Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	L	F	N	W	R	R	Q	A	V	L	N	A	M	P	L	V	K	P	D	Q	V	R	T	P	W	H	E	F	W	R	R	F	R	R	Q	H	M	A	M	T	A	A	L	F	V	I	L	L	I	V	V	A	I	F	A	R	W	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	P	Y	D	A	E	N	Y	F	D	Y	D	N	L	N	N	G	P	S	L	Q	H	W	F	G	V	D	S	L	G	R	D	I	F	S	R	V	L	V	G	A	Q	I	S	L	A	A	G	V	F	A	V	F	I	G	A	A	I	G	T
Secondary structure
SS confidence
Disorder									?								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	L	G	L	L	A	G	Y	Y	E	G	W	W	D	R	L	I	M	R	I	C	D	V	L	F	A	F	P	G	I	L	L	A	I	A	V	V	A	V	L	G	S	G	I	A	N	V	I	I	A	V	A	I	F	S	I	P	A	F	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	L	V	R	G	N	T	L	V	L	K	Q	Q	T	F	I	E	S	A	R	S	I	G	A	S	D	M	T	V	L	L	R	H	I	L	P	G	T	V	S	S	I	V	V	F	F	T	M	R	I	G	T	S	I	I	S	A	A	S	L
Secondary structure
SS confidence
Disorder												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		S	F	L	G	L	G	A	Q	P	P	T	P	E	W	G	A	M	L	N	E	A	R	A	D	M	V	I	A	P	H	V	A	V	F	P	A	L	A	I	F	L	T	V	L	A	F	N	L	L	G	D	G	L	R	D	A	L	D	P	K
Secondary structure
SS confidence
Disorder																																																												?	?
Disorder confidence
		.	.	.
Sequence		I	K	G
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3dhw chain A domain 1 Region: 97 - 291 Aligned: 187 Modelled: 195 Confidence: 99.9% Identity: 21% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2onk chain C Region: 33 - 293 Aligned: 235 Modelled: 242 Confidence: 99.9% Identity: 16% PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda Phyre2 PDB 2onk chain C domain 1 Region: 33 - 293 Aligned: 235 Modelled: 242 Confidence: 99.9% Identity: 16% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3d31 chain D Region: 95 - 289 Aligned: 188 Modelled: 194 Confidence: 99.8% Identity: 21% PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease PDBTitle: modbc from methanosarcina acetivorans Phyre2 PDB 3d31 chain C domain 1 Region: 95 - 289 Aligned: 188 Modelled: 194 Confidence: 99.8% Identity: 21% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain F domain 2 Region: 78 - 289 Aligned: 208 Modelled: 212 Confidence: 99.8% Identity: 13% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3fh6 chain F Region: 28 - 291 Aligned: 264 Modelled: 264 Confidence: 99.8% Identity: 13% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 2r6g chain G domain 1 Region: 32 - 291 Aligned: 257 Modelled: 260 Confidence: 99.8% Identity: 15% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain F Region: 97 - 289 Aligned: 192 Modelled: 193 Confidence: 99.8% Identity: 18% PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter Phyre2 PDB 1wz4 chain A Region: 296 - 303 Aligned: 8 Modelled: 8 Confidence: 36.6% Identity: 50% PDB header:gene regulation Chain: A: PDB Molecule:major surface antigen; PDBTitle: solution conformation of adr subtype hbv pre-s2 epitope Phyre2 PDB 2jwa chain A Region: 103 - 135 Aligned: 33 Modelled: 33 Confidence: 34.7% Identity: 15% PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: erbb2 transmembrane segment dimer spatial structure Phyre2 PDB 1umq chain A Region: 181 - 212 Aligned: 32 Modelled: 32 Confidence: 13.1% Identity: 13% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1umq chain A Region: 181 - 212 Aligned: 32 Modelled: 32 Confidence: 13.1% Identity: 13% PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity Phyre2 PDB 1ntc chain A Region: 181 - 212 Aligned: 32 Modelled: 32 Confidence: 10.5% Identity: 25% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1fip chain A Region: 181 - 213 Aligned: 33 Modelled: 33 Confidence: 10.1% Identity: 9% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 2cw1 chain A Region: 185 - 205 Aligned: 19 Modelled: 21 Confidence: 9.9% Identity: 32% PDB header:de novo protein Chain: A: PDB Molecule:sn4m; PDBTitle: solution structure of the de novo-designed lambda cro fold2 protein Phyre2 PDB 1eto chain B Region: 181 - 213 Aligned: 33 Modelled: 33 Confidence: 9.3% Identity: 9% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1p7b chain A domain 2 Region: 16 - 131 Aligned: 113 Modelled: 116 Confidence: 9.1% Identity: 8% Fold: Voltage-gated potassium channels Superfamily: Voltage-gated potassium channels Family: Voltage-gated potassium channels Phyre2 PDB 2voy chain B Region: 14 - 54 Aligned: 40 Modelled: 41 Confidence: 8.7% Identity: 10% PDB header:hydrolase Chain: B: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus Phyre2 PDB 1p7b chain B Region: 18 - 133 Aligned: 116 Modelled: 116 Confidence: 8.5% Identity: 7% PDB header:metal transport Chain: B: PDB Molecule:integral membrane channel and cytosolic domains; PDBTitle: crystal structure of an inward rectifier potassium channel Phyre2 1 d3dhwa1 2 c2onkC_ 3 d2onkc1 4 c3d31D_ 5 d3d31c1 6 d2r6gf2 7 c3fh6F_ 8 d2r6gg1 9 c2r6gF_ 10 c1wz4A_ 11 c2jwaA_ 12 d1umqa_ 13 c1umqA_ 14 d1ntca_ 15 d1fipa_ 16 c2cw1A_ 17 d1etob_ 18 d1p7ba2 19 c2voyB_ 20 c1p7bB_ 21 22 23 24 25 26 27 28 29 30

