Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	H	T	L	H	R	S	P	W	L	T	D	F	A	A	L	L	R	L	L	S	E	G	D	E	L	L	L	L	Q	D	G	V	T	A	A	V	D	G	N	R	Y	L	E	S	L	R	N	A	P	I	K	V	Y	A	L	N	E	D
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.
Sequence		L	I	A	R	G	L	T	G	Q	I	S	N	D	I	I	L	I	D	Y	T	D	F	V	R	L	T	V	K	H	P	S	Q	M	A	W
Secondary structure
SS confidence
Disorder										?	?	?	?																		?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2d1p chain C domain 1 Region: 1 - 95 Aligned: 95 Modelled: 95 Confidence: 100.0% Identity: 100% Fold: DsrEFH-like Superfamily: DsrEFH-like Family: DsrH-like Phyre2 PDB 2hy5 chain C domain 1 Region: 1 - 95 Aligned: 95 Modelled: 95 Confidence: 100.0% Identity: 35% Fold: DsrEFH-like Superfamily: DsrEFH-like Family: DsrH-like Phyre2 PDB 1x9a chain A Region: 2 - 94 Aligned: 85 Modelled: 93 Confidence: 100.0% Identity: 28% Fold: DsrEFH-like Superfamily: DsrEFH-like Family: DsrH-like Phyre2 PDB 2d1p chain B domain 1 Region: 2 - 95 Aligned: 94 Modelled: 94 Confidence: 99.2% Identity: 20% Fold: DsrEFH-like Superfamily: DsrEFH-like Family: DsrEF-like Phyre2 PDB 1jx7 chain A Region: 1 - 95 Aligned: 95 Modelled: 95 Confidence: 98.7% Identity: 18% Fold: DsrEFH-like Superfamily: DsrEFH-like Family: DsrEF-like Phyre2 PDB 2hy5 chain B domain 1 Region: 2 - 95 Aligned: 94 Modelled: 94 Confidence: 98.7% Identity: 24% Fold: DsrEFH-like Superfamily: DsrEFH-like Family: DsrEF-like Phyre2 PDB 2hy5 chain A domain 1 Region: 2 - 94 Aligned: 93 Modelled: 93 Confidence: 98.6% Identity: 15% Fold: DsrEFH-like Superfamily: DsrEFH-like Family: DsrEF-like Phyre2 PDB 2d1p chain A domain 1 Region: 2 - 94 Aligned: 93 Modelled: 93 Confidence: 98.4% Identity: 14% Fold: DsrEFH-like Superfamily: DsrEFH-like Family: DsrEF-like Phyre2 PDB 3mc3 chain A Region: 1 - 95 Aligned: 93 Modelled: 84 Confidence: 96.4% Identity: 12% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:dsre/dsrf-like family protein; PDBTitle: crystal structure of dsre/dsrf-like family protein (np_342589.1) from2 sulfolobus solfataricus at 1.49 a resolution Phyre2 PDB 1l1s chain A Region: 26 - 87 Aligned: 61 Modelled: 62 Confidence: 88.3% Identity: 15% Fold: DsrEFH-like Superfamily: DsrEFH-like Family: DsrEF-like Phyre2 PDB 2qs7 chain D Region: 26 - 93 Aligned: 67 Modelled: 68 Confidence: 88.0% Identity: 12% PDB header:oxidoreductase Chain: D: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative oxidoreductase of the dsre/dsrf-like2 family (sso1126) from sulfolobus solfataricus p2 at 2.09 a resolution Phyre2 PDB 2pd2 chain A Region: 12 - 88 Aligned: 77 Modelled: 77 Confidence: 67.8% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein st0148; PDBTitle: crystal structure of (st0148) conserved hypothetical from sulfolobus2 tokodaii strain7 Phyre2 PDB 3pnx chain F Region: 42 - 93 Aligned: 51 Modelled: 52 Confidence: 51.0% Identity: 14% PDB header:transferase Chain: F: PDB Molecule:putative sulfurtransferase dsre; PDBTitle: crystal structure of a putative sulfurtransferase dsre (swol_2425)2 from syntrophomonas wolfei str. goettingen at 1.92 a resolution Phyre2 PDB 2pk0 chain C Region: 21 - 77 Aligned: 56 Modelled: 57 Confidence: 24.2% Identity: 25% PDB header:signaling protein Chain: C: PDB Molecule:serine/threonine protein phosphatase stp1; PDBTitle: structure of the