LVKDLNSGLIGALLVCREGSLAKEKTQT. . LHKFILLFAVFDEGKSWHSSARAWP. . . . . . K
Template Known Secondary structure  SSS
S

B
BSS..

SS
STTTSSS

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   148.150.........160... ......170.........180.........190. ........200.........210...... .
 
   211........ 220........ .230.........240.........250.......
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Query Sequence  TLLVNGVQS. . . PYVEVSRGW. VRLRLLNASNSRRYQLQMNDGRPLHVISG. . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Sequence  MHTVNGYVNRSLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLLMDLGQFLLFC
Template Known Secondary structure 


GGG

TT







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SS







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SSS


SS



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SS






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   231........240.........250.........260.........270.........280.........290.........300.........310
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                                                                                 
Template Sequence  HISSHQHDGMEAYVKVDSCPEEPKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYTD
Template Known Secondary structure 

TT










SS







SS
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SSSSTTTT
S
SSS

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SS
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   311........320.........330.........340.........350.........360.........370.........380.........390
 
   258.260.........270.........280...
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . DQGFLPAPVSVKQLSLAPGERREILV
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Template Conservation                   
      
        
                                   
 
        
Template Sequence  ETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKW
Template Known Secondary structure  SSTTSB



TTTTT



TT
SSS



S
SSS
S

STT
SSSSSS


SS
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   434.....440.........450.........460.........470.........480.........490.........500.........510...
 
   284.....290 .........300.........310.........320.........330.. .......340
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Query Sequence  DMSNGDE. . . . . . . . . VSITCGEAASIVDRIRGFFEPSSILVSTLVLTLRPTGLLPLV. . . . . . . . . . . . . . TDSLPMRL
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Template Conservation                                                                                  
Template Sequence  TVTVEDGPTKSDPRCLTRYYSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQR
Template Known Secondary structure 

GGGS

SSS
S

SSSTTT



SSSSSS
SS




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   514.....520.........530.........540.........550.........560.........570.........580.........590...
 
   341........350.........360.........370.........380.........390 .........400.........410......
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Query Sequence  LPTEIMAGSPIRSRDISLGDDPGINGQLWDVNRIDVTAQQGTWERWTVRA. . . . DEPQAFHIEGVMFQIRNVNGAMPFPE
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Template Sequence  FLPNPAGVQLEDPEFQASNIMHSINGYVFD. . SLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKH. . . . . . . . . . .
Template Known Secondary structure  TSS

TT


S
TSTTB
TT..
S

B

TT
S

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SS

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   594.....600.........610.........620... ......630.........640.........650.........660
 
   417..420.........430.........440.........450.........460.........
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Query Sequence  DRGWKDTVWVDGQVELLVYFGQPSWAHFPFYFNSQTLEMADRGSIGQLLVNPV
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Template Sequence  KMVYEDTLTLFPFSGETVFMSMENPGL. . WILGCHNSDFRNRGMTALLKVSSC
Template Known Secondary structure  TTS
BS

SS




S
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BS
TTTTTSB



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   661........670.........680....... ..690.........700.........710.
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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