Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	S	M	N	I	A	A	S	S	E	L	V	S	R	L	S	S	H	R	R	V	V	A	L	G	D	T	D	F	T	D	V	A	A	V	V	I	T	A	A	D	S	R	S	G	I	L	A	L	L	K	R	T	G	F	H	L	P	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	L	Y	S	E	H	A	V	E	L	P	A	G	V	T	A	V	I	N	G	N	E	Q	Q	W	L	E	L	E	S	A	A	C	Q	Y	E	E	N	L	L	P	P	F	Y	D	T	L	T	Q	Y	V	E	M	G	N	S	T	F	A	C
Secondary structure
SS confidence
Disorder							?		?		?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	G	H	Q	H	G	A	F	F	K	K	H	P	A	G	R	H	F	Y	D	F	F	G	E	N	V	F	R	A	D	M	C	N	A	D	V	K	L	G	D	L	L	I	H	E	G	S	A	K	D	A	Q	K	F	A	A	K	V	F	H
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	D	K	T	Y	F	V	L	N	G	T	S	A	A	N	K	V	V	T	N	A	L	L	T	R	G	D	L	V	L	F	D	R	N	N	H	K	S	N	H	H	G	A	L	I	Q	A	G	A	T	P	V	Y	L	E	A	S	R	N	P
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		F	G	F	I	G	G	I	D	A	H	C	F	N	E	E	Y	L	R	Q	Q	I	R	D	V	A	P	E	K	A	D	L	P	R	P	Y	R	L	A	I	I	Q	L	G	T	Y	D	G	T	V	Y	N	A	R	Q	V	I	D	T	V	G
Secondary structure
SS confidence
Disorder										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		H	L	C	D	Y	I	L	F	D	S	A	W	V	G	Y	E	Q	F	I	P	M	M	A	D	S	S	P	L	L	L	E	L	N	E	N	D	P	G	I	F	V	T	Q	S	V	H	K	Q	Q	A	G	F	S	Q	T	S	Q	I	H	K
Secondary structure
SS confidence
Disorder																									?	?	?	?																				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		K	D	N	H	I	R	G	Q	A	R	F	C	P	H	K	R	L	N	N	A	F	M	L	H	A	S	T	S	P	F	Y	P	L	F	A	A	L	D	V	N	A	K	I	H	E	G	E	S	G	R	R	L	W	A	E	C	V	E	I	G
Secondary structure
SS confidence
Disorder				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		I	E	A	R	K	A	I	L	A	R	C	K	L	F	R	P	F	I	P	P	V	V	D	G	K	L	W	Q	D	Y	P	T	S	V	L	A	S	D	R	R	F	F	S	F	E	P	G	A	K	W	H	G	F	E	G	Y	A	A	D	Q
Secondary structure
SS confidence
Disorder															?						?	?	?	?	?	?			?																			?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		Y	F	V	D	P	C	K	L	L	L	T	T	P	G	I	D	A	E	T	G	E	Y	S	D	F	G	V	P	A	T	I	L	A	H	Y	L	R	E	N	G	I	V	P	E	K	C	D	L	N	S	I	L	F	L	L	T	P	A	E	S
Secondary structure
SS confidence
Disorder																		?		?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600
Sequence		H	E	K	L	A	Q	L	V	A	M	L	A	Q	F	E	Q	H	I	E	D	D	S	P	L	V	E	V	L	P	S	V	Y	N	K	Y	P	V	R	Y	R	D	Y	T	L	R	Q	L	C	Q	E	M	H	D	L	Y	V	S	F	D	V
Secondary structure
SS confidence
Disorder																						?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?								?						?	?			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660
Sequence		K	D	L	Q	K	A	M	F	R	Q	Q	S	F	P	S	V	V	M	N	P	Q	D	A	H	S	A	Y	I	R	G	D	V	E	L	V	R	I	R	D	A	E	G	R	I	A	A	E	G	A	L	P	Y	P	P	G	V	L	C	V	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?		?																?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.