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d3dhwa1 99.9 21 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 2 c2onkC_ 99.9 16 PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda 3 d2onkc1 99.9 16 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 4 c3d31D_ 99.8 21 PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease PDBTitle: modbc from methanosarcina acetivorans 5 d3d31c1 99.8 21 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 6 d2r6gf2 99.8 13 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 7 c3fh6F_ 99.8 13 PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli 8 d2r6gg1 99.8 15 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 9 c2r6gF_ 99.8 18 PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter 10 c1wz4A_ 36.6 50 PDB header:gene regulation Chain: A: PDB Molecule:major surface antigen; PDBTitle: solution conformation of adr subtype hbv pre-s2 epitope 11 c2jwaA_ 34.7 15 PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: erbb2 transmembrane segment dimer spatial structure 12 d1umqa_ 13.1 13 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 13 c1umqA_ 13.1 13 PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity 14 d1ntca_ 10.5 25 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 15 d1fipa_ 10.1 9 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 16 c2cw1A_ 9.9 32 PDB header:de novo protein Chain: A: PDB Molecule:sn4m; PDBTitle: solution structure of the de novo-designed lambda cro fold2 protein 17 d1etob_ 9.3 9 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 18 d1p7ba2 9.1 8 Fold:Voltage-gated potassium channels Superfamily:Voltage-gated potassium channels Family:Voltage-gated potassium channels 19 c2voyB_ 8.7 10 PDB header:hydrolase Chain: B: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus 20 c1p7bB_ 8.5 7 PDB header:metal transport Chain: B: PDB Molecule:integral membrane channel and cytosolic domains; PDBTitle: crystal structure of an inward rectifier potassium channel 21 d1g2ha_ not modelled 8.3 19 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 22 c2jpwA_ not modelled 7.8 21 PDB header:contractile protein Chain: A: PDB Molecule:troponin i, cardiac muscle; PDBTitle: solution structure of the bisphosphorylated cardiac2 specific n-extension of cardiac troponin i 23 d2axtk1 not modelled 6.6 31 Fold:Single transmembrane helix Superfamily:Photosystem II reaction center protein K, PsbK Family:PsbK-like 24 d2auwa1 not modelled 6.5 11 Fold:lambda repressor-like DNA-binding domains Superfamily:lambda repressor-like DNA-binding domains Family:NE0471 C-terminal domain-like 25 d1etxa_ not modelled 6.2 9 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 26 c3a0bk_ not modelled 6.1 28 PDB header:electron transport Chain: K: PDB Molecule:photosystem ii reaction center protein k; PDBTitle: crystal structure of br-substituted photosystem ii complex 27 c3a0bK_ not modelled 6.1 28 PDB header:electron transport Chain: K: PDB Molecule:photosystem ii reaction center protein k; PDBTitle: crystal structure of br-substituted photosystem ii complex 28 d1pjqa3 not modelled 5.9 34 Fold:Siroheme synthase middle domains-like Superfamily:Siroheme synthase middle domains-like Family:Siroheme synthase middle domains-like 29 d2bs2c1 not modelled 5.8 15 Fold:Heme-binding four-helical bundle Superfamily:Fumarate reductase respiratory complex transmembrane subunits Family:Fumarate reductase respiratory complex cytochrome b subunit, FrdC 30 c3e7lD_ not modelled 5.6 13 PDB header:transcription regulator Chain: D: PDB Molecule:transcriptional regulator (ntrc family); PDBTitle: crystal structure of sigma54 activator ntrc4's dna binding2 domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0