Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	T	L	L	L	L	A	A	L	S	S	Q	I	T	F	N	T	T	Q	Q	G	D	V	Y	T	I	I	P	E	V	T	L	T	Q	S	C	L	C	R	V	Q	I	L	S	L	R	E	G	S	S	G	Q	S	Q	T	K	Q	E	K
Secondary structure
SS confidence
Disorder		?	?	?	?			?	?		?	?	?																																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110
Sequence		T	L	S	L	P	A	N	Q	P	I	A	L	T	K	L	S	L	N	I	S	P	D	D	R	V	K	I	V	V	T	V	S	D	G	Q	S	L	H	L	S	Q	Q	W	P	P	S	S	E	K	S
Secondary structure
SS confidence
Disorder					?		?	?	?				?																							?					?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2xsk chain A Region: 11 - 105 Aligned: 93 Modelled: 95 Confidence: 100.0% Identity: 98% PDB header:chaperone Chain: A: PDB Molecule:csgc; PDBTitle: e. coli curli protein csgc - secys Phyre2 PDB 1x9l chain A Region: 33 - 100 Aligned: 67 Modelled: 68 Confidence: 42.4% Identity: 19% Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily: DR1885-like metal-binding protein Family: DR1885-like metal-binding protein Phyre2 PDB 1x99 chain A Region: 11 - 100 Aligned: 88 Modelled: 89 Confidence: 42.1% Identity: 16% Fold: Cytolysin/lectin Superfamily: Cytolysin/lectin Family: Fungal fruit body lectin Phyre2 PDB 2ofe chain A Region: 11 - 100 Aligned: 88 Modelled: 90 Confidence: 33.1% Identity: 15% PDB header:sugar binding protein Chain: A: PDB Molecule:sclerotium rolfsii lectin; PDBTitle: the crystal structure of sclerotium rolfsii lectin in complex with n-2 acetyl-d-glucosamine Phyre2 PDB 2k6z chain A Region: 31 - 100 Aligned: 70 Modelled: 70 Confidence: 30.9% Identity: 14% PDB header:metal transport Chain: A: PDB Molecule:putative uncharacterized protein ttha1943; PDBTitle: solution structures of copper loaded form pcua (trans2 conformation of the peptide bond involving the nitrogen of3 p14) Phyre2 PDB 2yhg chain A Region: 56 - 100 Aligned: 33 Modelled: 45 Confidence: 16.2% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:cellulose-binding protein; PDBTitle: ab initio phasing of a nucleoside hydrolase-related hypothetical2 protein from saccharophagus degradans that is associated with3 carbohydrate metabolism Phyre2 PDB 1dki chain A Region: 76 - 97 Aligned: 22 Modelled: 22 Confidence: 16.1% Identity: 23% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Papain-like Phyre2 PDB 1ex0 chain A domain 1 Region: 47 - 86 Aligned: 40 Modelled: 40 Confidence: 15.5% Identity: 13% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Transglutaminase N-terminal domain Phyre2 PDB 2wda chain A Region: 31 - 100 Aligned: 70 Modelled: 70 Confidence: 15.0% Identity: 14% PDB header:lyase Chain: A: PDB Molecule:putative secreted lyase; PDBTitle: the x-ray structure of the streptomyces coelicolor a32 chondroitin ac lyase in complex with chondroitin sulphate Phyre2 PDB 2e7m chain A Region: 49 - 103 Aligned: 49 Modelled: 55 Confidence: 13.7% Identity: 33% PDB header:structural protein Chain: A: PDB Molecule:protein kiaa0319; PDBTitle: solution structure of the pkd domain (329-428) from human2 kiaa0319 Phyre2 PDB 1pvj chain A Region: 76 - 97 Aligned: 22 Modelled: 22 Confidence: 13.7% Identity: 23% Fold: Cysteine proteinases Superfamily: Cysteine proteinases Family: Papain-like Phyre2 PDB 3bb7 chain A Region: 76 - 97 Aligned: 22 Modelled: 22 Confidence: 12.3% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:interpain a; PDBTitle: structure of prevotella intermedia prointerpain a fragment 39-3592 (mutant c154a) Phyre2 PDB 2kj6 chain A Region: 