Sequence		P	G	E	V	W	G	G	A	V	Q	R	Y	F	L	A	L	E	E	G	V	N	L	L	P	G	F	S	P	E	L	Q	G	V	Y	S	E	T	D	A	D	G	V	K	R	L	Y	G	Y	V	L	K
Secondary structure
SS confidence
Disorder																																																				?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1c4k chain A Region: 2 - 711 Aligned: 707 Modelled: 710 Confidence: 100.0% Identity: 54% PDB header:lyase Chain: A: PDB Molecule:protein (ornithine decarboxylase); PDBTitle: ornithine decarboxylase mutant (gly121tyr) Phyre2 PDB 2vyc chain A Region: 29 - 711 Aligned: 668 Modelled: 683 Confidence: 100.0% Identity: 32% PDB header:lyase Chain: A: PDB Molecule:biodegradative arginine decarboxylase; PDBTitle: crystal structure of acid induced arginine decarboxylase2 from e. coli Phyre2 PDB 3n75 chain E Region: 29 - 711 Aligned: 641 Modelled: 654 Confidence: 100.0% Identity: 34% PDB header:lyase Chain: E: PDB Molecule:lysine decarboxylase, inducible; PDBTitle: x-ray crystal structure of the escherichia coli inducible lysine2 decarboxylase ldci Phyre2 PDB 1c4k chain A domain 2 Region: 101 - 561 Aligned: 458 Modelled: 461 Confidence: 100.0% Identity: 62% Fold: PLP-dependent transferase-like Superfamily: PLP-dependent transferases Family: Ornithine decarboxylase major domain Phyre2 PDB 2x3l chain A Region: 102 - 685 Aligned: 409 Modelled: 447 Confidence: 100.0% Identity: 23% PDB header:lyase Chain: A: PDB Molecule:orn/lys/arg decarboxylase family protein; PDBTitle: crystal structure of the orn_lys_arg decarboxylase family2 protein sar0482 from methicillin-resistant staphylococcus3 aureus Phyre2 PDB 1rv3 chain A Region: 169 - 657 Aligned: 363 Modelled: 402 Confidence: 100.0% Identity: 17% Fold: PLP-dependent transferase-like Superfamily: PLP-dependent transferases Family: GABA-aminotransferase-like Phyre2 PDB 1bj4 chain A Region: 171 - 656 Aligned: 361 Modelled: 399 Confidence: 100.0% Identity: 16% Fold: PLP-dependent transferase-like Superfamily: PLP-dependent transferases Family: GABA-aminotransferase-like Phyre2 PDB 1eji chain A Region: 79 - 657 Aligned: 445 Modelled: 491 Confidence: 100.0% Identity: 14% Fold: PLP-dependent transferase-like Superfamily: PLP-dependent transferases Family: GABA-aminotransferase-like Phyre2 PDB 2z67 chain A domain 1 Region: 172 - 554 Aligned: 311 Modelled: 349 Confidence: 100.0% Identity: 11% Fold: PLP-dependent transferase-like Superfamily: PLP-dependent transferases Family: SepSecS-like Phyre2 PDB 2a7v chain A domain 1 Region: 171 - 656 Aligned: 329 Modelled: 362 Confidence: 100.0% Identity: 23% Fold: PLP-dependent transferase-like Superfamily: PLP-dependent transferases Family: GABA-aminotransferase-like Phyre2 PDB 2a7v chain A Region: 171 - 656 Aligned: 329 Modelled: 362 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:serine hydroxymethyltransferase; PDBTitle: human mitochondrial serine hydroxymethyltransferase 2 Phyre2 PDB 1c4k chain A domain 3 Region: 562 - 711 Aligned: 149 Modelled: 150 Confidence: 100.0% Identity: 46% Fold: Ornithine decarboxylase C-terminal domain Superfamily: Ornithine decarboxylase C-terminal domain Family: Ornithine decarboxylase C-terminal domain Phyre2 PDB 3hl2 chain D Region: 103 - 560 Aligned: 368 Modelled: 411 Confidence: 100.0% Identity: 13% PDB header:transferase Chain: D: PDB Molecule:o-phosphoseryl-trna(sec) selenium transferase; PDBTitle: the crystal structure of the human sepsecs-trnasec complex Phyre2 PDB 3h7f chain B Region: 169 - 576 Aligned: 322 Modelled: 372 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: B: PDB Molecule:serine hydroxymethyltransferase 1; PDBTitle: crystal structure of serine hydroxymethyltransferase from2 mycobacterium tuberculosis Phyre2 PDB 3bc8 chain A domain 1 Region: 169 - 562 Aligned: 336 Modelled: 360 Confidence: 100.0% Identity: 11% Fold: PLP-dependent transferase-like Superfamily: PLP-dependent transferases Family: SepSecS-like Phyre2 PDB 3ecd chain C Region: 167 - 574 Aligned: 297 Modelled: 337 Confidence: 100.0% Identity: 15% PDB header:transferase Chain: C: PDB Molecule:serine hydroxymethyltransferase 2; PDBTitle: crystal structure of serine hydroxymethyltransferase from burkholderia2 pseudomallei Phyre2 PDB 3n0l chain A Region: 171 - 573 Aligned: 298 Modelled: 339 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:serine hydroxymethyltransferase; PDBTitle: crystal structure of serine hydroxymethyltransferase from2 campylobacter jejuni Phyre2 PDB 1dfo chain A Region: 96 - 573 Aligned: 380 Modelled: 434 Confidence: 100.0% Identity: 18% Fold: PLP-dependent transferase-like Superfamily: PLP-dependent transferases Family: GABA-aminotransferase-like Phyre2 PDB 1kl1 chain A Region: 94 - 573 Aligned: 376 Modelled: 433 Confidence: 100.0% Identity: 17% Fold: PLP-dependent transferase-like Superfamily: PLP-dependent transferases Family: GABA-aminotransferase-like Phyre2 PDB 2dkj chain B Region: 167 - 576 Aligned: 319 Modelled: 359 Confidence: 100.0% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:serine hydroxymethyltransferase; PDBTitle: crystal structure of t.th.hb8 serine hydroxymethyltransferase Phyre2 1 c1c4kA_ 2 c2vycA_ 3 c3n75E_ 4 d1c4ka2 5 c2x3lA_ 6 d1rv3a_ 7 d1bj4a_ 8 d1ejia_ 9 d2z67a1 10 d2a7va1 11 c2a7vA_ 12 d1c4ka3 13 c3hl2D_ 14 c3h7fB_ 15 d3bc8a1 16 c3ecdC_ 17 c3n0lA_ 18 d1dfoa_ 19 d1kl1a_ 20 c2dkjB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419 420 421 422 423 424 425 426 427 428 429 430 431 432 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463