s. agalactiae serine/threonine phosphatase at 2.652 resolution Phyre2 PDB 3pu9 chain A Region: 21 - 41 Aligned: 21 Modelled: 21 Confidence: 21.6% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:protein serine/threonine phosphatase; PDBTitle: crystal structure of serine/threonine phosphatase sphaerobacter2 thermophilus dsm 20745 Phyre2 PDB 3t9q chain B Region: 21 - 35 Aligned: 15 Modelled: 15 Confidence: 11.8% Identity: 40% PDB header:hydrolase Chain: B: PDB Molecule:stage ii sporulation protein e; PDBTitle: structure of the phosphatase domain of the cell fate determinant2 spoiie from bacillus subtilis (mn presoaked) Phyre2 PDB 1txo chain A Region: 21 - 77 Aligned: 55 Modelled: 57 Confidence: 11.5% Identity: 27% Fold: PP2C-like Superfamily: PP2C-like Family: PP2C-like Phyre2 PDB 1eg4 chain A Region: 77 - 95 Aligned: 19 Modelled: 19 Confidence: 11.1% Identity: 26% PDB header:structural protein Chain: A: PDB Molecule:dystrophin; PDBTitle: structure of a dystrophin ww domain fragment in complex2 with a beta-dystroglycan peptide Phyre2 PDB 2j82 chain A Region: 21 - 47 Aligned: 27 Modelled: 27 Confidence: 10.2% Identity: 37% PDB header:hydrolase Chain: A: PDB Molecule:protein serine-threonine phosphatase; PDBTitle: structural analysis of the pp2c family phosphatase tppha2 from thermosynechococcus elongatus Phyre2 PDB 2jfs chain A Region: 21 - 77 Aligned: 55 Modelled: 57 Confidence: 9.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:ser-thr phosphatase mspp; PDBTitle: crystal structure of the ppm ser-thr phosphatase mspp from2 mycobacterium smegmatis in complex with cacodylate Phyre2 1 d2d1pc1 2 d2hy5c1 3 d1x9aa_ 4 d2d1pb1 5 d1jx7a_ 6 d2hy5b1 7 d2hy5a1 8 d2d1pa1 9 c3mc3A_ 10 d1l1sa_ 11 c2qs7D_ 12 c2pd2A_ 13 c3pnxF_ 14 c2pk0C_ 15 c3pu9A_ 16 c3t9qB_ 17 d1txoa_ 18 c1eg4A_ 19 c2j82A_ 20 c2jfsA_ 21 22 23 24 25 26 27 28 29

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2d1pc1 100.0 100 Fold:DsrEFH-like Superfamily:DsrEFH-like Family:DsrH-like 2 d2hy5c1 100.0 35 Fold:DsrEFH-like Superfamily:DsrEFH-like Family:DsrH-like 3 d1x9aa_ 100.0 28 Fold:DsrEFH-like Superfamily:DsrEFH-like Family:DsrH-like 4 d2d1pb1 99.2 20 Fold:DsrEFH-like Superfamily:DsrEFH-like Family:DsrEF-like 5 d1jx7a_ 98.7 18 Fold:DsrEFH-like Superfamily:DsrEFH-like Family:DsrEF-like 6 d2hy5b1 98.7 24 Fold:DsrEFH-like Superfamily:DsrEFH-like Family:DsrEF-like 7 d2hy5a1 98.6 15 Fold:DsrEFH-like Superfamily:DsrEFH-like Family:DsrEF-like 8 d2d1pa1 98.4 14 Fold:DsrEFH-like Superfamily:DsrEFH-like Family:DsrEF-like 9 c3mc3A_ 96.4 12 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:dsre/dsrf-like family protein; PDBTitle: crystal structure of dsre/dsrf-like family protein (np_342589.1) from2 sulfolobus solfataricus at 1.49 a resolution 10 d1l1sa_ 88.3 15 Fold:DsrEFH-like Superfamily:DsrEFH-like Family:DsrEF-like 11 c2qs7D_ 88.0 12 PDB header:oxidoreductase Chain: D: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of a putative oxidoreductase of the dsre/dsrf-like2 family (sso1126) from sulfolobus solfataricus p2 at 2.09 a resolution 12 c2pd2A_ 67.8 17 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein st0148; PDBTitle: crystal structure of (st0148) conserved hypothetical from sulfolobus2 tokodaii strain7 13 c3pnxF_ 51.0 14 PDB header:transferase Chain: F: PDB