Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	T	L	S	P	A	V	I	T	L	L	W	R	Q	D	A	A	E	F	Y	F	S	R	L	S	H	L	P	W	A	M	L	L	H	S	G	Y	A	D	H	P	Y	S	R	F	D	I	V	V	A	E	P	I	C	T	L	T	T	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																																?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	K	E	T	V	V	S	E	S	E	K	R	T	T	T	T	D	D	P	L	Q	V	L	Q	Q	V	L	D	R	A	D	I	R	P	T	H	N	E	D	L	P	F	Q	G	G	A	L	G	L	F	G	Y	D	L	G	R	R	F	E	S
Secondary structure
SS confidence
Disorder												?	?	?	?																		?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	P	E	I	A	E	Q	D	I	V	L	P	D	M	A	V	G	I	Y	D	W	A	L	I	V	D	H	Q	R	H	T	V	S	L	L	S	H	N	D	V	N	A	R	R	A	W	L	E	S	Q	Q	F	S	P	Q	E	D	F	T	L
Secondary structure
SS confidence
Disorder							?																																										?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	S	D	W	Q	S	N	M	T	R	E	Q	Y	G	E	K	F	R	Q	V	Q	E	Y	L	H	S	G	D	C	Y	Q	V	N	L	A	Q	R	F	H	A	T	Y	S	G	D	E	W	Q	A	F	L	Q	L	N	Q	A	N	R	A	P
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	S	A	F	L	R	L	E	Q	G	A	I	L	S	L	S	P	E	R	F	I	L	C	D	N	S	E	I	Q	T	R	P	I	K	G	T	L	P	R	L	P	D	P	Q	E	D	S	K	Q	A	V	K	L	A	N	S	A	K	D	R
Secondary structure
SS confidence
Disorder																																										?	?												?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	E	N	L	M	I	V	D	L	M	R	N	D	I	G	R	V	A	V	A	G	S	V	K	V	P	E	L	F	V	V	E	P	F	P	A	V	H	H	L	V	S	T	I	T	A	Q	L	P	E	Q	L	H	A	S	D	L	L	R	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		A	F	P	G	G	S	I	T	G	A	P	K	V	R	A	M	E	I	I	D	E	L	E	P	Q	R	R	N	A	W	C	G	S	I	G	Y	L	S	F	C	G	N	M	D	T	S	I	T	I	R	T	L	T	A	I	N	G	Q	I	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.
Sequence		C	S	A	G	G	G	I	V	A	D	S	Q	E	E	A	E	Y	Q	E	T	F	D	K	V	N	R	I	L	K	Q	L	E	K
Secondary structure
SS confidence
Disorder																																	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1i1q chain A Region: 2 - 452 Aligned: 445 Modelled: 447 Confidence: 100.0% Identity: 27% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1i7q chain A Region: 4 - 452 Aligned: 443 Modelled: 449 Confidence: 100.0% Identity: 28% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1k0g chain A Region: 1 - 453 Aligned: 420 Modelled: 429 Confidence: 100.0% Identity: 100% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 1qdl chain A Region: 8 - 452 Aligned: 410 Modelled: 429 Confidence: 100.0% Identity: 32% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 2g5f chain A domain 1 Region: 9 - 451 Aligned: 422 Modelled: 441 Confidence: 100.0% Identity: 20% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 2i6y chain A Region: 9 - 451 Aligned: 408 Modelled: 443 Confidence: 100.0% Identity: 21% PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i, putative; PDBTitle: structure and mechanism of mycobacterium tuberculosis salicylate2 synthase, mbti Phyre2 PDB 2fn0 chain A domain 1 Region: 8 - 451 Aligned: 400 Modelled: 420 Confidence: 100.0% Identity: 20% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3h9m chain A Region: 12 - 452 Aligned: 386 Modelled: 398 Confidence: 100.0% Identity: 28% PDB header:lyase Chain: A: PDB Molecule:p-aminobenzoate synthetase, component i; PDBTitle: crystal structure of para-aminobenzoate synthetase,2 component i from cytophaga hutchinsonii Phyre2 PDB 3os6 chain A Region: 33 - 451 Aligned: 358 Modelled: 367 Confidence: 100.0% Identity: 25% PDB header:isomerase Chain: A: PDB Molecule:isochorismate synthase dhbc; PDBTitle: crystal structure of putative 2,3-dihydroxybenzoate-specific2 isochorismate synthase, dhbc from bacillus anthracis. Phyre2 PDB 3hwo chain B Region: 48 - 451 Aligned: 365 Modelled: 367 Confidence: 100.0% Identity: 22% PDB