80 - 107 Aligned: 28 Modelled: 28 Confidence: 12.2% Identity: 21% PDB header:chaperone Chain: A: PDB Molecule:tubulin folding cofactor b; PDBTitle: nmr solution structure of a tubulin folding cofactor b2 obtained from arabidopsis thaliana: northeast structural3 genomics consortium target ar3436a Phyre2 PDB 1w8o chain A domain 1 Region: 76 - 100 Aligned: 25 Modelled: 25 Confidence: 12.2% Identity: 16% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: E-set domains of sugar-utilizing enzymes Phyre2 PDB 2ys4 chain A Region: 49 - 108 Aligned: 59 Modelled: 60 Confidence: 11.1% Identity: 22% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hydrocephalus-inducing protein homolog; PDBTitle: solution structure of the n-terminal papd-like domain of2 hydin protein from human Phyre2 PDB 1vjj chain A domain 1 Region: 38 - 86 Aligned: 49 Modelled: 49 Confidence: 10.4% Identity: 16% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Transglutaminase N-terminal domain Phyre2 PDB 2q3z chain A domain 1 Region: 48 - 86 Aligned: 39 Modelled: 39 Confidence: 10.3% Identity: 36% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: Transglutaminase N-terminal domain Phyre2 PDB 1z8g chain A domain 2 Region: 40 - 54 Aligned: 15 Modelled: 15 Confidence: 10.0% Identity: 20% Fold: SRCR-like Superfamily: SRCR-like Family: Hepsin, N-terminal domain Phyre2 PDB 2ezv chain A Region: 46 - 78 Aligned: 33 Modelled: 33 Confidence: 8.3% Identity: 27% PDB header:hydrolase/dna Chain: A: PDB Molecule:type ii restriction enzyme sfii; PDBTitle: crystal structure of tetrameric restriction endonuclease2 sfii bound to cognate dna. Phyre2 PDB 1ekr chain A Region: 64 - 92 Aligned: 29 Modelled: 29 Confidence: 7.8% Identity: 31% Fold: Ferredoxin-like Superfamily: Molybdenum cofactor biosynthesis protein C, MoaC Family: Molybdenum cofactor biosynthesis protein C, MoaC Phyre2 1 c2xskA_ 2 d1x9la_ 3 d1x99a_ 4 c2ofeA_ 5 c2k6zA_ 6 c2yhgA_ 7 d1dkia_ 8 d1ex0a1 9 c2wdaA_ 10 c2e7mA_ 11 d1pvja_ 12 c3bb7A_ 13 c2kj6A_ 14 d1w8oa1 15 c2ys4A_ 16 d1vjja1 17 d2q3za1 18 d1z8ga2 19 c2ezvA_ 20 d1ekra_ 21 22 23 24 25 26 27 28 29

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2xskA_ 100.0 98 PDB header:chaperone Chain: A: PDB Molecule:csgc; PDBTitle: e. coli curli protein csgc - secys 2 d1x9la_ 42.4 19 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:DR1885-like metal-binding protein Family:DR1885-like metal-binding protein 3 d1x99a_ 42.1 16 Fold:Cytolysin/lectin Superfamily:Cytolysin/lectin Family:Fungal fruit body lectin 4 c2ofeA_ 33.1 15 PDB header:sugar binding protein Chain: A: PDB Molecule:sclerotium rolfsii lectin; PDBTitle: the crystal structure of sclerotium rolfsii lectin in complex with n-2 acetyl-d-glucosamine 5 c2k6zA_ 30.9 14 PDB header:metal transport Chain: A: PDB Molecule:putative uncharacterized protein ttha1943; PDBTitle: solution structures of copper loaded form pcua (trans2 conformation of the peptide bond involving the nitrogen of3 p14) 6 c2yhgA_ 16.2 21 PDB header:hydrolase Chain: A: PDB Molecule:cellulose-binding protein; PDBTitle: ab initio phasing of a nucleoside hydrolase-related hypothetical2 protein from saccharophagus degradans that is associated with3 carbohydrate metabolism 7 d1dkia_ 16.1 23 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:Papain-like 8 d1ex0a1 15.5 13 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Transglutaminase N-terminal domain 9 c2wdaA_ 15.0 14 PDB header:lyase Chain: A: PDB Molecule:putative secreted lyase; PDBTitle: the x-ray structure of the streptomyces coelicolor a32 chondroitin ac lyase in complex with chondroitin sulphate 10 c2e7mA_ 13.7 33 PDB header:structural protein Chain: A: PDB Molecule:protein kiaa0319; PDBTitle: solution structure of the pkd domain (329-428) from human2 kiaa0319 11 d1pvja_ 13.7 23 Fold:Cysteine proteinases Superfamily:Cysteine proteinases Family:Papain-like 12 c3bb7A_ 12.3 27 PDB header:hydrolase Chain: A: PDB Molecule:interpain a; PDBTitle: structure of prevotella intermedia prointerpain a fragment 39-3592 (mutant c154a) 13 c2kj6A_ 12.2 21 PDB header:chaperone Chain: A: PDB Molecule:tubulin folding cofactor b; PDBTitle: nmr solution structure of a tubulin folding cofactor b2 obtained from arabidopsis thaliana: northeast structural3 genomics consortium target ar3436a 14 d1w8oa1 12.2 16 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:E-set domains of sugar-utilizing enzymes 15 c2ys4A_ 11.1 22 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hydrocephalus-inducing protein homolog; PDBTitle: solution structure of the n-terminal papd-like domain of2 hydin protein from human 16 d1vjja1 10.4 16 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Transglutaminase N-terminal domain 17 d2q3za1 10.3 36 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Transglutaminase N-terminal domain 18 d1z8ga2 10.0 20 Fold:SRCR-like Superfamily:SRCR-like Family:Hepsin, N-terminal domain 19 c2ezvA_ 8.3 27 PDB header:hydrolase/dna Chain: A: PDB Molecule:type ii restriction enzyme sfii; PDBTitle: crystal structure of tetrameric restriction endonuclease2 sfii bound to cognate dna. 20 d1ekra_ 7.8 31 Fold:Ferredoxin-like Superfamily:Molybdenum cofactor biosynthesis protein C, MoaC Family:Molybdenum cofactor biosynthesis protein C, MoaC 21 c3h8dC_ not modelled 7.8 29 PDB header:motor protein/signaling protein Chain: C: PDB Molecule:myosin-vi; PDBTitle: crystal structure of myosin vi in complex with dab2 peptide 22 c2ideE_ not modelled 7.4 31 PDB header:biosynthetic protein Chain: E: PDB Molecule:molybdenum cofactor biosynthesis protein c; PDBTitle: crystal structure of the molybdenum cofactor biosynthesis protein c2 (ttha1789) from thermus theromophilus hb8 23 c2xr4A_ not modelled 6.9 17 PDB header:sugar binding protein Chain: A: PDB Molecule:lectin; PDBTitle: c-terminal domain of bc2l-c lectin from burkholderia cenocepacia 24 d2zkmx2 not modelled 6.7 23 Fold:C2 domain-like Superfamily:C2 domain (Calcium/lipid-binding domain, CaLB) Family:PLC-like (P variant) 25 d1g0da1 not modelled 5.7 22 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:Transglutaminase N-terminal domain 26 c2zq0B_ not modelled 5.6 19 PDB header:hydrolase Chain: B: PDB Molecule:alpha-glucosidase (alpha-glucosidase susb); PDBTitle: crystal structure of susb complexed with acarbose 27 c2jnzA_ not modelled 5.2 9 PDB header:allergen Chain: A: PDB Molecule:phl p 3 allergen; PDBTitle: solution structure of phl p 3, a major allergen from2 timothy grass pollen 28 d1v7wa2 not modelled 5.1 18 Fold:Supersandwich Superfamily:Galactose mutarotase-like Family:Glycosyltransferase family 36 N-terminal domain 29 c2emcA_ not modelled 5.1 64 PDB header:transcription Chain: A: PDB Molecule:zinc finger protein 473; PDBTitle: solution structure of the c2h2 type zinc finger (region 641-2 673) of human zinc finger protein 473

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0