Molecule:putative sulfurtransferase dsre; PDBTitle: crystal structure of a putative sulfurtransferase dsre (swol_2425)2 from syntrophomonas wolfei str. goettingen at 1.92 a resolution 14 c2pk0C_ 24.2 25 PDB header:signaling protein Chain: C: PDB Molecule:serine/threonine protein phosphatase stp1; PDBTitle: structure of the s. agalactiae serine/threonine phosphatase at 2.652 resolution 15 c3pu9A_ 21.6 24 PDB header:transferase Chain: A: PDB Molecule:protein serine/threonine phosphatase; PDBTitle: crystal structure of serine/threonine phosphatase sphaerobacter2 thermophilus dsm 20745 16 c3t9qB_ 11.8 40 PDB header:hydrolase Chain: B: PDB Molecule:stage ii sporulation protein e; PDBTitle: structure of the phosphatase domain of the cell fate determinant2 spoiie from bacillus subtilis (mn presoaked) 17 d1txoa_ 11.5 27 Fold:PP2C-like Superfamily:PP2C-like Family:PP2C-like 18 c1eg4A_ 11.1 26 PDB header:structural protein Chain: A: PDB Molecule:dystrophin; PDBTitle: structure of a dystrophin ww domain fragment in complex2 with a beta-dystroglycan peptide 19 c2j82A_ 10.2 37 PDB header:hydrolase Chain: A: PDB Molecule:protein serine-threonine phosphatase; PDBTitle: structural analysis of the pp2c family phosphatase tppha2 from thermosynechococcus elongatus 20 c2jfsA_ 9.0 22 PDB header:hydrolase Chain: A: PDB Molecule:ser-thr phosphatase mspp; PDBTitle: crystal structure of the ppm ser-thr phosphatase mspp from2 mycobacterium smegmatis in complex with cacodylate 21 c2cm1A_ not modelled 7.7 33 PDB header:hydrolase Chain: A: PDB Molecule:serine threonine protein phosphatase pstp; PDBTitle: crystal structure of the catalytic domain of serine2 threonine protein phosphatase pstp in complex with3 2 manganese ions. 22 d1e8ca2 not modelled 7.7 17 Fold:MurD-like peptide ligases, peptide-binding domain Superfamily:MurD-like peptide ligases, peptide-binding domain Family:MurCDEF C-terminal domain 23 c3rnrB_ not modelled 6.9 40 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:stage ii sporulation e family protein; PDBTitle: crystal structure of stage ii sporulation e family protein from2 thermanaerovibrio acidaminovorans 24 c1dbgA_ not modelled 6.8 13 PDB header:lyase Chain: A: PDB Molecule:chondroitinase b; PDBTitle: crystal structure of chondroitinase b 25 c3h4sE_ not modelled 6.7 29 PDB header:motor protein/calcium binding protein Chain: E: PDB Molecule:kcbp interacting ca2+-binding protein; PDBTitle: structure of the complex of a mitotic kinesin with its2 calcium binding regulator 26 c3epmB_ not modelled 6.3 18 PDB header:biosynthetic protein Chain: B: PDB Molecule:thiamine biosynthesis protein thic; PDBTitle: crystal structure of caulobacter crescentus thic 27 c2wtzC_ not modelled 5.6 17 PDB header:ligase Chain: C: PDB Molecule:udp-n-acetylmuramoyl-l-alanyl-d-glutamate- PDBTitle: mure ligase of mycobacterium tuberculosis 28 c2i18A_ not modelled 5.6 18 PDB header:metal binding protein Chain: A: PDB Molecule:calcium-binding protein; PDBTitle: the refined structure of c-terminal domain of an ef-hand2 calcium binding protein from entamoeba histolytica 29 d1xm7a_ not modelled 5.5 27 Fold:Metallo-dependent phosphatases Superfamily:Metallo-dependent phosphatases Family:Hypothetical protein aq 1666

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0