header:isomerase Chain: B: PDB Molecule:isochorismate synthase entc; PDBTitle: crystal structure of escherichia coli enterobactin-specific2 isochorismate synthase entc in complex with isochorismate Phyre2 PDB 3bzn chain A domain 1 Region: 2 - 452 Aligned: 395 Modelled: 409 Confidence: 100.0% Identity: 19% Fold: ADC synthase Superfamily: ADC synthase Family: ADC synthase Phyre2 PDB 3r74 chain B Region: 96 - 451 Aligned: 351 Modelled: 356 Confidence: 100.0% Identity: 17% PDB header:lyase, biosynthetic protein Chain: B: PDB Molecule:anthranilate/para-aminobenzoate synthases component i; PDBTitle: crystal structure of 2-amino-2-desoxyisochorismate synthase (adic)2 synthase phze from burkholderia lata 383 Phyre2 PDB 3gse chain A Region: 17 - 447 Aligned: 377 Modelled: 399 Confidence: 100.0% Identity: 22% PDB header:isomerase Chain: A: PDB Molecule:menaquinone-specific isochorismate synthase; PDBTitle: crystal structure of menaquinone-specific isochorismate synthase from2 yersinia pestis co92 Phyre2 PDB 3nqk chain A Region: 388 - 424 Aligned: 37 Modelled: 37 Confidence: 35.2% Identity: 27% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a structural genomics, unknown function2 (bacova_03322) from bacteroides ovatus at 2.61 a resolution Phyre2 PDB 1cvr chain A domain 1 Region: 390 - 432 Aligned: 38 Modelled: 43 Confidence: 34.2% Identity: 24% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Gingipain R (RgpB), C-terminal domain Phyre2 PDB 1wqk chain A Region: 384 - 397 Aligned: 13 Modelled: 14 Confidence: 32.5% Identity: 46% PDB header:toxin Chain: A: PDB Molecule:toxin apetx1; PDBTitle: solution structure of apetx1, a specific peptide inhibitor2 of human ether-a-go-go-related gene potassium channels3 from the venom of the sea anemone anthopleura4 elegantissima: a new fold for an herg toxin Phyre2 PDB 1ugp chain A Region: 285 - 341 Aligned: 43 Modelled: 57 Confidence: 22.1% Identity: 23% Fold: Nitrile hydratase alpha chain Superfamily: Nitrile hydratase alpha chain Family: Nitrile hydratase alpha chain Phyre2 PDB 2qdy chain A domain 1 Region: 285 - 341 Aligned: 43 Modelled: 57 Confidence: 19.7% Identity: 12% Fold: Nitrile hydratase alpha chain Superfamily: Nitrile hydratase alpha chain Family: Nitrile hydratase alpha chain Phyre2 PDB 2k27 chain A Region: 266 - 323 Aligned: 52 Modelled: 58 Confidence: 16.7% Identity: 19% PDB header:transcription regulator Chain: A: PDB Molecule:paired box protein pax-8; PDBTitle: solution structure of human pax8 paired box domain Phyre2 PDB 2npb chain A Region: 390 - 452 Aligned: 61 Modelled: 63 Confidence: 14.3% Identity: 20% PDB header:oxidoreductase Chain: A: PDB Molecule:selenoprotein w; PDBTitle: nmr solution structure of mouse selw Phyre2 1 d1i1qa_ 2 d1i7qa_ 3 d1k0ga_ 4 d1qdla_ 5 d2g5fa1 6 c2i6yA_ 7 d2fn0a1 8 c3h9mA_ 9 c3os6A_ 10 c3hwoB_ 11 d3bzna1 12 c3r74B_ 13 c3gseA_ 14 c3nqkA_ 15 d1cvra1 16 c1wqkA_ 17 d1ugpa_ 18 d2qdya1 19 c2k27A_ 20 c2npbA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1i1qa_ 100.0 27 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 2 d1i7qa_ 100.0 28 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 3 d1k0ga_ 100.0 100 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 4 d1qdla_ 100.0 32 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 5 d2g5fa1 100.0 20 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 6 c2i6yA_ 100.0 21 PDB header:lyase Chain: A: PDB Molecule:anthranilate synthase component i, putative; PDBTitle: structure and mechanism of mycobacterium tuberculosis salicylate2 synthase, mbti 7 d2fn0a1 100.0 20 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 8 c3h9mA_ 100.0 28 PDB header:lyase Chain: A: PDB Molecule:p-aminobenzoate synthetase, component i; PDBTitle: crystal structure of para-aminobenzoate synthetase,2 component i from cytophaga hutchinsonii 9 c3os6A_ 100.0 25 PDB header:isomerase Chain: A: PDB Molecule:isochorismate synthase dhbc; PDBTitle: crystal structure of putative 2,3-dihydroxybenzoate-specific2 isochorismate synthase, dhbc from bacillus anthracis. 10 c3hwoB_ 100.0 22 PDB header:isomerase Chain: B: PDB Molecule:isochorismate synthase entc; PDBTitle: crystal structure of escherichia coli enterobactin-specific2 isochorismate synthase entc in complex with isochorismate 11 d3bzna1 100.0 19 Fold:ADC synthase Superfamily:ADC synthase Family:ADC synthase 12 c3r74B_ 100.0 17 PDB header:lyase, biosynthetic protein Chain: B: PDB Molecule:anthranilate/para-aminobenzoate synthases component i; PDBTitle: crystal structure of 2-amino-2-desoxyisochorismate synthase (adic)2 synthase phze from burkholderia lata 383 13 c3gseA_ 100.0 22 PDB header:isomerase Chain: A: PDB Molecule:menaquinone-specific isochorismate synthase; PDBTitle: crystal structure of menaquinone-specific isochorismate synthase from2 yersinia pestis co92 14 c3nqkA_ 35.2 27 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a structural genomics, unknown function2 (bacova_03322) from bacteroides ovatus at 2.61 a resolution 15 d1cvra1 34.2 24 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Gingipain R (RgpB), C-terminal domain 16 c1wqkA_ 32.5 46 PDB header:toxin Chain: A: PDB Molecule:toxin apetx1; PDBTitle: solution structure of apetx1, a specific peptide inhibitor2 of human ether-a-go-go-related gene potassium channels3 from the venom of the sea anemone anthopleura4 elegantissima: a new fold for an herg toxin 17 d1ugpa_ 22.1 23 Fold:Nitrile hydratase alpha chain Superfamily:Nitrile hydratase alpha chain Family:Nitrile hydratase alpha chain 18 d2qdya1 19.7 12 Fold:Nitrile hydratase alpha chain Superfamily:Nitrile hydratase alpha chain Family:Nitrile hydratase alpha chain 19 c2k27A_ 16.7 19 PDB header:transcription regulator Chain: A: PDB Molecule:paired box protein pax-8; PDBTitle: solution structure of human pax8 paired box domain 20 c2npbA_ 14.3 20 PDB header:oxidoreductase Chain: A: PDB Molecule:selenoprotein w; PDBTitle: nmr solution structure of mouse selw 21 c3c8lB_ not modelled 12.9 23 PDB header:unknown function Chain: B: PDB Molecule:ftsz-like protein of unknown function; PDBTitle: crystal structure of a ftsz-like protein of unknown function2 (npun_r1471) from nostoc punctiforme pcc 73102 at 1.22 a resolution 22 c2xt6B_ not modelled 12.8 23 PDB header:lyase Chain: B: PDB Molecule:2-oxoglutarate decarboxylase; PDBTitle: crystal structure of mycobacterium smegmatis alpha-ketoglutarate2 decarboxylase homodimer (orthorhombic form) 23 d1rp3b_ not modelled 12.5 12 Fold:Non-globular all-alpha subunits of globular proteins Superfamily:Anti-sigma factor FlgM Family:Anti-sigma factor FlgM 24 c2jo8B_ not modelled 10.5 35 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase 4; PDBTitle: solution structure of c-terminal domain of human mammalian2 sterile 20-like kinase 1 (mst1) 25 d1v29a_ not modelled 10.4 24 Fold:Nitrile hydratase alpha chain Superfamily:Nitrile hydratase alpha chain Family:Nitrile hydratase alpha chain 26 d1qusa_ not modelled 8.8 23 Fold:Lysozyme-like Superfamily:Lysozyme-like Family:Bacterial muramidase, catalytic domain 27 c1t2bA_ not modelled 8.8 11 PDB header:unknown function Chain: A: PDB Molecule:p450cin; PDBTitle: crystal structure of cytochrome p450cin complexed with its2 substrate 1,8-cineole 28 c2kztA_ not modelled 8.4 20 PDB header:apoptosis Chain: A: PDB Molecule:programmed cell death protein 4; PDBTitle: structure of the tandem ma-3 region of pdcd4 29 c2gutA_ not modelled 8.1 17 PDB header:transcription Chain: A: PDB Molecule:arc/mediator, positive cofactor 2 glutamine/q- PDBTitle: solution structure of the trans-activation domain of the2 human co-activator arc105 30 c2km1A_ not modelled 8.0 22 PDB header:protein binding Chain: A: PDB Molecule:protein dre2; PDBTitle: solution structure of the n-terminal domain of the yeast protein dre2 31 c2jgdA_ not modelled 7.6 38 PDB header:oxidoreductase Chain: A: PDB Molecule:2-oxoglutarate dehydrogenase e1 component; PDBTitle: e. coli 2-oxoglutarate dehydrogenase (e1o) 32 c3qyhG_ not modelled 7.2 21 PDB header:lyase Chain: G: PDB Molecule:co-type nitrile hydratase alpha subunit; PDBTitle: crystal structure of co-type nitrile hydratase beta-h71l from2 pseudomonas putida. 33 d1eyba_ not modelled 7.1 22 Fold:Double-stranded beta-helix Superfamily:RmlC-like cupins Family:Homogentisate dioxygenase 34 c1ey2A_ not modelled 7.1 22 PDB header:oxidoreductase Chain: A: PDB Molecule:homogentisate 1,2-dioxygenase; PDBTitle: human homogentisate dioxygenase with fe(ii) 35 c2crqA_ not modelled 7.0 24 PDB header:translation Chain: A: PDB Molecule:mitochondrial translational initiation factor 3; PDBTitle: solution structure of c-terminal domain of riken cdna2 2810012l14 36 c2qkdA_ not modelled 6.7 20 PDB header:signaling protein, cell cycle Chain: A: PDB Molecule:zinc finger protein zpr1; PDBTitle: crystal structure of tandem zpr1 domains 37 c2rg8A_ not modelled 6.6 20 PDB header:apoptosis, translation Chain: A: PDB Molecule:programmed cell death protein 4; PDBTitle: crystal structure of programmed for cell death 4 middle ma32 domain 38 c3mgxB_ not modelled 6.2 11 PDB header:oxidoreductase Chain: B: PDB Molecule:putative p450 monooxygenase; PDBTitle: crystal structure of p450 oxyd that is involved in the biosynthesis of2 vancomycin-type antibiotics 39 c3rrrB_ not modelled 5.9 33 PDB header:viral protein Chain: B: PDB Molecule:fusion glycoprotein f0; PDBTitle: structure of the rsv f protein in the post-fusion conformation 40 c1wxnA_ not modelled 5.9 38 PDB header:toxin Chain: A: PDB Molecule:toxin apetx2; PDBTitle: solution structure of apetx2, a specific peptide inhibitor2 of asic3 proton-gated channels 41 c3f8tA_ not modelled 5.8 16 PDB header:hydrolase Chain: A: PDB Molecule:predicted atpase involved in replication control, PDBTitle: crystal structure analysis of a full-length mcm homolog2 from methanopyrus kandleri 42 c3dupB_ not modelled 5.5 22 PDB header:hydrolase Chain: B: PDB Molecule:mutt/nudix family protein; PDBTitle: crystal structure of mutt/nudix family hydrolase from rhodospirillum2 rubrum atcc 11170 43 d1tiga_ not modelled 5.4 15 Fold:IF3-like Superfamily:Translation initiation factor IF3, C-terminal domain Family:Translation initiation factor IF3, C-terminal domain 44 c2yicC_ not modelled 5.2 31 PDB header:lyase Chain: C: PDB Molecule:2-oxoglutarate decarboxylase; PDBTitle: crystal structure of the suca domain of mycobacterium smegmatis2 alpha-ketoglutarate decarboxylase (triclinic form) 45 c2zp2B_ not modelled 5.1 11 PDB header:transferase inhibitor Chain: B: PDB Molecule:kinase a inhibitor; PDBTitle: c-terminal domain of kipi from bacillus subtilis 46 c2hlwA_ not modelled 5.1 15 PDB header:ligase, signaling protein Chain: A: PDB Molecule:ubiquitin-conjugating enzyme e2 variant 1; PDBTitle: solution structure of the human ubiquitin-conjugating2 enzyme variant uev1a

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0